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Scholarly Interest Report
         
Yizhi Jane Tao
Associate Professor
Associate Professor in Biochemistry and Cell Biology
 
e-mail:ytao@rice.edu
 
  • B.S. Biology (1992) Peking University, P.R. CHINA
  • Ph.D. Biological Sciences (1999) Purdue University
 
Primary Department
   Department of BioSciences
Picture
 
Department Affiliations
 
  • Department of BioSciences
  • Institute of Biosciences and Bioengineering
  •  
    Websites
     Tao Lab Website
     
    Research Areas
     Structural Biology; Virology; Influenza viruses; Birnaviruses; RNA viruses
     
    The mechanisms of viral RNA replication and transcription by RNA viruses 2010
     

    Tao's Research All RNA viruses encode a polymerase that catalyzes both replication and transcription of the viral genome. For many RNA viruses, replication and transcription are two distinct processes with different initiation and termination mechanisms. Furthermore, the rates of mRNA and viral genomic RNA synthesis often peak at different times during infection. Our laboratory is interested in the catalytic mechanisms of viral RNA polymerases and in how RNA viruses exert regulation over RNA synthesis through polymerase interactions with viral and cellular factors.

     
    Teaching Areas
     Virology, X-ray Crystallography, electron microscopy
     
    Selected Publications
     Abstracts
     

    Liu Z, Guu TS, Cao J, Li Y, Cheng L, Tao YJ, et al "Structure determination of a human virus by the combination of cryo-EM and X-ray crystallography." Biophys Rep, 2 (2) (2016) : 55-68.

     
     Refereed articles
     

    Chen H, Toh Y, Rossmann MG, Tao YJ. "Crystal structure of the bacteriophage T4 fibritin B1." In Progress

     
     

    Collier AM, Lyytinen OL, Guo YR, Toh Y, Poranen MM, Tao YJ " Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus." PLoS Pathogens, 12(4) (2016)

     
     

    Countryman P, Fan Y, Kaur P, Pan H, Wang X, Lin J, Chen H, Wang W, White C, You C, Wirth N, Tessmer I, Piehler J, Riehn R, Tao YJ, Wang H. "Cohesin SA2 is a sequence independent DNA binding protein that recognizes DNA ends and gaps." Nat CommunIn Revision

     
     

    Fan Y, Guo YR, Yuan W, Zhong W, Tao YJ. "Structure of the Orsay virus δ/CP-δ Protein Reveals its Role in Cell Entry. PLoS pathogens." In Revision

     
     

    Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, et al "Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing."  Nucleic Acids Res

     
     

    Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, et al "Data publication with the structural biology data grid supports live analysis." Nat Commun., 7 (206) : 10882.

     
     

    Meyerson NR, Zhou L, Guo YR, Tao YJ, Krug RM, Sawyer SL. "TRIM25 senses and restricts the influenza A virus ribonucleoprotein complex." Nature MicrobiologyIn Revision

     
     

    Toh Y, Harper J, Dryden KA, Yeager M, Arias CF, Mendez E, Tao YJ "Crystal Structure of the Human Astrovirus Capsid Protein." Journal of virology, 90(20) (2016) : 9008-17.

     
     

    Toh Y, Pan J, Vakharia V, Tao YJ "The structure and protein-priming activity of the Drosophila X virus VP1." In Progress

     
     

    Wang Y, Guo YR, Liu K, Liu R, Tan L, Yang P, Lee J, Du L, Xia Y, Hawke D, Zheng Y, Xing D, Tao YJ*, Lu Z* "Gcn5 Coupled with the α-KGDH Complex Acts as a Histone H3 Succinyltransferase." NatureIn Revision

     
     

    Zhang W, Zheng W, Betancourt B, Toh Y, Vakharia V, McNew J, Jin M, Tao YJ "Crystal structure of the infectious salmon anemia virus matrix protein M1." In Progress

     
     

    Peter A. Meyer, Stephanie Socias et al "Data publication with the structural biology data grid supports live analysis." Nature CommunicationIn Press

     
     

    Collier AM, Poranen MM, Tao YJ (In revision) Polymerase transcription and packaging by a small dsRNA virus. PLoS Pathog.

     
     

    Guo YR, Hryc CF, Jakana J, Jiang H, Wang D, Chiu W, Zhong W, Tao YJ.  2014.  

    Crystal structure of a nematode-infecting virus.  Proc Natl Acad Sci U S A.  111(35):12781-12786

     
     

    Zhang N, Jiang Y, Mao Q, Demeler B, Tao YJ, Pati D "Characterization of the interaction between the cohesin subunits Rad21 and SA1/2." PLoS One , 8 (2013) : e69458.

     
     

    Zheng W, Tao YJ. "Genome encapsidation by orthobunyavirus nucleoproteins." Proc Natl Acad Sci U S A, 110(22) (2013) : 8769-70.

     
     

    Zheng, W., Olson, J.S., Vakharia, V.V., Tao, Y.J. "The structure and RNA binding of an orthomyxovirus nucleoprotein." PLoS Pathog (2013) : e1003624.

     
     

    Zheng, W., Tao, Y.J. "Structure and assembly of the influenza A virus ribonucleoprotein complex." FEBS Lett, 587(8) (2013) : 1206-14.

     
     

    Fallas, J.A., Dong, J., Tao, Y.J., Hartgerink, J.D. "Structural insights into charge pair interactions in triple helical collagen-like proteins." J Biol Chem. , 287(11) (2012 Mar 9) : 8039-47.

     
     

    Jesper K. Marklund, Qiaozhen Ye, Jinhui Dong, Yizhi Jane Tao, Robert M. Krug "Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis." J Virol., 86(13) (2012 July) : 72927297.

     
     

    Jiang Y., Zhang N., Mao Q., Demeler B., Tao, Y.J., Pati, D. "Characterization of cohesion subunits Rad21 and SA2 interaction and its role in chromosomal segregation." J Biol ChemIn Revision

     
     

    Tao YJ, Zheng W. "Biochemistry. Visualizing the influenza genome. ." Science, 338(6114) (2012 Dec 21) : 1545-6.

     
     

    Ye Q, Guu TS, Mata DA, Kuo RL, Smith B, Krug RM, Tao YJ. "Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza a virus ribonucleoprotein ." MBio. , 4(1) (2012 Dec 26) : e00467.

     
     

    Dong, J., Dong, L., Mendez, E., Tao, Y.J. "Crystal structure of the human astrovirus capsid surface spike." PNAS, 108 (2011) : 12681-6.

     
     

    Tao, Y.J., Zheng W. "Chaperones and the maturation of steroid hormone receptor complexes." Oncotarget, 2 (2011) : 102-104.

     
     

    Tang, J. Pan, J., Havens, W.M., Ochoa, W.F., Guu, T.S., Ghabrial, S.A., Nibert, M.L., Tao, Y.J. (co-corresponding author), Baker, T.S "Backbone Trace of a Partitivirus Capsid Protein from Electron Cryomicroscopy and Homology Modeling." Biophysical J, 99 (2010) : 685-694.

     
     

    Tao Y.J., Ye, Q. "RNA virus replication complexes." PLoS Pathogens, 6:e1000943 (2010)

     
     

    Ye, Q., Mata, D.A., Kuo, R.L., KyTonthat, N., Guu, T., Schumacher, M.A., Krug, R.M., Tao, Y.J. "Model for the assembly of the influenza A virus nucleoprotein into double-helical ribonucleoproteins." PLoS Pathogens (2010) Submitted

     
     

    Guu, T., Liu, Z., Ye, Q., Mata, D.A., Li, K., Yin, C., Zhang, J., and Tao, Y.J. "Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding." Proc Natl Acad Sci USA, 106 (2009) : 12992-12997.

     
     

    McDonald, S.M., Tao, Y.J., Patton, J.T. "The Ins and Outs of the Four-Tunneled RNA-Dependent RNA Polymerases." Curr Opin Struct Biol., 19 (December 2009) : 775-782.

     
     

    McDonald, S.M., Tao, Y.J., and Patton, J.T. "The ins and outs of the four-tunneled RNA-dependent RNA polymerases." Curr Opin Struct Biol, 19 (2009) : 1-8.

     
     

    Newcomb, L., Kuo, R.L., Ye, Q.,, Jiang, Y., Tao, Y.J., and Krug, R.M. "Interaction of the influenza A virus nuclecapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication." J Virol, 83 (2009) : 29-36.

     
     

    Pan, J., Dong, L., Lin, L., Ochoa, W.F., Sinkovits, R.S., Havens, W.M., Nibert, M.L., Baker, T.S., Ghabrial, S.A., and Tao, Y.J. "Atomic structure reveals the unique capsid organization of a dsRNA virus." Proc Natl Acad Sci USA, 106 (2009) : 4225-4230.

     
     

    Pan, J., Lin, L., and Tao, Y.J. "Self-guanylylation of birnavirus VP1 does not require an intact polymerase activity site." Virology, 395 (2009) : 87-96.

     
     

    Tang, J., Pan, J., Ochoa, W.F., Sinkovits, R.S., Havens, W.M., Ghabrial, S.A., Nibert, M.L., Tao, Y.J., and Baker, T.S. "Atomic structure of a dsRNA fungal virus from cryo-electron microscopy reconstruction and homology modeling." StructureSubmitted

     
     

    Ye, Q., Mata, D.A., Kuo, R.L., KyTonthat, N., Guu T., Schumacher, M.A., Krug, R.M., and Tao, Y.J. "Polymerization of the influenza A virus nucleoprotein changes its structure and RNA-binding acdtivity." EMBO JSubmitted

     
     

    Guu, T.S., Dong, L., Wittung-Stafshede, P., and Tao, Y.J. "Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit." Virology, 379 (2008) : 135-142.

     
     

    Lu, X, McDonald, S.M., Tortorici, A., Tao, Y.J., Vasquez-Del Carpio, R., Nibert, M.L., Patton, J.T., Harrison, S.C. "Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1." Structure, 16 (2008) : 1678–1688.

     
     

    Newcomb, L.L., Kuo, R.L., Ye, Q., Jiang, Y., Tao, Y.J., Krug, R.M. "Interaction of the influenza A virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication." Journal of Virology, 83 (2008) : 29-36.

     
     

    Pan, J., Dong, L., Lin, L., Ochoa, W.F., Sinkovits, R.S., Havens, W.M., Nibert, M.L., Baker, T.S., Ghabrial, S.A., Tao, Y.J. "Atomic structure reveals the unique capsid organization of a dsRNA virus." PNAS, In press

     
     

    Pan, J., Lin. L., Tao. Y.J. "Self-guanylylation by birnavirus VP1 does not require the polymerase activity." Journal of Virology, Submitted

     
     

    Pan, J., Vakharia, V.N., and Tao, Y.J. "The structure of a birnavirus polymerase reveals a distinct active site topology." Proc. Natl. Acad. Sci. USA, 104 (2007) : 7385-7390.

     
     

    Ye Q, Krug RM, Tao YJ "The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA." Nature, 444 (2006) : 1078-83.

     
     

    Kim, J., Tao, Y., Reinisch, K.M., Harrison, S.C., and Nibert, M.L. "Orthoreovirus and Aquareovirus Cor Proteins: Conserved Enzymatic Surfaces, but not Protein-protein Interfaces." Virus Res., 101 (2004) : 15-28.

     
     

    Sayes, C.M., Fortner, J.D., Lyon, D., Boyd, A.M., Ausman K.D., Guo W., Tao Y., Sitharaman, B., Wilson, L.J., West, J.L., and Colvin, V.L. "The Differential Cytotoxicity of Water-Soluble Fullerenes." Nano Letters, 4 (2004) : 1881-1887.

     
     

    Allison. S.L., Tao, Y.J., O'Riordain, G., Mandl, C.W., Harrison, S.C., and Heinz, F.X. "Two distinct size classes of immature and mature subviral particles from tick-borne encephalitis virus." Journal of Virology, 77 (2003) : 11357-11366.

     
     

    Simpson, A.A., Leiman, P.G., Tao, Y., He, Y., Badasso, M.O., Jardine, P.J., Anderson, D.L, and Rossmann, M.G. "Crystal Structure Determination of the Head-Tail Connector of Bacteriophage f29." Acta Crystallogr. D Biol. Crystallogr., 57 (2001) : 1260-1269.

     
     

    Tao, Y., Farsetta, D.L., Nibert, M.L., and Harrison, S.C. "RNA Synthesis in a Cage -- Structural Studies on Reovirus Polymerase lambda-3." Cell, 111 (2002) : 733-745.

     
     

    Morais, M.C., Tao, Y., Olson, N.H., Grimes, S., Jardine, P.J., Anderson, D.L., Baker, T.S., and Rossmann, M.G. "Cryo-EM Image Reconstruction of Symmetry Mismatch in Bacteriophage f29." J. Struct. Biol., 135 (2001) : 38-46.

     
     

    Badasso, M.O., Leiman, P.G., Tao, Y., He, Y., Ohlendorf, D.H., Rossmann, M.G., and Anderson, D., "Purification, Crystallization and Initial X-ray Analysis of the Head-Tail Connector of Bacteriophage phi29." Acta Crystallog. D Biol. Crystallog., 56 (2000) : 1187-1190.

     
     

    Simpson, A.A., Tao, Y. (Equal contributors), Leiman, P.G., Badasso, M.O., He, Y ., Jardine, P.J., Olson, N.H., Morais, M.C., Grimes, S., Anderson, D.L., Baker, T.S., and Rossmann, M.G. "Structure of the Bacteriophage phi29 DNA Packaging Motor." Nature, 408 (2000) : 745-750.

     
     

    Tao, Y., and Zhang, W. "Review: Recent Developments in Cryoelectron Microscopy Reconstructing of Single Particles." Curr. Opin. Struct. Biol., 10 (2000) : 616-622.

     
     

    Rossmann, G.M., and Tao, Y. "Cryo-electron-microscopy Reconstruction of Partially Symmetric Objects." J. Struct. Biol., 125 (1999) : 196-208.

     
     

    Rossmann, M.G., and Tao, Y. "Review: Courageous Science: Structural Studies of Bluetongue Virus Core." Structure Fold Des., 7 (1999) : R43-46.

     
     

    Rossmann, M.G., and Tao, Y. "Review: Structural Insight into Insect Viruses." Nat. Struct. Biol., 6 (1999) : 717-719.

     
     

    Tao, Y., Olson, N.H., Xu, W., Anderson, D.L., Rossmann, M.G., and Baker, T.S., "Assembly of a Tailed Bacterial Virus and its Genome Release Studied in Three Dimensions." Cell, 95 (1998) : 431-437.

     
     Editor of books
     

    Wang, Q., and Tao, Y.J. (ed.). To be published. Influenza: Current Research.  Caister Academic Press, Norfolk, UK. 

     
     

    Wang, Q., and Tao, Y.J. "Influenza: Molecular Virology." Caister Academic Press (2010)

     
     Book chapters
     

    Zheng, W., Zhang, W., Guo, Y.R., Tao, Y.J. "Chapter 4: Structure and assembly of the influenza A virus ribonucleoprotien complex." Influenza: Current Research (2016)

     
     

    Dubois, R., Dryden, K.A., Yeager, M., Tao, Y.J. "Astrovirus Structure and Function ." Astrovirus Pathogegnesis (2012)

     
     

    Guu TS, Zheng W, Tao YJ. "Bunyavirus: structure and replication. ." Adv Exp Med Biol., 726 ( 2012) : 245-66.

     
     

    Nibert, M.L., Baker, T.S., Tao, Y.J. "Structure of Partitiviruses." Advances in Virus Research on Mycoviruses (2012)

     
     

    Ghabrial, S.A., Nibert, M.L., Baker, T.S., Tao, Y.J. "Chapter 49: Family Partitiviridae." Ninth report of the International Committee on Taxonomy of Viruses (ICTV) (2011)

     
     

    Tao, Y.J. "Bunyaviruses: Structure and Replication." In Viral Molecular Machines (2011)

     
     

    Zheng, L., Tao, Y.J., Zhang, J.Q. "Structures and function of Hepatitis E virus capsid." Viral Hepatitis (2011)

     
     

    Ghabrial, S.A., Nibert, M.L., Baker, T.S., Tao, Y.J. "Family Partitiviridae." Ninth report of the International Committee on Taxonomy of Viruses (ICTV) (2011) In Press

     
     

    Tao, Y.J. "Bunyaviruses." Viral Molecular Machines (2011) In Press

     
     

    Tao, Y.J. "The power of persistence - overcome flu." The Light of Life: Lecture Series on Life and Career (2009)

     
     

    Tao, Y.J., Harrison, S.C "Chapter 13: Crystal Structure of Reovirus Polymerase Lambda3 ." Segmented Double-stranded RNA Viruses: Structure and Molecular Biology (2007)

     
     Other
     

    Jan E, Tao YJ. 2015. Editorial overview: Virus structure and expression.  Curr Opin Virol. Jun;12:ix-x. doi: 10.1016/j.coviro.2015.05.005. Epub 2015 Jun 6

     
    Presentations
     Invited Papers
     

    "The structure of a birnavirus polymerase reveals a distinct active site topology." American Society for Virology, 26th Annual Meeting, Oregon State University, Corvallis, Oregon. (July 14-18, 2007) With Pan, J., Vikharia, V.V., Tao, Y.J.

     
     Invited Talks
     

    Structural studies of a fish-infecting orthomyxovirus provide functional insights into influenza virus replication Department of Veterinary Medicine, Western University, Pomona, CA. 2016. Invited by Mohammad Mir

     
     

    Structure and Assembly of the Infectious Salmon Anemia Virus. Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University. 2016. Invited by Mark Wan.

     
     

    Structure and function of a nematode-infecting virus. FASEB Science Research Conference on Virus Structure and Assembly. Steamboat Springs, CO, USA. 2016. Invited by Rebecca Craven.

     
     

    Structure of a pentameric fiber reveals the mechanism of Orsay virus attachment to host cells. 3rd International Symposium of Gunma University Medical Innovation Gunma, Japan

     
     

    The infection mechanism of a nematode-infecting virus. The 2016 Southwest American Chemistry Society Meeting. Galveston, TX. 2016. Invited by George Phillips.

     
     

    "

    Orthomyxovirus ribonucleoprotein complexes

    ." University of Minnesota, Minneapolis, MN. (March 27, 2013)

     
     

    "The crystal structure and RNA-binding of an orthomyxovirus nucleoprotein." XV International Conference on Negative Strand Viruses, Granada, Spain. (June 16 - 21, 2013) With Zheng, W., Olson, J., Vakharia, V.

     
     

    "Astrovirus Structure and Replication ." Center for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas Medical School , Houston, TX.. ( April 9, 2012)

     
     

    "Orthomyoxovirus ribonucleoprotein complex ." Structural Biology of Nucleoprotein Complexes: From Viruses to Humans , University of Virginia, Charlottesville, VA . (May 7-9)

     
     

    "Structural and Functional Characterization of the RNA Replication Mechanism of a Small dsRNA Virus ." Eleventh International Symposium on Double Stranded RNA viruses , San Juan, Puerto Rico. (Nov 27-Dec 1, 2012)

     
     

    "Model for the Assembly of the Influenza A Virus Nucleoprotein into Double-Helical Ribonucleoproteins." The 25th Anniversary Meeting of the Protein Society, Boston, MA. (July 23-27, 2011)

     
     

    "Structure of RNA viruses." Institutes of Life Sciences, ZheJiang University, Hangzhou, Zhejiang Province, China. (June 23, 2011)

     
     

    "Structure of RNA viruses." College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China. (June 24, 2011)

     
     

    "The structure and assembly of the influenza A virus nucleoprotein complex." UTMB Symposium on Structural Biology and Infectious Disease, Galveston, TX. (February 11, 2011)

     
     

    "Polymerization of the influenza A virus nucleoprotein changes its structure and RNA-binding activity." Negative Strand RNA Virus Meeting, Brugge, Belgium. (2010) With Ye Q., Mata D.A., Kuo R., Guu T.S.Y., KyTonthat N., Schumacher M.A., Krug R.M.

     
     

    "The structure of RNA virus replication complexes." Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX. (October 7, 2010)

     
     

    "Atomic structure reveals the unique capsid organization of a dsRNA virus." 6th International Virus Assembly Symposium/Dr. Polly Roy, Crete, Greece. (May 3-7) With J. Pan, L. Dong, L. Lin, W.F. Ochoa, R.S. Sinkovits, W.M. Havens, M.L. Nibert, T.S. Baker, S.A. Ghabrial

     
     

    "Influenza A virus nucleoprotein and ribonucleoprotein complex." Department of Biology/Dr. Cheng Kao, Indiana University, Bloomington, IN. (October 20)

     
     

    "Interaction of the influenza A virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication." American Society for Virology, 28th Annual Meeting, Vancouver, British Columbia, Canada. (July 11-16) With L. Newcomb, R.L. Kuo, Q. Ye, Y. Jiang, R.M. Krug

     
     

    "Structural insights into assembly and cell receptor binding by hepatitis E virus." Department of Microbiology and Immunology/Dr. Jianming Hu, Pennsylvania State University Medical Center, Hershey, PA. (October 1)

     
     

    "The role of nucleoprotein in the assembly of the influenza A virus ribonucleoprotein complex." 14th Annual Sealy Center for Structural Biology Symposium/Dr. Robert Fox, Galveston, TX. (March 27)

     
     

    "The structure of the influenza A virus nucleoprotein and its role in viral genome packaging." Department of Pathology/Dr. Qing Fan, Columbia University School of Medicine, New York, NY. (February 2)

     
     

    "The structure of the influenza A virus nucleoprotein and its role in viral genome packaging." Department of Microbiology/Dr. Karin Reinisch, Yale University School of Medicine, New Haven, CT. (January 22)

     
     

    "Revealing the architecture detail of influenza virus RNP." Dr. Mark Lemmon, Dept. of Biochemistry & Biophysics, University of Pennsylvania School of Medicine. (April 10, 2008)

     
     

    "Structure and function of the influenza A virus nucleoprotein." XIV International Congress in Virology, Istanbul, Turkey. (August 10-15, 2008)

     
     

    "The assembly of influenza virus RNP." 2008 International Symposium on Influenza Virus, Taiwan. (October 13-14, 2008)

     
     

    "The power of persistence: overcome influenza." Dr. Shiqiang Wang, School of Life Sciences, Peking University, Beijing, China. (May 7, 2008)

     
     

    "The structure of the influenza A virus nucleoprotein and its role in viral genome packaging." Department of Microbiology, Yale University School of Medicine, New Haven, CT. (January 22, 2008)

     
     

    "Towards a comprehensive understanding of the influenza A virus nucleoprotein." GCC Nanobiology Training Grant 2nd Annual Summer Symposium, Texas Medical Center, Houston, TX. (July 15, 2008)

     
     

    "Structural and functional studies of the influenza A virus nucleoprotein." Special Topic Symposium "Structural Biology in the Post-Genomic Era" held in conjunction with the American Association for the Advancement of Science SWARM Division 82nd Annual Meeting, Clear Lake, TX. (April 20, 2007)

     
     

    "The influenza virus nucleoprotein." The 2007 meeting of the American Crystallographic Association, Salt Lake City, Utah. (July 21-26, 2007)

     
     

    "The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA." Options for the control of Influenza VI, Toronto, Ontario, Canada. (June 17-23, 2007) With Ye, Q., Krug, R., Tao, Y.J.

     
     

    "The mechanisms by which influenza A virus nucleoprotein forms oligomers and binds RNA." American Society for Virology, 26th Annual Meeting, Oregon State University, Corvalis, OR. (July 14-18, 2007) With Ye, Q., Krug, R., Tao, Y.J.

     
     

    "Crystal Structure of an RNA Polymerase from the Infectious Bursal Disease Virus." Phage/Virus Assembly Meeting XIX, Winter Park, CO. (June 7 - June 12, 2005) With Junhua Pan

     
     

    "Influenza virus polymerase: the Central Machinery for Genome Replication and Transcription." UK-Texas Bioscience Collaboration, Infectious Diseases - Old Challenges - New Solutions, London, UK. (December, 2005)

     
     

    Invited speaker.  "Symmetry mismatches in biological assemblies studied by cryo-EM reconstruction." 21st annual meeting for the Houston Society for Bioengineering in Medicine and Biology, Houston, TX. (February 13, 2004) With Tao Y.J., Anderson, D.L., Nibert, M.L., Rossmann, M.G., Baker T.S.,

     
     

    "RNA replication by dsRNA viruses." Baylor Postoc Association, Baylor College of Medicine. (August 2003)

     
     

    "Structural studies of RNA replication by dsRNA viruses." Dr. Xiangwei He, University of Texas Medical Center. (October 6, 2003)

     
     

    "Structural studies of reovirus polymerase." 4th International virus assembly symposium, Sardinia, Italy. (September 20 - 24)

     
     

    "Structural studies of reovirus polymerase and implications for RNA synthesis by dsRNA viruses." Dr. Vik Vikharia, University of Maryland. (March 13, 2003)

     
     

    "Structural studies of reovirus polymerase lambda3." Keck / Dr. Hong Zhou, Rice University. (April 4, 2003)

     
     Posters
     

    "Biochemical and biophysical characterization of the capsid assembly and RNA packaging of a small dsRNA virus." American Society for Virology, 29th Annual Meeting, Bozeman, Montana. (2010) With Aaron M. Collier, Junhun Pan

     
     

    "Atomic structure reveals the unique capsid organization of a dsRNA virus." 14th Structural Biology Symposium, Galveston, TX. With J. Pan (presenter), L. Dong, L. Lin, W.F. Ochoa, R.S. Sinkovits, W.M. Havens, M.L. Nibert, T.S. Baker, S.A. Ghabrial, Y.C. Tao

     
     

    "Atomic structure reveals the unique capsid organization of a dsRNA virus." 1st Gordon Research Conference on Physical Virology, Galveston, TX. (February 15-20) With J. Pan, L. Dong, L. Lin, W.F. Ochoa, R.S. Sinkovits, W.M. Havens, M.L. Nibert, T.S. Baker, S.A. Ghabrial

     
     

    "Atomic structure reveals the unique capsid organization of a dsRNA virus." American Society for Virology, 28th Annual Meeting, Vancouver, British Columbia, Canada. (2009) With J. Pan (presenter), L. Dong, L. Lin, W.F. Ochoa, R.S. Sinkovits, W.M. Havens, M.L. Nibert, T.S. Baker, S.A. Ghabrial

     
     

    "Self-guanylylation by birnavirus VP1 does not require the polymerase activity." American Society for Virology, 28th Annual Meeting, Vancouver, British Columbia, Canada. (2009) With L. Li (presenter), J. Pan,

     
     

    "Structural analysis of the cohesin Rad21-SA2 complex." CSHL Meeting on Eukaryotic DNA Replication and Genome Maintenance, Cold Spring Harbor, NY. (2009) With Y. Jiang (presenter), N. Zhang, Y.J. Tao, D. Pati

     
     

    "The role of influenza A virus nucleoprotein in ribonucleoprotein (RNP) assembly." 21st IUBMB & 12th FAOBMB International Conference of Biochemistry and Molecular Biology, Shanghai, China. With Q. Ye (presenter), D.A. Mata, R.L. Guo, N. KyThonthat, T.S.Y. Guu, M.A. Schumacher, R.M. Krug

     
     

    "Unique capsid organization of a dsRNA virus revises the model for capsid assembly." 1st Gordon Research Conference on Physical Virology, Galveston, TX. (2009) With J. Pan (presenter), L. Dong, L. Lin, W.F. Ochoa, R.S. Sinkovits, W.M. Havens, M.L. Nibert, T.S. Baker, S.A. Ghabrial

     
     

    "Crystal Structure of the Influenza A Virus Nucleoprotein at 3.15 E resolution." The 2006 Southwest Macromolecular Symposium, Woodlands, TX. (June 16-18, 2006) With Qiaozhen Ye, Robert M. Krug

     
     

    PI.  "Crystal Structure of the Influenza A Virus Nucleoprotein at 3.15 E resolution.." The 11th Annual Structure Biology Symposium, Galveston, TX. (May 19-20, 2006) With Qiaozhen Ye, Robert M. Krug

     
     

    "The crystal structure of a birnavirus RNA polymerase reveals a distinct active site topology and a novel protein-priming domain." American Crystallographic Association 2006 Annual Meeting, Honolulu, Hawaii. (July 22-27, 2006) With Pan, J., Vakharia, V.

     
     

    PI.  "crystal structure of a birnavirus VP1 - a protein with both RNA polymerase and and protein primer functions ." 11th Structural Biology Symposium, UTMB, Galveston, Texas. (May 19-20, 2006) With Pan, J., Vakharia, V

     
     

    PI.  "crystal structure of a birnavirus VP1 - a protein with both RNA polymerase and protein primer functions." FASEB Summer Research Conferences - Virus assembly, Saxtons River, Vermont. (June 17-22, 2006) With Pan, J., Vakharia, V.

     
     

    PI.  "crystal structure of a birnavirus VP1, a protein with both RNA polymerase and protein primer functions." 2006 National Graduate Student Research Festival, NIH, Bethesda, Maryland. (October 12-13, 2006) With Pan, J., Vakharia, V.

     
     

    "An unusual polymerase with a novel active site." SCBA Texas Chapter 2005 Annual Symposium, Houston, TX. (April, 2005) With Junhua Pan

     
     

    Supervisor.  "Novel structure of birnavirus polymerase VP1 reveal evolutionary relationships between RNA viruses." Sealy Structural Biology Symposium, Galveston, TX. (May, 2005) With Junhua Pan

     
     

    Supervisor.  "The cap binding activity of reovirus polymerase lambda3." Sealy Structural Biology Symposium, Galveston, TX. (May, 2005) With Tom Guu

     
     

    Corresponding author.  "The high-order structure of influenza virus genome studied by 3-D EM reconstruction and nanoparticle labelling." NanoDays, Houston, TX. (October 29-30, 2004) With Jack Xie, Qiaozhen Ye, Vicki Colvin, Yizhi Jane Tao

     
     

    "Rotavirus Double-stranded RNA Synthesis: Formation of the Minus-strand Initiation Complex." 2003 Annual Meeting of American Society of Virology, University of California, Davis. (July 12-16)

     
     Seminar Speaker
     

    "Influenza A virus nucleoprotein." Molecular Basis of Infectious Diseases (MBID) seminar series, University of Texas Medical School, Houston, TX. (November 21, 2008)

     
     

    "Structure and function of nucleoproteins from negative-stranded RNA viruses.." ZhongShan University, Guangzhou, China. (March 12, 2007)

     
     

    "The influenza virus nucleoprotein." University of Texas at El Paso, Texas, El Paso, Texas. (October 5, 2007)

     
     

    "The influenza virus nucleoprotein." University of Texas A&M University, College Station, Texas.. (October 31, 2007)

     
     

    "The mechanisms by which influenza A virus nucleoprotein forms oligomers and binds RNA." Baylor University, Department of Microbiology, Houston, TX. (February 15, 2007)

     
     

    "Crystal Structure of Birnavirus Polymerase VP1." Purdue University. (October, 2005)

     
     

    "Structural Studies of viral RNA polymerases." Baylor College of Medicine. (February, 2005)

     
    Editorial Positions
     Editor for Special Issue, Viruses. MDPI. (2015 - 2016)

     Book Review Editor, Influenza: Current Research. Caister Academic Press. (2016 - 2016)

     Member of the Editorial Board, Computational and Structural Biotechnology Journal. (2011 - 2011)

     Member of the Editorial Board, AIMS Microbiology. AIMS Press. (2015 - 2015)

    Supervised Theses & Dissertations
     Angela Hale, M.A. Electrostatic Regulation of Oxygen Binding to the Neuronal Hemoglobin of Cerebratulus lacteus. (2004) (Thesis Committee Member)

     John Bruning, Ph.D. Structural and Thermodynamic Analysis of Human PCNA Bound to Peptides Derived from DNA Polymerase-delta p66-Subunit and Flap Endonuclease-1 (FEN1) Proteins. (2004) (Thesis Committee Member)

     Corey Wilson, Ph.D. Experimental and Theoretical Approaches to Protein Folding, Stability, and Assembly: A Thorough Assessment of Complex Behavior. (2005) (Thesis Committee Member)

     Erin Foley, Ph.D. Physiologically Relevant Reactions of Myoglobin and Hemoglobin with NO. (2005) (Thesis Committee Member)

     Liping Dong, M.A. Functional and Structural Studies of the Influenza A Virus Polymerase Subunit PB1 and its Subcomplex with the Subunit PA. (2007) (Thesis Director)

     Jinhua Pan, Ph.D. Structural and Functional Studies on Birnavirus RNA Polymerases - Insights into the Protein-priming Mechanism and Evolution of RNA Viruses. (2007) (Thesis Director)

     George Blouin, Ph.D. Alkyl Isocyanides as Transition State Analogs for Ligand Entry and Exit in Globins. (2007) (Thesis Committee Member)

     George Blouin, Ph.D. Alkyl Isocyanides as Transition State Analogs for Ligand Entry and Exit in Globins. (2008) (Thesis Committee Member)

     Megan Guelker, Ph.D. Overcoming the Challenges of Twinning and Pseudo Symmetry in Solving the Structure of Flavodoxin from Desulfovibrio desulfuricans 29577 by X-ray Crystallography. (2008) (Thesis Committee Member)

     Adina Maximiuc, Ph.D. Structural Basis for Calmodulin-mediated Regulation of the Ryanodine Receptor. (2008) (Thesis Committee Member)

     Tom Guu, PhD Structure of the hepatitis E subviral particle suggests mechanisms for virus assembly and receptor binding. (2009) (Thesis Director)

     Loren Stagg, Ph.D. Role of cell-like conditions in folding, structure, and stability of an a/b model protein, Desulfovibrio desulfuricans flavodoxin. (2009) (Thesis Committee Member)

     Faiza Hussein, PhD Managing the copper paradox: Protein stability, copper-binding and inter-protein interactions of copper chaperones. (2009) (Thesis Committee Member)

     Jia Xu, PhD Experimental characterization and molecular dynamics simulation of the allosteric transition in the Escherichia coli lactose repressor. (2009) (Thesis Committee Member)

     Peng Zhai, Ph.D. Escort protein regulation of the human mitochondrial molecular chaperone mtHsp70. (2010) (Thesis Committee Member)

     Peter Nguyen, Ph.D. Effect of protein thermostability on the cooperative function of split enzymes. (2010) (Thesis Committee Member)

     Wenjie Zheng, Ph.D. Structural and functional studies on the infectious salmon anemia virus nucleoprotein. (2013) (Thesis Director)

     Justin Harper, M.A. The Induction of Infectivity in Human Astrovirus in Response to Capsid Proteolysis. (2013) (Thesis Director)

     Zihan Lin, Ph.D. TBD. (2020) (Thesis Director)

     Yanlin Fan, PhD Structure and function studies of Orsay virus. (Thesis Director)

     Yusong Guo, PhD TBD. (Thesis Director)

     Miguel A Betancourt, PhD In vitro structure-function analysis of Drosophila atlastin. (Thesis Committee Member)

     Premila Samuels Mohan Das, PhD Engineering recombinant myoglobins and hemoglobins for optimized globin stability. (Thesis Committee Member)

     Xu Wang, PhD Structure-function studies of E. faecalis YybT and GshF associated with daptomycin resistance. (Thesis Committee Member)

     Fenbeng Wang, PhD Structural characterization of enzymes involved in the biosynthesis of anti-tumor natural products. (Thesis Committee Member)

    Awards, Prizes, & Fellowships
     Hamill Innovation Award, Rice University

     Hamill Foundation Award, (2012-2013)

     "You bring charm to the world as an influential Chinese" Award, Phoenix Satellite TV, Asia Newsweek & World Journal (March 2007)

     "Outstanding Youth Leaders" Award, The Southern People Magazine in China (May 2007)

     The semi-finalist award, Keck Foundation (June, 2005)

    Positions Held
     Member, American Society of Virology. (2014 - 2015)

     Member, American Crystallographic Association. (2014 - 2015)

     Member, Protein Society. (2014 - 2015)

     ad hoc Reviewer, NIH study sections. (2007 - 2014)