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Scholarly Interest Report
         
Kathleen S. Matthews
Professor
Stewart Memorial Professor of Biochemistry and Cell Biology
 
e-mail:ksm@rice.edu
 
  • Ph.D. Biochemistry (1970) University of California, Berkeley
  • B.S. Chemistry (1966) University of Texas, Austin
 
Primary Department
   Department of BioSciences
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Department Affiliations
 
  • Institute of Biosciences and Bioengineering
  • Keck Center for Quantitative Biomedical Sciences
  • Smalley Institute for Nanoscale Science and Technology
  •  
     
    Research Areas
     Structure and function of genetic regulatory proteins
     

    2012 Research Statement

     

    Examination of protein-DNA interactions involved in regulating gene expression is the major focus of research efforts in this laboratory. Genetic regulation is an essential function in all organisms and provides the ability to respond to signals that reflect environmental conditions, determine developmental processes, and communicate other information within an organism. matthews_research border= The lactose repressor (LacI) controls expression of the enzymes that metabolize lactose in E. coli. Our long-term goal is detailed insight into mechanisms by which both LacI recognition and regulation occur, and experiments with collaborators extend the applications of this protein. The Ultrabithorax gene encodes a member of the homeodomain family of proteins (Hox proteins) that participate in specifying segmental identity in the Drosophila embryo during development. Experiments are underway with collaborators to explore regulation of DNA recognition and transcriptional regulation and to understand the interesting materials properties of this protein.

     
    Selected Publications
     Abstracts
     

    Calabretta, M., Yuhas, B., Colvin, V., and Matthews, K.S. "Effects of bionanoconujugation on protein-DNA interactions in the Lac repressor system." 225th ACS National Meeting (2003) : Poster 218.

     
     

    Engelhardt, E.K., Bondos, S.E., and Matthews, K.S. "Using transcription activation mutants to identify Hox gene targets in vivo." Society for Developmental Biology 62nd Annual Meeting, 259 (2003) : 562.

     
     

    Shi, Y.E., Engelhart, E., and Bondos, S. "Rapid production of temperature-sensitive mutants for functional analysis in vivo." Society for Developmental Biology 62nd Annual Meeting, 259 (2003) : 588.

     
     

    Swint-Kruse, L., Flynn, T., Ma, J., and Matthews, K.S. "Asymmetric allosteric transition pathway in the LacI core domain homodimer." 17th Annual Gibbs Conference on Biothermodynamics (2003)

     
     Refereed articles
     

    Bondos, S.E., Swint-Kruse, L., and Matthews, K.S., Flexibility and disorder in gene regulation: LacI/GalR and Hox proteins, J. Biol. Chem. 290, 24669-24677 (2015).

     
     

    Tsai, S.-P., Howell, D.W., Huang, Z., Hsiao, H.-C., Lu, Y., Matthews, K.S., Lou, J., and Bondos, S.E., The effect of protein fusions on the production and mechanical properties of protein-based materials, Advanced Functional Materials 25, 1442-1450 (2015).

     
     

    Xu, H., Cruz, M., Gulati, J., Liu, S., and Matthews, K.S., Conversion of PurR from dimer to tetramer using the LacI C-terminus:  Can any tetramer form DNA loops?

     
     

    Xu, J., Hewitt, M., Cruz, M., Gulati, J., Liu, S., and Matthews, K.S., The hinge helix of lactose repressor protein promotes specific DNA binding 

     
     

    Churion, C., Liu, Y., Hsiao, H.-C., Matthews, K.S., and Bondos, S..E. Measuring Hox-DNA binding by electrophoretic mobility shift analysis, Methods in Molecular Biology, Protein Blotting and Detection 1196, 211-230 (2014).

     
     

    Hsiao, H.-C., Gonzalez, K.L., Catanese, D.J., Jr., Jordy, K.E., Matthews, K.S., and Bondos, S.E., The intrinsically disordered regions of the Drosophila melanogaster Hox protein Ultrabithorax can select protein interactions by topology, PLOS ONE 9, e108217 (2014).

     
     

    Hussain F, Gupta C, Hirning AJ, Ott W, Matthews KS, Josic K, Bennett MR. "Engineered temperature compensation in a synthetic genetic clock.." Proc Natl Acad Sci USA 111, 972-977 (2014)

     
     

    Tsai, S.-P., Howell, D.W., Huang, Z., Hsiao, H.-C., Lu, Y., Matthews, K.S., Lou, J., and Bondos, S.E..The effect of protein fusions on the production and mechanical properties of protein-based materials, Advanced Functional Materials, in press.

     
     

    Xu, J., McKearnan, S., Fleming, R., Liu, S., Zhan, H., and Matthews, K.S., The hinge helix of lactose repressor protein promotes specific DNA binding, in preparation. 

     
     

    Hussain F, Gupta C, Hirning AJ, Ott W, Matthews KS, Josic K, Bennett MR. "Engineered temperature compensation in a synthetic genetic clock." Proc Natl Acad Sci U S AIn Press

     
     

    Bondos, S.E., Catanese, D.J., Jr., Jordy, K.E., and Matthews, K.S. "Bondos, S.E., Catanese, D.J., Jr., Jordy, K.E., and Matthews, K.S., Network analysis of Drosophila protein interactions: Sorting by protein fold identifies false positives." in preparation

     
     

    Fleming, R., Liu, S., Xu, J., Zhan, H., and Matthews, K.S. "The hinge helix of lactose repressor protein promotes specific DNA binding." in preparation

     
     

    Norton, M., Xu, H., Liu, S., Zhan, H., and Matthews, K.S. "Conversion of PurR from dimer to tetramer using the LacI C-terminus: Introduction of DNA looping capacity ." in preparation

     
     

    Catanese, D.J., and Matthews, K.S. "Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT." Biochem. Biophys. Res. Commun., 414 (2011) : 506-511.

     
     

    Huang, Z., Salim, T., Brawley, A., Patterson, J., Matthews, K.S., and Bondos, S.E. "Functionalization and patterning of protein-based materials using active Ultrabithorax chimeras." Advanced Functional Materials, 21 (2011) : 2633-2640.

     
     

    Jamison, J.A., Bryant, E.L., Kadali, S.B., Wong, M.S., Colvin, V.L., Matthews, K.S., and Calabretta, M.K. "Altering protein surface charge with chemical modification modulates protein-gold nanoparticle aggregation." J. Nanopart. Res., 13 (2011) : 625-636.

     
     

    Liu, Y., Merchant, Z., Hsiao, H.-C., Gonzalez, K.L., Matthews, K.S., and Bondos, S.E. "Media composition influences yeast one- and two-hybrid results." Biological Procedures Online, 13 (2011) : 6.

     
     

    Xu, J., Liu, K.-W., Matthews, K.S., and Biswal, S.L. "Monitoring DNA binding to Escherichia coli lactose repressor using quartz crystal microbalance with dissipation." Langmuir, 27 (2011) : 4900-4905.

     
     

    Xu, J., Liu, S., Chen, M., Ma, J., and Matthews, K.S. "Altering residues N125 and D149 impacts sugar effector binding and allosteric parameters in Escherichia coli lactose repressor." BiochemistryIn Press

     
     

    Catanese, D.J., Jr., and Matthews, K.S., High affinity, dsRNA binding by disconnected interacting protein 1, Biochem. Biophys. Res. commun. 399, 186-191 (2010).

     
     

    Huang, Z., Lu, Y., Majitha, R., Shah, J., Meissner, K., Matthews, K.S., Bondos, S.E., and Lou, J., Size dictates mechanical properties for protein fibers self-assembled by the Drosophila Hox transcription factor Ubx, Biomacromolecules 11, 3644-3651 (2010).

     
     

    Jamison, J.A., Bryant, E.L., Kadali, S.B., Wong, M.S., Colvin, V.L., Matthews, K.S., and Calabretta, M.K., Altering protein surface charge with chemical modification modulates protein-gold nanoparticle aggregation, J. Nanopart. Res., in press (DOI 10.1007/s11051-010-0057-S) (2010).

     
     

    Zhan, H., Camargo, M., and Matthews, K.S., Positions 94-98 of the lactose repressor N-subdomain monomer•monomer interface are critical for allosteric communication, Biochemistry 49, 8636-8645 (2010).

     
     

    Greer, A., Huang, Z., Oriakhi, A., Matthews, K., and Bondos, S. "The Drosophila transcription factor Ultrabithorax self-assembles into protein-based biomaterials with multiple morphologies." Biomacromolecules, 10 (2009) : 829-837.

     
     

    Liu, Y., Matthews, K.S., and Bondos, S.E. "Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor." J Mol Biol, 390 (2009) : 760-774.

     
     

    Ruthauskas, D., Zhan, H., Matthews, K.S., Pavone, F.S., and Vanzi, F. "Tetramer opening in LacI-mediated DNA looping." Proc Natl Acad Sci USA, 106 (2009) : 16627-16632.

     
     

    Swint-Kruse, L., and Matthews, K.S. "Allostery in the LacI/GalR family: Variations on a theme." Current Opinion in Microbiology, 12 (2009) : 129-137.

     
     

    Xu, J., and Matthews, K.S. "Flexibility in the inducer binding region is crucial for allostery in Escherichia coli lactose repressor." Biochemistry, 48 (2009) : 4988-4998.

     
     

    Zhan, H., Sun, Z., and Matthews, K.S. "Functional impact of polar and acidic substitutions in the lactose repressor hydrophobic monomer•monomer interface with a buried lysine." Biochemistry, 48 (2009) : 1305-1314.

     
     

    Liu, Y., Matthews, K.S., and Bondos, S.E. "Multiple intrinsically disordered sequences after DNA binding by the homeodomain of the Drosophila Hox protein Ultrabithorax." J. Biol. Chem., 283 (2008) : 20874-20887.

     
     

    Taraban, M., Zahn, H., Whitten, A..E., Langley, D.B., Matthews, K.S., Swint-Kruse, L., and Trewhella, J. "Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein." J. Mol. Biol., 376 (2008) : 466-481.

     
     

    Wilson, C.J., Zhan, H., Swint-Kruse, L., and Matthews, K.S. "Ligand interactions with lactose repressor protein and the repressor-operator complex: The effects of ionization and oligomerization on binding." Biophys. Chem, 126 (2007) : 94-105.

     
     

    Wilson, C.J., Zhan, H., Swint-Kruse, L., and Matthews, K.S. "The lactose repressor system: Paradigms for transcription regulation, allosteric behavior, and protein folding." Cell. Mol. Life Sci., 64 (2007) : 3-16.

     
     

    Bondos, S.E., Tan, X.X., and Matthews, K.S. "Physical and genetic interactions link Hox function with diverse transcription factors and cell signaling proteins." Mol. Cell. Proteomics, 5 (2006) : 824-834.

     
     

    Calabretta, M.K., Matthews, K.S., and Colvin, V.L. "DNA binding to protein-gold nanocrystal conjugates." Bioconjugate Chemistry, 17 (2006) : 1156-1161.

     
     

    Zhan, H., Swint-Kruse, L., and Matthews, K.S. "Extrinsic interactions dominate helical propensity in coupled binding and folding of lactase repressor hinge helix." Biochemistry, 45 (2006) : 5896-5906.

     
     

    Bondos, S.E., Catanese, D.J., Jr., Jordy, K.E., and Matthews, K.S. "Network analysis of Drosophila protein interactions: Sorting by protein fold identifies false positives." Biochemistry (2005) Submitted

     
     

    Calabretta, M., Jamison, J.A., Falkner, J. C., Liu, Y., Yuhas, B.D., Matthews, K.S., and Colvin, V.L. "Analytical ultracentrifugation for characterizing nanocrystals and their bioconjugates." Nanoletters, 5 (2005) : 963-967.

     
     

    Das, P., Wilson, C.J., Fossati, G., Wittung-Stafshede, P., Matthews, K.S., and Clementi, C. "Characterization of the folding landscape of monomeric lactose repressor: Quantitative comparison of theory and experiment." Proc. Natl. Acad. Sci. U.S.A., 102 (2005) : 14569-14574.

     
     

    Wilson, C.J., Das, P., Clementi, C., Matthews, K.S., and Wittung-Stafshede, P. "The experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates." Proc. Natl. Acad. Sci. U.S.A., 102 (2005) : 14563-14568.

     
     

    Zhan, H., Swint-Kruse, L., and Matthews, K.S. "Dynamic asymmetry in a protein homodimer: experimental support for a computational prediction." Biochemistry, 44 (2005) : 11201-11213.

     
     

    Bondos, S., Tan, X.X., Catanese, D.J., Jr., Ware, A.A., Li, L., and Matthews, K.S. "Hox protein Ultrabithorax Ib interacts with disconnected interacting protein, a double-stranded RNA binding protein." J. Biol. Chem., 279 (2004) : 26433-26444.

     
     

    Flynn, T.C., Swint-Kruse, L., Kong, Y., Booth, C., Matthews, K.S., and Ma, J., "Allosteric transition pathways in the lactose repressor protein core domains: Asymmetric motions in a homodimer." Protein Science, 12 (2003) : 2523-2541.

     
     

    Swint-Kruse, L., Zhan, H., Fairbanks, B.M., Maheshwari, A., and Matthews, K.S., "Perturbation from a distance: Mutations that alter LacI function through long-range effects." Biochemistry, 42 (2003) : 14004-14016.

     
     

    Tan, X.X., Bondos, S., Catanese, D.J., Jr., Ware, A.A., Li, L., and Matthews, K.S. "Hom-C protein Ultrabithorax interacts with a dsRNA-binding protein, UbxBP-1."  (2002) In Revision

     
     

    Nichols, N.M., and Matthews, K.S. "Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability." Biochemistry, 41 (2002) : 170-178.

     
     

    Swint-Kruse, L., Larson, C., Pettitt, B.M., and Matthews, K.S. "Fine-tuning function: Correlation of hinge domain interactions with functional distinctions between LacI and PurR." Protein Science, 11 (2002) : 778-794.

     
     

    Tan, X.X., Li, L., Bondos, S., and Matthews, K.S. "Transcription activation by Ultrabithorax Ib protein requires a predicted alpha-helical region." Biochemistry, 41 (2002) : 2774-2785.

     
     

    Falcon, C.M., and Matthews, K.S. "Engineered Disulfide Linking the Hinge Regions within Lactose Repressor Dimer Increases Operator Affinity, Decreases Sequence Selectivity, and Alters Allostery." Biochemistry (in press) In Press

     
     

    Moraitis, M., Xu, H., and Matthews, K.S. "Ion Concentration and Temperature Dependence of DNA Binding: Comparison of PurR and LacI Repressor Proteins." Biochemistry, 40 (2001) : 8109-8117.

     
     

    Nichols, N.M., and Matthews, K.S. "Protein-DNA Binding Correlates with Structural Thermostability for the Full-length Human p53 Protein." Biochemistry, 40 (2001) : 3847-3858.

     
     

    Nichols, N.M., and Matthews, K.S. "p53 Unfolding Detected by CD But Not by Tryptophan Fluorescence." Biochemical and Biophysical Research Communications, 288 (2001) : 111-1115.

     
     

    Swint-Kruse, L., Elam, C.R., Lin, J., Beasley, D., Wycuff, D.R., and Matthews, K.S. "Plasticity of Quaternary Structure: Twenty-two Ways To Form a LacI Dimer." Protein Science, 10 (2001) : 262-276.

     
     

    Falcon, C.M., and Matthews, K.S. "Operator DNA Sequence Variation Enhances High Affinity Binding by Hinge Helix Mutants of Lactose Repressor Protein." Biochemistry, 39 (2000) : 11074-11083.

     
     

    Matthews, K.S., Falcon, C.M., and Swint-Kruse, L. "Relieving Repression." Nature Structural Biology, 7 (2000) : 184-187.

     
     

    Wycuff, D.R., and Matthews, K.S. "Generation of an AraC-araBAD-regulated T7 Expression System." Analytical Biochemistry, 277 (2000) : 67-73.

     
     

    Barry, J.K., and Matthews, K.S. "Substitutions at Histidine 74 and Aspartate 278 Alter Ligand Binding and Allostery in Lactose Repressor Protein." Biochemistry, 38 (1999) : 3579-3590.

     
     

    Barry, J.K., and Matthews, K.S. "Thermodynamic Analysis of Folding and Assembly in Lactose Repressor Protein." Biochemistry, 38 (1999) : 6520-6528.

     
     

    Falcon, C.M., and Matthews, K.S. "Glycine Insertion in the Hinge Region of Lactose Repressor Protein Alters DNA Binding." J. Biol. Chem., 274 (1999) : 30849-30857.

     
     

    Ozarowski, A., Barry, J.K., Matthews, K.S., and Maki, A.H. "Ligand-induced Conformation Changes in Lactose Repressor: A Phosphorescence and ODMR Study of Single-tryptophan Mutants." Biochemistry, 38 (1999) : 6715-6722.

     
     

    Barry, J.K., and Matthews, K.S. "Ligand-induced Conformational Changes in Lactose Repressor: A Fluorescence Study of Single Tryptophan Mutants." Biochemistry, 36 (1997) : 15632-15642.

     
     

    Matthews, K.S., and Nichols, J.C. "Lactose Repressor Protein: Functional Properties and Structure." Prog. Nucl. Acid Res. Mol. Biol., 58 (1998) : 127-164.

     
     

    Xu, H., Moraitis, M., Reedstrom, R.J., and Matthews, K.S. "Kinetic and Thermodynamic Studies of Purine Repressor Binding to Corepressor and Operator DNA." J. Biol. Chem., 273 (1998) : 8958-8964.

     
     Book chapters
     

    Swint-Kruse, L., and Matthews, K.S., lac operon, Encyclopedia of Biological Chemistry, Vol. 2 (Eds., Lennarz, W.J., and Lane, M.D.), 2nd Edition, in press.

     
     

    Swint-Kruse, L., and Matthews, K.S. "Gene expression in bacteria: The lac operon." Encyclopedia of Biological Chemistry (Eds., W.J. Lennarz and M. D. Lane), Vol. 2 (2004) : 529-535.

     
     

    Swint-Kruse, L., and Matthews, K.S. "Thermodynamics, protein modification, and molecular dynamics in characterizing the lactose repressor protein: Strategies for complex analyses of protein structure-function." Methods in Enzymology, Energetics of Biological Macromolecules, Part D (Eds., Holt, J. M., Johnson, M. L., and Ackers, G.K.), 379 (2004) : 1888-2009.

     
     

    Bondos, S., Swint-Kruse, L., and Matthews, K. "Protein Folding." McGraw-Hill Yearbook of Science and Technology (M. Licker, Publisher) (1999) : 361-363.

     
     Other
     

    Falcon, C.M., Swint-Kruse, L., and Matthews K.S., Lactose repressor proteins with increased operator DNA binding affinity, Application 10/197,053, issued as Patent No. 7390645, June 24, 2008.

     
    Presentations
     Invited Talks
     

    "CTE Teach Workshop." (September 2013)

     
     

    "DNA — Past, Present, Future." Alumni College, Rice University, Houston, TX. (March 2013)

     
     

    "From Arabinose Binding Protein to Lac Repressor." Baylor College of Medicine, Houston, TX. (September 2013)

     
     

    "Promotion & Tenure." Rice University Department Chairs, Houston, TX. (April 2013)

     
     

    "Promotion & Tenure." Rice University Assistant Professors, Houston, TX. (April 2013)

     
     

    "Regulating Context-dependent Nucleic Acid interactions through Sequences outside the Conserved DNA Binding Motif." Annual Meeting Biophysical Society, (3/3-3/07) With Ying Liu

     
     

    "Analytical Ultracentrifugation in Nanoscience: Solution Characterization of Protein-Nanocrystal Conjugates." CBEN-SLC, Rice University, Houston, Texas. (February 17, 2005) With M. Calabretta and V. Colvin

     
     

    "Envisioning Rice University." Conference for Rice Alumni Leaders, Rice University. (October 14, 2005)

     
     

    "Natural Sciences at Rice University." The Discussion Group, (April 20, 2005)

     
     

    "Research and Graduate/Post-doctoral Studies." Call to Conversation Events, Rice University. (August 20, August 26, October 1, October 7, October 28, 2005)

     
     

    "The Discovery of DNA Structure: History of Implications." Rice Continuing Studies Series on "The Shaping of our Times", Rice University. (October 6, 2005)

     
     

    "Allosteric Pathway in LacI." Biophysical Society, Baltimore, Maryland. (February 17, 2004)

     
     

    "Allosteric Pathway in LacI: Genetics, Biophysics and Modelling." University of Texas Health Science Center--Houston, Houston, Texas. (January 26, 2004)

     
     

    "Graduate School: Selection and Application." St. Edward's University, Austin, Texas. (September 26, 200)

     
     

    "Graduate Studies -- Opportunities and Applications." Welch Lecture, The University of Texas Pan American. (February 4, 2003)

     
     

    "Graduate Studies -- Opportunities and applications." Welch Lecture, Texas A&M University Corpus Christi. (February 5, 2003)

     
     

    "Pathway to Present." Association of Women Faculty, UT Health Science Center, Houston, Texas. (January 31, 2003)

     
     

    "Protein Structure and Function: Cehmistry in Action." Welch Lecture, Texas A&M University Corpus Christi. (February 5, 2003)

     
     

    "Protein Structure and Function: Chemistry in Action." Chemistry in Texas: Fifty Years of the Welch Foundation, Robert A. Welch Foundation 47th Conference on Chemical Research, Houston, Texas. (October 27, 2003)

     
     

    "Protein Structure and Function: Chemistry in Action." Welch Lecture, The University of Texas Pan American. (February 4, 2003)

     
     

    "Protein Structure and Function: Chemistry in Action." Welch Lecture, Texas A&M International University. (February 3, 2003)

     
     

    "The Discovery of DNA Structure: History and Implications." Rice Continuing Studies Series on Cultures of Creativity: The Centennial Exhibition of the Nobel Prize Series, Houston Museum of Natural Science. (April 8, 2003)

     
     

    "Frontiers of the Future." National Honor Society Initiation Address, Duchesne Academy. (November 2002)

     
     

    "Nano-Bio-Info-Enviro." Homecoming Address, Rice University, Houston, Texas. (November 2002)

     
     Other
     

    Convener, GCC Workshop, Mentoring in an Interdisciplinary Context, December 9, 2010.

     
     

    "At the Dawn of a New Era." Commencement Address, University of Texas-Houston Graduate School of Biomedical Sciences, Houston, Texas. (Mary 2002)

     
     

    "A Potential Network of Proteins Interacting with UbxIb." 14th Annual Gibbs Conference on Biothermodynamics, (October 2000) With with Tan, X.X., and Bondos, S.E.

     
     

    "Frontiers for the Future." Families Week-end, Rice University, Houston, Texas. (October 6, 2000)

     
     

    "Frontiers of the Future." Society of Rice University Women, Rice University, Houston, Texas. (April 10, 2000)

     
     

    "Natural Sciences into the Future." ROMEO, Rice University, Houston, Texas. (April 14, 2000)

     
     

    "Ten Events that Shaped our Century." Continuing Studies, Rice University, Houston, Texas. (March 29, 2000)

     
     

    "Forum on Teaching." CSST, Houston, Texas. (March, 1999)

     
     

    "Natural Sciences Perspectives." Rice Women's Conference, Houston, Texas. (February, 1999)

     
     

    "Prospects for Natural Sciences." Fund Council, (May, 1999)

     
     

    "Ten Events that Shaped our Century." Continuing Studies, Rice University, Houston, Texas. (November, 1999)

     
     Panelist
     

    Understanding the Promotion and Tenure Process, NIFP Workshop, ADVANCE, September 20, 2010.

     
     Posters
     

    "Evolution of Ubx Transcription Activation Domains." 48th Annual Drosophila Conference, Philadelphia. (3/7-3/11/07) With Ying Liu

     
     

    "Modulating Context-dependent Functions Through Oltrabithorax Microexons." 15th Annual Texas Protein Folders Meeting, Navasota, Texas. (3/30/07-4/1/07) With Ying Liu

     
     

    "An Old Dog Invents New Tricks: Insertions Diversify Hox Transcription Regulation." BCB Department Retreat, Chain O' Lakes Resort, Texas. (August 2005) With Y. Liu, K. Munjal, A. Philips and S.E. Bondos

     
     

    "Blocking the Path: Hydrophobic Mutations at Position 84 Impair Inducibility in the Lactose Repressor Protein." 49th Annual Biophysical Society Meeting, Long Beach, California. (February 2005) With H. Zhan and L. Swint-Kruse

     
     

    "Broadly Applicable Techniques for the Characterization of Nanocrystal Bioconjugates." NanoDays Conference, Rice University, Houston, Texas. (October 2005) With M. Calabretta and V. Colvin

     
     

    "Examination of the Role of Specific Regions in the Lactose Repressor Allosteric Response." 10th Annual Structural Biology Symposium, Galveston, Texas. (May 2005) With J. Xu

     
     

    "Extrinsic Interactions Dominate Helical Propensity for the Functionally-related Hinge-Helix Folding in Lactose Repressor Protein." 10th Annual Structural Biology Symposium, Galveston, Texas. (May 2005) With H. Zhan and L. Swint-Kruse

     
     

    "Extrinsic Interactions Dominate Helical Propensity in Coupled Binding and Folding of Lactose Repressor Protein Hinge Helix." 19th Annual Gibbs Conference on Biothermodynamics, (October 2005) With H. Zhan and L. Swint-Kruse

     
     

    advisor.  "Non-biasing Method for Filtering Single Molecule Dynamic TPM Data and Measuring Protein/DNA Association and Dissociation Kinetics. Measurements on Wild-type Lac Repressor and Mutants of the Hinge Region." 49th Annual Biophysical Society Meeting, Long Beach, California. (February 2005) With F. Vanzi, C. Broggio, L. Sacconi, H. Zhan and F.S. Pavone

     
     

    "The Experimental and Theoretical Folding Landscape of Monomeric Lactose Repressor: A Quantitative Comparison of Theory and Experiment." US-Japan Symposium on Folding, Design and Dynamics, Philadelphia, Pennsylvania. (2005) With C.J. Wilson, P. Das, P. Wittung-Stafshede and C. Clementi

     
     

    "The Folding Landscape of Monomeric Lactose Repressor: A Comparison of Theory and Experiment." W.M. Keck Center for Computational Biology, 15th Annual Research Conference, Houston, Texas. (October 2005) With C.J. Wilson, P. Das, C. Clementi and P. Wittung-Stafshede

     
    Supervised Theses & Dissertations
     Jie Xiao, Ph.D. Structural Characterization and Kinetic Evaluation of RecA-Mediated Strand Exchange. (2002) (Committee Member)

     Markos Moraitis, Ph.D. Polyelectrolyte and Hydrophobic Effects in Protein-DNA Interactions: PurR, LacI, and Human p53 Proteins. (2002) (Thesis or Dissertation Director)

     Han Xu, Ph.D. Repressor Proteins: Ligand Binding, Thermodynamics and Assembly. (2002) (Thesis or Dissertation Director)

     Jeffrey C. Myers, Ph.D. Human UP1 as a Model for Understanding Purine Recognition in the Family of Proteins Containing the RNA Recognition Motif (RRM). (2004) (Committee Member)

     Erin Foley, Ph.D. Physiologically Relevant Reactions of Myoglobin and Hemoglobin with NO. (2005) (Committee Member)

     Hongli Zhan, Ph.D. Biophysical Characterization of the Allosteric Transition in Lactose Repressor Protein (LacI). (2005) (Thesis or Dissertation Director)

     Jamie Catanese, Ph.D. Biophysical and Biochemical Characterization of the Disconnected Interacting Protein 1, DIP1, from Drosophila melanogaster. (2005) (Thesis or Dissertation Director)

     Corey Wilson, Ph.D. Protein Folding, Stability, and Assembly: A Thorough Assessment of Complex Behavior. (2005) (Thesis or Dissertation Director)

     Michelle K. Calabretta, Ph.D. Biophysical Characterization of Gold Nanocrystal Protein Conjugates: Formation, Stoichiometry and Function. (2005) (Thesis or Dissertation Director)

     Angela Noel Hvitved, Ph.D. NO Dioxygenation in Mammalian Hemoglobins and Microbial Flavohemoglobins. (2007) (Committee Member)

     Ying Frances Liu, Ph.D. Exploration of DNA Binding Selectivity, Transcriptional Regulation, and Evolutionary Relationships of the Hox Protein Ultrabithorax. (2007) (Thesis or Dissertation Director)

     Jennifer A. Jamison, Ph.D. Characterization of Nanocrystals and Gold Nanoparticle-Protein Assemblies. (2009) (Co-Director)

     Zhao George Huang, Ph.D. Formation of Materials by a Hox Protein Ultrabithorax. (2011) (Thesis or Dissertation Director)

     Jonathan Dornell, PhD PhD Dissertation Committee Member. (Committee Member)

     Jonathan Clinger, Ph.D. PhD Dissertation Committee Member. (Committee Member)

     Sam Kwiatkowski, PhD Dissertation Committee Member. (Committee Member)

     Alicia Jones, PhD PhD Dissertation Committee Member. (Committee Member)

     Andrew Hirning, PhD PhD Dissertation Committee Member (Co-Mentor). (Committee Member)

     Erin O'Brien, Ph.D. PhD Dissertation Committee Member. (Committee Member)

    Awards, Prizes, & Fellowships
     William C. Rose Award, ASBMB

     Luncheon honoring decade of service as chair of the GCC oversight committee, The Gulf Coast Consortia (March 15)

     BioHouston Women in Science Award, BioHouston (October 2010)

     Impact Award, Rice University Women's Center (2007)

     YMCA 2002 Outstanding Woman of Achievement in Medicine, Science and Technology, YMCA (2002)

     Member, Finance Committee, ASBMB, (2001-)

     Member, Houston Philosophical Society,

     Member, American Chemical Society,

     Member, Leadership Rice Community Advisory Board,

     Fellow, Scientia,

     Member, Protein Society,

     Fellow, American Association for the Advancement of Science,

     Member, HHMI Panel for Predoctoral Fellowships, (2001)

     Attendee, R.A. Welch Conference, Houston, Texas, (October 22, 2001)

     Elected Member, Texas Philosophical Society, (2001-)

     Member, American Association for the Advancement of Science,

     Member, AmericAn Society of Biochemistry and Molecular Biology,

     Fellow, Scientia

     Member, Protein Society

     Member, Nominating Committee, ASBMB

     Fellow, American Association for the Advancement of Science

     Member, American Chemical Society

     Member, Houston Philosophical Society

     Attendee, Robert A. Welch Conference, Houston, Texas (October 23-24, 2000)

     Member, American Society of Biochemistry and Molecular Biology

     Member, American Association for the Advancement of Science

     Attendee, Robert A. Welch Conference, Houston, Texas (October 25-26, 1999)