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Scholarly Interest Report
         
Rudy Guerra
Professor
Professor of Statistics
 
e-mail:rguerra@rice.edu
 
  • Ph.D. Statistics (1992) University of California, Berkeley
  • M.A. Mathematics (1987) University of California, Berkeley
  • B.S. Applied Mathematics (1984) University of Texas, San Antonio
 
Primary Department
   Department of Statistics
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Department Affiliations
 
  • Kinder Institute for Urban Research
  •  
    Other Affiliations
     
  • Baylor College of Medicine
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    Websites
     Dr. Guerra's Webpage
     
    Research Areas
     Statistical methodology, statistical genetics, bioinformatics, proteomics, social science
     
    Selected Publications
     Refereed articles
     

    Li, X., Guerra, R., Chen, J. "Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes." Molecular Systems Biology, 11: 775.

     
     

    Assmann, G., Guerra, R., Fox., G., Cullen, P., Schulte, H., Willett., D. and Grundy, S. "Harmonizing the Definition of the Metabolic Syndrome: Comparison of the Criteria of the Adult Treatment Panel III and the International Diabetes Federation of the US American and European Populations." American Journal of Cardiology, 99 (2007) : 541-548.

     
     

    Bush, C., Havens, J., Necela, B., Su, W., Chen, L., Yanagisawa, M., Anastasiadis, P., Guerra, R., Luxon, B. and Thompson, E. "Functional Genomic Analysis Reveals Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) and Calcium Signaling in Human Colorectal Cancer Cells." Journal Biological Chemistry, 282(32) (2007) : 2387-401.

     
     

    Chatman, J., Donato, K. and Guerra, R. "Infant Mortality and Hispanic Paradox: A Meta-Analysis." American Journal of Public Health (2007) Submitted

     
     

    Guerrero, T., Castillo, R., Noyola-Martinez, J., Torrez, M., Zhou, X., Guerra, R., Cody, D., Komaki, R. and Travis, E. "Reduction of Pulmonary Compliance Found with High-Resolution Computed Tomography in Irradiated Mice." International Journal of Radiation Oncology, Biology and Physics, 67 (3) (2007) : 879-887.

     
     

    Mendes, K., Nicorici, D., Cogdell, D., Tabus, I., Yli-Harja, O., Guerra, R., Hamilton, S. and Zhang, W. "Analysis of Signaling Pathways in 90 Cancer Cell Lines by Protein Lysate Array." Journal of Proteome Research, 6(7) (2007) : 2753-67.

     
     

    Rossell, D., Scott, C. and Guerra, R. "A Semi-Parametric Approach for Differential Gene Expression." Statistical Applications in Genetics and Molecular Biology (2007) Submitted

     
     

    Yaremko, B., Guerrero, T., McAleer, M., Bucci, M., Noyola-Martinez, J., Nguyen, L., Balter, P., Guerra, R., Komaki, R. and Liao, Z. "Determination of Respiratory Motion for Distal Esophagus Cancer Using Four-Dimensional Computed Tomography." International Journal of Radiation Oncology, Biology, and Physics (2007) In Press

     
     

    Yaremko, B., Guerrero, T., Noyola-Martinez, J., Guerra, R., Lege, D., Nguyen, L., Balter, P., Cox, J.D. and Komaki, R. "Reduction of Normal Lung Irradiation in Locally Advanced Non Small Cell Lung Cancer Patients Using Ventilation Images for Functional Avoidance." International Journal of Radiation Oncology, Biology, Physics, 68(2) (2007) : 562-71.

     
     

    Yu, Z. and Guerra, R. "The Impact of Marker Selection Strategies, Density, and Sample Size on Haplotype Block Estimation." PLoS Biology. (2006) Submitted

     
     

    Allen, G.I., Christian, J.B., Chiranand, W., Pletcher, S., Gustin, M.C. and Guerra, R. "Comprehensive Analysis of Chromosomal Spatial Correlation of Gene Expression." Bioinformatics (2006) Submitted

     
     

    Guerra, R. and Yu, Z. "Single Nucleotide Polymorphisms and Their Applications." Computational and Statistical Approaches to Genomics (2006) Submitted

     
     

    Guerrero, T., Castillo, R., Noyola-Martinez, J., Torres, M., Zhou, X., Guerra, R., Cody, D., Komaki, R. and Travis, E. "Reduction of Pulmonary Compliance Found With High-Resolution Computed Tomography in Irradiated Mice." International Journal of Radiation Oncology, Biology, and Physics (2007)

     
     

    Neeley, S., Scott, C., Zhang, W., Shmulevich, I., Cogdell, D. and Guerra, R. "Sources of Variation in Protein Lysate Array Slides." Bioinformatics (2006)

     
     

    Christian, B., Shaw, C., Noyola-Martinez, J., Gustin, M., Scott, D. and Guerra, R. "Spatial Correlation of Expression in P. Falciparum." Proceedings of the Critical Assessment of Microarray Data Analysis Conference (2005) In Press

     
     

    Frye, S.R., Eskin, S.G., Guerra, R., Cong, X. and McIntire, L.V. "cDNA Microarray Analysis of Human Umbilical Vein Endothelial Cells Subjected to Cyclic Mechanical Strain." Physiologiccal Genomics (2005) In Press

     
     

    Guerra, R. and Yu, Z. "Single Nucleotide Polymorphisms and Their Applications, in W. Zhang and I. Shmulevich (eds),." Computational and Statistical Approaches to Genomics (2005) In Press

     
     

    Guerra, R., Yu, Z., Marcovina, S., Peshock, R., Cohen, J., Hobbs, H. and the Dallas Heart Study "Lipoprotein(a) and Apoliopoprotein(a) Isoforms Are Not Associated with Coronary Artery Calcification in Middle-Aged African-Americans and Caucasians." Circulation (2005) In Press

     
     

    Jain, T., Peshock, R., McGuire, D.K., Willett, D., Yu, Z., Vega, G., Guerra, R., Hobbs, H.H., Grundy, S.M. and the The Dallas Heart Study Investigators "African-Americans and Caucasians Have a Similar Prevalence of Coronary Calcium in the Dallas Heart Study." Journal of the American College of Cardiology, 44(5) (2004) : 1011-1017.

     
     

    Valentine, J., Guerra, R., Stephan, P., Scoggins, E., Clagett, G.P. and Cohen, J. "Family History is a Major Determinant of Subclinical Peripheral Arterial Disease in Young Adults." Journal of Vascular Surgery, 39(2) (2004) : 351-356.

     
     

    Han, J. and Guerra, R. "Cost Efficiency of Genetic Linkage Studies Using Mixtures of Selected Sib-Pairs. Science and Statistics for Terenece Speed." Institute of Mathematical Statistics, Lecture Notes-Monograph Series, 40 (2003)

     
     

    Berge, K., von Bergmann, K., Lutjohann, D., Guerra, R., Grundy, S., Hobbs,H. and Cohen, J. "Heritability of Plasma Noncholesterol Sterols and Relationships to DNA Sequence Polymorphism in ABCG5 and ABCG8." Journal of Lipid Research, 43: 486-494.

     
     

    Etzel, C., R. Guerra "Meta-analysis of Genetic Linkage Analysis of Quantitative Trait Loci." American Journal of Human Genetics, 71 (2002) : 56-65.

     
     

    Han, J. and Guerra, R. "Cost Efficiency of Genetic Linkage Studies Using Mixtures of Selected Sib-Pairs." Institute of Mathematical Statistics, Lecture Notes-Monograph Series, 40 (2003) In Press

     
     

    Shohet, R.V., Vega, G.L., Bersot, T.P., Mahley, R.W., Grundy, S.M., R. Guerra, Cohen, J.C. "Sources of Variability in Genetic Association Studies: Insights From the Analysis of Hepatic Lipase." Human Mutation, 19: 536-542.

     
     Articles
     

    Li, X., Guerra, R., Chen, J. "Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes." Molecular Systems Biology, 10(12):5504 (2014)

     
     

    Li, X., White, B., Guerra, R., Chen, J. "A Standardized Scoring System for Affinity Purification/Mass Spectrometry Data." MOLECULAR & CELLULAR PROTEOMICS, 13(8):23 (2014)

     
     

    Battula, V.L., Shi, Y., Jacamo, R., Evans, K., Guerra, R., Sahin, A., Marini, F., Hortobagyi, G.N., Mani, S., Andreeff, M. "Ganglioside GD2 identifies Breast Cancer Stem Cells: Targeting GD3 Synthase Inhibits GD2 Expression and Tumor Growth." Journal of Clinical Investigation, 22(6) (2013) : 2066-78.

     
     

    Hollier , B.G., Tinnirello, A.A., Werden, S.J., Evans, K.W., Taube, J.H., Sphyris, N., Shariati, M., Kumar, S.V., Battula, V.L., Herschkowitz, J.I., Guerra, R., Chang, J.T., Miura, N., Rosen, J.M. "FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer." , 73(6) (2013) : 1981-92.

     
     

    53. Battula, V.L., Evans, K., Hollier, B.G., Shi, Y., Marini, F.C., Ayyanan, A., Brisken, C., Guerra, R., Andreeff, M., Mani, S.A. "Epithelial-mesenchymal transition-derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells." Stem Cells (2010)

     
     

    Guo, B., Villagran, A., Vannucci, M., Wang, J., Davis, C., Man, T.K., Lau, C. and Guerra, R. "Bayesian Estimation of Genomic Copy Number with Single Nucleotide Polymorphism Genotyping Arrays." BMC Research Notes, 3 (2010) : 350.

     
     

    Christian, J.B. and Guerra, R. "Incorporating Gene Ontology in Gene Expression Trait Loci Mapping." Meta-analysis and Combing Information in Genetics and Genomics (2009)

     
     

    Cruz-Marcelo, A., Guerra, R., Vannucci, M., Li, Y., Lau, C.C. and Man, T-K. "Comparison of Algorithms for Pre-Processing of SELDI-TOF Mass Spectrometry Data." Bioinformatics, 24(19) (2008) : 2129-2139.

     
     

    Mendes, K., Nicorici, D., Cogdell, D., Tabus, I., Yli-Harja, O., Guerra, R., Hamilton, S. and Zhang, W. "Analysis of Signaling Pathways in 90 Cancer Cell Lines by Protein Lysate Array." Journal of Proteome Research, 6(7) (2008) : 2753-2767.

     
     

    Rossell, D., Guerra, R. and Scott, C. "Semi-Parametric Differential Expression Analysis via Partial Mixture Estimation." Statistical Applications in Genetics and Molecular Biology, 7: Iss. 1 Article 15 (2008)

     
     

    Yaremko, B., Guerrero, T., McAleer, M., Bucci, M., Noyola-Martinez, J., Nguyen, L., Balter, P., Guerra, R., Komaki R. and Liao, Z. "Determination of Respiratory Motion for Distal Esophagus Cancer using Four-Dimensional Computed Tomography." International Journal of Radiation Oncology, Biology, Physics, 70(1) (2008) : 145-53.

     
     

    Noyola-Martinez, J., Shaw, C., Christian, B., Fox, G., Stevens, M., Garg, N., Gustin, M. and Guerra, R. "Oxidative Stress Genes in Plasmodium Falciparum as Indicated by Temporal Gene Expression." Methods for Microarray Data Analysis V (2005) In Press

     
     

    Christian, B., Shaw, C., Noyola-Martinez, J., Gustin, M., Scott, D. and Guerra, R. "Chromosomal Spatial Correlation of Gene Expression in P. Falciparum." Methods for Microarray Data Analysis V (2005) In Press

     
     

    Frye, S.R., Yee, A., Eskin, S.G., Guerra, R., Cong, X. and McIntire, L.V. "cDNA Microarray Analysis of Endothelial Cells Subjected to Cyclic Mechanical Strain: Importance of Motion Control." Physiological Genomics, 21 (2005) : 124-130.

     
     

    Guerra, R., Yu, Z., Marcovina, S., Peshock, R., Cohen, J. and Hobbs, H. "Lipoprotein(a) and Apolipoprotein(a) Isoforms: No Association with Coronary Artery Calcification in the Dallas Heart Study." Circulation, 111 (2005) : 1471-79.

     
     

    Guerrero, T., Sanders, K., Noyola-Martinez, J., Castillo, E., Zhang, Y., Tapia, R., Guerra, R., Borghero, Y. and Komaki, R. "Quantification of Regional Ventilation from Treatment Planning CT." International Journal of Radiation Oncology, Biology, Physics, 62(3) (2005) : 630-4.

     
     Books
     

    Guerra, R. and Goldstein, D. "Meta-Analysis and Combing Information in Genetics and Genomics."  (2009)

     
     Book chapters
     

    Guerra, R. "Meta-analysis in Human Genetics Studies." Biostatistical Genetics and Genetic Epidemiology (2002)

     
     Conference papers
     

    Noyola-Martinez, J., Guerrero, T., Borghero, Y., Sanders, K., Stevens, C., Guerrero, M. and Guerra, R. "Mapping Gross Tumor Volumes From Exhale to Inhale Breadth-Hold Computed Tomography Images." VIIP 2005 (2005)

     
     Other
     

    with J. Wang, C. Man and C. Lau "Copy Number Variation in a Normal Human Population."  (2007)

     
     

    with J. Wang, C. Man and C. Lau "Estimating Copy Number Variation: A Case Study of Aneuploidy Subjects."  (2007)

     
     

    with Z.Yu. "Comparison of Single-Marker and Haplotype-Marker Analyses in Genetic Association Studies."  (2007)

     
     

    Guerra, R., Fox, G., Willett, D., Hobbs, H.H. and Grundy, S.G. "Harmonization of Metabolic Syndrome Criteria: Comparison of the Adult Treatment Panel III and International Diabetes Federation Criteria." American Journal of Cardiology (2005) Submitted

     
     

    Neeley, S., Scott, C., Zhang, W., Shmulevich, I., Cogdell, D. and Guerra, R. "Sources of Variation in Protein Lysate Microarray Slides." Bioinformatics (2005) Submitted

     
     

    Yu, Z. and Guerra, R. "Single-SNP vs Haplotype-SNP Based Association Studies." American Journal of Human Genetics (2005) Submitted

     
     

    Yu, Z. and Guerra, R. "The Impact of Marker Selection Strategy, Density and Sample Size on Haplotype Block Estimation." Nature Genetics (2005) Submitted

     
     

    Christian, B., Shaw, C., Noyola-Martinez, J. and Guerra, R. "Nonparametric Statistical Analysis for the Correlation Between Gene Expression and Chromosomal Location."  (2004)

     
     

    Yu, Z. and Guerra, R. "A New Measure of Genetic Linkage Disequilibrium with Application to Haplotype Block Reconstruction."  (2004)

     
     

    Yu, Z., Hobbs, H.H., Cohen, J.C. and Guerra, R. "Single-SNP and Haplotype-SNP Variation in Quantitative Traits."  (2004)

     
     

    Guerra, R. "Comments on Some Advice to Advisors: A Word to the Advisees." STATS, Winter (2001)

     
     

    Guerra, R. "The Statistics of Baseball Rankings: Hitters." STATS, Fall (2001)

     
     

    Guerra, R. and Sain,S. "Classification Methods for Mulitvariate Data Arising in Environmental Equity."  (In progress)

     
     

    Han, J. and Guerra, R. "Cost Efficiency of Mixtures of Selected Sib-Pairs in Linkage Studies of Quantitative Traits." Genetic Epidemiology (2001)

     
     

    Fine, K.D., Do, K., Schulte, K., Ogunji, F., Guerra, R., Osowski, L. and McCormak, J. "High Prevalence of Celiac Sprue-Like HLA-DQ Genes and Enteropathy in Patients With the Microscopic Colitis Syndrome." American Journal of Gastroenterology, 95 (2000) : 1974-1982.

     
     

    Guerra, R., Sain, S.R. and Carney, G. "Statistical Issues Arising In Environmental Equity: A Case Study in Louisiana." Proceedings of the American Statistical Association, Biometrics Section (2000)

     
    Presentations
     Invited Talks
     

    "AP Statistics Redesign Project." College Board, Atlanta, Georgia. (November 8, 2014)

     
     

    "Sequence Determinants of Amp C P99 β-Lactamase Substrate Specificity at High Resolution ." ICAAC, Washington, D.C. with R. Mikulski and T. Palzkill. (September 7, 2014)

     
     

    "Statistical Methods for Protein-Protein Interactions, Society for the Advancement of Chicanos and Native Americans (SACNAS)." Los Angeles, CA. (October 18, 2014)

     
     

    "Statistics for Undergraduates, Modern Math Workshop & Statistical and Applied Mathematical Sciences Institute (SAMSI)." Los Angeles, CA. (October 15, 2014)

     
     

    "Chromosomal spatial correlation of gene expression." SRCOS Meeting, Kerrville, Texas. (June 4-7, 2006)

     
     

    "Genetic association studies: a critical assessment and new contributions." Fifth Annual Short Course in Statistical Genetics, School of Public Health, University of Alabama, Birmingham. (May 16-19, 2005)

     
     

    "Haplotype blocks and their use in genetic association studies." Chinese Society of Probability and Statistics/Institute of Mathematical Statistics Conference, Beijing. (July 2005)

     
     

    "Genetic association studies: a critical assessment and new contributions." Fifth Annual Short Course in Statistical Genetics, University of Alabama. (May 2005)

     
     

    "Haplotype blocks and their use in genetic association studies." Chinese Society of Probability and Statistics/Institute of Mathematical Statistics Conference, Beijing, China. (July 2005)

     
     

    "Some statistical problems in bioinformatics and statistical genetics." Society for the Advancement of Chicanos and Native Americans in Science, Austin, Texas. (October 2004)

     
     

    "Spatial correlation of expression in P. falciparum (CAMDA),." Annual Conference for the Critical Assessment of Microarray Data Analysis, Duke University. (November 2004)

     
     

    "Cost efficiency of genetic linkage studies using mixtures of selected sib-pairs.." Houston Area Chapter of the American Statistical Association (HACASA), Rice University, Houston. (2002)

     
     

    "Use of Sampling Weights in the Dallas Heart Study." University of Texas Southwestern Medical Center, (2003)

     
     

    "Statistical issues in environmental equity." American Indian Science and Engineering Society (AISES), Albuquerque, New Mexico. (November, 2001)

     
     

    "Meta-Analysis for Genetic Linkage Studies." American Society of Human Genetics, Philadelphia, PA. (October 2000)

     
     

    "Statistical Issues Arising in Environmental Justice Studies: Lessons Learned From A Case Study in Louisiana ." Joint Statistical Meetings, Indianapolis, IN. (August 2000)

     
    Editorial Positions
     Associate Editor, BMC Genetics. (2014 - 2017)

     Associate Editor, Journal of the American Statistical Association. (2005 - 2005)

     Associate Editor, STATS . (2000 - 2000)

     Associate Editor, Journal of the American Statistical Association. (2006 - 2006)

    Supervised Theses & Dissertations
     Zhaoxia Yu, Ph.D Hapoltype Block and Genetic Association. (2005) (Thesis or Dissertation Director)

     Bo Peng, Ph.D. Forward-time population genetics simulation and its applications in the mapping of complex human diseases. (2006) (Committee Member)

     Jamie Chatman, Ph.D. Computing Diversity in Undergraduate Admissions Decisions. (2008) (Thesis or Dissertation Director)

     Garrett Fox, Ph.D. A Bayesian Hierarchical Haplotype Model for Unphased Genotypic SNP Data. (2008) (Thesis or Dissertation Director)

     Jason Andrew Gershman, Ph.D. Clustering Time-Course Gene-Expression Array. (2008) (Thesis or Dissertation Director)

     J. Blair Christiam, Ph.D. Incorporating Annotation Data in Quantitative Trait Loci Mapping with mRNA Transcripts. (2009) (Thesis or Dissertation Director)

     Zhaoxia Yu, Ph.D Haplotype blocks and association studies. (Thesis or Dissertation Director)

     Blair Christian, Ph.D. Gene Mapping for expression trait loci. (Thesis or Dissertation Director)

     Garrett Fox, Ph.D. Multiple testing for genome scans based on haplotypes. (Thesis or Dissertation Director)

     Jason Gershman, Ph.D. Genetic epidemiology. (Thesis or Dissertation Director)

    Awards, Prizes, & Fellowships
     Kinder Institute Fellow , (2016)

     Best Presentation, Critical Assessment of Microarray Data Analysis (CAMDA), Duke University (2004)

     Study Section SNEM-5, National Institute of Health, (2001)

    Positions Held
     Co-Director, Urban Data Platform, Kinder Institute, Rice University. (2016 - 2016)

     Houston Education Research Consortium, Rice University, Faculty, Secondary Position. (2013 - 2013)

     Member, National Institutes of Health, Study Section SNEM-5. (2002 - 2002)

     Associate Editor, Journal of the American Statistical Association. (2005 - 2005)

     Director, Gulf Coast Consortia Center for Bioinformatics. (2006 - 2006)

     Associate Editor, Journal of the American Statistical Association. (2004 - 2004)

     Program Co-Chair, Southern Regional Council of Statistics (SRCOS). (2003 - 2003)

     Member, University of Alabama Diversity Promotional Panel,. (2005 - 2005)

     Faculty Member, Graduate Program in Structural and Computational Biology and Molecular Biophysics (SCBMB) at Baylor College of Medicine. (2006 - 2006)

     Member, University of Alabama Diversity Promotional Panel. (2004 - 2004)

     Program Chair, Conference of Texas Statisticians (COTS). (2002 - 2002)

     Program co-Chair, Southern Regional Council of Statistics (SRCOS) Annual Meeting. (2002 - 2002)

     Section BMRD (formerly SNEM-5),, National Institutes of Health. (2005 - 2005)

     Member, University of Alabama Diversity Promotional Panel. (2006 - 2006)

     Faculty, Keck Center. (2002 - 2002)

     Member, American Statistical Association. (2006 - 2006)

     Member, American Society of Human Genetics. (2006 - 2006)

     Member, Society of Genetic Epidemiology. (2006 - 2006)

     Member, Society for the Advancement of Chicanos and Native Americans in Science. (2006 - 2006)