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Scholarly Interest Report
         
Jonathan (Joff) Silberg
Associate Professor
Associate Professor of Biochemistry and Cell Biology
 
e-mail:joff@rice.edu
 
  • B.S. Biology (1994) University of California Irvine, Irvine, California
  • B.S. Chemistry (1994) University of California Irvine, Irvine, California
  • Ph.D. Biology (2000) University of California Irvine, Irvine, California
 
Primary Department
   Department of BioSciences
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Department Affiliations
 
  • Department of Bioengineering
  • Institute of Biosciences and Bioengineering
  • Keck Center for Quantitative Biomedical Sciences
  • Systems, Synthetic, and Physical Biology
  •  
    Websites
     Silberg Research Group
     
    Research Areas
     Chaperones, Laboratory Evolution, Mitochondrial Biochemistry, and Protein Design
     

    Research Interests

     

    The objective of our group is to elucidate and manipulate the functions of proteins. Our biochemical research is focused on: silberg_figure (i) investigating if a protein’s mutational tolerance reports on its functionally important motions, (ii) using structure-guided protein recombination to understand sequence-structure-function relationships within protein complexes, and (iii) understanding the regulation Fe-S cluster biosynthesis. Our synthetic biology research is focused on: (iv) developing new methods for laboratory evolution that accelerate our ability to overcome component limitations, (v) building new enzyme technologies for increasing spatial and temporal control over metabolic labeling, and (vi) establishing reporters for biosensing in hard-to-image conditions, e.g., animals, biochars, and soils. Our expertise in biochemistry and biomolecular design puts us in a unique position to study living systems, as we take advantage of classical methods for biochemical inquiry and develop and apply novel biotechnologies to support these lines of research. Our philosophy is that transformative advances occur when biochemical studies are extended to conditions that reflect those within living cells and the environment, and important synthetic biology advances occur when experimental observations can be anticipated using physical models.

     
    Teaching Areas
     Physical Chemistry for the Biosciences, First year graduate course in Molecular Interactions
     
    Selected Publications
     Refereed articles
     

    Ho, M.L., Adler, B., Torre, M., Silberg, J.J., and Suh, J. "SCHEMA computational design of virus capsid chimeras: calibrating how DNA packaging, protection, and transduction correlate with calculated disruption." ACS Synth. Biol., 2 (2013) : 724-733.

     
     

    Judd, J., Ho, M.L., Tiwari, A., Gomez, E.J., Dempsey, C., Van Vliet, K., Igoshin, O., Silberg, J.J., Agbandje-McKenna, M., and Suh, J. "Tunable virus nanonodes programmed to compute proteolytic signatures." in review (2013) Submitted

     
     

    LeCroy, C., Masiello, C.A., Rudgers, J.A., Hockaday, W.C., and Silberg, J.J. "Nitrogen, biochar, and mycorrhizae: Alteration of the symbiosis and oxidation of the char surface." Soil Biology and Biochemistry, 58 (2013) : 248-254.

     
     

    Mahdavi, A., Segall-Shapiro, T.H., Kou, S., Jindal, G.A., Hoff, K.G., Liu, S., Chitsaz, M., Ismagilov, J.J., Silberg, J.J., and Tirrell, D.A. " A genetic AND gate for selective interrogation of cellular protein synthesis." JACS, 135 (2013) : 2979-2982.

     
     

    Masiello, C.A., Ye, C., Gao, G., Liu, S., Cheng, H.Y., Bennett, M.R., Rudgers, J.A., Wagner, D.S., Zygourakis, K., and Silberg, J.J. "Biochar and microbial signaling: production conditions determine effects on microbial communication." Environ. Sci. Technol. , 47 (2013) : 11496-11503.

     
     

    Zhao, W., Bonem, M., McWhite, C., Silberg, J.J., and Segatori, L. "The Deg-On system: a mammalian synthetic gene circuit to quantify proteasomal degradation." in review (2013) Submitted

     
     

    Judd, J., Wei, F., Nguyen, P.Q., Tartaglia, L. J., Agbandje-McKenna, M., Silberg, J.J., and Suh, J. "Random insertion of mCherry into the VP3 domain of adeno-associated virus (AAV) yields fluorescent capsids with no loss of infectivity." Molecular Therapy Ė Nucleic Acids, 1 (2012) : e1.

     
     

    Mehta, M, Liu, S., and Silberg, J.J. "A transposase strategy for creating libraries of circularly permuted proteins." Nucleic Acids Research, 40(9) (2012) : e71.

     
     

    Vu, M, Zhai, P., Lee, J, Guerra, C., Liu, S., Gustin, M.C., and Silberg, J.J. "The DNLZ/HEP zinc-binding domain is critical for regulation of the mitochondrial chaperone HSPA9." Protein Science, 21 (2012) : 258-267.

     
     

    McGuire, R.M., Silberg, J.J., Pereira, F.A., and Raphael, R.M. "Selective cell-surface labeling of the molecular motor prestin." Biochem. Biophys. Res. Comm. , 410 (2011) : 134-139.

     
     

    Segall-Shapiro, T.H., Nguyen, P.Q., Dos Santos, E., Subedi, S., Suh, J., and Silberg, J.J. "Mesophilic and hyperthermophilic adenylate kinases differ in their tolerance to random fragmentation." J. Mol. Biol., 406 (2011) : 135-148 .

     
     

    Zhai, P., Vu, M.T., Hoff, K.G., and Silberg, J.J. "A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity." Biochem. Biophys. Res. Comm. , 408 (2011) : 589-594.

     
     

    Nguyen, P.Q. and Silberg, J.J. "A selection for detecting protein-protein interactions within a thermophilic bacterium." Prot. Eng. Des. & Sel., 23 (2010) : 529-536.

     
     

    Hoff, K.G., Culler, S. J., Nguyen, P. Q., McGuire, R.M., Silberg, J. J., and Smolke, C. D. "In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2." Chemistry & Biology, 16 (2009) : 1299-1308.

     
     

    Hoff, K.G., Li, R., Goodlitt, R., Smolke, C. D., and Silberg, J.J., "Fluorescence detection of protein-bound 2Fe2S clusters." ChemBioChem, 10 (2009) : 667-670.

     
     

    Nguyen, P.Q., Liu, S., Thompson, J., and Silberg, J.J. "Thermostability promotes the cooperative function of adenylate kinase fragments.." Prot. Eng. Des. Sel., 21 (2008) : 303-310.

     
     

    Zhai, P., Stanworth, C., Liu, S., and Silberg, J.J. "The human hsp70 escort protein Hep binds to the ATPase domain of mitochondrial Hsp70 and regulates nucleotide hydrolysis." J. Biol. Chem., 283 (2008) : 26098-26106.

     
     

    Bloom, J.D., Silberg, J.J., Wilke, C., Drummond, D.A., Adami, C., and Arnold, F.H. "Thermodynamic prediction of protein neutrality." Proc. Nat'l. Acad. Sci. U.S.A., 102 (2005) : 606-611.

     
     

    Drummond, D.A., Silberg, J.J., Wilke, C.O., Meyer, M.M., and Arnold, F.H. "On the conservative nature of intragenic recombination." Proc. Nat'l. Acad. Sci. U.S.A., 102 (2005) : 5380-5385.

     
     

    Cupp-Vickery, J.R., Silberg, J.J., Ta, D.T., and Vickery, L.E. "Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli." J. Mol. Biol., 338 (2004) : 127-137.

     
     

    Endelman, J.B., Silberg, J.J., Wang, Z.G., and Arnold, F.H. "Protein chimera library design as a shortest-path problem." Prot. Eng. Des. & Sel., 17 (2004) : 589-594.

     
     

    Otey, C., Silberg, J.J., Endelman, J.B., Bandara, G., Voigt, C.A., and Arnold, F.H. "Functional evolution and structural conservation in chimeric cytochromes P450: Calibrating a structure-guided approach." Chemistry & Biology, 11 (2004) : 309-318.

     
     

    Silberg, J.J., Tapley, T.L., Hoff, K.G., and Vickery, L.E. "Regulation of the Hsc66 ATPase reaction cycle by the J-type cochaperone Hsc20 and the iron-sulfur escort protein IscU." J. Biol. Chem., 279 (2004) : 53924-53931.

     
     

    Meyer, M.M., Silberg, J.J., Voigt, C.A., Endelman, J.B., Mayo, S.L., Wang, Z.G., and Arnold, F.H. "Library analysis of SCHEMA-guided recombination." Protein Science, 12 (2003) : 1686-1693.

     
     

    Hoff, K.G., Ta, D., Tapley, T.L., Silberg, J.J., and Vickery, L.E. "Hsc66 substrate specificity is directed towards a discrete region of the Fe/S template protein IscU." J. Biol. Chem., 277 (2002) : 27353-27359.

     
     

    Silberg, J.J., Hoff, K.G., Tapley, T.L., and Vickery, L.E. "The Fe/S-escort protein IscU behaves as a substrate for the molecular chaperone Hsc66 from Escherichia coli." J. Biol. Chem., 276 (2002) : 1696-1700.

     
     

    Urbina, H.D., Silberg, J.J., Hoff, K.G., and Vickery, L.E. "Transfer of sulfur from IscS to IscU during iron-sulfur cluster assembly." J. Biol. Chem., 276 (2001) : 44521-44526.

     
     

    Hoff, K.G., Silberg, J.J., and Vickery, L.E. "Interaction of the iron-sulfur cluster assembly protein IscU with the Hsc66/Hsc20 molecular chaperone system in Escherichia coli." Proc. Nat'l. Acad. Sci. U.S.A., 97 (2000) : 7790-7795.

     
     

    Silberg, J.J., and Vickery, L.E. "Kinetic characterization of the ATPase cycle of the molecular chaperone Hsc66 from Escherichia coli." J. Biol. Chem., 275 (2000) : 7779-7786.

     
     Articles
     

    Silberg, J.J. "Synthetic genome a necessary first step to new life." Houston Chronicle Online (Jan. 24, 2008)

     
     Book chapters
     

    Silberg, J.J., Nguyen, P.Q., and Stevenson, T. "Computational design of chimeric protein libraries for directed evolution." Methods in Molecular Biology: Topics in Computational Biology , 673 (2010) : 175-188 .

     
     

    Silberg, J.J., and Nguyen, P.Q. "Models predicting optimized strategies for protein evolution." The Metabolic Pathway Engineering Handbook , 2 (2009)

     
     

    Silberg, J.J., Endelmen, J.B., and Arnold, F.H. "SCHEMA-guided protein recombination." Methods Enzymology (D. Robertson and J.P. Noel, Eds.), 388 (2004)

     
     

    Meinhold, P., Joern, J., and Silberg, J.J. "Analysis of shuffled libraries by oligonucleotide probe hybridization." Methods in Molecular Biology (F.H. Arnold and G. Georgiou, Eds.,), 231 (2003) : 177-188.

     
     

    Udit, A.K., Silberg, J.J., and Sieber, V. "Sequence homology-independent protein recombination (SHIPREC)." Methods in Molecular Biology (F.H. Arnold and G. Georgiou, Eds.), 231 (2003) : 153-164.

     
     Conference papers
     

    Judd, J., Silberg, J, and Suh, J. "Optimization of High-Risk Adeno-Associated Virus (AAV) Libraries for Directed Evolution of Novel Gene Vectors. (AICHE Annual Meeting, Salt Lake City, UT)."  (2010)

     
     

    Silberg, J.J., Vu, M., and Zhai, P. "Human DNLZ regulates the solubility and ATPase activity of the mitochondrial hsp70 (HSPA9). (FASEB Summer Research Conferences: Protein Folding in the Cell, Saxton City, VT)."  (2010)

     
     

    Silberg, J.J., and Nguyen, P.Q. "A Selection that Reports on Protein-Protein Interactions within a Living Thermophilic Bacterium. (Astrobiology Science Conference 2010: Evolution and Life: Surviving Catastrophes and Extremes on Earth and Beyond, League City, Texas)."  (2010)

     
     

    Vu, M., Zhai, P., and Silberg, J.J. "Molecular dissection of the human Hsp70 escort protein Hep to identify residues important for regulation of mtHsp70 activity. (18th Annual Texas Protein Folders Meeting, Navasota, TX)."  (2010)

     
     

    Vu, M., Zhai, P., and Silberg, J.J. "Molecular dissection of the human Hsp70 escort protein Hep to identify residues important for regulation of mtHsp70 activity. (UTMB Structural Biology Symposium, Galveston, TX)."  (2010)

     
     

    Hoff, K.G., Silberg, J.J., Smolke, C.D. "Fluorescent Sensors for Detection of Iron Sulfur Cluster Biogenesis. (Society for Biological Engineering 2nd Intíl Conference on Biomolecular Engineering, Santa Barbara, CA) ."  (2009)

     
     

    Judd, J., Nguyen, P., Silberg, J., Suh, J. "Construction of a Directed Evolution Library Platform for Modifying Adeno-Associated Viruses for Gene Therapy Applications. (AIChE Annual Fall Meeting, Nashville, TN)."  (2009)

     
     

    Judd, J., Nguyen, P., Silberg, J., Suh, J. "Construction of a directed evolution library platform for modifying adeno-associated viruses for gene therapy applications. (BMES Annual Fall Meeting, Pittsburgh, PA)."  (2009)

     
     

    McConnell-Schweller, R., Diehl, M., Silberg, J., Suh, J. "Virus microarrays for investigating stem cell behavior. (AIChE Annual Fall Meeting, Nashville, TN)."  (2009)

     
     

    McConnell-Schweller, R., Diehl, M., Silberg, J., Suh, J. "Virus microarrays for investigating stem cell behavior. (BMES Annual Fall Meeting, Pittsburgh, PA)."  (2009)

     
     

    Nguyen, P.Q., Silberg, J.J. "A split adenylate kinase sensor for detecting protein-protein interactions in thermophiles. (AIChE Annual Fall Meeting, Nashville, TN)."  (2009)

     
     

    Segall-Shapiro, T., Nguyen, P.Q., Judd, J., Suh, J., Silberg, J.J. "Accelerating the design of split proteins with a range of cooperative functions. (AIChE Annual Fall Meeting, Nashville, TN)."  (2009)

     
     

    Silberg, J.J., Hoff, K.G. "Fluorescent Sensors for Detection of Iron Sulfur Cluster Biogenesis. (Gordon Conference on Cell Biology of Metals, Newport, RI)."  (2009)

     
     

    Silberg, J.J., Hoff, K.G. "Imaging iron-sulfur cluster binding to human glutaredoxin 2 using fluorescent protein reporters. (5th International Conference on Fe-S Cluster Biogenesis and Regulation, Athens, GA)."  (2009)

     
     

    Zhai, P., Silberg, J.J. "Mutations in the Human Hsp70 Escort Protein Hep that Affect Binding to MtHsp70 and Regulation of Chaperone ATPase Activity (21st IUBMB & 12th FAOBMB Intíl Congress of Biochemistry and Molecular Biology, Shanghai, China)."  (2009)

     
     

    Zhai, P., Silberg, J.J. "Regulation of the human mitochondrial chaperone mtHsp70 by the hsp70 escort protein Hep. (The American Society of Biochemistry & Molecular Biology Meeting, New Orleans, LA)."  (2009)

     
     

    Nguyen, P.Q. and Silberg, J.J. "Creating an assay to examine the effects of temperature on protein-protein interactions." Astrobiology, 8 (2008) : 333.

     
     

    Zhai, P., Stanworth, C., Liu, S., and Silberg, J.J. "Hsp70 escort proteins promote the solubility of non-cognate mitochondrial chaperones and require bound zinc for solubility." FASEB Journal, 22 (2008) : 1032.4.

     
    Presentations
     Invited Talks
     

    "Evolving proteins through fission and permutation for fundamental and applied research." University of Houston, Houston, TX. (March, 2013)

     
     

    "Evolving proteins through random fission and permutation." Department of Chemistry and Biochemistry, University of Texas, Austin, TX. (March, 2013)

     
     

    "Interdisciplinary summer research program in Biological Networks." School of Engineering Fair, San Jacinto Community College, Houston, TX . (November, 2013)

     
     

    "Interdisciplinary summer research program in Biological Networks." Chemistry Department, San Jacinto Community College, Houston, TX . (December, 2013)

     
     

    "Pyrolysis temperature determines biochar effects on microbial communication on the time scale of growth and signaling." North American Biochar Symposium, University of Massachusetts, Amherst, MA. (October, 2013)

     
     

    "Pyrolysis temperature determines biochar effects on microbial communication on the time scale of growth and signaling." Bacterial Interest Group, Texas Medical Center, Houston, TX. (December, 2013)

     
     

    "A chaperone for a chaperone: DNLZ regulation of the human mitochondrial hsp70." Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI. (May, 2012)

     
     

    "Synthetic biology: from new components to environmental applications." Exxon-Mobil, Houston TX. (December, 2012)

     
     

    "Transposase mutagenesis strategies for discovering protein mutants with new Boolean logic." Genomatica, San Diego, CA. (June, 2012)

     
     

    "Transposase-mediated protein mutagenesis: libraries for fundamental & applied research." Gulf Coast Consortium Keck Seminar Series, Houston, TX. (September, 2012)

     
     

    "Using laboratory evolution to study protein dynamics." Department of Chemistry, Virginia Commonwealth University, Richmond, VA. (May, 2012)

     
     

    "Ironing out strategies for designing split protein biosensors." Department of Biochemistry and Molecular Biology, Wayne State University, Detroit, MI. (November 2011)

     
     

    "Ironing out strategies for designing split protein biosensors." 19th Annual Texas Protein Folders Meeting, Navasota, TX. (March 2011)

     
     

    "Ironing out the regulation of mitochondrial hsp70 chaperones by DNL-type zinc proteins." Department of Biology, Virginia Commonwealth University, Richmond, VA. (November 2011)

     
     

    "Using protein fragmentation to create new biotechnologies." Department of Biology, St. Thomas University, Houston, TX. (April 2011)

     
     

    "Designing protein-based biosensors for metallomic and proteomic applications." AAAS-SWARM Meeting , Houston, TX. (April 2010)

     
     

    "Ironing out strategies for designing split protein biosensors." Department of Biology, Texas Southern University, Houston, TX. (October 2010)

     
     

    "Protein biosensors for imaging mitochondrial 2Fe2S clusters." 2nd cardiac summit in Friedreichís ataxia, Philadelphia, PA. (June 2010)

     
     

    "Imaging iron-sulfur cluster binding to glutaredoxin 2 (GRX2) using fluorescent protein reporters." 5th International Conference on Fe-S Cluster Biogenesis and Regulation, University of Georgia, Athens . (Sept, 2009)

     
     

    "In vivo fluorescent detection of 2Fe2S clusters coordinated by human glutaredoxin 2." Cell Biology of Metals Gordon Conference, Salve Regina University, RI. (Aug, 2009)

     
     

    "Designing protein-based biosensors for metallomic and proteomic applications." Dept. of Bioengineering, Rice University, Houston, Texas. (November, 2008)

     
     

    "Evolving strategies for protein engineering." Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas. (March 2008)

     
     

    "Evolving Strategies for Protein Engineering." 15th Annual Texas Protein Folders Meeting, Navasota, Texas. (March 2007)

     
     

    "Evolving Strategies for Protein Engineering." Rice University, Department of Biochemistry & Cell Biology Retreat, Chain O' Lakes Resort, Texas. (August 2005)

     
     

    "Exploring Sequence Space by Structure-guided Recombination." Rice University, Department of Chemical and Biomolecular Engineering, Houston, Texas. (2005)

     
     

    "On the Conservative Nature of Protein Recombination." The University of Kansas Medical Center, Department of Biochemistry & Molecular Biology, (2005)

     
     

    "Exploring sequence space by structure-guided recombination." Department of Biochemistry & Cell Biology, Rice University, Houston, Texas. (February 2004)

     
     

    "Exploring sequence space by structure-guided recombination." College of Pharmacy, University of Utah, (February 2004)

     
     

    "Exploring sequence space by structure-guided recombination." Department. of Chemistry, Boston University, (February 2004)

     
     

    "On the conservative nature of protein recombination." Department of Physics, Instituto Venezolano de Investigaciones Cientificas, (2004)

     
     Posters
     

    "Biobeer: resveratrol producing yeast for fermentation." Fifth Int'l Genetically Engineered Machine Competition, MIT, Cambridge, MA. (2008) With Duke, S., Layman, A., Ouyang, D., Segall-Shapiro, T., Shiehk, S., Stevenson, T., Beason, B., Bennett, G., Cox, K., Igoshin, O., Judd, J., Nguyen, P.Q., Suh, J.

     
     

    "Creating an assay to examine the effect of temperature on protein-protein interactions." Fifth Astrobiology Science Conference, Santa Clara, CA. (2008) With Nguyen, P.Q.

     
     

    "Effects of cysteine mutations on prestin function and oligomerization." Association for Research in Otolaryngology, Phoenix, AZ. (2008) With McGuire, R.M., Pereira, F.A., and Raphael, R.M.

     
     

    "Hsp70 escort proteins promote the solubility of non-cognate mitochondrial chaperones and require bound zinc for solubility." The American Society of Biochemistry & Molecular Biology Meeting, San Diego, CA. (2008) With Zhai, P., Stanworth, C., and Liu, S.

     
     

    "Monitoring hyperthermophilic protein-protein interactions using an adenylate kinase fragment complementation assay." UTMB Structural Biology Symposium, Galveston, TX. (2008) With Nguyen, P.Q.

     
     

    "Nucleotides regulate the binding of human Hsp70 escort protein Hep to the ATPase domain mitochondrial mtHsp70." 16th Annual Texas Protein Folders Meeting, Navasota, TX. (2008) With Zhai, P. and Liu, S.

     
     

    "The human hsp70 escort protein Hep binds to the ATPase domain of mitochondrial mtHsp70 and regulates nucleotide hydrolysis." UTMB Structural Biology Symposium, Galveston, TX. (2008) With Zhai, P.

     
     

    "Thermostability promotes the cooperative function of adenylate kinase fragments." 16th Annual Texas Protein Folders Meeting, Navasota, TX. (2008) With Nguyen, P.Q. and Liu, S

     
     

    "Directed Evolution Identifies Residues that Mediate Cysteine Desulfurases IscS Binding to the Fe/S-cluster Scaffold Protein IscU." 12th Annual Structural Biology Symposium, UTMB, Galveston, TX. (May 18-19, 2007) With Zhai, P.

     
     

    "Genetic Circuits for Monitoring Dynamic Changes in Post-translational Modifications." Eight International Conference on Systems Biology, Long Beach, CA. (October 1-6, 2007) With Hoff, K. G.

     
     

    "Phage that Select against Antibiotic Resistance." Fourth International Genetically Engineered Machine Competition, MIT, Cambridge, MA. (Nov. 5-7, 2007) With Chen, T., Kim, D., Layman, A., Segall-Shapiro, T., Stevenson, T., Walker, A., Beason, B., Mukhopadhyay, B., Nguyen, P., Peebles, C., and Raol, J.

     
     

    "The Hsp70 Escort Protein Hep1 Supports the Production of Soluble Recombinant Human Mitochondrial Hsp70." 12th Annual Structural Biology Symposium, UTMB, Galveston, TX. (May 18-19, 2007) With Stanworth, C.

     
     

    "Thermostability Promotes the Cooperative Function of Adenylate Kinase Fragments." 12th Annual Structural Biology Symposium, UTMB, Galveston, TX. (May 18-19, 2007) With Nguyen, P. Q. and Thompson, J.

     
    Supervised Theses & Dissertations
     Rui Li, MA Monitoring the 2Fe2S Cluster Content of Human Glutaredoxin 2 Using Fluorescence Proteins. (2007) (Thesis or Dissertation Director)

     Jay Raol, MA Modeling Phage Lamda via Ordinary Differential Equations. (2007) (Committee Member)

     Crystal Stanworth, M.A. The Saccharomyces cerevisiae Hsp70 Escort Protein, Hep1, Exhibits Broad-spectrum Chaperone Activity. (2008) (Thesis or Dissertation Director)

     Vittal Srinivas, PhD Analytical approach to studying sequence fragments of glycosaminoglycan biopolymer on aggrecan. (2009) (Committee Member)

     Loren Stagg, PhD Role of cell-like conditions in folding, structure, and stability of an a/b model protein, Desulfovibrio desulfuricans flavodoxin. (2009) (Committee Member)

     Peng Zhai, Ph.D. Escort Protein Regulation of the Human Mitochondrial Molecular Chaperone mtHsp70. (2010) (Thesis or Dissertation Director)

     David Culbertson, Ph.D. Role of Heme in the Folding and Assembly of Globins. (2010) (Committee Member)

     Peter Nguyen, Ph.D. Effect of Protein Thermostability on the Cooperative Function of Split Enzymes. (2010) (Thesis or Dissertation Director)

     Leticia Vega, Ph.D. The Impact of Nickel on Lux I/LuxR‐Type Quorum Sensing and Biofilm Formation of Environmental Proteobacterial Species. (2013) (Committee Member)

     Justin Judd, Ph.D. Encryption of Adeno-Associated Virus for Protease-Controlled Targeted Gene Therapy . (2013) (Committee Member)

     Andria Denmon, Ph.D. The Role of Base Modification on Tyrosyl-tRNA Thermodynamics, Structure, and Function in Bacillus subtilis and Bacillus anthracis. (2013) (Committee Member)

    Awards, Prizes, & Fellowships
     CAREER Award, National Science Foundation (2012)

     Hamill Innovation Award, Hamill Foundation (2008)

     Distinguished Faculty Associate, Martel College (2007)