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Scholarly Interest Report
         
Marian Fabian
Senior Faculty Fellow
Senior Faculty Fellow in Biochemistry and Cell Biology
 
e-mail:fabian@rice.edu
 
  • Ph.D. Biophysics (1981) Moscow State University, Moscow, USSR
  • M.Sc. Biophysics (1974) Charles University, Prague, Czechoslovakia
 
Primary Department
   Department of BioSciences
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Selected Publications
 Abstracts
 

Stupak, M., Palmer, G. and Fabian, M. "A new method of preparation of cytochrome c oxidase vesicles from bovine heart mitochondria." Biochim. Biophys. Acta, EBEC Abstract Book, 1797 (2010) : 14.

 
 Refereed articles
 

Musatov, A., Fabian, M. and Varhac, R. "Elucidating the mechanism of ferrocytochrome c heme disruption by peroxidized cardiolipin." J Biol Inorg Chem, 18 (2013) : 137–144.

 
 

Ekworomadu, M. T., Poor. C. B., Owens, C. P., Balderas, M. A., Fabian, M., Olson, J. S., Murphy, F., Balkabasi, E., Honsa, E. S., He, C., Goulding, C. W., Maresso, A. W. "Differential Function of Lip Residues in the Mechanism and Biology of an Anthrax Hemophore." PLoS Pathogens, 8 (2012) : 1-16.

 
 

Honsa, E. S., Fabian, M., Cardenas, A. M., Olson, J. S. and Maresso, A. W. "The Five Near-iron Transporter (NEAT) Domain Anthrax Hemophore, IsdX2, Scavenges Heme from Hemoglobin and Transfers Heme to the Surface Protein IsdC." J. Biol. Chem., 286 (2011) : 33652-660.

 
 

Kakar, S.,Hoffman, F. G., Storz, J. F., Fabian, M. and Hargrove. M. S. "Structure and reactivity of hexacoordinate hemoglobin’s." Biophysical Chemistry, 152 (2010) : 1-14.

 
 

Parul, D., Palmer, G., and Fabian, M. "Ligand Trapping by Cytochrome c Oxidase: Implications for Gating at the Catalytic Center." J. Biol. Chem., 285 (2010) : 4536-4543.

 
 

Ran, Y., Liu, M., Zhu, H., Nygaard, T. K., Brown, D. E., Fabian, M., Dooley, D. M., and Lei, B. "Spectroscopic Identification of Heme Axial Ligands in HtsA That Are Involved in Heme Acquisition by Streptococcus pyogenes." Biochemistry, 49 (2010) : 2834-2842.

 
 

Sedlak, E., Fabian, M., Robinson, N. C. and Musatov, A. "Ferricytochrome c protects mitochondrial cytochrome c oxidase against hydrogen peroxide-induced oxidative damage." Free Radical Biology and Medicine, 49 (210) : 1574-1581.

 
 

Tarlovsky, Y., Fabian, M., Olson, J.S., and Maresso, A. W. "An S-Layer Homology Protein Mediates Heme Delivery to the Isd system in the Bacillus anthracis." J. Bacteriology, 192 (2010) : 3503-3511.

 
 

Tsai, A-l., Berka, V., Martin, F., Ma, X., van den Akker, F., Fabian, M., and Olson, J. S. "Is Nostoc HNOX a Gaseous Sensor or a Redox Switch." Biochemistry, 49 (2010) : 6587-6599.

 
 

Bagelova, J., Fedunova, D., Gazova, Z., Fabian, M., and Antlik, M. "Influence of NaCl and sorbitol on the stability of conformations of cytochrome c." Biphys. Chem., 135 (2008) : 110-115.

 
 

Zhu, H., Xie, G., Liu, M., Olson, J.S., Fabian, M., Dooley, D.M., and Lei, B. "Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphyloccus aureus." J. Biol. Chem., 283 (2008) : 18450-18460.

 
 

Brand, S. E., Rajagukguk, S., Ganesan, K., Geren, L., Fabian, M., Han, D., Gennis, R. B., Durham, B., and Millett, F. "A new ruthenium complex to study single-electron reduction of the pulsed OH state of the detergent-solubilized cytochrome oxidase." Biochemistry (2007) In Press

 
 

Ran, Y., Zhu, H., Liu, M., Fabian, M., Olson, J. S., Aranda, R., Phillips, Jr., G. N., Dooley, D. M., and Lei, B. "Bis-methionine ligation to heme iron in the Streptococcal cell surface protein Shp facilitates rapid hemin transfer to HtsA of the HtsABC transporter." J. Biol. Chem., 282 (2007) : 31380-31388.

 
 

Fabian, M., Jancura, D., Bona, M., Musatov, A., Baran, M., and Palmer, G. "The influence of reduction of heme a and CuA on the oxidized catalytic center of cytochrome c oxidase: Insight from organic solvents." Biochemistry, 45 (2006) : 4277-4283.

 
 

Jancura, D., Antalik, M., Berka, V., Palmer, G., and Fabian, M. "Filling the catalytic site of cytochrome c oxidase with electrons: Reduced CuB facilitates internal electron transfer to heme a3." J. Biol. Chem., 281 (2006) : 20003-20010.

 
 

Jancura, D., Berka, V., Antalik, M., Bagelova, J., Gennis, R. G., Palmer, G., and Fabian, M. "Spectral and kinetic equivalence of oxidized cytochrome c oxidase as isolated and ‘activated’ by reoxidation." J. Biol. Chem., 281 (2006) : 30319-30325.

 
 

Nygaard, T.K., Blouin, G.C., Liu, M., Fukumura, M., Olson, J.S., Fabian, M., Dooley, D.M., and Lei, B. "The mechanism of direct heme transfer from the Streptococcal cell surface protein Shp to HtsA of the HtsABC transporter." J. Biol. Chem., 281 (2006) : 20761-20771.

 
 

Siletsky, S., Han, D., Brand, S., Morgan, J.E., Fabian, M., Geren, L., Millett, F., Durham B., Konstantinov, A.A., and Gennis, R.B. "Single-electron photoreduction of the PM Intermediate of Cytochrome c Oxidase." Biochim. Biophys. Acta, 1757 (2006) : 1122-1132.

 
 

Zhou, S., Olson, J.S., Fabian, M., Weiss, M.J., and Gow, A.J. "Biochemical fates of alpha hemoglobin bound to alpha hemoglobin stabilizing protein (AHSP)." J. Biol. Chem., 281 (2006) : 32611-32618.

 
 

Antalik, M., Jancure, D., Palmer, G., and Fabian, M. "A role for the protein in internal electron transfer to the catalytic center of cytchrome c oxidase." Biochemistry, 44 (2005) : 14881-14889.

 
 

Fabian, M., Jancura, D., Bona, M., Mustav, A., Baran, M., and Palmer, G. "The influence of reduction of heme a and CuA on the oxidized catalytic canter of cytochrome c oxidase: Insight from organic solvent." J. Biol. Chem. (2005) Submitted

 
 

Parul, D., Palmer, G., and Fabian, M. "Proton interactions with hemes a and a3- in bovine heart cytochrome c oxidase." Biochemistry, 44 (2005) : 4562-4571.

 
 

Fabian, M., Jancura, D., and Palmer, G. "Two sites of interaction of anions with cytochrome a in oxidized bovine cytochrome c oxidase." J. Biol. Chem., 279 (2004) : 16170-16177.

 
 

Fabian, M., Skultety,, L., Jancura, D. and Palmer, G. "Implications of ligand binding studies for the catalytic mechanism of cytochrome c oxidase." Biochim. Biophys. Acta, 1655 (2004) : 298-305.

 
 

McMahon, B.H., Fabian, M., Tomson, F., Causgrove, T.P., Bailey, J.B., Rein, F.N.R. Dyer, B., Palmer, G., Gennis, R.B., and Woodruff, W.H. "FTIR studies of internal proton transfer reactions linked to inter-heme electron transfer in bovine cytochrome c oxidase." Biochim. Biophys. Acta, 1655 (2004) : 321-331.

 
 

Fabian, M., Jancura, D. and Palmer, G. "Two sites of interactions of anions with cytochrome a in oxidized bovine cytochrome c Oxidase." J. Biol. Chem. (2003) Submitted

 
 

Fabian, M., Skultety, L., Jancura, D., and Palmer, G., "Implications of ligand binding studies for the catalytic mechanism of cytochrome c oxidase." Biochim. Biophys. Acta (2003) Submitted

 
 

Fabian, M., and Palmer, G. "Proton involvement in the transition of "peroxy" to "ferryl" intermediate of cytochrome c oxidase." Biochemistry, 40 (2001) : 1867-1874.

 
 Articles
 

Fabian, M., Jancura, D., and Palmer, G. "Interaction of ligands with cytochrome a in fully oxidized bovine cytochrome c oxidase." BBA EBEC Short Reports, 12 (2002) : 84.

 
 Other
 

Fabian, M., Skultety, L., Brunel, C., and Palmer, G. "The cyanide stimulated dissociation of chloride from the catalytic center of oxidized oxidase." Biochemistry, 40 (2001) : 6061-6069.

 
 

Fabian, M., and Palmer, G. "Proton Involvement in Transition of "Peroxy" to "Ferryl" Intermediate of Cytochrome c Oxidase." Biochim. Biophys. Acta, EBEC Short Reports, 11 (2000) : 228.

 
 

Fabian, M., Wong, W.W., Gennis, R.B., and Palmer, G. "Mass Spectrometric Determination of Dioxygen Bond Splitting in the "Peroxy" Form of Cytochrome c Oxidase." Proc. Natl. Acad. Sci. USA, 96 (1999) : 13114-13117.

 
 

Fabian, M., and Palmer, G. "The Redox State of Peroxy and Ferryl Intermediates in Cytochrome c Oxidase Catalysis." Biochemistry, 38 (1999) : 6270-6275.

 
 

Fabian, M., and Palmer, G. "Hydrogen Peroxide Is Not Released Following Reaction of Cyanide with Several Catalytically Important Derivatives of Cytochrome c Oxidase." FEBS Letters, 422 (1998) : 1-4.

 
Presentations
 Invited Talks
 

"Irreversible Autooxidation of Cytochrome c Oxidase." Structure and Stability of Biomacromolecules, Kosice, Slovak Republic. With Jancura, D., Stanicova, J.and Palmer, G.

 
 

"Control of Internal Electron Transfer in Cytochrome c Oxidase." Structure and Stability of Biomacromolecules, Kosica, Slovak Republic. (September 2005) With M. Antalik, V. Berka, D. Jancura and G. Palmer

 
 

"The influence of reduction of cytochrome a and CuA on the oxidized binuclear center of cytochrome c oxidase: study in organic solvent." International Conference: "Structure and stability of biomacromolecules SSB 03, Kosice, Slovakia. (September 3-5, 2003) With Jancura, D., Bona, M., Baran, M., and Palmer, G.¿

 
 Other
 

"Ferryl Intermediates of Cytochrome c Oxidase." Lecture at Conference "Structure and Stability of Biomacromolecules", Kosice, Slovakia. (September 12-14, 2001) With with G. Palmer

 
 Posters
 

"Proton interactions with heme a3 in bovine heart cytochrome c oxidase." 13th European Bioenergetics Conference, Pisa, Italy. (August 2004) With D. Parul and G. Palmer

 
 

"Spectral sensitivity of cytochrome a3 in fully oxidized bovine cytochrome oxidase is determined by ionization state of single group with pKa=6.7." Gordon Research Conference, Cellular and Molecular Bioenergetics, Andover. (June 2004) With D. Parul and G. Palmer

 
 

"What controls the rate of internal electron transfer to cytochrome a3 during full reduction of cytochrome c oxidase." Gordon Research Conference, Cellular and Molecular Bioenergetics, Andover. (June 2004) With M. Antalik and G. Palmer