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Scholarly Interest Report
         
Ka-Yiu San
Professor
E. D. Butcher Professor in Bioengineering and Professor of Chemical Engineering
 
e-mail:ksan@rice.edu
 
  • B.S. (1978) Rice University
  • M.S. (1981) California Institute of Technology
  • Ph.D. (1984) California lnstitute of Technology
 
Primary Department
   Department of Bioengineering
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Department Affiliations
 
  • Department of Chemical and Biomolecular Engineering
  •  
    Websites
     Ka-Yiu San
     Metabolic Engineering and Systems Biotechnology Laboratory
     
    Research Areas
     Systems biotechnology; metabolic engineering; biochemical engineering; Design and modeling of genetic and metabolic networks; Modeling, computer control and optimization of bioreactors.
     
    Research Statement
     

    Our laboratory is mainly concerned with the development of new concepts and novel approaches of designing and manipulating metabolic routes using recombinant DNA technology to improve cellular activities and to achieve more advanced production systems. The main focus is on the development of a framework for the systematic analysis of the cellular responses in regulating its metabolic activities upon precise genetic perturbations. Understanding these responses is critical to design organisms and processes for efficient and reliable manufacturing of gene products from recombinant cells.



    • Metabolic Engineering - Cofactor Manipulations in Escherichia Coli
      Most current metabolic engineering studies have focused on manipulations of enzyme levels and the effect of amplification, addition or deletion of a particular pathway. A newer focal area in our laboratory is the manipulation of cofactors, which play a major role in cell physiology and in the production of many important fermentation products. Additionally these cofactors are essential for a large class of enzymatic reactions. For example, the NADH/NAD+ pair serves as donor and/or acceptors of electrons in many biological redox reactions. The focus of our current research is to investigate the effect of different cofactor manipulations using cofactor-dependent products as model systems.

    • Plant Metabolic Engineering
      In a joint project with Dr. Shanks of Iowa State University and Dr. Gibson, our lab explores the area of metabolic engineering in plants. We are particularly interested in the metabolic engineering of the indole pathway and its subsequent effect on indole alkaloid biosynthesis in Catharanthus roseus hairy roots. C. roseus produces a wide variety of indole alkaloids including the anti-cancer drugs vincristine and vinblastine. Hairy roots have a number of advantages over cell cultures including increased genetic stability and substantially higher alkaloid content. Quantitative Systems Biotechnology: Recent rapid accumulation of enormous amount of genomic and pathway information provides a unique opportunity for the optimal design of genetic circuits and/or metabolic pathways to achieve a specific cellular behavior. Our laboratory is interested in the development of new analysis and design methodologies for the efficient utilization of these massive genomic and pathway knowledge.

    • Quantitative Systems Biotechnology
      Recent rapid accumulation of enormous amount of genomic and pathway information provides a unique opportunity for the optimal design of genetic circuits and/or metabolic pathways to achieve a specific cellular behavior. Our laboratory is interested in the development of new analysis and design methodologies for the efficient utilization of these massive genomic and pathway knowledge.

     
    Selected Publications
     Abstracts
     

    C Thakker, K-Y San, GN Bennett. Cottonseed meal derived soluble sugars as an economical feedstock for the fermentative production of C4 dicarboxylic acid using engineered E. coli. Society of Industrial Microbiology (SIM) Annual Meeting, San Diego, CA, August 11-15, 2013.

     
     

    G Balzar, C Thakker, K-Y San, GN Bennett. Metabolic engineering of E. coli to minimize byproduct formate during succinate production by heterologous overexpression of NAD+-dependent formate dehydrogenase. Society of Industrial Microbiology (SIM) Annual Meeting, San Diego, CA, August 11-15, 2013.

     
     

    H Wu, K-Y San.  Efficient odd straight chain free fatty acid production by metabolically engineered Escherichia coli. Society of Industrial Microbiology (SIM) Annual Meeting, San Diego, CA, August 11-15, 2013.

     
     

    K-Y San. Microbial carboxylic acid production. CBiRC meeting, ISU, Ames IA, October 6-8, 2013

     
     

    S Han, K-Y San, Short chain fatty acid production. Annual CBiRC meeting, ISU, Ames IA, May 14-17, 2013.

     
     

    S Han, S Xie, K-Y San, Short Chain Fatty Acid Production in Engineered Bacteria, UKC2013, Meadowland, NJ, August 7-10, 2013. 

     
     

    W Li, K-Y San. Optimization of carboxylic acid production in E. coli. Annual CBiRC meeting, ISU, Ames IA, May 14-17, 2013.

     
     

    Ka-Yiu San, "Metabolic pathway design and reconstruction for efficient succinate production in Escherichia coli," Singapore Catalysis Forum, Singapore, May 17, 2010

     
     

    Ka-Yiu San, "The important role of cofactor manipulation in metabolic engineering", Singapore Catalysis Society Short Course, Singapore, May 18, 2010

     
     

    Ka-Yiu San, "Vision and the role of microbial metabolic in a recently established Center for Renewable Chemicals (CBiRC)," Singapore Catalysis Society Short Course, Singapore, May 18, 2010.

     
     

    C.A.M. Peebles, J. V. Shanks, and K.-Y. San,Overexpression of Multiple Terpenoid Indole Alkaloid Pathway Genes Increases Alkaloid Accumulation in Catharanthus Roseus Hairy Roots, 2009 AIChE Annual Meeting: Nashville, TN, November 8-13, 2009

     
     

    I. Martinez, G.G. Bennett and K.-Y. San, Effect of Fumarase and Formate Reductase Gene Deletions On Escherichia Coli Fermentation Product, 2009 AIChE Annual Meeting: Nashville, TN, November 8-13, 2009.

     
     

    M. Li, C.A.M. Peebles, J. V. Shanks, and K.-Y. San, Effects of Nitric Oxide On Growth, Terpenoid Indole Alkaloid Production and Some of the TIAs Genes Transcripts in Catharanthus Roseus Hairy Root Cultures, 2009 AIChE Annual Meeting: Nashville, TN, November 8-13, 2009.

     
     

    M. Li, X. Zhang, and K.-Y. San, Production of Methyl Ketones in E. coli, 2009 AIChE Annual Meeting: Nashville, TN, November 8-13, 2009.

     
     

    X, Zhang, M. Li, and K.-Y. San, Engineering Metabolism in E. Coli for High Level Production of Fatty Acids From Glucose, 2009 AIChE Annual Meeting: Nashville, TN, November 8-13, 2009.

     
     14K.-Y. San, Manipulating and balancing reducing equivalents through metabolic engineering, Department of Chemical and Biomolecular Engineering, University of Maryland, October 14, 2008.
     
     P.V. Vadlani, K.-Y. San, G.N. Bennett, Production of Natural Flavor Chemicals: Isoamyl Acetate Biosynthesis from Renewable Sugars Using Engineered Escherichia coli, Philadelphia, PA, November 12-16, 2008.
     
     P.V. Vadlani, K.-Y. San, G.N. Bennett, Production of Platform Chemicals from Renewable Sugars: Low-Cost Succinic Acid Fermentation Using Engineered Escherichia coli, Philadelphia, PA, November 12-16, 2008.
     
     

    A. M. Sanchez, G. N. Bennett, K.-Y. San "Development of high yield Escherichia coli succinate production systems through \pathway reconstruction." Annual AIChE meeting (11/04)

     
     

    A. M. Sanchez, G. N. Bennett, K.-Y. San "Two stage fermentations using high yield succinate producing Escherichia coli systems." Annual AIChE meeting (11/04)

     
     

    A. M. Sanchez, G.N. Bennett and K.-Y. San "Pathway Engineering of the Anaerobic Central Metabolic Pathway in Escherichia coli to Increase Succinate Yield and Productivity." Twenty First Conference on Biomedical Engineering Research in Houston (2004/02)

     
     

    A. M. Sanchez, G.N. Bennett and K.-Y. San "Pathway engineering of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity." 227th ACS National Meeting (3/28-4/1)

     
     

    A. M. Sanchez, I. Hussain, G. N. Bennett, K.-Y. San "Metabolic Engineering of NADPH availability on the productivity of poly(3-hydroxybutyrate) in Escherichia coli." 227th ACS National Meeting (3/28-4/1)

     
     

    C. A. Peebles, E. Hughes, S.-B. Hong, S. Gibson, J. V. Shanks, and K.-Y. San "Metabolic engineering of indole alkaloid pathways In Catharanthus roseus hairy roots." Twenty First Conference on Biomedical Engineering Research in Houston (2004/02)

     
     

    C. A. Peebles, E. Hughes, S.-B. Hong, S. Gibson, J. V. Shanks, and K.-Y. San "Metabolic engineering of the terpenoid indole alkaloid pathways in Catharanthus roseus hairy roots: The effects of terpenoid precursor feeding on transgenic ASab hairy roots." 227th ACS National Meeting (3/28-4/1)

     
     

    C. A. Peebles, S. Gibson, J. V. Shanks, and K.-Y. San "Metabolic Engineering of the Terpenoid and Indole Pathways in Catharanthus roseus hairy roots." Annual AIChE meeting (11/04)

     
     

    C. A. Peebles, S. Gibson, J. V. Shanks, and K.-Y. San "Transient effect of overexpressing ASab on terpenoid indole alkaloid production in Catharanthus roseus hairy roots." Annual AIChE meeting (11/2004)

     
     

    C. R. Dittrich, G. N. Bennett, K.-Y. San "Production of Isoamyl Acetate in E. coli Mutant Strains with Deletion of the ackA-pta and poxB Pathways." Annual AIChE meeting (11/04)

     
     

    C. R. Dittrich, G.N. Bennett and K.-Y. San "Metabolic engineering of Escherichia coli to study the effects of ackA-pta and poxB deletions on the control of acetate production." 227th ACS National Meeting (3/28-4/1)

     
     

    C. R. Dittrich, R.V Vadali, A. M. Sanchez, G.N. Bennett and K.-Y. San "Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB Pathways." Twenty First Conference on Biomedical Engineering Research in Houston (2004/02)

     
     

    G.N. Bennett and K.-Y San "Cofactors in metabolic engineering of ester production." 228th ACS National Meeting (2004/08)

     
     

    G.W. Sasnder, E. Hughes, K.-Y. San, S. Gibson, J.V. Shanks "NMR flux maps of Catharanthus roseus with induced ASalpha activity for increased tryptophan production." Annual AIChE meeting (11/04)

     
     

    H. Lin, A. Sanchez, G.N. Bennett and K.-Y. San "A metabolic engineering application: pathway design and engineering for enhancing succinate productivity in both aerobic and anaerobic fermentation processes." Metabolic Engineering Conference (2004/09)

     
     

    H. Lin, G. N. Bennett, K.-Y. San "Batch reactor design and optimization for large-scale succinate production under absolute aerobic conditions using a metabolically engineered aerobic succinate production system in Escherichia coli." Annual AIChE meeting (11/04) Submitted

     
     

    H. Lin, G. N. Bennett, K.-Y. San "Metabolic network engineering and optimization of the aerobic central metabolism of Escherichia coli for achieving the maximum theoretical yield of succinate under absolute aerobic conditions." Annual AIChE meeting (11/2004)

     
     

    H. Lin, G.N. Bennett and K.-Y. San "Metabolic engineering of the central metabolic pathways of Escherichia coli: A systematic approach to study the metabolic response to multiple pathway manipulations for the production of fermentation products." Twenty First Conference on Biomedical Engineering Research in Houston (2004/02)

     
     

    H. Lin, G.N. Bennett, and K.-Y. San "Characterization of a metabolically engineered Escherichia coli mutant designed for aerobic production of succinate: A systematic approach to study the metabolic responseto multiple pathway manipulations in the central metabolism." 227th ACS National Meeting (3/28-4/1)

     
     

    H. Lin, G.N. Bennett, and K.-Y. San "Genetic reconstruction of the tricarboxylic acid cycle in Escherichia coli for the complete aerobic production of succinate through the glyoxylate bypass." 227th ACS National Meeting

     
     

    J. V. Shanks, K.-Y San, S. I. Gibson, S.-B. Hong, E. Hughes, G. Sriram, C. Peebles, and G. Sander "An integrated metabolic engineering study of hairy roots for alkaloid production." Metabolic Engineering Conference (2004/09)

     
     

    K.-Y. San, G. N.Bennett, S. Shalel Levanon, S. Cox "Modeling of the oxygen Sensing/Regulatory Circuit in E. coli." 227th ACS National Meeting (3/28-4/1)

     
     

    K.-Y. San, G.N. Bennett, R. Vadali, H. Lin and A. Sanchez "Co-factor engineering as a metabolic engineering tool to increase process productivity." Metabolic Engineering Conference

     
     

    K.-Y. San, G.N. Bennett, S. Shalel Levanon, S. Cox, B. Peercy, J. V. Shanks, and R. Gonzalez "A genetic network driven metabolic flux analysis scheme." Metabolic Engineering Conference (2004/09)

     
     

    K.-Y. San, J. V. Shanks, R. Gonzalez "Development of a genetic network driven model for sugar-utilization regulatory systems." Annual AIChE meeting (11/04)

     
     

    K.-Y. San, S. Shalel Levanon, H. Lin, G. N.Bennett, S. Cox "Development of a metabolic network design and optimization framework incorporating implementation constraints." 227th ACS National Meeting (3/28-4/1)

     
     

    N.-R. Yun, K.-Y San, and George Bennett "Function of E. coli global redox sensor/ regulator, ArcAB, in anaerobic metabolic regulation and cellular responses." American Society for Microbiology (ASM) 104th General Meeting (2004/05)

     
     

    N.-R. Yun, K.-Y. San, and George Bennett "Function of redox proteins, Ndh and Nuo, in anaerobic metabolic regulation and cellular responses in E. coli." ASM Conference on Integrating Metabolism and Genomics (4/30-5/3)

     
     

    Peercy, B., Shalel Levanon, S., Bennett, G.N., Cox, S.J., San, K.-Y. "Oxygen Sensing and Regulation of Cytochromes in E. coli." Gordon Research Conference on Theoretical Biology and Biomathematics (2004/06)

     
     

    R. Singh, G. N. Bennett, K.-Y. San "Role of nuo gene cluster during anaerobic pyruvate metabolism in Escherichia coli." Annual AIChE meeting (11/04)

     
     

    S. Cox, S. Shalel Levanon, G. N. Bennett, and K.-Y. San "Modeling of the oxygen sensing/regulatory circuit and metabolism in E. coli." Annual AIChE meeting (11/04)

     
     

    S. Cox, S. Shalel Levanon, H. Lin, A.M. Sanchez, G. N. Bennett, and K.-Y. San "A practical metabolic network design and optimization framework to guide pathway reconstruction." Annual AIChE meeting (11/04)

     
     

    S. Portle, M. Harrison, K.-Y. San, G.N. Bennett, N. Mantzaris "Construction and Characterization of a Gene-Switching Network." Annual AIChE meeting (11/04)

     
     

    S. Shalel Levanon, K.-Y. San, G. N. Bennett "Effect of oxygen on the E. coli global redox sensing/regulation networks and cellular responses." Annual AIChE meeting (11/04)

     
     

    S. Shalel Levanon, K.-Y. San, G. N. Bennett "Effect of oxygen on the E. coli global redox sensing/regulation networks and cellular responses." 227th ACS National Meeting (3/28-4/1)

     
     

    S.-. Hong, C. Peeble, J.V. Shanks, K.-Y. San, and S. I. Gibson "Expression of the Arabidopsis Feedback-insensitive Anthranilate Synthase Holoenzyme and Tryptophan Decarboxylase Genes in Catharanthus roseus Hairy Roots." ASPB's Annual Meeting (2004/07)

     
     

    Y. Dharmadi, Y. Moon, J.V. Shanks, K.-Y. San, R. Gonzalez "A Systems Biology Approach for Metabolic Engineering of E. coli Sugar-Utilization Regulatory Systems." Annual AIChE meeting (11/04)

     
     Refereed articles
     

    Thakker C, Martínez I, San KY, Bennett GN. "Metabolic engineering of carbon and redox flow in the production of small organic acids." J Ind Microbiol Biotechnol: 42: 403-422.

     
     

    Wang D, Thakker C, Lui P, Bennett GN, San KY. "Efficient Production of Free Fatty Acids from Soybean Meal Carbohydrates. ." Biotechnology and Bioengineering, in press In Press

     
     

    Wang D, Wu H, Thakker C, Beyersdorf J, Bennett GN, San KY "Efficient free fatty acid production in engineered Escherichia coli strains using soybean oligosaccharides as feedstock. ." Biotechnol Prog.

     
     

    Wu H, Lee J, Karanjikar M, San KY. "Simultaneous utilization of glucose and mannose from woody hydrolysate for free fatty acid production by metabolically engineered Escherichia coli." Bioresource Tehncology

     
     

    Wu H, Tuli L, Bennett GN, San KY. "Metabolic Control of Respiratory Levels in Coenzyme Q Biosynthesis-Deficient Escherichia coli Strains Leading to Fine-tune Aerobic Lactate Fermentation." Biotechnol Bioeng.

     
     

    Wu H, Tuli L, Bennett GN, San KY. "Metabolic transistor strategy for controlling electron transfer chain activity in Escherichia coli.." Escherichia coli.: Metab Eng. 28:159–168.

     
     

    Thakker C, Martínez I, San KY, Bennett GN "Metabolic engineering of carbon and redox flow in the production of small organic acids." JIMB

     
     

    Wu H, Karanjikar M, San KY "Metabolic engineering of Escherichia coli for efficient free fatty acid production from glycerol." Metab Eng, 25: 82-91.

     
     

    Wu H, Lee J, Karanjikar M, San KY "Efficient free fatty acid production from woody biomass hydrolysate using metabolically engineered Escherichia coli." Bioresource Tehncology, 169: 119-25.

     
     

    Wu H, San KY "Efficient odd straight medium chain free fatty acid production by metabolically engineered Escherichia coli." Biotechnol Bioeng, 111(11): 2209-19 .

     
     

    Wu H, San KY. "Engineering Escherichia coli for odd straight medium chain free fatty acid production." Appl Microbiol Biotechnol, 98(19): 8145-54.

     
     

    Balzer GJ, Thakker C, Bennett GN, San KY. Metabolic engineering of E. coli to minimize byproduct formate and improving succinate productivity through increasing NADH availability by heterologous expression of NAD+-dependent formate dehydrogenase. Metabolic Engineering (2013). PMID: 23876411. doi: 10.1016/j.ymben.2013.07.005

     
     

    Joanna J, Martinez I, Wang Y, Bennett GN, San KY. Metabolic engineering and transhydrogenase effects on NADPH availability in Escherichia coli. Biotechnology Progress (2013), accepted. doi: 10.1002/btpr.1765.   PMID: 23794523

     
     

    Thakker C, San K-Y, Bennett GN. Production of succinic acid using soluble sugars of feedstock soybeans by engineered E. coli strains under aerobic fermentation conditions. Bioresource Technology, Bioresource Technology 130: 398–405 (2013).

     
     

    Wang Y, San KY, Bennett GN. Cofactor engineering for advancing chemical biotechnology. Curr Opin Biotechnol. 24:1-6 (2013) PMID: 23611567

     
     

    Wang Y, San KY, Bennett GN. Improvement of NADPH Bioavailability in Escherichia coli by Replacing NAD+ Dependent Glyceraldehydes-3-phosphate Dehydrogenase GapA with NADP+ Dependent GapB from Bacillus subtilis and NAD Kinase. Journal of Industrial Microbiology & Biotechnology, accepted (2013)  PMID: 24048943

     
     

    Wang Y, San KY, Bennett GN. Improvement of NADPH Bioavailability in Escherichia coli through the use of Phosphofructokinase Deficient Strains. Appl Microbiol Biotechnol. 97(15):6883-93, (2013). PMID: 23558585

     
     

    Chung, I.-M., Ali, M, Yang, Y.-M., Peebles, C.A.M, Chun, S.-C., Lee, S.-J., San, K. Y. and Ahmad, A "Identification of New Compounds from Catharanthus roseus Hairy Root Cultures." Bull. Korean Chem. Soc, 28 (2007) : 1294-1298.

     
     

    Chung, I.-M., Ali, M., Chun, S.-C., San, K.-Y., Peebles, C.A.M., and Ahmad, A. "New Sesquiterpene Glycosides from Cultures Hairy Roots of Catharanthus roseus." Chinese Journal of Chemistry, 25 (2007) : 1695 -1699.

     
     

    Chung, I.-M., Hong, S.-B., Peebles, C.A.M., and San, K.-Y. "Effect of the engineered indole pathway on accumulation of phenolic compounds in Catharanthus roseus hairy roots." Biotechnology Progress, 23 (2007) : 327-32.

     
     

    Chung, I.-M., Park, H.-Y., Ali, M., San, K.-Y., Peebles, C.A.M, Hong, S.-B., and Ahmad, A. "A new chemical constituent from the hairy root cultures of Catharanthus roseus." Bull. Korean Chem. Soc., 28(2) (2007) : 229-234.

     
     

    Park, Y.C., Yun, N.R., San, K.-Y., and Bennett, G.N. "Characterization of alcohol dehydrogenase 1 and 3 from Neurospora crassa FGSC2489." Appl Microbiol Biotechnol, 76(2) (2007) : 349-56.

     
     

    Peebles, C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y "A study on the long-term maintenance of a transgenic Catharanthus roseus hairy root line." Biotech (2007) In Press

     
     

    Peebles, C.A.M., Gibson, S.I., Shanks, J.V., and San, K.-Y. "Characterization of an ethanol inducible promoter system in Catharanthus roseus hairy roots." Biotechnology Progress, 23 (2007) : 1258-1260.

     
     

    Portle, S., Causey, T. B., Wolf, K., Bennett, G. N., San, K.-Y., and Mantzaris, N. V. "Cell population heterogeneity in expression of a gene-switching network with fluorescent markers of different half-lives." J. Biotechnol, 128(2) (2007) : 362-75.

     
     

    Zhu, J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y "The YfiD protein contributes to the pyruvate formate-lyase flux in an E. coli arcA mutant strain." Biotechnology and Bioengineering, 97 (2007) : 138-43.

     
     

    Berrios-Rivera, S. J., Sanchez, A. M., Bennett, G. N., San, K. Y. "Effect of different levels of NADH availability on metabolite distribution in Escherichia coli on minimal and complex media." Applied Microbiology and Biotechnology, 65(4) (2004) : 426-432.

     
     

    Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y. "Redistribution of Metabolic Fluxes in the Central Aerobic Metabolic Pathway of E. coli Mutant Strains with Deletion of the ackA-pta and poxB Pathways for the Synthesis of Isoamyl Acetate ." Biotechnology Progress (2004) In Press

     
     

    Hughes, E. H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y. "Expression of a Feedback-Resistant Anthranilate Synthase in Catharanthus roseus Hairy Roots Provides Evidence for Tight Regulation of Terpenoid Indole Alkaloid Levels." Biotechnology and Bioengineering, 86 (2004) : 718-727.

     
     

    Hughes, E. H., Hong, S.-B., Gibson, S. I., Shanks, J. V., San, K.-Y. "Metabolic Engineering of the Indole Pathway in Catharanthus roseus Hairy Roots and Increased Accumulation of Tryptamine and Serpentine." Metabolic Engineering, 6 (2004) : 268-276.

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Effect of Sorghum phosphoenolypyruvate carboxylase and Lactococcus lactis pyruvate carboxylase coexpression on metabolite production in Escherichia coli." Applied Microbiology and Biotechnology (2004) In Press

     
     

    Lin, H., Vadali, R.V., Bennett, G. N., and San, K.-Y. "Increasing the acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli." Biotechnology Progress, 20 (2004) : 1599-1604.

     
     

    Sanchez, A. M., Bennett, G. N., and San, K.-Y. "Effect of Different Levels of NADH Availability on Metabolic Fluxes of Escherichia coli Chemostat Cultures in Defined Medium."  (2004) Submitted

     
     

    Shalel Levanon, S., San, K.-Y., and Bennett, G. N. "Effect of Oxygen on the E. coli ArcA and FNR Regulation Systems and Metabolic Responses." Biotechnology and Bioengineering (2004) In Press

     
     

    Vadali, R.V., Bennett, G. N., San, K. Y "Enhanced Isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli." Biotechnology Progress, 20(3) (2004) : 692-7.

     
     

    Vadali, R.V., Bennett, G. N., San, K. Y. "Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli." Metabolic Engineering, 6 (2004) : 294-299.

     
     

    Vadali, R.V., Bennett, G. N., San, K. Y. "Cofactor engineering of CoA/acetyl-CoA and its effect on metabolic flux redistribution in Escherichia coli." Metabolic Engineering, 6 (2004) : 133-139.

     
     

    Vadali, R.V., Horton, C.E., Rudolph, F.B., Bennett, G. N., San, K. Y. "Production of isoamyl acetate in ackA-pta and/or ldh mutants of Escherichia coli." Applied Microbiology and Biotechnology, 63 (2004) : 698-704.

     
     Articles
     

    Joanna J, Martinez I, Wang Y, Bennett GN, San KY. Metabolic engineering and transhydrogenase effects on NADPH availability in Escherichia coli. (submitted 2012)

     
     

    Li M, Zhang X, Argawal A, San K-Y. Effect of acetate formation pathway and long chain fatty acid CoA-ligase on the free fatty acid production in E. coli expressing acyl-ACP thioesterase from Ricinus communis. Metabolic Engineering, 14: 380-387 (2012). PMID: 22480945

     
     

    Park J, Rodríguez-Moyá M, Li M, Pichersky E, San KY, Gonzalez R. Synthesis of methyl ketones by metabolically engineered Escherichia coli. J Ind Microbiol Biotechnol. 39(11):1703-12 (2012). PMID: 22850984

     
     

    Thakker C, Martínez I, San K-Y, Bennett GN. Succinate production in Escherichia coli. Biotechnol J. 7:213-224 (2012). PMID: 21932253

     
     

    Wang Y., San K.-Y., Bennett, G. N. Improvement of NADPH Bioavailability in Escherichia coli by Replacing NAD+ Dependent Glyceraldehydes-3-phosphate Dehydrogenase GapA with NADP+ Dependent GapB from Bacillus subtilis and NAD Kinase. Submitted (2012)

     
     

    Wang Y., San K.-Y., Bennett, G. N. Improvement of NADPH Bioavailability in Escherichia coli through the use of Phosphofructokinase Deficient Strains. Submitted (2012)

     
     

    Zhang X, Argawal A, San K-Y. Improving fatty acid production in Escherichia coli through the overexpression of malonyl coA-Acyl carrier protein transacylase. Biotechnology Progress, 28:60-65 (2012). PMID: 22038854

     
     

    Chung IM, Kim E-H, Li M, Peebles CAM, Sung W-S, Song H-K, Ahn J-K, San K-Y. Screening sixty-four cultivars Catharanthus roseus for the production of vindoline, catharanthine and serpentine. Biotechnology Process, 27: 937–943 (2011).

     
     

    Li M, Peebles CAM, Shanks JV, San K-Y. Effect of sodium nitroprusside on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures. Biotechnology Progress, 27:625-630 (2011).

     
     

    Martínez I, Bennett GN, San K-Y. Culture conditions’ impact on succinate production by a high succinate producing Escherichia coli strain. Biotechnology Progress, 27: 1225-1231 (2011). DOI: 10.1002/btpr.641

     
     

    Peebles CAM, Sander GW, Hughes EH, Peacock R, Shanks JV, San K-Y. The expression of 1-deoxy-D-xylulose synthase and geraniol 10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metabolic Engineering, 13:234-40 (2011).

     
     

    Thakker C, Zhu J, San K-Y, Bennett GN. Heterologous pycA gene expression under various natural and engineered promoters in Escherichia coli for improved succinate production. Journal of Biotechnology, 155(2):236-43 (2011).

     
     

    Wang J, Zhu J, Bennett GN, San K-Y. Succinate production from different carbon sources under anaerobic conditions by metabolic engineered Escherichia coli strains. Metabolic Engineering, 13:328-35 (2011).

     
     

    Wang J, Zhu J, Bennett GN, San K-Y. Succinate production from sucrose by metabolic engineered Escherichia coli strains under aerobic conditions. Biotechnology Progress, 27: 1242-1247 (2011). DOI: 10.1002/btpr.661

     
     

    Zhang X, Argawal A, San K-Y. Improving fatty acid production in Escherichia coli through the overexpression of malonyl coA-Acyl carrier protein transacylase. Biotechnology Progress, accepted, web published (2011).

     
     

    Zhang X, Li M, Argawal A, San K-Y. Efficient free fatty acid production in Escherichia coli using plant acyl-ACP thioesterases. Metabolic Engineering, 13:713-722 (2011).

     
     

    Zhu J, Thakker C, San K-Y, Bennett GN. Culture Condition Optimization for the Production of Succinate in Fed-Batch Cultures Using a Metabolic Engineered Escherichia coli Strain. Applied Microbiology and Biotechnology, 92(3):499-508 (2011). PMID: 21667087

     
     

    Chung, I. M., Kim, E-H., Li, M., Peebles, C.A.M., Sung, W-S., Song, H-K., Ahn, J-K., San, K.-Y., "Screening sixty-four cultivars Catharanthus roseus for the production of vindoline, catharanthine and serpentine", under revision (2010)

     
     

    Irene, M., Bennett, G.N., San, K.-Y., "Metabolic impact of the level of aeration during cell growth on anaerobic succinate production by an engineered Escherichia coli strain", Metabolic Engineering, in print (2010).

     
     

    Li, M. Peebles, C.A.M., Shanks, J.V., San, K.-Y., "Effect of nitric oxide on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures", submitted (2010).

     
     

    Peebles, C.A.M., Sander, G.W., Hughes E.H., Peacock, R., Shanks, J.V., San, K.-Y., "The expression of 1-deoxy-D-xylulose synthase and geraniol 10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots", Metabolic Engineering, under revision (2010).

     
     

    Wang, J., Zhu, J., Bennett, G.N., San, K.-Y., "Succinate production from different carbon sources under anaerobic conditions by metabolic engineered Escherichia coli strains", submitted (2010).

     
     

    Zhu, J., Thakker, C., Bennett, G.N., San, K.-Y.,  "Culture Condition Optimization for the Production of Succinate in Fed-Batch Cultures Using a Metabolic Engineered Escherichia coli Strain", submitted (2010).

     
     

    Binder, B.Y.K., Peebles, C.A.M., Shanks, J.V., and San, K.-Y., "The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots", Biotechnology Progress, 25:861-865 (2009).

     
     

    Chung, I.-M., Ali, M., Ahmad, A., Lee,O-K. Kim, J-H., Yoon, D-Y., Peebles, C.A.M., and San, K.-Y., "Flavonoid Glucosides from the Hairy Roots of Catharanthus roseus", J Natural Products, 72(4):613-20 (2009).

     
     

    Dittrich, C.R., Bennett, G.N., San, K.-Y., "Metabolic Engineering of the anaerobic central metabolic pathway in Escherichia coli for the simultaneous anaerobic production of isoamyl acetate and succinic acid", Biotechnology Progress, 25(5):1304-1309 (2009).

     
     

    Nikel, P. I., Zhu, J., San, K.-Y., Méndez, B. S., and Bennett, G. N., "Metabolic flux analysis of carbon catabolism in Escherichia coli creB and arcA mutants based on 13C-labeling experiments under microaerobic conditions", J. Bacteriology, 191:5538-5548 (2009).

     
     

    Peebles, C.A.M., Hughes, E., Shanks, J.V., and San, K.-Y., "Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time", Metabolic Engineering, 11:76-86 (2009).

     
     

    Peebles, C.A.M., Sander, G.W., Li, M., Shanks, J.V., and San, K.-Y., "Five year maintenance of the inducible expression of anthranilate synthase in Catharanthus roseus hairy roots", Biotechnology and Bioengineering, 102:1521-5 (2009).

     
     

    Peebles, C.A.M., Shanks, J.V., and San, K.-Y., "The role of the octadecanoid pathway in the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots under normal and UV-B stress conditions", Biotechnology and Bioengineering, 103(6):1248-54 (2009).

     
     

    Portle, S., Iadevaia1, S., San, K.-Y., Bennett, G.N., Mantzaris, N., "Environmentally-modulated changes in fluorescence distribution in cells with oscillatory network dynamics," J Biotechnology, 140(3-4):203-17. (2009).

     
     Binder, B.Y.K., Peebles, C.A.M., Shanks, J.V., and San, K.-Y., The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots, Biotechnology Progress, accepted (2008).
     
     Chung, I. M., Ali, M., Chun, S. C., San, K.-Y., Peebles, C. A. M., and Ahmad, A., New catharanthusopimaranoside A And B from hairy root cultures of Catharanthus roseus, Chemistry of Natural Compounds, 44(4):458-462 (2008).
     
     Chung, I.-M., Ali, M., Ahmad, A., Lee,O-K. Kim, J-H., Yoon, D-Y., Peebles, C.A.M., and San, K.-Y., Flavonoid Glucosides from the Hairy Roots of Catharanthus roseus, submitted (2008).
     
     Dittrich, C.R., Bennett, G.N., San, K.-Y., Metabolic Engineering of the anaerobic central metabolic pathway in Escherichia coli for the simultaneous anaerobic production of isoamyl acetate and succinic acid, submitted (2008).
     
     Martinez, I., Zhu, J., Lin, H., Bennett, G.N., San, K.-Y., " Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways, Metabolic Engineering, accepted (2008).
     
     Peebles, C.A.M., Hughes, E., Shanks, J.V., and San, K.-Y., Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time, Metabolic Engineering, accepted (2008).
     
     Peebles, C.A.M., Sander, G.W., Li, M., Shanks, J.V., and San, K.-Y., Five year maintenance of the inducible expression of anthranilate synthase in Catharanthus roseus hairy roots, Biotechnology and Bioengineering, accepted (2008).
     
     Peebles, C.A.M., Shanks, J.V., and San, K.-Y., The role of the octadecanoid pathway in the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots under normal and UV-B stress conditions, submitted (2008)
     
     Portle, S., Iadevaia1, S., San, K.-Y., Bennett, G.N., Mantzaris, N., Environmentally-modulated changes in fluorescence distribution in cells with oscillatory network dynamics, submitted (2008).
     
     Singh, R., Vadlani, P.V., Harrison, M. L., Bennett, G.N., San, K.-Y., Aerobic production of isoamyl acetate by overexpression of the yeast alcohol acetyl-transferase AFT1 and AFT2 in Escherichia coli and using low-cost fermentation ingredients Bioprocess and Biosystems Engineering, 31:299-306
     
     Wong, M.S., Causey, T.B., Bennett, G.N., and San, K.-Y., Engineering Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Copolymer Composition in E. coli, Biotechnology and Bioengineering, 99(4):919-28 (2008).
     
     Wong, M.S., Wu, S., Causey, T.B., Bennett, G.N., and San, K.-Y., ¿Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production¿, Metabolic Engineering, 10(2):97-108 (2008).
     
     

    K.-Y.. San, J. Zhu, Shalel Levanson, G.N. Bennett "Effect of the global redox sensing/regulation networks on Escherichia coli and metabolic flux distribution based on C-13 labeling experiments." Metabolic Engineering, 8 (2006) : 619-27.

     
     

    K.-Y.. San, Y.C. Park, N.R., Yun, G.N.Bennett "Molecular cloning and characterization of the alcohol dehydrogenase ADH1 gene of Candida utilis ATCC 9950." J Ind Microbiol Biotechnol (2006) In Press

     
     

    K.Y.San, A.M. Sánchez, G.N. Bennett "Batch culture characterization and metabolic flux analysis of succinate producing Escherichia coli strains." Metabolic Engineering, 8 (2006) : 209-226.

     
     

    K.Y.San, A.M. Sánchez, J. Andrew, I Hussein, G.N. Bennett "Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli”, Biotechnology Progress." Biotechnology Progress, 22(2) (2006) : 420-5.

     
     

    K.Y.San, B.E. Peercy, S.J. Cox, Shalel-Levanon, G.N. Bennett "A Kinetic Model of Oxygen's Regulation of Cytochrome Oxidase bo3 and Cytochrome Oxidase bd through the Sensor/Regulators FNR and Two Component ArcAB in Escherichia coli." Journal of Theoretical Biology, 242(3) (2006)

     
     

    K.Y.San, C.M. Peebles, S.B. Hong, S.I. Gibson, J.V. Shanks "The effect of terpenoid precursor feeding on Catharanthus roseus hairy root over-expressing the alpha or the alpha and beta subunits of anthranilate synthase." Biotechnology and Bioengineering, 93(3) (2006) : 534-40.

     
     

    K.Y.San, G.N. Bennett, R. Singh, Y.T.Yang, Y.B. Liu "Expression of the pfl gene and resulting metabolite flux distribution in nuo and ackA-pta E. coli mutant strains." Biotechnology Progress, 22(3) (2006) : 898-902.

     
     

    K.Y.San, H. Lin, S.J.Cox, Shalel Levanon, A. Sánchez, B. Peercy, G.N. Bennett "Development of a metabolic network design and optimization framework incorporating implementation constraints: a succinate production case study." Metabolic Engineering, 8 (2006) : 46-57.

     
     

    K.Y.San, H. Lin, N.M. Castro, G.N. Bennett "Acetyl-CoA synthetase overexpression in Escherichia coli demonstrates more efficient acetate assimilation and lower acetate accumulation: a potential tool in metabolic engineering." Applied Microbiology and Biotechnology, 71(6) (2006) : 870-4.

     
     

    K.Y.San, S.B. Hong, C.M. Peebles, J.V. Shanks, S.I. Gibson "Expression of the arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots." Journal of Biotechnology, 122 (2006) : 28-38.

     
     

    K.Y.San, S.B. Hong, C.M. Peebles, J.V. Shanks, S.I., Gibson "Terpenoid Indole Alkaloid Production by Catharanthus roseus Hairy Roots induced by Agrobacterium tumefaciens harboring rol ABC genes." Biotechnology and Bioengineering, 93(2) (2006) : 386-90.

     
     

    Cox, S.J., Shalel Levanon, S., Bennett, G. N., and San, K.-Y. "Genetically constrained metabolic flux analysis." Metabolic Engineering (2005) In Press

     
     

    Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y. "Characterization of the acetate-producing pathways in Escherichia coli." Biotechnology Progress, 21: 1062-7.

     
     

    Dittrich, C. R., Vadali, R.V. Bennett, G. N., and San, K.-Y. "R Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB pathways for the synthesis of isoamyl acetate." Biotechnology Progress, 21 (2005) : 627-631.

     
     

    Dittrich, C.R., San, K.-Y., and Bennett, G.N. "Cofactors in metabolic engineering of ester production, Proceedings of the American Chemical Society Symposium on Genetic Engineering in Flavor Chemistry: Applications and Potentials." ACS Press (2005) In Press

     
     

    Hong, S.-B., Peebles C.M., Shanks, J V., San, K.-Y., and Gibson, S. I. "Terpenoid indole alkaloid production by Catharanthus roseus hairy roots induced by Agrobacterium tumefaciens harboring rol ABC genes." Biotechnology and Bioengineering (2005) In Press

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production: a study of the modified metabolic network based on metabolite profile, enzyme activity and gene expression profile." Metabolic Engineering (2005) In Press

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Effect of Sorghum vulgare phosphoenolypyruvate carboxylase and Lactococcus lactis pyruvate carboxylase coexpression on succinate production in mutant strains of Escherichia coli." Applied Microbiology and Biotechnology, 67: 515-23.

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Effect of carbon sources differing in oxidation state and transport route on succinate production in metabolically engineered Escherichia coli." Journal of Industrial Microbiology & Biotechnology, 32 (2005) : 87-93.

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Fed batch culture of a metabolically engineered Escherichia coli strain designed for high level succinate production and yield under aerobic conditions." Biotechnology and Bioengineering, 90 (2005) : 775-9.

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate." Biotechnology and Bioengineering, 89 (2005) : 148-156.

     
     

    Lin, H., Bennett, G. N., and San, K.-Y. "Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield." Metabolic Engineering, 7 (2005) : 116-127.

     
     

    Peebles C.M., Hong, S.-B., Gibson, S. I. And Shanks, J V., San, K.-Y. "The transient effects of over-expressing anthranilate synthase alpha and beta subunits in Catharanthus roseus hairy root." Biotechnology Progress, 21 (2005) : 1572-1576.

     
     

    Sanchez, A. M., Bennett, G. N., and San, K.-Y., "Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli." Submitted

     
     

    Shalel Levanon, S., San, K.-Y., and Bennett, G. N. "Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions." Biotechnology and Bioengineering (2005) In Press

     
     

    Shalel Levanon, S., San, K.-Y., and Bennett, G. N. "Effect of oxygen on the E. coli ArcA and FNR regulation systems and metabolic responses." Biotechnology and Bioengineering, 89 (2005) : 556-64.

     
     

    Shalel Levanon, S., San, K.-Y., and Bennett, G. N. "Effect of oxygen, and ArcA and FNR regulators on the expression of genes related to the electron transfer chain and the TCA cycle in Escherichia coli." Metabolic Engineering (2005) In Press

     
     

    S¿nchez, A. M., Bennett, G. N., and San, K.-Y. "Effect of different levels of NADH availability on metabolic fluxes of Escherichia coli chemostat cultures in defined medium." Journal of Biotechnology, 117: 395-405.

     
     

    S¿nchez, A. M., Bennett, G. N., and San, K.-Y. "Efficient succinate production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant." Biotechnology Progress, 21 (2005) : 358-365.

     
     

    S¿nchez, A. M., Bennett, G. N., and San, K.-Y. "Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity." Metabolic Engineering, 7 (2005) : 229-239.

     
     

    Vadali, R.V., Bennett, G. N., San, K. Y. "Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli." Biotechnology Progress, 21 (2005) : 1558-1561.

     
     

    Yun, N.-R., San, K.-Y., and Bennett, G.N. "Effect of inactivation of adhE or pta-ackA in NADH dehydrogenase-deficient Escherichia coli on the pattern of anaerobic metabolic products." Journal of Applied Microbiology, 99 (2005) : 1404¿1412.

     
     

    Berrios-Rivera, S. J., Sanchez, A. M., Bennet, G. N., San, K. Y. "Effect of different levels of nadh availability on metabolite distribution in Escherichia coli on minimal and complex media."  (2003) Submitted

     
     

    Berr¿os-Rivera, S. J., San, K.-Y., and Bennett, G. N. "The Effect of Carbon Sources and Lactate Dehydrogenase Deletion on 1,2-Propanediol Production in Escherichia coli." Journal of Industrial Microbiology and Biotechnology, 30 (2003) : 34-40.

     
     

    Hong, S.-B., Hughes, E.H., Shanks, J.V., San, K.-Y., and Gibson, S. I. "Role of the Non-Mevalonate Pathway in Indole Alkaloid Production by Catharanthus roseus Hairy Roots." Biotechnology Progress, 19 (2003) : 1105  1108.

     
     

    San, Ka-Yiu and Bennett, G.N., Meyers, R.A. (ed.) "Expression Systems for DNA Processes, in the Encyclopedia of Molecular Cell Biology And Molecular Medicine." VCH (2003) In Press

     
     

    Berrios-Rivera, S. J., K.-Y. San, and Bennett, G. N. "The Effect of Naprtase Overexpression on the Total Levels Of NAD, the NADH/NAD+ Ratio, and the Distribution of Metabolites in Escherichia coli." Metabolic Engineering, 4 (2002) : 238-247.

     
     

    Hughes, E. H., Hong, S.-B., Shanks, J. V., K.-Y. San, Gibson, S. I. "Characterization of an Inducible Promoter System in Catharanthus roseus Hairy Roots." Biotechnology Progress (2002) : 1183-1186.

     
     

    K.-Y. San, Bennett, G.N., Berr¿os-Rivera, S.J., Vadali, R.V., Yang, Y.-T., Horton, E., Rudolph, F.B., Berna Sariyar, B., Backwood, K. "Metabolic Engineering through Cofactor Manipulation and Its Effects on Metabolic Flux Redistribution in Escherichia coli." Metabolic Engineering, 4 (2002) : 182-192.

     
     Books
     

    George N. Bennett and Ka-Yiu San "Metabolic Engineering of biochemical pathways." McGraw-Hill Education Yearbook of Science and Technology 2014

     
     

    A Saterbak, L V McIntire, K San "Bioengineering Fundamentals." , ISBN-10: 0130938386 (January 2007)

     
     Book chapters
     

    San, K.-Y. and Bennett, G.N. "Expression Systems for DNA Processes." in the Encyclopedia of Molecular Cell Biology And Molecular Medicine, 4 (2004) : 355-377.

     
     Refereed conference papers
     

    Thakker C, Martínez I, San KY, Bennett GN "Soybean carbohydrates as a renewable feedstock for the fermentative production of succinic acid and ethanol." ACS Symposium Series volume "Soy-Based Chemicals and Materials."

     
     

    Cheryl R. Dittrich, Ka-Yiu San and George N. Bennett "Cofactors in metabolic engineering of ester production." Submitted

     
     Conference papers
     

    San, K.-Y. "Integration of undergraduate research in the BIOE curriculum at Rice University."  (2005)

     
     

    A. M. Sanchez, G.N. Bennett and K.-Y. San "Cofactor and pathway engineering: A precise strategy to increase productivity of industrially useful compounds in Escherichia coli." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    A. M. Sanchez, R.V. Vadali, G.N. Bennett and K.-Y. San "Effects of NADH/NAD+ and NADPH/NADP+ cofactor pair manipulations in Escherichia coli." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    A. Sanchez, San, G.N. Bennett and K.-Y. San "Cofactor Metabolic Engineering: Comparative Study of the Effect of Increasing NADH Availability in E. coli Chemostat Cultures on Minimal and Complex Medium." 225th American Chemical Society National Meeting (03.23-7.03)

     
     

    A. S¿nchez, H. Lin, K.-Y. San, and G.N. Bennett "Effect of increased NADH regeneration on succinate production in Escherichia coli using NAD+-dependent formate dehydrogenase." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    A. S¿nchez, K-Y. San, and G.N. Bennett "Manipulation of NADH availability as a metabolic engineering tool on cofactor dependent production systems." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    C. A. Peebles, E. Hughes, S.-B. Hong, S. Gibson, J. V. Shanks, and K.-Y. San "Metabolic engineering of indole alkaloid pathways In Catharanthus roseus hairy roots." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    C. R. Dittrich, R.V Vadali, A. M. Sanchez, G.N. Bennett and K.-Y. San "Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB Pathways." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    E. Hughes, S-B. Hong, S. Gibson, J. Shanks, and K-Y. San "Metabolic engineering of indole alkaloid pathways in Catharanthus Roseus hairy roots." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    E. Hughes, S.-B. Hong, S. Gibson, J. V. Shanks, and K.-Y. San "metabolic engineering of indole alkaloid pathways in catharanthus roseus hairy roots." 225th American Chemical Society National Meeting (03.23-7.03)

     
     

    G. Bennett, S. Cox, S. Levanon, and K-Y. San "Metabolic flux analysis based on dynamic genomic information." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    G.N. Bennet and K.-Y. San "Regulating cofactors as a metabolic engineering strategy." Society for Industrial Microbiology (08.14.03)

     
     

    H. Lin, G.N. Bennet and K.-Y. San "Metabolic engineering of the central metabolic pathways of Escherichia coli: A systematic approach to study the metabolic response to multiple pathway manipulations for the production of fermentation products." 2003 Annual AIChE Meeting (11.16-21.3)

     
     

    H. Lin, G.N. Bennet and K.-Y. San "Metabolic engineering of the central metabolic pathways of Escherichia coli: A systematic approach to study the metabolic response to multiple pathway manipulations for the production of fermentation products." 2003 Annual AIChE Meeting (11.16-21.3)

     
     

    H. Lin, G.N. Bennett and K.-Y. San "Increasing acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli." 225th American Chemical Society National Meeting (03.23-7.03)

     
     

    H. Lin, G.N. Bennett, and K-Y. San "Metabolic engineering of a succinate-producing mutant Escherichia coli strain to enhance succinate productivity." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    H. Lin, G.N. Bennett, and K-Y. San "Production of succinate through metabolic engineering of Escherichia coli with coexpression of sorghum phosphoenolpyurvate carboxylase and lactococcus lactis pyruvate carboxylase." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    K.-Y. San, S. Cox, G.N. Bennett "Metabolic flux analysis based on dynamic genomic information."  (03.23-7.03)

     
     

    R.V Vadali, E. Horton, K.-Y. San, F. B. Rudolph, and G.N. Bennett "Cofactor engineering of acetyl-CoA and its subsequent effect on metabolic fluxredistribution and the production of ester in Escherichia coli." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    R.V. Vadali, E. Horton, K.-Y. San, F. B. Rudolph, and G.N. Bennett "Production of isoamyl acetate in genetic engineered Escherichia coli." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    R.V. Vadali, G.N. Bennett and K.-Y. San "Cofactor engineering of CoA/acetyl-CoA: A novel metabolic engineering technique to enhance process productivity in Escherichia coli." 2003 Annual AIChE meeting: 11.16-21.3.

     
     

    R.V. Vadali, G.N. Bennett and K.-Y. San "Enhanced isoamyl acetate production in Escherichia coli upon manipulation of the acetyl-CoA node." 225th American Chemical Society National Meeting (03.23-7.03)

     
     

    R.V. Vadali, Y. Fu, G.N. Bennett and K.-Y. San "Effect of pathway manipulations on the production of lycopene In metabolically engineered Escherichia coli." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    S-B. Hong, E.H. Hughes, J.V. Shanks, K-Y. San, and S.I. Gibson "Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     

    S. Iadevaia, R.V Vadali, A. M. Sanchez, K.-Y. San and N. Mantzaris "Modeling and experimental studies for improved poly-3-hydroxybutyrate (PHB) production In E. coli." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    S. Shalel Levanon, K.-Y. San, G.N. Bennett and S. Cox "A data driven mathematical model of the O2 sensing/regulatory circuit in E. coli." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    S. Shalel Levanon, K.-Y. San, and G.N. Bennett "Analysis of E. coli global redox sensing/regulation networks and cellular responses." 2003 Annual AIChE meeting (11.16-21.3)

     
     

    S.-B. Hong, E. H. Hughes, J. V. Shanks, K.-Y. San, and S. I. Gibson "Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots." 225th American Chemical Society National Meeting (03.23-7.03)

     
     

    Y. Fu, R.V. Vadali, G.N. Bennett, and K-Y. San "Effect of pathway manipulations on the production of lycopene in metabolically engineered Escherichia coli." Twentieth Conference on Biomedical Engineering Research in Houston (04.3-4.03)

     
     Other
     

    Bennett, G.N. and San, K.-Y. "Microbial formation, biotechnological production and applications of 1,2-propanediol." App. Micro. Biotech., 55 (2001) : 1-9.

     
     

    Berrios-Rivera, S. J., San, K.-Y., and Bennett, G. N. "The Effect of Naprtase Overexpression on the Total Levels Of NAD, the NADH/NAD+ Ratio, and the Distribution of Metabolites in Escherichia Coli."  (submitted)

     
     

    Sauer, S. G., Yang, Y.-T., Mistry, A., Chapman, W.C., San, K.-Y. "Effects of Temperature and Salt Concentration on the Solubility of Amino Acids and Dipeptides."  (submitted)

     
     

    Wardwell, S.A., Yang, Y.-T., Chang H.-Y., San, K.-Y., Rudolph, F.B., Bennett, G.N. "Expression of the Klebsiella pneumoniae CG21 Acetoin Reductase Gene in Clostridium acetobutylicum ATCC 824." J Ind Microbiol Biotechnol,, 27 (2001) : 220-7.

     
     

    Yang, Y.-T, Bennett, G. N., and San, K.-Y. "Expression Analysis of the Escherichia coli Genome During Low and High Cell Density Growth."  (submitted)

     
     

    Yang, Y.T., Bennett, G.N., and San, K.Y. "The Effects of Feed and Intracellular Pyruvate Levels on the Metabolic Fluxes Redistribution in Escherichia coli with Fermentative Lactate Dehydrogenase Overexpression." Metablic Engineering, 3 (2001) : 115-123.

     
     

    Susana J. Berr¿os-Rivera, Yang, Y.-T., Bennett, G. N., San, K.-Y. "Effect of Glucose Analog Supplementation on Metabolic Flux Distribution in Anaerobic Chemostat Cultures of Escherichia coli." Metabolic Engineering, 2 (2000) : 149-154.

     
     

    Yang, Y.-T, Bennett, G. N., and San, K.-Y. "The Effect of nuo and ackA-pta Inactivation on the Expression of the Pyruvate Formate-Lyase (pfl) Gene of Escherichia coli."  (submitted)

     
     

    Yang, Y.-T, Peredelchuk, M., Bennett, G. N., and San, K.-Y. "The Effect of Variation of Klebsiella pneumoniae Acetolactate Synthase Expression on Metabolic Fluxes Redistribution in Escherichia coli." Biotechnology and Bioengineering, 69 (2000) : 150-159.

     
     

    Aristidou, A.A., Bennett, G.N., and San, K.Y. "Improvement of Biomass Yield and Recombinant Gene Expression in Escherichia coli by Using Fructose as the Primary Carbon Source." Biotechnology Progress, 15(1) (1999) : 140-145.

     
     

    Aristidou, A.A., Bennett, G.N., and San, K.Y. "Metabolic Flux Analysis of Escherichia coli Expressing the Bacillus subtilis Acetolactate Synthase in Batch and Continuous Cultures." Biotechnology and Bioengineering, 63 (1999) : 737-749.

     
     

    Yang, Y.-T, Bennett, G. N., and San, K.-Y. "The Interactions of Nuo and Ack/pta Mutations on Metabolic Flux Redistribution in Escherichia coli." Biotechnology and Bioengineering, 65 (1999) : 291-297.

     
     

    Yang, Y.T., Bennett, G.N., and San, K.Y. "Metabolic Flux Analysis of E. coli Deficient in the Acetate Production Pathway and Expressing the B. subtilis Acetolactate Synthase." Metabolic Engineering, 1 (1999) : 26-34.

     
     

    Yang, Y.T., Bennett, G.N., and San, K.Y. "Redistribution of Metabolic Fluxes in Escherichia coli with Fermentative Lactate Dehydrogenase Overexpression and Deletion." Metabolic Engineering, 1 (1999) : 141-145.

     
     

    Berrios-Rivera, S.J., Yang, Y.T., San, K.Y., and Bennett, G.N. "Effect of Glucose Analog Supplementation in Anaerobic Chemostat Cultures of Escherichia coli." Proceeding XVIII Interamerican Congress of Chemical Engineering, San Juan, Puerto Rico (December 1998)

     
     

    Liu, C.H., Niranjan, S.C., Clark, J.W., Jr., San, K.Y., Zwischenberger, J.B. and Bidani, A. "Airway Mechanics, Gas Exchange and Blood Flow in a Nonlinear Model of the Human Lung." J. Appl. Physiol. (HEG), 84 (4) (1998) : 1447-1469.

     
     

    Yang, Y.T., Bennett, G.N., and San K.Y. "The Interactions of Nuo and Ack/pta Mutations on Metabolic Flux Redistribution in Escherichia coli." Applied Microbial and Environmental Biotechnology (submitted)

     
     

    Yang, Y.T., Bennett, G.N., and San, K.Y. "Genetic and Metabolic Engineering." Electronic Journal of Biotechnology (1998)

     
    Presentations
     Invited Talks
     

      Wu H, Tuli L, Bennett GN, San KY. Metabolic transistor strategy for controlling electron transfer chain activity in Escherichia coli. Metab Eng. 28:159–168 (2015) doi: 10.1016/j.ymben.2015.01.002

     
     

    S Han and K-Y San. Modification of Fatty Acid Production by Metabolic Engineering of E. coli for Efficient Production, Annual CBiRC working meeting, ISU, Ames IA, October 5-7, 2014.

     
     

    S Han and K-Y San. Alleviating the toxicity triggered by short chain fatty acid. Annual CBiRC meeting, ISU, Ames IA, May 12-15, 2014.

     
     

    W Li and K-Y San., Cofactor metabolic engineering of carboxylic acid production in E. coli, Annual CBiRC working meeting, ISU, Ames IA, October 5-7, 2014.

     
     

    W Li and K-Y San., Cofactor metabolic engineering of carboxylic acid production in E. coli. Annual CBiRC meeting, ISU, Ames IA, May 12-15, 2014.

     
     

    K-Y San. Combining chemical- and bio-catalyst for efficient bioconversion. Green Chemistry Gordon Research Conference. July 27-August 2, Hong Kong.

     
     

    K-Y San, JM Yoon and J Shanks. Elucidation of metabolic changes at different growth phases and identification of fermentation parameters in carboxylic acid production. Annual CBiRC meeting, ISU, Ames IA, May 12-15, 2014.

     
     

    H Wu, K-Y San.  Metabolic engineering of Escherichia coli for efficient free fatty acid production from glycerol. ACS Annual Meeting, Dallas, Texas, March 16-20, 2014.

     
     

    S Han and K-Y San. Production of Short Chain Fatty Acid by Using Engineered Escherichia coli. ACS Annual Meeting, Dallas, Texas, March 16-20, 2014.

     
     K.-Y. San, G.N. Bennett, Strategies to enhance recombinant protein production in Escherichia coli by reducing acetate accumulation, Society of Industrial Microbiology (SIM) Annual Meeting, San Diego, CA, August 10-14, 2008.
     
     

    "Improvement of production of biochemicals through metabolic engineering." SIM Annual Meeting, Denver, CO. (July 29 - August 2, 2007) With G. N. Bennett

     
     

    "Increasing intracellular reducing equivalents to enhance productivity in Escherichia coli." Third Conference on Renewable Resources and Biorefineries, Ghent, Belgium. (June 4-6, 2007) With G. N. Bennett

     
     

    "Metabolic engineering of Catharanthus roseus hairy roots." The Sixth Osong International Symposium, Cheong-ju, S. Korea. (November 1-2, 2007)

     
     

    "Succinate and glyoxylate cycle." 2nd ASM Conference on Integrating Metabolism and Genomics (IMAGE2),, Montreal, Quebec, Canada. (April 30 - May 3, 2007)

     
     

    "Design and analysis of highly efficient Escherichia coli succinate production systems." 62nd Southwest Regional Meeting of the ACS, Houston, TX. (October 19-22, 2006) With G.N. Bennett

     
     

    "Development of efficient succinate production systems." Ludwigshafen, Germany. (February 20, 2006) With G.N. Bennett

     
     

    "Efficient succinate production systems." Archer Daniels Midland Company (ADM), Decadal, Illinois. (January 19, 2006)

     
     

    "Genetically constrained metabolic flux analysis." 106th ASM General Meeting, Orlando, FL. (May 21-25, 2006)

     
     

    "Highly efficient Escherichia coli systems for succinate production." 2006 World Congress on Industrial Biotechnology and Bioprocessing, Toronto, Canada. (July 11 - 14, 2006)

     
     

    "Pathway engineering for enhanced succinate production." 2006 Annual Meeting, Industrial Microbiology and Biotechnology Meeting, Baltimore, MD. (July 30-August 3, 2006)

     
     

    "Design of biocatalyst for the synthesis of biorenewable-derived platform chemicals." NSF workshop - Design of Catalyst Systems for Biorenewables, Washington DC. (June 23-24, 2005) With K.-Y. San

     
     

    "Development of efficient Escherichia coli succinate production strains." International Conference of Renewable Resources and Biorefineries, Ghent, Belgium. (September, 19-21, 2005) With K.-Y. San

     
     

    "Development of efficient Escherichia coli succinate production systems." Biochemical Engineering XIV, Harrison Hot Springs, BC, Canada. (July 10-14, 2005) With K.-Y. San, G. N. Bennett, A. M. Sanchez, and H. Lin

     
     

    "Efficient succinate production systems." Cargill Inc.. (October 25, 2005.)

     
     

    "Pathway design and engineering to improve succinate productivity." The Second World Congress on Industry Biotechnology and Bioprocessing, Orlando, FL. (April 2005) With K.-Y. San, G. N. Bennett, A. M. Sanchez, and H. Lin

     
     Other
     M. Li, J. Zhu, R. Simonette, M.L. Harrison, S. Portle, G.N. Bennett, K.-Y. San, Construction and Analysis of Cell Population Heterogeneity of Negative Feedback Gene Auto-Regulatory Systems In Escherichia coli, Philadelphia, PA, November 12-16, 2008.
     
     M. Li, C.A.M. Peebles, J.V. Shanks, and K.-Y. San, Effects of Nitric Oxide on Growth and Terpenoid Indole Alkaloid Production In Catharanthus Roseus Hairy Root Culture, Philadelphia, PA, November 12-16, 2008.
     
     

    ""Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Production in Escherichia Coli."." (Feb 8-9, 2007) With M. S. Wong, T. S. Causey, N. Mantzaris, G. N. Bennett

     
     

    ""Complex Inducer-Controlled Behavior in Cell Populations with Oscillatory Genetic Network Dynamics."." (November 4-9, 2007) With Stephanie Portle, George Bennett, Nikos V. Mantzaris

     
     

    ""Computational modeling and metabolic analysis of succinate production in engineered Escherichia Coli."." (April 29-May 2 2007) With G. Bennett, A. Sanchez, H. Lin, S. Cox, Shalel Levanon, B. Peercy

     
     

    ""Construction and Characterization of Negative Feedback Gene Regulation Systems in Escherichia coli."." (November 4-9, 2007) With M. Li, J. Zhu, N. V. Mantzaris, G. N. Bennett

     
     

    ""Development of a Mechanistic Model for Sugar-Utilization Regulatory Systems."." (February 8-9 2007) With R. Peacock, J. Zhu, J. V. Shanks, R. Gonzalez.

     
     

    ""Development of a Mechanistic Model for Sugar-Utilization Regulatory Systems."." (November 4-9, 2007) With J. Zhu, J. V. Shanks, R. Gonzalez

     
     

    ""Exploration of the Role of the Octadecanoid Pathway for Terpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots."." (November 4-9, 2007) With C. A. M. Peebles, J. V. Shanks

     
     

    ""Increasing the In Vivo Availability of Reducing Equivalents by Metabolic Engineering in Escherichia coli."." (November 4-9, 2007) With I. Martinez, J. Zhu, H. Lin, G. N. Bennett

     
     

    ""Manipulation of NADPH Availability in Escherichia coli by Genetic Modfication of the Glycolytic Pathway."." (February 8-9, 2007) With I. Martinez, J. Zhu, G. N. Bennett

     
     

    ""Metabolic Engineering of Escherichia coli to Overproduce C4 Compounds."." (November 4-9, 2007) With A. Lee, I. Martinez, G. N. Bennett

     
     

    ""Metabolic Engineering of Pyruvate Metabolism by Combining Pathway Mutations and Manipulating Nadh Availability."." (November 4-9, 2007) With J. Zhu, G. N. Bennett

     
     

    ""Metabolic Engineering of the Terpenoid and Indole Pathways in Catharanthus Roseus Hairy Roots."." (November 4-9, 2007) With Chrisite A.M. Peebles, Susan I. Gibson, Jacqueline V. Shanks

     
     

    ""Reduction of Acetate Production in Escherichia coli for Increased Recombinant Protein Production."." (November 4-9, 2007) With M. S. Wong, S. Wu, T. B. Causey, G. N. Bennett

     
     

    ""The Effect of Uvb Light on Terpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots."." (November 4-9, 2007) With B. Y. K. Binder, C. A. M. Peebles, J. V. Shanks

     
     

    ""The Transient Effect of Overexpressing ORCA3 Plus Jasmonic Acid Feeding in Catharanthus Roseus Hairy Roots."." (Feb 8-9, 2007) With C. Peebles, S. I. Gibson, J. V. Shanks

     
     

    ""Unraveling the Sugar Utilization Regulatory Systems in Escherichia coli."." (November 4-9, 2007) With Y. Dharmadi, R. Gonzalez, J. V. Shanks

     
     

    ""User-Controlled Changes is Fluorescence Distribution Cells with Oscillatory Genetic Network Dynamics."." February 8-9, 2007.

     
     

    ""Value-added Chemicals from Grain Sorghum: Isoamyl acetate and Succinic Acid Biosynthesis via Fermentation and Engineered Escherichia coli."." (October 7-10, 2007) With P. V. Vadlani, G. N. Bennett

     
     

    "Bosynthesis of Ethyl Esters in Recombinant Escherichia coli Expressing Alcohol Acyltransferase from Strawberry and Thiolase from Clostridium acetobutylicum." 106th ASM General Meeting, Orlando, FL. (May 21-25, 2006) With Y-C. Park, L. Sullivan, G. N. Bennett

     
     

    "Construction of a Genetic Toggle Switch for Polyhydroxyalkanoate Production in Escherichia coli." 106th ASM General Meeting, Orlando, FL. (May 21-25, 2006) With T. B. Causey, S. Portal, N. Mantzaris, G. N. Bennett

     
     

    "Development of a Mechanistic Model for Sugar-Utilization Regulatory Systems." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With J. Zhu, R. Peacock, J.V. Shanks, R. Gonzalez

     
     

    "Effect of Operating Conditions on the Performance of Efficient Succinate-Producing Escherichia coli Strains." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With I. Martinez, G. N. Bennett

     
     

    "Effect of yfiD and poxB Gene Disruption on Microaerobic Pyruvate Catabolization and Metabolic Flux Distributions Based on C-13 Labeling Experiments." 2006 Annual AIChE meeting, San Francisco, CA,. (November 12-17, 2006) With J. Zhu, S. Shalel Levanon, G. N. Bennett

     
     

    "Increasing the in vivo Nadph Availability by Metabolic Engineering in Escherichia coli." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With I. Martinez, J. Zhu, H. Lin, G. N. Bennett

     
     

    "Manipulation of the Terpenoid Indole Alkaloid Pathway in Catharanthus roseus Hairy Roots." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks

     
     

    "Metabolic Engineering of Artemisia Annua Hairy Roots." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With B.Y.K. Binder, C.A.M. Peebles, D.J. Morales,

     
     

    "Metabolic Engineering of the Terpenoid and Indole Pathways in Catharanthus roseus Hairy Roots." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks

     
     

    "Metabolic Flux Map of E. coli Ptsg Mutant and Wild Type Consuming Glucose/Xylose under Anaerobic Condition." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With M. Choudhary, Y. Dharmadi, R. Gonzalez, J.V. Shanks

     
     

    "The Transient Effect of Jasmonic Acid Feeding along with Orca3 Overexpression in Catharanthus roseus Hairy Roots." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks,

     
     

    "User-Controlled Changes in Fluorescence Distribution in Cells with Oscillatory Genetic Network Dynamics." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With S. Portle, T. B. Causey, G. N. Bennett, N. V. Mantzaris

     
     

    "Utilization of a Genetic Toggle in the Control of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Composition in Recombinant Escherichia coli." 2006 Annual AIChE meeting, San Francisco, CA. (November 12-17, 2006) With M. Wong, T. B. Causey, N. V. Mantzaris, G. N. Bennett

     
     

    "A Systems Biology Approach for Metabolic Engineering of E. coli Sugar-Utilization Regulatory Systems." Biochemical Engineering XIV, Harrison Hot Springs, BC, Canada. (July 10-14, 2005) With R. Gonzalez, Y. Dharmadi, J.V. Shanks, K.-Y. San

     
     

    "Batch Reactor Design and Optimization for Large-scale Succinate Production under Absolute Aerobic Conditions Using a Metabolically Engineered Aerobic Succinate Production System in Escherichia coli." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With H. Lin, G.N. Bennett and K-Y. San

     
     

    "Characterization of a Gene-Switching Network." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With S. Portle, M. Harrison, K-Y.San, G.N. Bennett and N. Mantzaris

     
     

    "Characterization of the ecdysone agonist-inducible promoter and the ethanol inducible promoter in Catharanthus roseus hairy roots." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks, K.-Y. San

     
     

    "Chemostat culture characterization of metabolically engineered Escherichia coli mutant strains designed for optimal aerobic production of succinate: A study of the metabolic response to multiple pathway perturbations in aerobic central metabolism." ACS National Meeting, San Diego, CA. (March 2005) With H. Lin, G. N. Bennett, K.-Y. San

     
     

    "Construction of a Genetic Toggle Switch for Polyhydroxyalkanoate Production in Escherichia coli." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With T. B. Causey, S. Portle, K.-Y. San, N. V. Mantzaris and G. N. Bennett

     
     

    "Construction of a genetic toggle switch for the production of polyhydroxyalkanoates in Escherichia coli." ACS National Meeting, San Diego, CA. (March 2005) With T. B. Causey, S. Portle, K.-Y. San, and G. N. Bennett

     
     

    "Development of a Genetic Network Driven Model for Sugar-Utilization Regulatory Systems." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With R. Peacock, J.V. Shanks, R. Gonzalez and K-Y. San

     
     

    "Development of a mechanistic model for sugar-utilization regulatory systems." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With R. Peacock, J. Zhu, J. V. Shanks, R. Gonzalez and K.-Y. San

     
     

    "Dynamics of Cell Populations Carrying Gene-Switching Networks with Fluorescent Protein Markers of Different Half-Lives." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With S. Portle, T. B. Causey, K.-Y. San, G. N. Bennett and N. V. Mantzaris

     
     

    "Effect Of Oxygen on the Escherichia coli Global Redox Sensing/Regulation Networks and Cellular Responses." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With S.S. Levanon, K-Y. San and G.N. Bennett

     
     

    "Effect of Gene Inactivation of adhE or pta-ackA in NADH Dehydrogenase-Deficient Escherichia coli on Anaerobic Metabolic Pathway." 2005 Annual Meeting & International Symposium of the Korean Society for Microbiology and Biotechnology (KMB), Seoul, Korea. (June 30, 2005 ¿ July 1, 2005) With N.R. Yun, K-Y San, and G.N. Bennett

     
     

    "Effect of acetyl-CoA synthetase overexpression in Escherichia coli on metabolite production in the presence of glucose and acetate carbon sources." ACS National Meeting, San Diego, CA. (March 2005) With H. Lin, N. M. Castro, G. N. Bennett, K.-Y. San

     
     

    "Effect of gene inactivation of arcA and/or fnr in Escherichia coli on anaerobic metabolic pathway." 2005 International Meeting of the Microbiological Society of Korea, Whengsung, Kangwon-do. Korea. (May 12-13. 2005) With N.R. Yun, K-Y San, and G.N. Bennett

     
     

    "Effect of oxygen on the E. coli global redox sensing/regulation networks and cellular responses." ACS National Meeting, San Diego, CA. (March 2005) With S. Shalel Levanon, K.-Y. San, and G. N. Bennett

     
     

    "Effect of oxygen on the E. coli global redox sensing/regulation networks and metabolic flux distribution based on C-13 labeling experiments." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With J. Zhu, S. Shalel Levanon, G. N. Bennett2 and K.-Y. San

     
     

    "Integration of undergraduate research in the BIOE curriculum at Rice University." 2005 ASEE Annual Conference, Portland, OR. (June 12-16, 2005) With K.-Y. San

     
     

    "Mathematical Model of Oxygen Sensing in Escherichia coli." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With B. Peercy, S. S. Levanon, G.N. Bennett, S. Cox and K-Y. San

     
     

    "Metabolic Engineering of Artemisia annua hairy roots." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With C.A.M. Peebles, D. J. Morales, K.-Y. San

     
     

    "Metabolic Engineering of Two Pathways, the Indole and Terpenoid Pathways, in Catharanthus roseus hairy roots." Biochemical Engineering XIV, Harrison Hot Springs, BC, Canada. (July 10-14, 2005) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks, K.-Y. San

     
     

    "Metabolic Network Engineering and Optimization of the Aerobic Central Metabolism of Escherichia coli for Achieving the Maximum Theoretical Yield of Succinate under Absolute Aerobic Conditions." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With H. Lin, G.N. Bennett and K-Y. San

     
     

    "Metabolic engineering of the terpenoid indole alkaloid pathways in Catharanthus roseus hairy roots." ACS National Meeting, San Diego, CA. (March 2005) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks, K.-Y. San

     
     

    "Metabolic engineering of the terpenoid indole alkaloid pathways in Catharanthus roseus hairy roots: Overexpression of the terpenoid branch genes for geraniol 10-hydroxylase and 1-deoxy-D-xylulose 5-phosphate synthase." ACS National Meeting, San Diego, CA. (March 2005) With R..W. S. Peacock, C.A.M. Peebles, S. I. Gibson, J. V. Shanks, and K.-Y. San

     
     

    "Overexpression of geraniol 10-hydroxylase and 1-deoxy-D-xylulose 5-phosphate synthase in Catharanthus roseus hairy roots." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With C.A.M. Peebles, R. Peacock, S. I. Gibson, J. V. Shanks, K.-Y. San

     
     

    "Population Distribution Patterns in Cells with Oscillatory Genetic Network Dynamics." Annual AIChE Meeting, Cincinnati, OH. (Oct 30-Nov 4, 2005) With S. Portle, M. L. Harrison, K.-Y. San, G. N. Bennett and N. V. Mantzaris

     
     

    "Role of nuo Gene Cluster during Anaerobic Pyruvate Metabolism in Escherichia coli. Twenty Second Conference on Biomedical Engineering Research in Houston." Houston, Texas. (February10-11, 2005) With R. Singh, G.N. Bennett and K-Y. San

     
     

    "Role of nuo gene cluster during anaerobic pyruvate metabolism in Escherichia coli." ACS National Meeting, San Diego, CA. (March 2005) With R. Singh, G. N. Bennett, and K.-Y. San

     
     

    "The effect of overexpressing AS-alpha and DXS in Catharanthus roseus hairy roots on the terpenoid indole alkaloid pathway." ACS National Meeting, San Diego, CA. (March 2005) With C.A.M. Peebles, S. I. Gibson, J. V. Shanks, K.-Y. San

     
     

    "Transient Effect of Overexpressing As-alpha on Terpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots." Twenty Second Conference on Biomedical Engineering Research in Houston, Houston, Texas. (February10-11, 2005) With C. Peebles, S. Gibson, J.V. Shanks and K-Y. San

     
     

    "Unique BIOE Undergraduate Courses at Rice University." Whitaker Foundation Biomedical Engineering Educational Summit Meeting, Leesburg, Virginia. (March, 2005) With K.-Y. San and A. Saterbak

     
     

    "A Strategy for Manipulation of Alkaloid Flux in Catharanthus Roseus Hairy Roots." Nineteenth Conference on Biomedical Engineering Research in Houston, Houston, Texas. (Feb 8-9, 2001) With E. Hughes, S-B. Hong, S. Gibson, J. Shanks

     
     

    "A Strategy for Manipulation of Indole Alkaloid Flux in Catharanthus roseus Hairy Roots." American Society of Plant Physiologists Annual Meeting, Providence, Rhode Island. (July 21-25, 2001) With S.-B. Hong, E. Hughes, J.V. Shanks and S. Gibson

     
     

    "An Inducible Promoter for the Study of Alkaloid Flux in Catharanthus roseus Hairy Roots." 2001 Annual AIChE meeting, Reno, Nevada. (November 4-9, 2001) With E. Hughes, S-B. Hong, S. Gibson, J. V. Shanks

     
     

    "Application of Metabolic and Biochemical Engineering Techniques for the Enhancement of Metabolic Flux Throughput in Escherichia coli." Nineteenth Conference on Biomedical Engineering Research in Houston, Houston, Texas. (Feb 8-9, 2001) With A. Chhiber, K-Y. San and G.N. Bennett

     
     

    "Cofactor Engineering of Acetyl-CoA and Its Subsequent Effect on the Production of Ester in Escherichia coli." Nineteenth Conference on Biomedical Engineering Research in Houston, Houston, Texas. (Feb 8-9, 2001) With R.V. Vadali, E. Horton, F.B. Rudolph and G.N. Bennett

     
     

    "Cofactor engineering of Acetyl-CoA and its subsequent effect on metabolic flux redistribution in Escherichia coli." 2001 Annual AIChE meeting, Reno, Nevada. (November 4-9, 2001) With R.V. Vadali, E. Horton, G.N. Bennett and F.B. Rudolph

     
     

    "Development of a Novel Foundation Course for Biomedical Engineering Curriculum." 2001 ASEE Annual Conference, Albuquerque, New Mexico. (June 24-27, 2001) With A. Saterbak and L. V. McIntire

     
     

    "Effect of different carbon sources on the succinate production in Escherichia coli with overexpression of the feedback resistant Sorghum PEPC system." 2001 Annual AIChE meeting, Reno, Nevada. (November 4-9, 2001) With H. Lin, S. G. Patel, A. Chhiber, G. N. Bennett

     
     

    "Expression Analysis of the Escherichia coli Genome during Low and High Cell Density Growth in Batch and Chemostat Modes." Nineteenth Conference on Biomedical Engineering Research in Houston, Houston, Texas. (Feb 8-9, 2001) With Y-T. Yang, G.N. Bennett

     
     

    "The Effect of Genetic Manipulations on the NAD(H+) Levels, the NADH/NAD+ Ratio and the Metabolic Flux Redistribution in Escherichia coli." Nineteenth Conference on Biomedical Engineering Research in Houston, Houston, Texas. (Feb 8-9, 2001) With S.J. Berrios-Rivera and G.N. Bennett

     
     

    "The Effect of Manipulating NADH Availability on the Distribution of Metabolites in Escherichia coli." 2001 Annual AIChE meeting, Reno, Nevada. (November 4-9, 2001) With S. J. Berrios-Rivera and G.N. Bennett

     
     

    "Amino Acid and Dipeptide Solubility in Aqueous Solution: Temperature and Salt Concentration Dependence." AIChE Annual Meeting, Los Angeles, California. (November 12-17, 2000) With S.G. Sauer, Y-T. Yang, A. Mistry, W.G. Chapman

     
     

    "Bioengineering Fundamentals: Conservation Principles in Biology and Medicine." Whitaker Foundation Biomedical Engineering Educational Summit, Leesburg, Virginia. (December 7-10, 2000) With A. Saterbak and L.V. McIntire

     
     

    "Effects of Temperature and Salt Concentration on the Solubility of Amino Acids and Di-Peptides." Eighteenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (2000) With S.G. Sauer, Y-T. Yang, A. Mistry, W.G. Chapman

     
     

    "Effects of Temperature on the Solubility of Amino Acids and Di-peptides: An Experimental and Theoretical Study." AIChE Annual Meeting, Los Angeles, California. (November 12-17, 2000) With S.G. Sauer, Y-T. Yang, A. Mistry, W.G. Chapman

     
     

    "Effects of Temperature on the Solubility of Amino Acids and Di-peptides: An Experimental and Theoretical Study." AIChE Annual Meeting, Los Angeles, California. (November 12-17, 2000) With S.G. Sauer, Y-T. Yang, A. Mistry, W.G. Chapman

     
     

    "Expressional Analysis of Escherichia coli Genome During Low and High Cell Density Growth." Metabolic Engineering III, Colorado Springs, Colorado. (November 22-27, 2000) With Y-T. Yang, G.N. Bennett

     
     

    "Expressional Analysis of Escherichia coli Genome during Low and High Cell Density Growth." Eighteenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (2000) With Y-T. Yang, G.N. Bennett

     
     

    "Metabolic Engineering through cofactor manipulation and its effects on metabolic flux redistribution in Escherichia coli." Metabolic Engineering III, Colorado Springs, Colorado. (November 22-27, 2000) With G.N. Bennett, S. J. Berrios-Rivera, R. V. Vadali and B.Sariyar, K. Blackwood

     
     

    "New Undergraduate Curriculum on Cellular and Tissue Engineering at Rice University." 2000 ASEE Annual Conference, St.Louis, Missouri. (June 18-21, 2000) With L.V. McIntire

     
     

    "Protein and Nonprotein Nitrogen in C. roseus Hairy Roots." AIChE Annual Meeting, Los Angeles, California. (November 12-17, 2000) With E.H. Hughes, J.V. Shanks

     
     

    "The Effect of NADH Manipulations on the NADH/NAD+ Ratio and Metabolic Flux Redistribution in Escherichia coli." Eighteenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (2000) With S.J. Berrios-Rivera and G.N. Bennett

     
     

    ""Effect of Glucose Analog Supplementation in Anaerobic Chemostat Cultures of Escherichia coli"." Seventeenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (1999) With S.J. Berrios-Rivera, Y-T.Yang, K-Y. San and G.N. Benne 83. S. J. Berrios-Rivera, Y.-T. Yang, K.-Y. San and G. N. Bennett, 83. S. J. Berrios-Rivera, Y.-T. Yang, K.-Y. San and G. N. Bennett, 83. S. J. Berrios-Rivera, Y.-T. Yang, K.-Y. San and G. N. Bennett,

     
     

    ""Effects Of Temperature And Salts On The Solubility Of Asp-Gly And Gly-Asp In Aqueous Solutions: Measurements And Modeling"." Seventeenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (1999) With Y.-T. Yang, S. G. Sauer, W. G. Chapman and K.-Y. San

     
     

    ""Effects of Temperature and Salt Concentration on the Solubility of Amino Acids and Di-peptides: An Experimental and Theoretical Study"." AIChE Annual Meeting, Dallas, Texas. (October 31 - November 5, 1999) With S. G. Sauer, Y.-T. Yang, A. Mistry, W. G. Chapman and K.-Y. San

     
     

    ""The Effect of Inactivation of nuo and ackA-pta on the Expression of the Pyruvate Formate-Lyase (pfl) Gene in Escherichia coli"." AIChE Annual Meeting, Dallas, Texas. (October 31 - November 5, 1999) With Y.-T. Yang, B. Lu, G. N. Bennett, and K.-Y. San

     
     

    ""The Effect of NADH Recycling on the NADH/NAD + Ratio and Metabolic Flux Redistribution in Escherichia Coli"." AIChE Annual Meeting, Dallas, Texas. (October 31 - November 5, 1999) With S. J. Berrios-Rivera, B. Lu, Y.-T. Yang, K.-Y. San and G. N. Bennett

     
     

    ""The Effect of nuo and acka-pta Deletion on the Redistribution of Metabolic Fluxes in Escherichia coli"." Seventeenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (1999) With Y.-T. Yang and G. N. Bennett

     
     

    ""The Effect of nuo and acka-pta Deletion on the Redistribution of Metabolic Fluxes in Escherichia coli"." Seventeenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (1999) With Y.-T. Yang, G. N. Bennett and K-Y. San

     
     

    "Effect of Glucose Analog Supplementation in Anaerobic Chemostat Cultures of Escherichia Coli." XVIII Interamerican Congress of Chemical Engineering, San Juan, Puerto Rico. (December 1998)

     
     

    "The Effects of Intracellular Pyruvate Levels on Metabolic Fluxes Redistribution in Escherichia coli with LDHA Overexpression." Sixteenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (1998) With Y.T. Yang and G.N. Bennett

     
     

    "The Effects of Variations in Acetolactate Synthase Activity on the Redistribution of Metabolic Fluxes in Escherichia coli." Sixteenth Conference on Biomedical Engineering Research in Houston, Houston, TX. (1998) With Y.T. Yang and G.N. Bennett

     
     Seminar Speaker
     

    K.-Y. San, Manipulation of reducing equivalents through metabolic engineering, Department of Energy, Environmental and Chemical Engineering, Washington University, St. Louis, Mo, March 20, 2009.

     
     

    K-Y San, Metabolic Engineering of E. coli for the production of fatty acid like chemicals from biorenewables, SIM Annual Meeting, Toronto, Canada, July 26-30, 2009.

     
     

    K-Y. San, Production of Fatty Acid/Polyketide like Chemicals from Biorenewables, Fifth International Conference on Renewable Resources and Biorefineries, Ghent, Belgium, 10-12 June 2009.

     
     

    "Role of Reducing Equivalent in the Biosynthesis of Biochemicals." ACS National Meeting, Washington, DC. (August 17, 2009)

     
     

    K.-Y. San, Manipulating and balancing reducing equivalents through metabolic engineering, Department of Chemical and Biomolecular Engineering, University of Maryland, October 14, 2008.

     
     

    "Design and construction of microbial strains for efficient succinate production from renewable resources." Iowa State University, Ames, IO. (September 13, 2007)

     
     

    "Metabolic and Cofactor Engineering." Tufts University, Medford, MA. (October 22, 2007)

     
     

    "Pathway design and reconstruction for efficient succinate production in Escherichia coli." The University of California at Los Angeles, Los Angeles, CA. (April 6, 2007)

     
     

    "Metabolic pathway design and reconstruction for efficient succinic acid production." University of Massachusetts, (November 17, 2005) With K.-Y. San

     
    Editorial Positions
     Member of the Editorial Board, Metabolic Engineering. (2010 - 2010)

     Member of the Editorial Board, Current Opinion in Biotechnology . (2013 - 2013)

     Member of the Editorial Board, Metabolic Engineering. (2013 - 2013)

     Member of the Editorial Board, The Open Systems Biology Journal . (2013 - 2013)

     Member of the Editorial Board, Electronic Journal of Biotechnology . (2013 - 2013)

     Member of the Editorial Board, The Open Systems Biology Journal. (2011 - 2011)

     Member of the Editorial Board, The Open Systems Biology Journal. (2010 - 2010)

     Member of the Editorial Board, Electronic Journal of Biotechnology. (2012 - 2012)

     Member of the Editorial Board, Metabolic Engineering. (2012 - 2012)

     Member of the Editorial Board, Current Opinion in Biotechnology. (2012 - 2012)

     Member of the Editorial Board, Current Opinion in Biotechnology. (2010 - 2010)

     Member of the Editorial Board, Metabolic Engineering. elsevier. (2006 - 2006)

     Member of the Editorial Board, Metabolic Engineering. (2004 - 2004)

     Member of the Editorial Board, Metabolic Engineering. (2003 - 2003)

     Member of the Editorial Board, Metabolic Engineering. (2005 - 2005)

     Member of the Editorial Board, Metabolic Engineering. (2007 - 2007)

     Member of the Editorial Board, Metabolic Engineering. (2008 - 2008)

     Other, Metabolic Engineering. (2001 - 2001)

     Other, Journal of Electronic Biotechnology. (2001 - 2001)

     Member of the Editorial Board, Journal of Electronic Biotechnology. (2005 - 2005)

     Member of the Editorial Board, Journal of Electronic Biotechnology. (2007 - 2007)

     Member of the Editorial Board, Journal of Electronic Biotechnology. (2003 - 2003)

     Member of the Editorial Board, Electronic Journal of Biotechnology. (2008 - 2008)

     Member of the Editorial Board, Journal of Electronic Biotechnology. (2006 - 2006)

     Member of the Editorial Board, Journal of Electronic Biotechnology. (2004 - 2004)

     Member of the Editorial Board, The Open Systems Biology Journal. (2008 - 2008)

     Editor for Special Issue, Metabolic Engineering. (2008 - 2008)

    Supervised Theses & Dissertations
     Sharon Sauer, PhD Effect of Polar Functional Groups on the Phase Behavior of Amino Acids, Peptides and Polymers. (2001) (Co-Director)

     Ravishankar V. Vadali, Engineering 1. CoA/acetyl-CoA: A novel strategy to enhance isoamyl acetate production in Escherichia coli. (2004) (Thesis or Dissertation Director)

     Ailen Sanchez, Ph.D., Director. (2005) (Committee Member)

     Randeep Singh, M.S., Director. (2005) (Committee Member)

     Cheryl Dittrich, M.S., Director. (2005) (Committee Member)

     Henry Lin, Ph.D., Director. (2005) (Committee Member)

     Christie Peebles, PhD Metabolic Engineering of the Terpenoid Indole Alkaloid Pathway of Catharanthus roseus Hairy Roots. (2008) (Thesis or Dissertation Director)

     Stephanie Portle, Ph.D Elucidating the Connection Between Cell Population Heterogeneity and Genetic Regulatory Architecture in Specific Artificial Networks. (2008) (Thesis or Dissertation Director)

     Irene Martinez, Ph.D. Metabolic Engineering of the Flow of Reducing Equivalents for the Production of Biochemicals in Escherichia coli. (2010) (Thesis or Dissertation Director)

     Joanna Jan, MS Metabolic Engineering and Transhydrogenase Effects on NADPH Availability in Escherichia coli. (2012) (Thesis or Dissertation Director)

     Joanna Jan, PhD Metabolic engineering of E. coli. (2015) (Thesis or Dissertation Director)

     Donna Pattison, Ph.D. Donna Pattison. (Committee Member)

     Emily Horton, Ph.D. Emily Horton. (Committee Member)

     Jin Yang, Ph.D. Jin Yang. (Committee Member)

    Awards, Prizes, & Fellowships
     AAAS Fellow, AAAS

     Hamill Innovation Award ,

     Fellow- American Institute for Medical and Biological Engineering, (1999-)

     Hershel M. Rich Invention Award, Hershel M. Rich (2005)

     Ailen Sanchez:Hershel M. Rich Invention Award, Hershel M. Rich (2005)

     Henry Lin: Hershel M. Rich Invention Award, Hershel M. Rich (2005)

     Student Award: Ailen Sanchez, Lodieska Stockbridge Vaughn Fellowship (2004)

     Student Award: Christie Peebles , National Science Foundation Graduate Fellowship Fellows (2004)

     Student Award: Cheryl Dittrich, First Place - poster competition, IGERT Retreat (2004)

     2004 Hershel M. Rich Invention Award, Rice G.R. Brown School of Engineering (2004)

     Student Award: Henry Lin, Second Place, poster competition, IGERT Retreat (2004)

     Student Award: Ravi V. Vadali, Hershel M. Rich Invention Award (2004)

     Reviewer, NSF (2001)

     Member, Ad Hoc Proposal Review Panel, NSF (2000-present)

     Member, American Institute of Chemical Engineers

     Reviewer, A number of Technical Journals

     Sigma Xi,

     Phi Lambda Epsilon,

     Phi Beta Kappa,

     Member, American Society for Engineering Education

     Member, American Chemical Society

     Fellow, American Institute for Medical and Biological Engineering (2001)

     Member, Editorial Board, Metabolic Engineering (1998-present)

     Member, Editorial Board, Journal of Electronic Biotechnology (1998-present)

     Tau Beta Pi,

     Member, American Association for the Advancement of Science

     American Association for the Advancement of Science,

     American Institute of Chemical Engineers ,

     Elected as Fellow, American Institute for Medical and Biological Engineering (1999)

     Reviewer, NSF, National Research Council

     Member, Editorial Board, Electronic Journal of Biotechnology

     Member, Editorial Board, Metabolic Engineering

    Positions Held
     Member, Editorial Board, Metabolic Engineering. (1998 - 2015)

     Member, Editorial Board, Current Opinion in Biotechnology . (2010 - 2015)

     Fellow, American Institute for Medical and Biological Engineering . (1999 - 2015)

     Member, Editorial Board, The Open Systems Biology Journal . (2010 - 2010)

     Member, Editorial Board, The Open Systems Biology Journal. (2008 - 2015)

     Member, Editorial Board, Journal of Electronic Biotechnology. (1998 - 2015)

     Fellow, American Institute for Medical and Biological Engineering. (2012 - 2012)

     Fellow, American Institute for Medical and Biological Engineering. (2004 - 2004)

     Fellow, American Institute for Medical and Biological Engineering. (2003 - 2003)

     Member, American Institute of Chemical Engineers. (2004 - 2004)

     Member, American Institute of Chemical Engineers. (2003 - 2003)

     Member, American Association for the Advancement of Science. (2004 - 2004)

     Member, American Association for the Advancement of Science. (2003 - 2003)

     Member, American Chemical Society. (2004 - 2004)

     Member, American Chemical Society. (2003 - 2003)

     Member, American Society for Engineering Education. (2004 - 2004)

     Member, American Society for Engineering Education. (2003 - 2003)

     Conference and Session Chairman, Twentieth Conference on Biomedical Engineering Research in Houston. (2004 - 2004)

     Conference and Session Chairman, Twentieth Conference on Biomedical Engineering Research in Houston. (2003 - 2003)

     Member, American Society for Microbiology. (2004 - 2004)

     Member, Phi Beta Kappa (Academic Honor Society). (2004 - 2004)

     Member, Phi Lambda Epsilon (Chemical Honor Society). (2004 - 2004)

     Member, Sigma Xi (Scientific Research Society). (2004 - 2004)

     Member, Tau Beta Pi (Engineering Honor Society). (2004 - 2004)

     Member, Steering Committee, Metabolic Engineering Conference. (2004 - 2004)