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Scholarly Interest Report
         
John W. Clark, Jr.
Professor
Professor in Electrical and Computer Engineering
 
e-mail:jwc@rice.edu
 
  • B.S. (1962) Christian Brothers College
  • M.S. (1965) Case Western University
  • Ph.D. (1967) Case Western University
 
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Department Affiliations
 
  • Department of Bioengineering
  • Keck Center for Quantitative Biomedical Sciences
  • Ken Kennedy Institute for Information Technology
  •  
    Websites
     John W. Clark Jr
     
    Research Areas
     Biological Systems Modeling, Bioelectric Phenomena, Analysis of Nonlinear Dynamic Systems
     

    Research Interests: Neuron and Cardiac Cell Modeling.  Development of a Combined Human Cardiovascular and Respiratory System (H-CVRS) Model

     

    Research is centered on the area of Computational Biology and Medicine. Dr. Clark's Laboratory develops detailed mechanistic models of biological processes on several levels of scale: from molecular, cellular and tissue modeling to the development of interactive multiple-organ system models. Examples of cellular models include cardiac cell and neuron modeling with mechanistic ion channel descriptions and modulation via second messengers. At the multiple-organ level, work is focused on the development of large-scale models of the human cardiovascular and respiratory systems, as they interact and are controlled by the central nervous system.  This later H-CVRS model has been applied to the study of a variety of problems in critical care medicine including congestive heart failure.

     
    Teaching Areas
     Bioengineering, Nonlinear Dynamic Systems Analysis
     
    Selected Publications
     Abstracts
     Qiao F, T. Pan, J.W. Clark Jr and O.R. Mawlawi, Region of Interest Motion Compensation for PET Image Reconstruction, Phys. Med. Biol. 52(10): 2675-89, 2007.
     
     Ha RR, Wang D, Zwischenberger JB, Clark JW Jr. Hemodynamic Analysis and Design of a Paracorporeal Artificial Lung Device, Cardiovascular Engineering 6(1):10-29, 2006
     
     Refereed articles
     

    Chang T, Diab RH, Clark JW Jr, Mawlawi OR "Investigating the use of nonattenuation corrected PET images for the attenuation correction of PET data." 

     
     

    Krishna A, Valderrábano M, Palade PT, Clark JW Jr. "Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study.." 

     
     

    J Appl Clin Med Phys. 2012 May 10;13(3):3599. PMID: 22584164

     
     

    Med Phys. 2012 Oct;39(10):5891-5900.PMID: 23039628

     
     

    Theoretical Biology and Medical Modelling 2012,Nov 21; 9(1):48 PMID: 23171697

     
     

    J. Theoretical Biology and Medical Modeling. 2011 May 9;8:14. PMID: 21554684

     
     

    International Journal of Radiation Oncology • Biology • Physics 2011 Dec 22.  PMID:  22197228

     
     

    Physics Medicine and Biology 2011 Aug 21; 56(16):5275-85.  PMID: 21791730

     
     Chang G, Pan T, Clark JW Jr, Mawlawi OR, Optimization of super-resolution processing using incomplete image sets in PET imaging Medical Physics 2008;35(12):5748-57.
     
     Comparison Between Two Super-resolution Implementations in PET Imaging (in press)
     
     Luo, C., D. L. Ware, J. B. Zwischenberger and J. W. Clark Jr., A Mechanical Model of the Human Heart Relating Septal Function to Myocardial Work and Energy, J. Cardiovascular Engrineering, 8(3):174-184, 2008.
     
     Yue, Y., J.W. Clark Jr. and D. Khoury, Speckle Tracking in Intracardiac Echocardiography for the Assessment of Myocardial Deformation,IEEE Trans. on Biomed. Engr (in press)
     
     Luo, C., D. L. Ware, J. B. Zwischenberger and J. W. Clark Jr., Using a Human Cardiopulmonary Model to Study and Predict Normal and Diseased Ventricular Mechanics, Septal Interaction, and Atrio-Ventricular Blood Flow Patterns, J. Cardiovasc. Engr. 7:1731, 2007.
     
     Qiao F, T. Pan, J.W. Clark Jr and O.R. Mawlawi, Joint Model of Motion and Anatomy for PET image Reconstruction, Med. Physics, 34(12):4626-4639, 2007.
     
     

    Amini, B., A. Bidani, J.B. Zwischenberger, and J.W. Clark, Jr. "A model of the rat phrenic motor neuron." IEEE Trans. on Biomed. Engr., 51 (2004) : 1103-1114.

     
     

    C. Luo, J.W. Clark Jr., C.C. Canavier, D.A. Baxter and J.H. Byrne "Multimodal behavior in a four neuron ring circuit: Mode switching." IEEE Trans. on Biomed. Engr., 51(2) (2004) : 205-218.

     
     

    C. Luo, J.W. Clark Jr., T.A. Heming and A. Bidani "A Simplified Model for V-ATPase H+ Extrusion." I.E.E.E. Transactions on Nanobioscience, 3 (2004) : 257-264.

     
     

    Lu, K., J.W. Clark Jr., F.H. Ghorbel, C.S. Robertson, D.L. Ware, "Cerebral autoregulation and gas exchange studied with a human cardiopulmonary model." Amer. J. Physiol., 286 (2004) : H584-H601.

     
     

    J. Yang, C. Robertson, R.M. Bryan, J.Clark, Jr. "The myogenic response in isolated rat cerebrovascular arteries: Smooth muscle cell model." Medical Engineering Physics, 25(8) (2003) : 691-709.

     
     

    J. Yang, R.M. Bryan, C. Robertson, J. Clark, Jr. "The myogenic response in isolated rat cerebrovascular arteries: Vessel model." Medical Engineering Physics, 25(8) (2003) : 711-717.

     
     

    Lu, K., J.W. Clark Jr., F.H. Ghorbel, D.L. Ware, J.B. Zwischenberger, and A. Bidani "Whole-body gas exchange in human predicted by a cardiopulmonary model." J. Cardiovascular Engineering: An International Journal, 3 (2003) : 1-19.

     
     Articles
     F. Qiao, T. Pan, J.W Clark Jr. and O.R. Mawlawi,A Motion-incorporated Reconstruction Method for Gated PET Studies, Phys. Med. Biol. 51:37693783, 2006
     
     Luo, C., J.W. Clark Jr., T.A. Heming, A. Bidani, A Macrophage Cell Model for pH and Volume Regulation, J. Theoretical Biology,238:449 463, 2006.
     
     Yue, Y., M.M. Croitoru, A. Bidani, J.B. Zwischenberger and J.W. Clark, Jr., Nonlinear Multiscale Wavelet, Diffusion for Speckle Suppression and Edge Enhancement in Ultrasound Images,¿ IEEE Trans. Medical Imaging, 25(3): 297-311, 2006.
     
     

    Amini B., A. Bidani, J.B. Zwischenberger, and J.W. Clark, Jr. "A Model of the Pacemaking Neuron of the Respiratory Central Pattern Generator." IEEE Transactions on Neural Systems and Rehabilitation Engineering, 13(2) (2005) : 120-124.

     
     

    Ha, R.R., J. Qian , D.L. Ware, J.B. Zwischenberger, A. Bidani, and J.W. Clark Jr. "An integrative cardiovascular model of the standing and reclining sheep." Cardiovascular Engineering, 5(2) (2005) : 53-76.

     
     

    Luo, C., J.W. Clark Jr., T.A. Heming, A. Bidani "A Macrophage Cell Model for pH and Volume Regulation." J. Theoretical Biology (2005) In Press

     
     

    Yang, J., J.W. Clark Jr., R.M. Bryan, and C.S. Robertson "Mathematical Modeling of the Nitric Oxide/cGMP Pathways in the Vascular Smooth Muscle Cell." Amer. J. Physiology, 289 (2005) : H886-H897.

     
     Refereed conference papers
     

    M. Valiollahzadeh M, Clark JW Jr and Mawlawi, OR "Image Evaluation of penalizing functions in compressed Sensing to recover undersampled data in PET Imaging." 

     
     

    Valiollahzadeh, M Clark, JW Jr and Mawlawi OR "Image Dictionary Learning in Compressed Sensing Using Undersampled Data in PET Imaging ." 

     
     

    Valiollahzadeh, M , Clark, JW Jr, and Mawlawi OR "Image Poisson Compressive Sensing Image Reconstruction in PET Scanners with Only Partial Detector Observation ." 

     
     Conference papers
     

    Conf. Proc. IEEE Eng Med. Biol. Soc. Aug; 2011: 2403-2409. PMID: 22254826

     
     F. Qiao, T. Pan, J.W. Clark, Jr. and O. Mawlawi, "Region of Interest Motion Compensation in PET Image Reconstruction," 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop, October 29  Nov. 4, 2006, San Diego, CA. Paper M11-319 on CD-ROM of Proceedings.
     
     

    B. Amini, A. Bidani, J.B. Zwischenberger and J.W. Clark Jr. "A Model of the Respiratory Central Pattern Generator." Proc. 26th Annual Conference of the IEEE Engineering in Medicine and Biology Society (1-5 Sep 04) : paper 11.7.1.5, pp 4580-4583.

     
     

    R. Ha, J. Qian, D. Wang, J.B. Zwischenberger, A. Bidani, J.W. Clark Jr. "A Closed-Loop Model of the Ovine Cardiovascular System." Proc. 26th Annual Conference of the IEEE Engineering in Medicine and Biology Society (1-5 Sep 04) : paper 10.3.5.6, pp 3781-3784.

     
     

    Y. Yue, M.M. Croitoru, J.B. Zwischenberger, J.W. Clark, Jr. "Ultrasonic Speckle Suppression Using Robust Nonlinear Wavelet Diffusion for LV Volume Quantification." Proc. 26th Annual Conference of the IEEE Engineering in Medicine and Biology Society (1-5 Sep 04) : paper 11.7.1.5, pp 4580-4583.

     
     

    K. Lu, J.W. Clark, F.H. Gorbel, C.S. Robertson, D.L. Ware, J.B. Zwischenberger, and A. Bidani "Cerebral Autoregulation and Gas Exchange Studied Using a Human Cardiopulmonary Model." Proc. 25th Annual International Conference of IEEE/EMBS, Cancun, Mexico, 17-21 September, 2003, Paper 1.7.1.5: 3 pages.

     
     

    L. Sun, J.W. Clark Jr., J-S. Fan, and P.T. Palade "A Mathematical Model of Calcium-release and Calcium Balance During Systole in Rat Ventricular Myocytes." Proc. 25th Annual International Conference of IEEE/EMBS, Cancun, Mexico, 17-21 September, 2003, Paper 1.1.1.7: 3 pages.

     
     

    A. Bidani, C. Luo, T.A. Heming, J.Clark, Jr. "Ion Transport in Lung Cells: From Cellular Homeostasis to Pulmonary Gas Exchange." Proceedings 2nd Proc. 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 6.3.3.1 (02/10/24) : 2.

     
     

    B. Amini, A. Bidani, J.B. Zwischenberger, J.Clark, Jr. "A Model of the Rat Phrenic Motor Neuron." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 6.3.5.2 (02/10/25) : 2 pages.

     
     

    C. Luo, A. Bidani, J. Clark, Jr. "Development of a GUI-based Platform for Analysis of Alveolar Cell pH and Ion Regulation." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 14.1.2.2 (02/10/24) : 2 pages.

     
     

    C. Luo, T.A. Heming, A. Bidani, J. Clark, Jr. "Mathematical Analysis of Alveolar Macrophage pH Regulation." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 6.3.7.10 (02/10/23-6) : 2 pages.

     
     

    J. Qian, K. Lu, Ghorbel, F., A. Bidani, J. Zwischenberger, J.Clark, Jr. "A Closed-loop Model of the Ovine Cardiovascular System." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 6.4.3.5 (02/10/26) : 2 pages.

     
     

    J. Yang, R.M. Bryan, C. Robertson, J. Clark, Jr. "A Mechanistic Model of the Myogenic Response." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 14.4.1.3 (02/10/24) : 2 pages.

     
     

    K. Lu, Ghorbel, F., A. Bidani, D.L. Ware, K. Lu, Ghorbel, F., A. Bidani, D.L. Ware, Clark, J. Clark, Jr.. "A Closed-loop Model of Human Gas Exchange." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 6.3.7.6 (02/10/25) : 2 pages.

     
     

    K.N. Daniel, L. Sun, K. Spitzer, W.R. Giles, J. Clark, Jr. "Mathematical Model of the Rabbit Ventricular Myocyte." Proc. 2nd Joint EMBS-EMBS Conference, 23-26 October, 2002, Houston, TX, 6.2.1.2 (02/10/23) : 2 pages.

     
     

    L. Sun, C.S. Martin, J.L. Lacy, N. Nayak , J. Clark, Jr. "Motion Correction in Treadmill First-pass Radionuclide Angiography." Proceedings 2nd Joint EMBS-EMBS Conference, Houston, TX, 23-26 October,, 5.1.1.1 (02/10/23) : 2 pages.

     
     Other
     

    J. Yang, J.W. Clark, R. Bryan, and C. Robertson "A Cellular Based Model of the Myogenic Response in Isolated Cerebral Arteries." Proc. 23rd Annual Conference , IEEE/EMBS, Istanbul, Turkey (25-28 October, 2001) : 3 pages.

     
     

    K. Lu, J.W. Clark, F.H. Ghorbel, D.L. Ware and A. Bidani "A Human Cardiopulmonary System Model Applied to the Analysis of the Valsalva Maneuver." Amer. J. Physiol., 281 (2001) : H2661-H2679.

     
     

    K. Lu, J.W. Clark, F.H. Gorbel, D.L. Ware, and A. Bidani "An Integrated Model of the Human Cardiopulmonary System." Proc. 23rd Annual Conference , IEEE/EMBS, Istanbul, Turkey (25-28 October, 2001) : 3 pages.

     
     

    L. Sun, J.W. Clark, J-S. Fan, and P.T. Palade ""Ca2+ -induced Calcium Release in a Rat Ventricular Cell: A Model Study." Proc. 23rd Annual Conference , IEEE/EMBS, Istanbul, Turkey (25-28 October, 2001) : 2 pages.

     
     

    Athanasiades, A., F. Ghorbel, J.W. Clark Jr., S.C. Niranjan, J.Olansen, J.B. Zwischenberger, and A. Bidani "Energy Analysis of a Nonlinear Model of the Normal Human Lung." Biological Systems, 8 (2000) : 115-139.

     
     

    Athanasiades, A., J.W. Clark Jr., F. Ghorbel and A. Bidani "An Ionic Current Model for Medullary Respiratory Neurons." J. Computational Neuroscience, 9 (2000) : 237-257.

     
     

    Baxter, D.A., C.C. Canavier, J.W. Clark Jr. and J.H. Byrne "Computational Model of the Serotonergic Modulation of Sensory Neurons in Aplysia." J. Neurophysiology, 82 (1999) : 2914-2935.

     
     

    C. Luo, J.W. Clark, A.A. DeFranceschi, C.C. Canavier, D.A. Baxter and J.H. Byrne "Multimodal behavior in a biologically inspired gait generation circuit." Journal of Computational Neuroscience (submitted for publication)

     
     

    J.B. Olansen, F. Ghorbel, J.W. Clark Jr. and A. Bidani "Using Virtual Instrumentation to Develop a Modern Biomedical Engineering Laboratory." International J. Engineering Education, 16 (2000) : 244-254.

     
     

    K.D. Alfrey, J.H. Schild, J.W. Clark, Jr., D.L. Kunze and M.C. Andresen "Modeling the ionic mechanisms of rat arterial baroreceptor mechanotransduction: I. Static characteristics." American Journal of Physiology (submitted for publication)

     
     

    K.D. Alfrey, J.H. Schild, J.W. Clark, Jr., D.L. Kunze and M.C. Andresen "Modeling the ionic mechanisms of rat arterial baroreceptor mechanotransduction: II. Dynamic characteristics." American Journal of Physiology (submitted for publication)

     
     

    L. Sun, J-S. Fan, J.W. Clark and P.T. Palade "A model of the L-type Ca2+ channel in rat ventricular myocytes: Ion selectivity and inactivation mechanisms." J. Physiology (London), 529 (2000) : 139-158.

     
     

    Olansen, J.B., Clark, J.W., Khoury, D., Ghorbel, F. and Bidani, A. "A closed-loop model of the canine cardiovascular system that includes ventricular interaction." Computers in Biomedical Research, 33 (2000) : 260-295.

     
     

    V.L. Lowes, A. Nygren, R.B. Clark, F. Eriksson, J.W. Clark and W.R. Giles "K+ accumulation during activation of K+ currents in Xenopus Oocytes." Biophysical Journal (submitted for publication)

     
     

    Amini, B., Clark, J.W. Jr. and Canavier, C.C. "Calcium Dynamics Underlying Pacemaker-Like and Burst Firing Oscillations in Midbrain Dopaminergic Neurons: A Computational Study." J. Neurophysiology, 82 (1999) : 2249-2261.

     
     

    Baxter, D.A., C.C. Canavier, J.W. Clark Jr. and J.H. Byrne "Computational Model of the Serotonergic Modulation of Sensory Neurons in Aplysia." J. Neurophysiology (accepted for publication)

     
     

    C.C. Canavier, D.A. Baxter, J.W. Clark and J.H. Byrne "Control of Multistability in Ring Circuits of Oscillators." Biological Cybernetics, 80 (1999) : 87-102.

     
     

    D.A. Baxter, H.A. Lechner, C.C. Canavier, R.J. Butera, A.A. DeFranceschi, J.W. Clark, and J.H. Byrne "Coexisting Stable Oscillatory States in Single Cell and Multi cellular Neuronal Oscillators." Oscillations in Neural Systems, D.S. Levine V.R. Brown, and V.T. Shirley, eds. (1999) : 51-77.

     
     

    Niranjan, S.C., Bidani, A., Ghorbel, F., Zwischenberger, J.B. and Clark Jr., J.W. "Analysis of Inspiratory Waveforms on Pulmonary Blood Flow and Gas Exchange During Mechanical Ventilation." Computers in Biomedical Research, 32 (1999) : 355-390.

     
     

    R.O. Dror, C.C. Canavier, R.J. Butera, J.W. Clark and J.H. Byrne "A Mathematical Criterion Based on Phase Response Curves for Stability in a Ring of Coupled Oscillators." Biological Cybernetics, 80 (1999) : 11-23.

     
     

    S.S. Demir, J.W. Clark and W.R. Giles "Parasympathetic Modulation of Sinoatrial Node Pacemaker Activity in Rabbit Heart: A Unifying Model." Amer. J. Physiol., 2 (1999) : H2221-H2244.

     
     

    A. Nygren, C. Fiset, L. Firek, J.W. Clark, D. S. Lindblad, R.B. Clark, and W.R. Giles "A Mathematical Model of An Adult Human Atrial Cell: The Role of K+ Currents in Repolarization." Circulation Research, 82 (1998) : 63-81.

     
     

    C.H. Liu, S.C. Niranjan, J.W. Clark, Jr., K.Y. San, J.B. Zwischenberger, and A. Bidani "Airway Mechanics, gas Exchange and Blood Flow in a Nonlinear Model of the Human Lung." Journal of Applied Physiology, 84 (1998) : 1447-1469.

     
     

    D.A. Baster, C.C. Canavier, H.A. Lechner, R.J. Butera, A.A.DeFrancieschi, J.W. Clark, and J.H. Byrne "Coexisting Stable Oscillatory States in Single Cell and Multi Cellular Neuronal Oscillators." Oscillations in Neural Systems

     
     

    J.B. Olansen, F. Ghorbel, J.W. Clark Jr., D. Deyo, J.B. Zwischenberger, and A. Bidani "An Automated LabVIEW-Based Data Acquisition System for Analysis of Pulmonary Function." Journal of Clinical Engineering, 23 (1998) : 279-287.

     
     

    J.W. Clark "The Origin of Biopotentials." Medical Instrumentation: Application and Design, 3rd edition (1998) : 121-182.

     
     

    R.0. Dror, C.C. Canavier, R.J. Butera, J.W. Clark and J.H. Byrne "A Mathematical Criterio Based on Phase Response Curves for Stability in a Ring of Coupled Oscillators." Biological Cybernetics

     
     

    S.S. Demir, J.W. Clark and W.R. Giles, "Parasympapthetic Modulation of Sinoatrial Node Pacemaker Activity in Rabbit Hert: A Unifying Model." Amer. J. Physiol.

     
    Presentations
     Invited Talks
     Mechanisms Underlying Cardiac Tamponade and Pulsus Paradoxus: Utilization of a Human Cardiovacular-Respiratory System Model, D. P. Ramachandran, C. Luo, T. Ma, J. W. Clark, Jr., Invited Talk presented by J.W. Clark Jr. at the European Communications of Mathematical and Theoretical Biology (ECMTB) Conference at the University of Edinburgh, Edinburgh, Scotland, 29 June ¿ 4 July, 2008.
     
     A Human Cardio-Respiratory Model: Applications in Critical Care Medicine, C. Luo and J.W. Clark Jr., presented at Biomedical Modeling and Cardiovascular-Respiratory Control: Theory and Practice Workshop, Schloss Seggau, Leibnitz, Austria 2-4 August 2007. Invited talk presented by J.W. Clark Jr. at Workshop http://www.uni.at/mc_training_schools/graz/workshop/
     
     Using a Human Cardiopulmonary Modeto Study Left Ventricular Diastolic Dysfunction (LVDD)," C. Luo, D.L. Ware, J.B. Zwischenberger and J.W. Clark Jr..Invited talk presented by J.W. Clark Jr. at Annual Conference of the Biomedical Engineering Society (BMES)at the Renaissance Hollywood Hotel, 26-29 September 2007, Los Angeles, CA
     
     

    "A Large-Scale Model of the Human Cardiovascular-Respiratory System." Department of Computer Science, University of Houston. (12/11/2006)

     
     Other
     

    "A Mathematical Model of the Human Cardiopulmonary System." K. Lu, J.W. Clark, F. Ghorbel, and A. Bidani, Abstracts of the 19th Annual Houston Conference on Biomedical Engineering Research, Houston, TX, , pg 56, held at University Hilton Hotel, Houston, TX.. (8-9 Feb, 2001)

     
     

    "A Model of the SR Ca2+ Release Complex in Rat Ventricular Myocytes." L. Sun, J-S. Fan, J.W. Clark and P.T. Palade, Abstracts of the 19th Annual Houston Conference on Biomedical Engineering Research, Houston, TX, , pg 107,, held at University Hilton Hotel, Houston, TX.. (8-9 February, 2001)

     
     

    "Electrical and Mechanical Activity of the Rat Cerebrovascular Smooth Muscle Cell: A Modeling Study." J. Yang, J.W. Clark, R. Bryan, and C. Robertson, Abstracts of the 19th Annual Houston Conference on Biomedical Engineering Research, Houston, TX, , pg 119, held at University Hilton Hotel, Houston, TX.. (8-9 February, 2001)

     
     

    "Implementation and Performance of a Motion Tracking System for Stationary MWGC Heart Imaging." L. Sun, J.L.Lacy, C.S. Martin, N. Nayak and J.W. Clark, Abstracts of the 19th Annual Houston Conference on Biomedical Engineering Research, Houston, TX, , pg 151,, held at University Hilton Hotel, Houston, TX.. (8-9 February, 2001)

     
     

    "A Model of Human Cardiopulmonary System." K. Lu, J. Olansen, J.W. Clark, F. Ghorbel and A. Bidani,, Abstracts of the 18th Houston Conference on Biomedical Engineering Research, Houston, TX,. (10-11 Feb, 2000, pg 72)

     
     

    "A Model of Sarcolemmal Ca2+ Current and Cytosolic Ca2+ Transients in a Rat Ventricular Cell." L. Sun, J-S Fan, J.W. Clark, and P.T. Palade, Abstracts of the 18th Houston Conference on Biomedical Engineering Research, Houston, TX. (10-11 Feb, 2000, pg 119)

     
     

    "Closed Loop Pacing: Can Cardiovascular System Models be Used as Conceptual Testbeds for Design?." J.W. Clark, K. Alfrey, J.B. Olansen, F. Ghorbel, A. Bidani, M.C. Andresen and D.L. Kunze, Abstracts of the 18th Houston Conference on Biomedical Engineering Research, Houston, TX. (10-11 Feb, 2000, pg 72)

     
     

    "Mathematical Model of Cytosolic pH, Cell Volume and Ion Regulation in Alveolar Macrophages" A. Bidani, T. Heming and J. W. Clark Abstracts of the 18th Houston Conference on Biomedical Engineering Research, Houston, TX, 10-11 Feb, 2000, pg 16.." 18th Houston Conference on Biomedical Engineering Research, Houston, TX, University Hilton Hotel, Houston, TX.

     
     

    "Modeling the Electrical Activity of Cardiac Cells." Keck Center for Computational Biology, Keck Bldg., Rice University. (6 October, 2000)

     
     

    "Neural Regulation of Respiration: A Modeling Approach." A. Athanasiades, J.W. Clark, F. Ghorbel and A. Bidani, Abstracts of the 18th Houston Conference on Biomedical Engineering Research, Houston, TX. (10-11 Feb, 2000, pg 83)

     
     

    "The Role of Proximal Arterial Pathways in a Model of the Rat Systemic Arterial System." K. Alfrey, L. Cherian, C. S. Robertson and J.W. Clark, Abstracts of the 18th Houston Conference on Biomedical Engineering Research, Houston, TX. (10-11 Feb, 2000, pg 146)

     
     

    "3D Conduction in the Bullfrog Trabeculum." Abstracts of the Joint Meeting Biomedical Engineering Society (BMES) and the IEEE/Engineering in Medicine and Biology Society (EMBS), Atlanta, GA. (October 13-16, 1999) With S. Cox and J.W. Clark

     
     

    "A Hemodynamic Model of the Rat Systemic Arterial System." 17th Houston Conference on Biomedical Engineering Research, Houston, TX. (2-3 April, 1999) With K. Alfrey, J.B. Olansen, I.K. Krishnappa, E.M. Golding, C.S. Robertson and J.W. Clark

     
     

    "A Model of Sarcolemmal Ca2+ Current and Cytosolic Ca2+ Transient in a Rat Ventricular Cell." Abstracts of the Joint Meeting Biomedical Engineering Society (BMES) and the IEEE/Engineering in Medicine and Biology Society (EMBS), Atlanta, GA. (October 13-16, 1999) With L. Sun, J.W. Clark, J.S. Fan

     
     

    "An Ionic Current Model for Respiratory Neurons in the Rat Ventral Nucleus Tractus Solitarii." 17th Houston Conference on Biomedical Engineering Research, Houston, TX. (11-12 February, 1999) With A. Athanasiades, J.W. Clark, F. Ghorbel and A. Bidani

     
     

    "An Ionic Current Model for Respiratory Neurons in the Rat vNTS and Guinea Pig Nucleus Ambiguus." Abstracts of the Joint Meeting Biomedical Engineering Society (BMES) and the IEEE/Engineering in Medicine and Biology Society (EMBS), Atlanta, GA. (October 13-16, 1999) With A. Athanasiades, J.W. Clark, F. Ghorbel and A. Bidani

     
     

    "Baroreceptor Response to Modeled Aortic Pressure." Abstracts of the Joint Meeting Biomedical Engineering Society (BMES) and the IEEE/Engineering in Medicine and Biology Society (EMBS), Atlanta, GA. (October 13-16, 1999) With K. Alfrey, J.W. Clark, J.H. Schild and M. Andresen

     
     

    "Gait Generation Characterized by the Phase Sensitive Properties of Synaptically Coupled Neurons." Abstracts of the Joint Meeting Biomedical Engineering Society (BMES) and the IEEE/Engineering in Medicine and Biology Society (EMBS), Atlanta GA. (October 13-16, 1999) With C. Luo, A.A. DeFrancheshi, J.W. Clark, C.C. Canavier, D.A. Baxter and J.H. Byrne

     
     

    "Integration of Classical Biomedical Experimentation with Modern Data Acquisition and Analysis." 17th Houston Conference on Biomedical Engineering Research, Houston, TX. (2-3 April, 1999) With J.B. Olansen, F. Ghorbel and J.W. Clark

     
     

    "Modeling Central Pattern Generators." Structural and Computational Biology and Molecular Biophysics Graduate Program , Baylor College of Medicine. (1 December, 1999)

     
     

    "Modeling and Identification of Cardiovascular Hemodynamics in a Closed-Loop Model with Ventricular Interaction." Abstracts of the Joint Meeting Biomedical Engineering Society (BMES) and the IEEE/Engineering in Medicine and Biology Society (EMBS), Atlanta, GA. (October 13-16, 1999) With J.B. Olansen, J.W. Clark, D. Khoury, F. Ghorbel and A. Bidani

     
     

    "Nonlinear Analysis of Neuronal Models." The Bioengineering Research Center, University of Houston, Houston, TX. (19 November, 1999)

     
     

    "Research Activities of the Biological Systems and Instrumentation Group." Computer and Information Technology Institute (CITI), Rice University, Houston, TX. (10 December, 1999)

     
    Editorial Positions
     Member of the Editorial Board, Reviews in Biomedical Engineering. IEEE. (2013 - 2013)

     Member of the Editorial Board, Reviews in Biomedical Engineering. IEEE. (2012 - 2012)

     Member of the Editorial Board, IEEE Reviews in Biomedical Engineering. Institute of Electrical and Electronic Engineers. (2011 - 2011)

     Member of the Editorial Board, Journal of Biological Systems. World Scientific. (2003 - 2003)

     Editorial Board, J. Cardiovascular Engineering. Kluwer Academic/Plenum Publishers. (2000 - 2000)

     Editorial Board, J. Cardiovascular Engineering. , Kluwer Academic/Plenum Publishers. (2001 - 2001)

     Editorial Board, J. Biological Systems. World Scientific. (2000 - 2000)

     Editorial Board, J. Biological Systems. World Scientific Publishing Co., Pte, Ltd,. (2001 - 2001)

     Member of the Editorial Board, Cardiovascular Engineering: An International Journal. Kluwer Academic/Plenum Publishers. (2003 - 2003)

    Supervised Theses & Dissertations
     Kim Daniel, M.S. A Mathematical Model of the Mammalian Ventricular Cell: Mechanistic Explanations of Long Q-T Syndrome. (2002) (Thesis or Dissertation Director)

     Junhui Qian, M.S. A Closed-Loop Model of the Ovine Cardiovascular System. (2003) (Thesis or Dissertation Director)

     Jin Yang, PhD Modeling Vascular Smooth Muscle. (2004) (Thesis or Dissertation Director)

     Kun Lu, Ph.D. Human Whole-Body Gas Exchange and Cerebral Autoregulation Studied Using A Cardiopulmonary Model. (2004) (Co-Director)

     Deepa Ramachandran, Ph.D. Clinical Applications of a Human Cardiovascular-Respiratory Model: Studying Ventricular Mechanics in Disease and Treatment. (2011) (Thesis or Dissertation Director)

     Kai Lou, M.S. Applied Physics A Phantom Study of In-beam PET Imaging for Proton Beam Range Verification. (2013) (Co-Director)

     Olen Henry Rambow, M.S. Applied Physics Direct Water and Fat Determination in Two-Point Dixon Imaging by Dixon Imaging. (2013) (Co-Director)

     Qiong Huang, Neural Connectivity Study of Autism using Diffusion Tensor Imaging. (Co-Director)

    Awards, Prizes, & Fellowships
     Special Award, Houston Society for Engineering in Medicine and Biology (7 February 2008)

     Proclamation:, Mayor Bill White, City of Houston (February 7, 2008)

     General Conference Co-chair, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE/EMBS), IEEE Engineering in Medicine and Biology Society (23-26 August 2007)

     Founding Fellow, Biomedical Engineering Society (01/01/05)

     Fellow, Institute of Electrical and Electronic Engineers, Inc. (01/01/05)

     Member Program Committee, 23rd International Conference of the IEEE/EMBS, held in Istanbul, Turkey , EMB Society, Institute of Electrical and Electronic Engineers (IEEE). (25-28 October, 2001)

     Faculty Member, 4th International IEEE/EMBS Summer School on Biocomplexity, Bioscaling, and Biosignal Interpretation, held at Dartmouth College, Hanover, NH, and sponsored by NSF, IEEE Engineering in Medicine and Biology Society (EMBS) (24 June-1 July, 2001)

     Cardiopulmonary Systems Theme Chair for the IEEE/EMBS Conference, held in Istanbul, Turkey, 25-28 October, 2001,

     Member Conference Committee, Engineering in Medicine and Biology Society (EMBS), Institute of Electrical and Electronics Engineers IEEE, (2000-) ,

     Program Co-Chair (with L.V. McIntire, Rice University) of the Joint EMBS/BMES Conference on Engineering in Medicine and Biology, to be held in Houston, TX 23-26 Oct. 2002., IEEE Engineering in Medicine and Biology Society (EMBS) and Biomedical Engineering Society (BMES).

     Chaired Committee to Organize the 19th Annual Houston Conference on Biomedical Engineering Research, Houston, TX, 8-9 February, 2001,

     Member Administration Committeee of the Engineering in Medicine and Biology Society (EMBS) representing Region V , Institute of Electrical and Electronics Engineers (IEEE) (2000-2002)

     President-Elect, IEEE Engineering in Medicine and Biology Society (1 Jan 2001-31 Dec 2001)

     Member Program Committee, 23rd International Conference of the IEEE/EMBS to be held in Istanbul, Turkey 25-28 October, 2001, Institute of Electrical and Electronic Engineers (IEEE)

     Member Conference Committee, Engineering in Medicine and Biology Society (EMBS), Institute of Electrical and Electronics Engineers IEEE (2000-)

     Program Co-Chair (with L.V. McIntire, Rice University) of the Joint EMBS/BMES Conference on Engineering in Medicine and Biology, to be held in Houston, TX 23-26 Oct. 2002., Engineering in Medicine and Biology Society (EMBS) and Biomedical Engineering Society (BMES)

     Visiting Professor, Laboratory MECAL, University of Lyon, Lyon, France (May 15-July 15, 2000)

     Member Administration Committeee of the Engineering in Medicine and Biology Society (EMBS) representing Region V, Institute of Electrical and Electronics Engineers (2000-2002)

     Elected Region V Representative to Administrative Committee, IEEE Engineering in Medicine and Biology Society (for 1/1/00 to 12/31/02)

     Appointed General Chairman, 24th Annual Conference, IEEE Engineering in Medicine and Biology Society (to be held October, 2002)

    Positions Held
     Chair, Technical Activities Committee, IEEE Engineering in Medicine and Biology Society (EMBS). (2006 - 2006)

     President, IEEE Engineering in Biology and Medicine Society (EMBS). (2003 - 2003)

     President-Elect, IEEE Engineering in Biology and Medicine Society (EMBS). (2002 - 2002)

     Chair Theme 9: Cardiovascular and Respiratory Systems, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Marriott Marquis Hotel, New York City, NY 30 August - 3 September 2006. (2006 - 2006)

     Member, International Advisory Committee of the 5th International Conference on Bioelectromagnetism, International Society of Bioelectromagnetism. (2003 - 2003)

     Chair, International Program Committee EMBC 06, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Marriott Marquis Hotel, New York City, NY 30 August - 3 September 2006. (2006 - 2006)

     Theme Chair: Cardiovascular and Respiratory Systems for 25th Annual EMBS International Conferenec, San Francisco, CA 1-4 September, 2004, IEEE Engineering in Medicine and Biology Society. (2003 - 2003)

     Chair, Steering Committee, Houston Society for Engineering in Medicine and Biology (HSEMB). (2006 - 2006)

     Conference Chair, 23rd Annual Conference on Biomedical Engineering Research (HSEMB 06), Houston Society for Engineering in Medicine and Biology. (2006 - 2006)