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Scholarly Interest Report
         
Ramon Gonzalez
Professor
Professor in Chemical and Biomolecular Engineering; Associate Professor of Bioegineering
 
e-mail:Ramon.Gonzalez@rice.edu
 
  • Ph.D. Chemical Engineering (2001) University of Chile, Chile
  • M.S. Biochemical Engineering (1999) Catholic University of Valparaiso, Chile, Chile
  • B.S. Chemical Engineering (1993) Central University of Las Villas, Cuba, Cuba
 
Primary Department
   Department of Chemical and Biomolecular Engineering
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Department Affiliations
 
  • Department of Bioengineering
  •  
    Websites
     Gonzalez_ARPA-E
     Gonzalez_CHBE
     Gonzalez_EEi
     Gonzalez_Research Group
     Metabolic Engineering and Synthetic & Systems Biology Laboratory
     Department Faculty Page
     The Gonzalez Research Group: Metabolic Engineering and Systems Biology Laboratory
     
    Research Areas
     Metabolic Engineering and Synthetic Biology Microbial and Cellular Metabolism Functional Genomics and Systems Biology
     

    Metabolic Engineering and Synthetic & Systems Biology Laboratory

     

    The full potential of biological systems remains unrealized due to critical knowledge gaps in our understanding of how these systems function and in our ability to engineer and control them. Our research group seeks to fill in these gaps by: 1) designing and implementing novel approaches to engineer biological systems; and 2) elucidating the metabolic and regulatory networks that control the functioning of biological systems. Our ultimate goal is to effectively engineer biology and enable applications in energy and chemical production, environmental remediation, pharmaceutical production, and agricultural systems.


    Our research program is organized into two general areas: 1) Metabolic Engineering and Synthetic Biology; and 2) Microbial and Cellular Metabolism. Our laboratory has successfully:


    - engineered a functional reversal of the b-oxidation cycle as an efficient platform for the synthesis of higher-chain (C ≥ 4) fuels and chemicals;


    - established a new metabolic engineering platform for the production of fuels and chemicals using glycerol as the carbon source;


    - discovered that E. coli and other bacteria can anaerobically ferment glycerol, a previously unknown metabolic capability of this organism, establishing a new paradigm for the fermentative metabolism of glycerol in bacteria; and


    - developed and used systems biology tools to achieve an improved understanding of carbon and energy metabolism in bacterial and mammalian cell cultures


     


    Metabolic Engineering and Synthetic Biology


     


    Metabolic engineering and synthetic biology are emerging disciplines that enable the design and engineering of biological systems for a wide range of applications. In this area, we have pioneered the engineering of glycerol fermentation and metabolism of waste fatty acids for the synthesis of fuels and chemicals and the development of a functional reversal of the b-oxidation cycle as an efficient platform for the synthesis of longer-chain (C ≥ 4) products.


    The knowledge base created by fundamental studies of glycerol metabolism in our laboratory (see Microbial and Cellular Metabolism below) has laid the foundation to establish glycerol fermentation as a new metabolic engineering platform for fuel and chemical production. We pioneered the engineering of bacteria to efficiently convert glycerol to fuels and chemicals such as succinate, ethanol, hydrogen, formate, and D-lactate. We have also established a novel platform for the production of fuels and chemicals from fatty acid-rich feedstocks by engineering a respiro-fermentative metabolic mode that enables the efficient production of target products in combination with adequate catabolism of FAs. For the first time, we engineered efficient synthesis of ethanol, butanol, acetate, acetone, isopropanol, succinate, and propionate from fatty acids in bacteria.


    Advanced, higher-chain (C ≥ 4) fuels and chemicals are generated from short-chain, 2- or 3-C metabolic intermediates through pathways that require carbon-chain elongation. While we have engineered native carbon-chain elongation pathways, such as the fatty acid biosynthesis pathway, to produce higher-chain molecules like methylketones, this pathway suffers from major energy constraints. Motivated in part by these limitations, we recently engineered a functional reversal of the β-oxidation cycle that can be used as a general platform for the synthesis of short-, medium- and long-chain products with structural and functional diversity. Through a systems-level, quantitative assessment of the metabolic capabilities of the engineered reversal of the β-oxidation cycle, we demonstrated that product synthesis can be coupled to cell growth and achieved at high fluxes, titers and yields. The superior capabilities of the β-oxidation reversal, when compared to other pathways used for carbon-chain elongation, originate from its higher energetic efficiency, which is enabled by the use of acetyl-CoA as an extender unit. This engineered b-oxidation reversal is currently being exploited in our laboratory for the production of alcohols, alkanes, and omega-functionalized products.


    Our laboratory, in collaboration with Dr. Wong and Dr. Halas, has recently explored the engineering of light-triggered bionanoparticles (LTBNP) for cellular reprogramming. In this concept, a laser is used as a discrete signal that leads to localized photothermal heating of LTBNPs, which in turn control protein and cellular functioning. Our first publication in this area demonstrated the in vitro feasibility of this concept.


     


    Microbial and Cellular Metabolism


     


    Metabolism is a complex system that encompasses all biochemical reactions and processes that occur in living organisms along with their interaction and regulation. Our incomplete knowledge of metabolism greatly limits our ability to engineer biological systems. To address this issue, our laboratory engages in fundamental studies that contribute to the creation of the knowledge base require to the effective engineering of metabolism.


    Our discovery that the bacterium E. coli can anaerobically ferment glycerol led us to propose a new model for the fermentative utilization of glycerol in E. coli and other bacteria. The knowledge base created by these studies enabled the engineering of bacteria for the synthesis of a wide arrange of products, as described under “Metabolic Engineering & Synthetic Biology”.


    We have demonstrated that using a system-level approach provides an unprecedented understanding of microbial metabolism otherwise not achievable through classical biochemical and molecular genetic approaches. For example, using in silico and in vivo metabolic flux analysis we discovered the role of the pyruvate dehydrogenase complex on the fermentative metabolism of glucuronate and glucose in E. coli. Prior to the work conducted in our laboratory, the role of PDHC in the fermentative metabolism of E. coli remained unknown and this enzyme was thought unable to support fermentative growth. In this area we have also developed new methods and tools that facilitate the system-level analysis of microbial and cellular metabolism.


    We have also used system-level methods and tools to elucidate key aspects of microbial and cellular metabolism. For example, we conducted a quantitative analysis of the fermentative metabolism of glycerol in E. coli through the use of kinetic modeling and Metabolic Control Analysis and elucidated the control structure of the pathways involved in glycerol utilization and ethanol synthesis. These findings were then used to identify key targets for genetic manipulation that enhanced product synthesis. Similar approaches enabled an improved understanding of apoptosis in Chinese Hamster Ovary (CHO) cell cultures during the production of recombinant proteins and the anaerobic metabolism of E. coli during glucose fermentation. We have also continued fundamental studies to establish the mechanisms and pathways enabling glycerol fermentation in bacteria. 

     
    Teaching Areas
     Metabolic Engineering
    Transport Phenomena II
    Undergraduate Chemical Engineering Laboratory
     
    Selected Publications
     Abstracts
     Gonzalez, R. Murarka. A., Dharmadi, Y., and Yazdani, S. S. (2008). A New Model for the Anaerobic Fermentation of Glycerol in Enteric Bacteria: Trunk and Auxiliary Pathways in Escherichia coli. Metab. Eng. 10 (5): 234-245.
     
     4. Yazdani, S. S., and Gonzalez, R. (2008). Engineering Escherichia coli for the Efficient Conversion of Glycerol to Ethanol and co-Products. Metab. Eng. 10 (6): 340-351.
     
     Murarka. A., Dharmadi, Y., Yazdani, S. S., and Gonzalez, R. (2008). Fermentative Utilization of Glycerol in Escherichia coli and its Implications for the Production of Fuels and Chemicals. App. Environ. Microbiol. 74 (4): 1124-1135
     
     Refereed articles
     

    Cintolesi, A., Clomburg, J.M., Gonzalez, R. (2014). In silico assessment of the metabolic capabilities of an engineered functional reversal of the β-oxidation cycle for the synthesis of longer-chain (C ≥ 4) productsMetabolic Engineering. 23: 100-115.

     
     

    Clomburg, J.M., Blankschien, M. D., Vick, J.E., Chou, A., Kim, S., and Gonzalez, R.* (2015). "Integrated engineering of β-oxidation reversal and ω-oxidation pathways for the synthesis of medium chain ω-functionalized carboxylic acids. ." Metab. Eng. (DOI: 10.1016/j.ymben.2015.01.007).In Press

     
     

    Conrado, R., and Gonzalez R. (2014). Envisioning the Bioconversion of Methane to Liquid FuelsScience. 343(6171): 621-623.

     
     

    Haynes. C.A., and Gonzalez, R. (2014). Rethinking biological activation of methane and conversion to liquid fuelsNat. Chem. Biol. 10, 331-339.

     
     

    Kim, S., Clomburg, J.M., and Gonzalez, R. (2015). Synthesis of medium-chain length (C6-C10) products via β-oxidation reversal in Escherichia coli. " J. Industrial Microbiol. Biotechnol. (DOI: 10.1007/s10295-015-1589-6).." In Press

     
     

    Vergara, M., Becerra, S., Berrios, J., Osses, N., Reyes, J., Rodriguez-Moya, M., Gonzalez, R. Altamirano, C. (2014).Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.PLoS ONE. 9(4): e93865. DOI: 10.1371/journal.pone.0093865.

     
     

    Vick, J.E., Clomburg, J.M., Blankschien, M. D., Chou, A., Kim, S., and Gonzalez, R.* (2015). "Escherichia coli enoyl-acyl carrier protein reductase (FabI) supports efficient operation of a functional reversal of the β-oxidation cycle. ." Appl. Environ. Microbiol. (In Press: doi:10.1128/AEM.03521-14).In Press

     
     

    Zhao, Z., Arentz, J., Pretzer, L.A., Limpornpipat, P., Clomburg, J.M., Gonzalez, R., Schweitzer, N., Wu, T., Miller, J.T., and Wong, M.W. (2014). "Volcano-shape glycerol oxidation activity of palladium-decorated gold nano particles." Chem. Sci. , 5: 3715-3728.

     
     

     Mattam A.J, Clomburg J.M., Gonzalez R., Yazdani S.S. (2013). Fermentation of glycerol and production of valuable chemical and biofuel molecules. Biotechnology Letters. 35(6): 831-842.

     
     

    Blankschien, M., Pretzer, L., Huschka, R., Halas, H., Gonzalez, R., Wong, M. (2013). Light-tiggered biocatalysis using thermophilic enzyme-gold nanoparticle complexesACS Nano. 7(1): 654-663.

     
     

    Cintolesi, A., Rodriguez-Moya, M., and Gonzalez, R. (2013). Fatty Acid Oxidation: Systems Analysis and Applications. WIREs System Biology and Medicine. 5(5): 575-585.

     
     

    Clomburg, J.M., and Gonzalez, R. (2013). Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicalsTrends in Biotechnology. 31(1): 20-28.

     
     

    Gonzalez R. (2013). Metabolic engineering: Use of system-level approaches and application to fuel production in Escherichia coliElectronic Journal of Biotechnology. 16(3): 13.

     
     

    Mazumdar, S., Blankschien, M. D., Clomburg, J. M., and Gonzalez, R. (2013). Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coliMicrobial Cell Factories. 12(7).

     
     

    Rastogi G., Gurram R., Bhalla A., Gonzalez R., Bischoff K., Hughes S., Kumar S., and Sani R.K. (2013). Presence of glucose, xylose, and glycerol fermenting bacteria in the deep biosphere of the former Homestake gold mine, South DakotaFrontier in Microbiotechnology, Ecotoxicology and Bioremediation. 4: 18.

     
     

    Cintolesi, A., Clomburg, J.M., Rigou, V., Zygourakis, K., and Gonzalez, R. (2012). Quantitative analysis of the fermentative metabolism of glycerol in Escherichia coliBiotechnology and Bioengineering, 109 (1): 187-198.

     
     

    Clomburg, J.M., Vick, J.E., Blankschien, M. D., Rodriguez-Moya, M., Gonzalez, R. (2012). A synthetic biology approach to engineer a functional reversal of the beta-oxidation cycleACS Synthetic Biology. 1(11): 541-554.

     
     

    Park, J., Rodríguez-Moyá, M., Li, M., Pichersky, E., San, K-Y., Gonzalez, R. (2012). Synthesis of methyl ketones by metabolically engineered Escherichia coli. Journal of Industrial Microbiology and Biotechnology. 39 (11): 1703-1712.

     
     

    Posada, J.A., Cardona, C.A., and Gonzalez, R. (2012). Analysis of the production process of optically pure D-lactic acid from raw glycerol using engineered Escherichia coli strainsApplied Biochemistry and Biotechnology. 166 (3): 680-699.

     
     

    Becerra, S., Vergara, M., Gonzalez, R., Osses, N., Altamirano, C. (2011). Condition of mild hypothermia does not promote an increase in specific productivity of recombinant protein at high specific growth rate. Current Opinion in Biotechnology, 22 (S1): S35-S36.

     
     

    Berrios, J., Altamirano, C., Osses, N., Gonzalez, R. (2011). Continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source: metabolic analysis and scale-up simulationChemical Engineering Science, 66 (11): 2431-2439.

     
     

    Dellomonaco, C., Clomburg, J.M., Miller, E.N., and Gonzalez, R. (2011). Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals. Nature, 476: 355-359. Featured in the Research Highlights Section of the Journal Nature Chemical Biology.

     
     

    Zhu, H., Gonzalez, R., and Bobik, T.A. (2011). Co-production of acetaldehyde and hydrogen from glucose fermentation by Escherichia coliApplied and Environmental Microbiology. 77 (18): 6441-6450.

     
     

    Berrios, J., Gonzalez, R., and Altamirano, C. (2011). Metabolic analysis of continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source. Chem. Eng. Sci. (MS in Review, Revisions Returned).

     
     

    Blankschien, M. D., Clomburg, J. M., and Gonzalez, R.* (2010). Metabolic engineering of Escherichia coli for the production of succinate from glycerol. Metab. Eng. 12 (5): 409-419. 

     
     

    Choudhary, M. K., Moon, J. Y., Gonzalez, R., and Shanks, J.V. (2011). Re-examination of Metabolic Fluxes in Escherichia coli during Anaerobic Fermentation of Glucose Using 13C Labeling Experiments and 2-dimensional Nuclear Magnetic Resonance (NMR) Spectroscopy. Biotechnol. Bioprocess. Eng. (In Press).

     
     

    Clomburg, J. M., and Gonzalez, R.* (2010). Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology. App. Microbiol. Biotechnol. 86 (2): 419-434.

     
     

    Clomburg, J., and Gonzalez, R.* (2011). Metabolic engineering of Escherichia coli for the production of 1,2-propanediol from glycerol. Biotechnol. Bioeng. (In Press, DOI 10.1002/bit.22993)

     
     

    Dellomonaco, C., Fava, F., and Gonzalez, R.* (2010). The path to next generation biofuels: successes and challenges in the era of metabolic engineering and synthetic biology. Microbial Cell Factories 9:3.

     
     

    Dellomonaco, C., Rivera, C., Campbell, P., and Gonzalez, R.* (2010). Engineered respiro-fermentative metabolism for the production of biofuels and biochemicals from fatty acid-rich feedstocks. Appl. Environ. Microbiol. 76 (15): 5067-5078

     
     

    Dharmadi, Y., and Gonzalez, R.* (2010). Elementary Network Reconstruction: A framework for the analysis of regulatory networks in biological systems. J. Theor. Biol. 263(4): 499-509. 

     
     

    Gonzalez R.*, Campbell, P., and Wong, M. (2010). Production of ethanol from thin stillage by metabolically engineered Escherichia coli. Biotechnol. Lett. 32 (3): 405-411. 

     
     

    Mazumdar, S., Clomburg, J. M., and Gonzalez, R.* (2011). Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli. Microb. Cell Fact. (MS in Review).

     
     

    Mazumdar, S., Clomburg, J. M., and Gonzalez, R.* (2010). Engineered Escherichia coli strains for the homofermentative production of D-lactic acid from glycerol. Appl. Environ. Microbiol. 76 (13): 4327-4336.

     
     

    Murarka, A., Clomburg, J. M., Moran, S., Shanks, J.V., and Gonzalez, R.* (2010). Metabolic analysis of wild-type Escherichia coli and a pyruvate dehydrogenase complex (PDHC)-deficient derivative reveals the role of PDHC in the fermentative metabolism of glucose. J. Biol. Chem. 285 (41): 31548-31558

     
     

    Murarka, A., Clomburg, J., and Gonzalez, R.* (2010). Metabolic flux analysis of wild-type Escherichia coli and mutants deficient in pyruvate-dissimilating enzymes during fermentative metabolism of glucuronate. Microbiology-SGM 156 (6): 1860 - 1872. 

     
     

    Rodriguez-Moya, M., and Gonzalez, R.* (2010). Systems biology approaches for the microbial production of biofuels. Biofuels 1(2): 291–310.

     
    Presentations
     Invited Talks
     

    "14th World XTL Summit, London, UK, 2014.."

     
     

    "5th Annual Next Generation Bio-Based & Sustainable Chemicals Summit, San Diego, CA, 2014.."

     
     

    "Advanced Biofuels Leadership Conference, Washington, DC, 2014.."

     
     

    "Cold Spring Harbor Laboratory (CSHL), Cold Spring Harbor, NY, 2014.."

     
     

    "Colorado State University, Department of Chemical & Biological Engineering, Fort Collins, CO, 2014.."

     
     

    "Energy Frontiers International, Gas-to-Market & Energy Conversion Forum, Pittsburgh, PA, 2014."

     
     

    "ExxonMobil, Annandale, NJ, 2014.."

     
     

    "SMi’s 17th Annual GTL Conference, London, UK, 2014.."

     
     

    "SMi’s GTL North America Conference, Houston, TX, 2014.."

     
     

    "Symposium on Microbial Biotechnology for Production of Advanced Biofuels and Biochemicals, 114th ASM General Meeting, Boston, MA, 2014.."

     
     

    "The 5th International Symposium of Innovative BioProduction Kobe (iBioK), Kobe University, Japan, 2014.."

     
     

    "Tufts University, Department of Chemical & Biological Engineering, Medford, MA, 2014.."

     
     

    "University of Pittsburg, Center for Energy, Pittsburg, PA, 2014.."

     
     

    Gonzalez, R. Harnessing the microbial fermentation of glycerol for the production of fuels and chemicals. 2010 Annual Meeting of the American Oil Chemists' Society. Phoenix, AZ, May 16-20, 2010.

     
     

    Invited Speaker. Annual Meeting, Society for Industrial Microbiology. San Francisco, CA, August 3, 2010.

     
     

    Gonzalez, R., Clomburg, J.M., Murarka, A., Shanks, J.V., Cintolesi, A.   Systems analysis of the fermentative metabolism of glycerol and sugars in Escherichia coli. 2010 Annual Meeting, Society for Industrial Microbiology. San Francisco, CA, August 1-5, 2010.

     
     

    "2008 National Biodiesel Conference & Expo, Orlando, FL, 2008."

     
     

    "235th ACS National Meeting and 2008 AIChE Spring National Meeting, New Orleans, LA, 2008."

     
     

    "BIO KOREA 2008 OSONG, Osong Bio-Technopolis, Cheongju City, Korea, 2008."

     
     

    "Korean Society for Biotechnology and Bioengineering, 2008 Annual Meeting, Jeju Island, Korea, 2008."

     
     

    "Pusan National University, Department of Chemical and Biochemical Engineering, Busan, Korea, 2008."

     
     Gonzalez, R. Understanding and harnessing microbial fermentation of glycerol: A new path to biofuels and biochemicals. 236th ACS National Meeting & Exposition, Philadelphia, PA, August 17-21, 2008
     
     Keynote Speaker
     

    "Biofuels and Sustainable Energy Session, 247th ACS National Meeting, Dallas, TX, 2014.."

     
     

    "Emerging Technologies in Clean Energy for the Twenty-First Century, 2014 AIChE Spring Meeting, New Orleans, LA, 2014. ."

     
     Lectures
     

    Gonzalez, R.  Engineered metabolism for the production of fuels and chemicals from glycerol and fatty acids: The role of synthetic and systems biology. 32nd Symposium on Biotechnology for Fuels and Chemicals. Clearwater Beach, FL, April 19-22, 2010.

     
     

    Gonzalez, R.  Engineered metabolism for the production of fuels and chemicals from glycerol and fatty acids: The role of synthetic and systems biology. Metabolic Engineering VIII: Metabolic Engineering for Green Growth. Jeju Island, Korea, June 13-17, 2010.

     

     
     

    Murarka, A., Clomburg, J. M., Moran, S., Shanks, J.V., and Gonzalez, R. Systems analysis of the fermentative metabolism of Escherichia coli. 2010 Annual AIChE meeting, Salt Lake City, UT, November 7-12, 2010.

     

     
     Yazdani, S. S., and Gonzalez, R. Engineering Escherichia coli for the efficient conversion of glycerol to ethanol and co-products. 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, May 4-7, 2008
     
     Gupta, A., and Gonzalez, R. Microbial Fermentation of Glycerol for the Production of Ethanol. 2008 Annual AIChE meeting, Philadelphia, PA, November 16-21, 2008
     
     Gonzalez, R. Understanding and Harnessing the Microbial Fermentation of Glycerol: A New Path for the Production of Biochemicals. 2008 Annual AIChE meeting, Philadelphia, PA, November 16-21, 2008
     
     Gonzalez, R., Clomburg, J., Yazdani, S.S., Murarka, A., and Dharmadi, Y. Understanding and harnessing the microbial fermentation of glycerol: a new path for the production of biochemicals. Metabolic Engineering VII: Health and Sustainability, Puerto Vallarta, Mexico, September 14-19, 2008.
     
     Other
     

    Program Chair of the 2011 Society for Industrial Microbiology Annual Meeting, July 24-28, 2011, New Orleans, LA.

     
     

    Gonzalez, R. Engineered metabolism for the production of fuels and chemicals from glycerol and fatty acids: the role of synthetic and systems biology. 2010 Annual AIChE meeting, Salt Lake City, UT, November 7-12, 2010.

     

     
     Posters
     

    Dellomonaco, C., and Gonzalez, R. Synthetic respiro-fermentative metabolism for the conversion of bio-oils to fuels and chemicals: A new biorefinery paradigm. 239th ACS National Meeting, San Francisco, CA, March 21-25, 2010.

     
     

    Gonzalez, R., Clomburg, J.M., Murarka, A., Shanks, J.V., Cintolesi, A. Systems analysis of the fermentative metabolism of Escherichia coli. Metabolic Engineering VIII: Metabolic Engineering for Green Growth. Jeju Island, Korea, June 13-17, 2010.

     
     Berríos, J., Gonzalez, R. and Altamirano, C. Relationship between energetic metabolism and sialic acid levels of r-tPA: flux banalysis under different hexose concentration in continuous culture of CHO cells. Metabolic Engineering VII: Health and Sustainability, Puerto Vallarta, Mexico, September 14-19, 2008
     
     Seminar Speaker
     

    Invited Seminar Speaker, Purdue University, School of Chemical Engineering, West Lafayette, IN, September 14, 2010.

     
     

    Invited Seminar Speaker. Texas Tech University, Department of Chemical Engineering, Lubbock, TX, October 29, 2010.

     
     

    Invited Seminar Speaker. University of Houston, Department of Chemical and Biomolecular Engineering, Houston, TX, August 27, 2010.

     
     

    Invited Seminar Speaker. Pohang University of Science and Technology (POSTECH), Department of Chemical Engineering, Pohang, South Korea, June 11, 2010.

     
     

    Invited Seminar Speaker. Pusan National University, Department of Chemical and Biochemical Engineering, Busan, Korea, June 10, 2010. 

     
     

    "National Autonomous University of Mexico (UNAM), The Biotechnology Institute, Cuernavaca, Mexico, 2008."

     
     

    "Trinity University, Department of Biology, San Antonio, TX, 2008 ."

     
     Session Chair
     

    Session Chair. Session "Environmental Biotechnology: Green Bioprocessing". 2010 Annual AIChE meeting, Salt Lake City, UT, November 7-12, 2010.

     
     

    Session Chair. Session “Upstream Processes: Advances in Biocatalysis”, 239th ACS National Meeting & Exposition, March 2010, San Francisco, CA.

     
     

    Session Chair: Session "Systems Biology Approaches in Metabolic Engineering", 2010 SIM Annual Meeting and Exhibition, August 2010, San Francisco, CA.

     
     

    "“Advances in Environmental Technology: Green Bioprocessing (15C11)”." 2008 Annual AIChE meeting, Philadelphia, PA. (November 16-21, 2008)

     
     

    "“Biobased Fuels and Chemicals I (15C08)”." 2008 Annual AIChE meeting, Philadelphia, PA. (November 16-21, 2008)

     
     

    "“Biobased Fuels and Chemicals II (15C00)”." 2008 Annual AIChE meeting, Philadelphia, PA. (November 16-21, 2008)

     
    Editorial Positions
     Associate Editor, Journal of Industrial Microbiology and Biotechnology. Springer. (2010 - 2015)

     Editor for Special Issue, Journal of Industrial Microbiology and Biotechnology. (2015 - 2015)

     Member of the Editorial Board, Applied Biochemistry and Biotechnology. (2009 - 2015)

     Member of the Editorial Board, Biotechnology Journal. (2014 - 2015)

     Member of the Editorial Board, Science. (2014 - 2015)

     Member of the Editorial Board, Metabolic Engineering Communications. Springer. (2014 - 2015)

     Member of the Editorial Board, Food Biotechnology. Taylor & Francis. (2010 - 2015)

     Member of the Editorial Board, Applied and Environmental Microbiology. American Society for Microbiology. (2011 - 2015)

    Supervised Theses & Dissertations
     Venetia Rigou, M.S. Kinetics and Statistical Approaches in Metabolic Networks. (2008) (Thesis or Dissertation Director)

     James M Clomburg, PhD Understanding the Microbial Utilization of Glycerol under Fermentative Conditions . (2011) (Thesis or Dissertation Director)

     Clementina Dellomonaco, PhD Engineering Microbial Platforms for the Production of Chemicals and Fuels from Oils/Fats Feedstocks. (2011) (Thesis or Dissertation Director)

     Ruiqiang Sun, PhD Improved Understanding of Apoptosis in Chinese Hamster Ovary Cell Cultures using Functional Genomics Approaches. (2011) (Thesis or Dissertation Director)

     John Park, PhD Engineering Escherichia coli for the production of polyketide-based platform chemicals. (2013) (Thesis or Dissertation Director)

     Maria Rodriguez-Moya, PhD Systems biology approaches for metabolic engineering: harnessing the polyketide biosynthetic potential of Escherichia coli for the production of platform chemicals. (2013) (Thesis or Dissertation Director)

     Angela Cintolesi, PhD Kinetic and Stoichiometric Modeling of the Metabolism of Glycerol and Fatty Acids in E. coli. (2013) (Thesis or Dissertation Director)

     Ahmed Kothawala , PhD Novel technologies for the detection of alpha-synuclein misfolded toxic species. (2013) (Committee Member)

     Juan Velazquez, PhD Design, synthesis and optimization of a Pd/Au/Al2O3 catalyst for the hydrodehalogenation of low molecular weight halocarbons under atmospheric conditions . (2014) (Committee Member)

     Abhishek Murarka, Ph.D. Metabolic Flux Analysis of Fermentative Carbon Metabolism in Escherichia coli. (Thesis or Dissertation Director)

    Awards, Prizes, & Fellowships
     Distinguished Faculty Associate, Baker College, Rice University, 2009-2010 Academic Year.

     Faculty Teaching and Mentoring Award, Graduate Student Association, Rice University

     SDA/NBB Glycerine Innovation Research Award, American Oil Chemists' Society

     Hershel M. Rich Invention Award, Rice University

    Positions Held
     Visiting Professor, School of Biochemical Engineering, Catholic University of Valparaiso, Chile. (2008 - 2008)