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Scholarly Interest Report
         
Christy Landes
Professor
Professor of Chemistry & Electrical and Computer Engineering
 
e-mail:cflandes@rice.edu
 
  • B.S. Chemistry (1998) George Mason University, Fairfax, Virginia
  • Ph.D. Chemistry and Biochemistry (2003) Georgia Institute of Technology, Atlanta, Georgia
 
Primary Department
   Department of Chemistry
Picture
 
Websites
 Landes Research Group
 
Research Areas
 • Interfacial dynamics at the single molecule scale • Separation and purification at the single analyte scale • Image processing and analysis development • Nanomaterials/biomolecular surface chemistry • Plasmonic materials surface chemistry • Biophysics of dynamic structure-function relationships • Single molecule spectroscopy methods development
 

Research Statement 2015

 

As experimental physical chemists, the overall goal of our research is to understand the frequently complex structure-function relationships in biological processes and to use this information to inspire innovation for materials design.


Practical goals in materials engineering include minimal cost, maximum efficiency, and optimized longevity. As our experimental and theoretical methods to study nature’s molecular-scale design principles have improved, we have begun to understand that one reason nature can be so successful is that her engineering strategy often differs from ours. Whereas humans usually design materials with a single, well-defined function, nature often acts through redundant or degenerate channels that are individually not as efficient, but collectively, and in the face of damage or wear, outperform their synthetic cousins. 


Obtaining clues from the biological structure-function interplay presents challenges for theory, experiment, and data analysis. When we study one molecule at a time, we eliminate ensemble averaging, thereby accessing any underlying conformational complexity. However, we must develop new methods to increase information content in the resulting low signal-to-noise single-molecule data. Thus, our research efforts have focused on three specific objectives necessary to achieve the overall goal discussed above:


1) Develop experimental data acquisition and analysis methods to optimize information retrieval in single-molecule and single- particle spectroscopies.


2) Characterize biological examples of heterogeneous structure-function relationships.


3) Identify, understand, and optimize heterogeneous structure-function relationships in synthetic systems. 


Selected Publications


Byers, C.P.; Zhang, H.; Swearer, D.F.; Yorulmaz, M.; Hoener, B.S.; Huang, D.; Hoggard, A.; Chang, W.S.; Mulvaney, P.; Ringe, E.; Halas, N.J.; Nordlander, P.; Link, S.; Landes, C.F. “From tunable core-shell nanoparticles to plasmonic drawbridges: Active control of nanoparticle optical properties” Science Advances 2015, 1, e1500988.


Kisley, L.; Brunetti, R.; Tauzin, L.J.; Shuang, B.; Yi, X.; Kirkeminde, A.W.; Higgins, D.A.; Weiss, S.; Landes, C.F. “Characterization of Porous Materials by fcsSOFI” ACS Nano 2015, 9 9158-9166.


Cooper, D.; Dolino, D.; Jaurich, H.; Shuang, B.; Ramaswamy, S.; Chen, J.; Jayaraman, V.; Landes, C.F. “Conformational Transitions in the Glycine-Bound GluN1 NMDA Receptor LBD via Single Molecule FRET” Biophys. J. 2015, 109, 66-75.


Kisley, L.; Landes, C.F. "A Molecular Approach to Chromatography using Single Molecule Spectroscopy" Analytical Chemistry 2015, 87, 83-89.


Landes, C.F. "Next Generation Fluroescence Microscopy Methods to Elucidate Bacterial Structure/Function" Molecular Microbiology, 2015, 96,1-3.


Kisley, L.; Chen, J.; Mansur, A.P.; Kourentzi, K.; Poongavanam, M.V.; Chen, W.S.; Dhamane, S.; Willson, R.P. Landes, C.F. "Unified Super-Resolution Experiments and Stochastic Theory Provide Mechanistic Insight into Protein Ion-Exchange Adsorptive Separations" PNAS, 2014, 111, 2075-2080.


Hu, Z.; Adachi, T.; Haws, R.; Shuang, B.; Ono, R.J.; Bielawski, C.W.; Landes, C.F.; Rossky, P.J.; Vanden Bout D.A. "Excitonic Energy Migration in Conjugated Polymers: The Critical Role of Interchain Morphology" J. Am. Chem. Soc. 2014, 136, 16023-16031.


 Shuang, B.; Chen, J.; Kisley, L.; Landes, C.F. "Troika of Single Particle Tracking Programming: SNR Enhancement, Particle Identification, and Mapping" PCCP, 2014, 16, 624-634.


Chen, J.; Bremauntz, A.; Kisley, L.; Shuang, B.; Landes, C. F. "Super-Resolution mbPAINT for Optical Localization of Single Stranded DNA" ACS Appl. Materials and Interfaces, 2013, 5, 9338-9343.


Dominguez-Medina, S.; Blankenburg, J.; Olson, J.; Landes, C.F.; Link, S. “Stable isotonic saline solutions of gold nanoparticles via albumin adsorption” ACS Sustainable Chemistry and Engineering, 2013, 1, 833-842.


Shuang, B.; Byers, C.P.; Kisley, L.; Wang, L.Y.; Zhao, J.; Morimura, H.; Link.S.; Landes, C.F. “Improved Analysis for Determining Diffusion Coefficients from Short Single-molecule Trajectories with Photoblinking” Langmuir, 2013, 29, 228-234.


Reznik, C.; Landes, C.F. “Transport in Supported Polyelectrolyte Brushes” Accounts of Chemical Research, 2012, 45, 1927-1935.


Daniels, C.; Kisley, L.; Kim, H.; Chen, W.; Vivek, M.; Reznik, C.; Kourentzi, K.; Willson, R.C.; Landes, C.F. “Single-molecule Observations of Protein Interactions with Clustered-charge Peptide Adsorbates” J. Molecular Recognition, 2012, 25, 435-442.


Landes, C.F.; Rambhadran, A.; Taylor, J.N.; Salatan, F.; Jayaraman, V. “Structural Landscape of the Isolated Agonist Binding Domain of the AMPA Receptor Studied by Single Molecule FRET”, Nature Chemical Biology, 2011, 7, 168-173.


Daniels, C.R.; Reznik, C.; Kilmer, R.; Felipe, M.J.; Tria, M.C.R.; Kourentzi, K.; Willson, R.C.; Advincula, R.C.; Landes, C.F. “Permeability of Anti-Fouling Pegylated Surfaces Probed by Fluorescence Correlation Spectroscopy” Colloids and Surfaces, 2011, 88, 31-38.


Taylor, J.N.; Landes, C.F. “Improved Resolution of Complex Single-Molecule FRET Systems via Wavelet Shrinkage” J. Phys. Chem. B 2011, 115, 1105-1114.


Daniels, C.R.; Reznik, C.; Landes, C.F. “Dye Diffusion at Surfaces: Charge Matters” Langmuir, 2010, 26, 4807-4812.


Taylor, J. N.; Makarov, D.E.; Landes, C.F. “Denoising Single-Molecule FRET Trajectories with Wavelets and Bayesian Inference” Biophys. J., 2010, 98, 164-173.


Reznik, C.; Estillore, N.; Advincula, R.; Landes, C.F. “Single Molecule Spectroscopy Reveals Heterogeneous Ion Transport in a Polyelectrolyte Polymer Brush” J. Phys. Chem. B  2009, 113, 14611-14618. 


Tcherniak, A.; Reznik, C.; Link, S.; Landes, C.F. "Fluorescence Correlation Spectroscopy: Criteria for Analysis in Complex Systems" Analytical Chem., 2009, 81, 746-754.


 


 

 
Selected Publications
 Refereed articles
 

Byers, C.P.; Zhang, H.; Swearer, D.F.; Yorulmaz, M.; Hoener, B.S.; Huang, D.; Hoggard, A.; Chang, W.S.; Mulvaney, P.; Ringe, E.; Halas, N.J.; Nordlander, P.; Link, S.; Landes, C.F. “From tunable core-shell nanoparticles to plasmonic drawbridges: Active control of nanoparticle optical properties” Science Advances 2015, 1, e1500988.

 
 

Cooper, D.; Dolino, D.; Jaurich, H.; Shuang, B.; Ramaswamy, S.; Chen, J.; Jayaraman, V.; Landes, C.F. “Conformational Transitions in the Glycine-Bound GluN1 NMDA Receptor LBD via Single Molecule FRET” Biophys. J. 2015, 109, 66-75. 

 
 

Dolino, D. M.; Cooper, D.; Ramaswamy, S.; Jaurich, H.; Landes, C.F.; Jayaraman, V. “Structural Dynamics of the Glycine-Binding Domain of the N-Methyl-D-
Aspartate Receptor” J. Biol. Chem. 2015, 290, 797-804.

 
 

Dominguez-Medina, S.; Chen, S.; Blankenburg, J.; Swanglap, P.; Landes, C.F.; Link, S. “Measuring the Hydrodynamic Size of Nanoparticles using Fluctuation Correlation Spectroscopy” Ann. Rev. Phys. Chem., 2016, in press.

 
 

Huang, D.; Byers, C.P.; Wang, L.-Y.; Hoggard, A.; Hoener, B.; Chang, W.-S. Landes, C.F.; Link, S. “Photoluminescence of a Plasmonic Molecule” ACS Nano 2015, 9, 7072-7079.

 
 

Kisley, L.; Brunetti, R.; Tauzin, L.J.; Shuang, B.; Yi, X.; Kirkeminde, A.W.; Higgins, D.A.; Weiss, S.; Landes, C.F. “Characterization of Porous Materials by fcsSOFI” ACS Nano 2015, 9 9158-9166.

 
 

Kisley, L.; Kourentzi, K.; Willson, R.C.; Landes, C.F. “pH dependence of single protein adsorption and diffusion at a liquid chromatographic interface” J. Sep. Sci. 2015, 00, 1-7.

 
 

Kisley, L.; Landes, C.F. “A Molecular Approach to Chromatography using Single Molecule Spectroscopy” (invited review) Anal. Chem. 2015, 87, 83-98.

 
 

Landes, C.F. “Next Generation Fluorescence Microscopy Methods to Elucidate Bacterial Structure/Function” (invited micro-commentary) Molecular Microbiology 2015, 96, 1-3.

 
 

Poongavanam, M.V.; Kisley, L.; Kourentzi, K.; Landes, C.F.; Willson, R.C. “Ensemble and Single-Molecule Biophysical Characterization of D17.4 DNA Aptamer-IgE Interactions” BBA Proteins and Proteomics 2015, in press.

 
 

Taylor, J.N.; Li, C.B.; Cooper, D.R.; Landes, C.F.; Komatsuzaki, T. “Error-based extraction of states and energy landscapes from experimental single-molecule time-series” Sci. Rep. 2015, 5, 9174.

 
 

Shuang, B.; Chen.; J.; Kisley, L.; Landes, C.F. “Troika of Single Particle Tracking Programming: SNR Enhancement, Particle Identification, and Mapping” (invited perspective), PCCP, 2014, 16, 624-634.

 
 

Byers, C.P.; Hoener, B.S.; Chang, W.S.; Link, S.; Landes, C.F. “Single-particle spectroscopy reveals heterogeneity in electrochemical tuning of the localized surface plasmon”  J. Phys. Chem. B, 2014, 118, 14047-14055. 

 
 

Chen. J.; Poddar, N.K.; Tauzin, L.T.; Kolomeisky, A.B.; Landes, C.F. “Single-Molecule FRET Studies of HIV TAR-DNA Hairpin Unfolding Dynamics” J. Phys. Chem. B. 2014, 118, 12130-12139.

 
 

Hu, Z.; Adachi,T.; Haws, R; Shuang, B.; Ono, R.J.; Bielawski, C.W.; Landes, C.F.;  Rossky, P.J.; Vanden Bout, D.A. “Excitonic Energy Migration in Conjugated Polymers: The Critical Role of Interchain Morphology”, J Am. Chem. Soc. 2014, 136, 16023-16031.

 
 

Kisley, L.; Chen. J.; Mansur, A.P.; Dominguez-Medina, S.; Kulla, E.; Kang, M.; Shuang, B.; Kourentzi, K.; Poongavanam, M.V.; Dhamane, S.; Willson, R.C.; Landes, C.F. “High ionic strength narrows the population of sites participating in protein ion-exchange adsorption: A single-molecule study” J. Chromatography A, 2014, 1343, 135-142.

 
 

Kisley, L.; Chen, J.; Mansur, A.P.; Shuang, B.; Kourentzi, K.; Poongavanam, M. V.; Chen, W.S.; Dhamane, S.; Willson, R.P.; Landes, C.F. “Unified Super-Resolution Experiments and Stochastic Theory Provide Mechanistic Insight into Protein Ion-Exchange Adsorptive Separations” PNAS, 2014, 111, 2075-2080.

 
 

Landes, C.F.; Link. S.; Wine, P.H.; Zhang, Z.J. “2013 Southeastern Regional ACS Meeting. Nanochemistry and Spectroscopy: Symposium Honoring Mostafa El-Sayed” (editorial) J. Phys. Chem. B 2014, 14009-14009.

 
 

Shuang, B.; Cooper, D.; Taylor, J. N.; Kisley, L.; Chen, J.; Wang, W. Li, C-B.; Komatsuzaki, T.; Landes, C.F. “Fast Step Transition and State Identification (STaSI) for Single-Molecule Data Analysis” J. Phys. Chem. Lett. 2014, 5, 3157-3161.

 
 

Tauzin, L.J.; Shuang, B.; Kisley, L.; Mansur, A.; Chen. J.; de Leon, A.; Advincula, R.C.; Landes, C.F; “Charge-Dependent Transport Switching of Single Molecular Ions in a Weak Polyelectrolyte Multilayer” Langmuir, 2014, 30, 8391-8399.

 
 

B. Shuang, C. P. Byers, L. Kisley, L. Y. Wang, J. Zhao, H. Morimura, S. Link, C. F. Landes "Improved Analysis for Determining Diffusion Coefficients from Short Single-molecule Trajectories with Photoblinking." Langmuir, 29 (2013) : 228-234.

 
 

C. R. Daniels, L. J. Tauzin, E. Foster, R. C. Advincula, C. F. Landes "pH Responsive, Charge Selective Polymer-mediated Transport Probed by Traditional and Scanning FCS." J. Phys. Chem. B, 117 (2013) : 4284-4290.

 
 

D. Cooper, H. Ulm, L. Tauzin, N. Poddar, C. F. Landes "Photobleaching Lifetimes of Cyanine Dyes Used for Single Molecule Förster Resonance Energy Transfer in the Presence of Various Oxygen Scavenging Systems." Chem. Bio. Chem., 14 (2013) : 1075-1080.

 
 

J. Chen, A. Bremauntz, L. Kisley, B. Shuang, C. F. Landes "Super-Resolution mbPAINT for Optical Localization of Single-Stranded DNA." ACS Appl. Mater. Interfaces, 5 (2013) : 9338-9343.

 
 

J. N. Taylor, B. Shuang, C. Clementi, C. F. Landes "A Coarse-Grained Model for Molecular Ionic Transport of Rhodamine 6G within a Polystyrene Sulfonate Polymer Brush."  (2013) In Revision

 
 

L. Kisley, J. Chen, A. P. Mansur, S. Dominguez-Medina, E. Kulla, M. Kang, B. Shuang, K. Kourentzi, M. V. Poongavanam, S. Dhamane, R. C. Willson, C. F. Landes "High ionic strength narrows the population of sites participating in protein ion-exchange adsorption: A single-molecule study." J. Chromatogr. A (2013) Submitted

 
 

L. Kisley, W.-S. Chang, D. Cooper, A. Mansur, C. F. Landes "Extending single molecule fluorescence observation time by amplitude modulated excitation." Method. Appl. Fluoresc., 1 (2013) : 037001-037007.

 
 

N. K. Poddar, J. Chen, L. T. Tauzin, A. B. Kolomeisky, C. F. Landes "Multi-loop DNA Hairpin Folding/Unfolding."  (2013) In Revision

 
 

S. Dominguez-Medina, J. Blankenburg, J. Olson, C. F. Landes, S. Link "Stable isotonic saline solutions of gold nanoparticles via albumin adsorption." ACS Sustainable Chem. Eng., 1 (2013) : 833-842.

 
 

S. Kawai, D. Cooper, C. F. Landes, H. D. Mootz, H. Yang, T. Komatsuzaki "Numerical Construction of Estimators for Single-molecule Fluorescence Measurements." J. Phys. Chem. B, 117 (2013) : 8061-8074.

 
 

Daniels, C. R.; Tauzin, L. J.; Foster, E.; Advincula, R. C.; Landes, C. F. "pH Responsive, Charge Selective Polymer-mediated Transport Probed by Traditional and Scanning FCS." J. Phys. Chem. B. (2012) In Press

 
 

Daniels, C.; Kisley, L.; Kim, H.; Chen, W.; Vivek, M.; Reznik, C.; Kourentzi, K.; Willson, R. C.; Landes, C. F. "Single-molecule Observations of Protein Interactions with Cluster-charge Peptide Adsorbates ." J. Mol. Recognit., 25 (2012) : 435-442.

 
 

Dominguez-Medina, S.; McDonough, S.; Swanglap, P.; Landes, C. F.; Link, S. "In situ Measurement of Bovine Serum Albumin Interaction with Gold Nanospheres." Langmuir, 28 (2012) : 9131-9139.

 
 

Kisley, L.; Chen, J.; Mansur, A. P.; Kourentzi, K.; Poongavanam, M. V.; Chen, W. S.; Dhamane, S.; Willson, R. C.; Landes, C. F. "Super-resolution Single Molecule Imaging Demonstrates that Charge Clustering Dominates Ion Exchange Adsorption of Proteins." Proc. Nat. Acad. Sci. USA (2012) Submitted

 
 

Poddar, N.; Chen, J.; Tauzin, L. T.; Kolomeisky, A. B.; Landes, C. F. "Multi-loop DNA Hairpin Folding/Unfolding." J. Am. Chem. Soc. (2012) Submitted

 
 

Poddar, N.; Taylor, J. N.; Harrington, J. L.; Kahakaraj, I.; Kourentzi, K.; Willson, R. C.; Landes, C. F. "Folding Heterogeneity of an Anti-VEGF Aptamer."  (2012) In Revision

 
 

Ramaswamy, S.; Cooper, D.; Poddar, N.; MacLean, D. M.; Rambhadran, A.; Taylor, J. N.; Uhm, H.; Landes, C. F. "Role of Conformational Dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Partial Agonism." J. Biol. Chem., 287 (2012) : 43557-53564.

 
 

Reznik, C.; Landes, C. F. "Transport in Supported Polyelectrolyte Brushes." Acc. Chem. Res., 45 (2012) : 1927-1935.

 
 

Shuang, B.; Byers, C. P.; Kisley, L.; Wang, L. Y.; Zhao, J.; Morimura, H.; Link, S.; Landes, C. F. "Improved Analysis for Determining Diffusion Coefficients from Short Single-molecule Trajectories with Photoblinking." Langmuir, 29 (2013) : 228-234.

 
 

Taylor, J, N,; Shuang, B.; Clementi, C.; Landes, C. F. "A Coarse-Grained Model for Molecular Ionic Transport of Rhodamine 6G within a Polystyrene Sulfonate Polymer Brush."  (2012) In Revision

 
 

Daniels, C.R.; Reznik, C.; Kilmer, R.; Felipe, M.J.; Tria, M.C.R.; Kourentzi, K.; Chen, W.-H.; Advincula, R.C.; Willson, R.C.; Landes, C.F. "Permeability of Anti-Fouling PEGylated Surfaces Probed by Fluorescence Correlation Spectroscopy." Colloids Surf., B, 88 (2011) : 31-38.

 
 

Landes, C.F.; Rambhadran, A.; Taylor, J.N.; Salatan, F.; Jayaraman, V. "Structural Landscape of the Isolated Agonist Binding Domain of the AMPA Receptor Studied by Single Molecule FRET." Nat. Chem. Biol., 7 (2011) : 168-173.

 
 

Reznik, C.; Berg, R.; Foster, E.; Advincula, R.C.; Landes, C.F. "Transient 3-dimensional orientation of molecular ions in an ordered polyelectrolyte membrane." J. Phys. Chem. Lett., 2 (2011) : 592-598.

 
 

Taylor, J.N.; Landes, C.F. "Improved Resolution of Complex Single-Molecule FRET Systems via Wavelet Shrinkage." J. Phys. Chem. B, 115 (2011) : 1105-1114.

 
 

Tcherniak, A.; Dominguez-Medina, S.; Chang, W.S.; Swanglap, P.; Slaughter, L.S.; Landes, C.F.; Link, S. "One-photon Plasmon Luminescence and its Application to Correlation Spectroscopy as a Probe for Rotational and Translational Dynamics of Gold Nanorods." J. Phys. Chem. C, 115 (2011) : 15938-15949.

 
 

Daniels, C.R.; Reznik, C.; Landes, C.F. "Dye Diffusion at Surfaces: Charge Matters" Langmuir, 2010, 26, 4807-4812.

 
 

Taylor, J. N.; Makarov, D.M.; Landes, C.F. "Denoising single-molecule FRET trajectories with wavelets and bayesian inference." Biophys. J. 2010, 98, 164-173.

 
 

Reznik, C.; Estillore, N.; Advincula, R. C.; Landes, C. F. "Single molecule spectroscopy reveals heterogeneous transport mechanisms for molecular ions in a polyelectrolyte polymer brush" J. Phys. Chem. B 2009, 113, 14611-14618.

 
 

Tcherniak, A.; Reznik, C.; Link, S.; Landes, C. F. "Fluorescence Correlation Spectroscopy: Criteria for Analysis in Complex Systems." Anal. Chem., 81 (2009) : 746-754.

 
 

Darugar, Q.; Kim, H.; Gorelick, R. J.; Landes, C. F. "Human t-cell lympotropic virus type 1 nucleocapsid protein-induced structural changes in transactivation response DNA measured by single molecule fluorescence resonance energy transfer" J. Virol. 2008, 92, 12164-12171.

 
 

Reznik, C.; Darugar, Q.; Wheat, A.; Fulghum, T.; Advincula, R. C.; Landes, C. F. "Single ion diffusive transport within a poly(styrene sulfonate) polymer brush matrix probed by fluorescence correlation spectroscopy" J. Phys. Chem. B 2008, 112, 10890-10897.

 
 

Taylor, J. N.; Darugar, Q.; Kourentzi, K.; Willson, R. C.; Landes, C. F. "Dynamics of an anti-vegf aptamer: A single molecule study" Biochem. Biophys. Res. Comm. 2008, 373, 213-218.

 
 Other
 

El-Sayed, M.; Masuhara, H.; Pileni, M. P.; Landes, C. "Editorial, Nano and Molecular Science and Technology Special Issue Honoring Paul Barbara ." Acc. Chem. Res., 45 (2012) : 1842-1843.

 
Presentations
 Invited Talks
 

“A Mechanistic Study of Serum Albumin Interaction with Therapeutic Nanoparticles” 2015 Spring ACS National Meeting in Denver, CO, Mar 22-26, 2015. Host: David Masiello.

 
 

“Active Control of Surface Chemistry on Plasmonic Nanomaterials” 2015 Spring ACS National Meeting in Denver, CO, Mar 22-26, 2015. Host: Eric Borquet.

 
 

“Active Control of Surface Chemistry on Plasmonic Nanomaterials” Single-Molecule Fluorescence and Imaging Symposium, Pacifichem, Honolulu, HI, Dec. 15-20, 2015. Host: Hiroaki Misawa.

 
 

“Hit ‘em where they ain’t: super-resolution imaging of porous nanomaterials” Challenges in Plasmonic Photochemistry Symposium, Pacifichem, Honolulu, HI, Dec. 15-20, 2015. Host: Peng Chen.

 
 

“How do you measure something smaller than your ruler: The 2014 Nobel in Chemistry, Super-Resolution Imaging” Whitman College, Walla Walla, WA, Apr. 3, 2015. Host: Marion Gotz.

 
 

“Single Molecule Methods to Quantify Adsorptive Separations” Quantitative Bioimaging III, Paris, France, Jan. 7-9, 2015. Host: Raimund Ober.

 
 

“Single-Molecule Methods to Quantify Adsorptive Separations” Physical Chemistry of Interfaces and Nanomaterials XIV, SPIE, Aug. 9-13, 2015. Host Eric Bittner.

 
 

Invited Oral Presentation: “Charge Clustering Dominates Protein Ion-Exchange Separations” in 2014 Chromatography Forum of Delaware Valley Nogare Award Symposium Honoring Dr. Mary Wirth, 2014 Pittsburgh Conference, Chicago, IL, Mar. 2-6, 2014. Host: Mary Wirth.

 
 

Invited Oral Presentation: “In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function” University of Victoria, Victoria, British Colombia, Canada, Jan. 20, 2014, Host: Keng Chou.

 
 

Invited Oral Presentation: “In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function” University of Victoria, Victoria, British Colombia, Canada, Jan. 20, 2014, Host: Dennis Hore.

 
 

Invited Oral Presentation: “In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function” University of British Columbia, Vancouver, British Colombia, Canada, Jan. 21, 2014, Host: Tim Storr.

 
 

Invited Oral Presentation: “Solute Dynamics in Thin Films” 3M Corporate Research Laboratory, St. Paul, MN, Feb. 7, 2014, Host: Corey Radloff. 

 
 

Invited Oral Presentation: “Spectroelectrochemistry of Single Gold Nanorods” Physics of Quantum Electronics Conference, Snowbird, UT, Jan. 5-9 2014. Hosts: Peter Nordlander and Naomi Halas.

 
 

Invited Oral Presentation: “Spectroelectrochemistry of plasmonic nanoparticles” ACS National Meeting San Francisco, CA, August 10-14, 2014. Host: Franz Geiger.

 
 

Invited Oral Presentation: “Super-Resolution Analysis of Protein Ion-Exchange Separations” Workshop on Applications of Supported Bilayers at the 58th Annual Meeting of the Biophysical Society, San Francisco, CA, Feb. 15-19, 2014. Host: Vasanthi Jayaraman.

 
 

Invited Oral Presentation: “Super-resolution methods for understanding adsorptive protein separations” ACS National Meeting, San Francisco, CA, August 10-14, 2014. Host: Ning Fang. 

 
 

Invited Oral Presentation “Unified super-resolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations” ACS National Meeting, Dallas, TX, March 17, 2014. Host: Dan Schwartz.

 
 

"Environmental Separations from a Single Molecule Perspective." Research Partnership Workshop on Water, Energy and the Environment for Women Scientists from the U.S., Morocco, Algeria and Tunisia, Casa Blance, Morocco. (March 6-8, 2013)

 
 

"Fundamentals of Fluorescence Spectroscopy at the Single Molecule/Particle Limit." 2nd International Summer Course and Workshop on 'Single Molecule/Nanoparticle Spectroscopy and Imaging', National Chiao Tung University, Hsinchu, Taiwan. (June 15-26, 2013)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." Department of Chemistry and Biochemistry, Ohio State University , Columbus, Ohio. (January 24, 2013)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." Colorado State University, Fort Collins, Colorado. (May 2, 2013)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." Department of Chemistry and Biochemistry, University of Notre Dame, South Bend, Indiana. (March 28, 2013)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." James Franck Institute, University of Chicago, Chicago, Illinois. (April 16, 2013)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." Los Alamos National Laboratory, Los Alamos, New Mexico. (January 17, 2013)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." Department of Biochemistry, University of Houston, Houston, Texas. (March 20, 2013)

 
 

"Overcoming Signal Intermittency in Particle Tracking Experiments." 2nd International Summer Course and Workshop on 'Single Molecule/Nanoparticle Spectroscopy and Imaging', National Chiao Tung University, Hsinchu, Taiwan. (June 27-28, 2013)

 
 

"Overcoming Signal Intermittency in Short Particle Tracking Trajectories." Physics of Quantum Electronics Colloquium, Snowbird, Utah. (January 9, 2013)

 
 

"Overcoming Signal Intermittency in Short Particle Tracking Trajectories." 26th International Conference on Photochemistry, Leuven, Belgium. (July 21-26, 2013)

 
 

"Diffusion Coefficient Estimation for Short Single-Particle Trajectories with Photoblinking." Southwest Regional Meeting of the American Chemical Society, Baton Rouge, Louisiana. (November 6, 2012)

 
 

"In Search of Concurrence between Biological and Synthetic Single Moledule Structure/Function." Department of Chemistry, Georgia Institute of Technology, Atlanta, Georgia. (April 17, 2012)

 
 

"In Search of Concurrence between Biological and Synthetic Single Moledule Structure/Function." Department of Chemistry, University of Wisconsin, Madison, Wisconsin. (April 24, 2012)

 
 

"In Search of Concurrence between Biological and Synthetic Single Moledule Structure/Function." Department of Chemistry, University of Maryland, College Park, Maryland. (November 12, 2012)

 
 

"In Search of Concurrence between Biological and Synthetic Single Moledule Structure/Function." Frontiers of Plasmonics II, Chengdu, China. (April 2-12, 2012)

 
 

"In Search of Concurrence between Biological and Synthetic Single Moledule Structure/Function." Southern Biomedical Engineering Conference, Houston, Texas. (May 5, 2012)

 
 

"In Search of Concurrence between Biological and Synthetic Single Moledule Structure/Function." Department of Chemistry, Emory University, Atlanta, Georgia. (April 16, 2012)

 
 

"In Siitu Measurement of Bovine Serum Albumin Interaction with Gold Nanospheres." Southwest Regional Meeting of the American Chemical Society, Baton Rouge, Louisiana. (November 6, 2012)

 
 

"When Complexity Meets Function: Enhanced Analysis of Noisy Single Molecula Data." Department of Chemistry, Trinity University, San Antonio, Texas. (February 9, 2012)

 
 

"When Complexity Meets Function: Enhanced Analysis of Noisy Single Molecula Data." American Chemical Society 243rd National Meeting, San Diego, California. (March 25, 2012)

 
 

"When Complexity Meets Function: Enhanced Analysis of Noisy Single Molecula Data." Physics of Quantum Electronics 2012, Snowbird, Utah. (January 3, 2012)

 
 

"Dynamic Heterogeneity and Function." Physical Chemistry Seminar/Host: Carsten Sonnichsen, Mainz, Germany. (01/10/2011)

 
 

"In Search of Concurrence between Biological and Synthetic Single Molecule Structure/Function." 1st Joint Meeting of Women Chemists from the United States and China/Host: Gerri Richmond, Beijing, China. (10/25/2011)

 
 

"Transient 3D Transport in Ordered Polyelectrolyte Membranes." ACS Fall Meeting/Host: Christine Payne, Denver, CO. (08/29/2011)

 
 

"Wavelet Shrinkage to Resolve Single Molecule FRET Structural Landscape of the Isolated Ligand Binding Domain of the AMPA Receptor." ACS Fall Meeting/Host: Gerri Richmond, Denver, CO. (08/28/2011)

 
 

Invited Oral Presentation: “Single Molecule Biophysical Chemistry” Austin College Chemistry Departmental Seminar, Sherman, TX, Feb. 10, 2010.

 
 

Invited Oral Presentation: “When Structure Complexity Meets Function: Enhanced Analysis of Noisy Single Aptamer Data” ACS National Meeting, San Francisco, CA Mar. 22, 2010.

 
 

"Dynamic Complexity Meets Functionality." Telluride Research Center Workshop on Chemical Dynamics in Complex Environments, Telluride, Colorado. (JUNE 22-26, 2009)

 
 

"Dynamic Complexity Meets Functionality." Nanobiology Training Program Summer Symposium, Houston, Texas. (July 10, 2009)

 
 

"Weak-binding aptamers: The role of structural dynamics in inhibitor functionality." NCTU/NAIST Workshop on Molecular/Nano Science, Hsinchu, Taiwan. (November 13, 2009)

 
 Other
 

"Understanding Molecular-Scale Separations on Agarose Supported Peptide Surfaces." Conference on Quantitative Bioimaging, Albuquerque, New Mexico. (January 11-12, 2013)

 
 

"Understanding Molecular-Scale Separations on Agarose Supported Peptide Surfaces." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April 7-11, 2013)

 
 Posters
 

"Wavelet Shrinkage to Resolve Single Molecule Fret Structural Landscape of the Isolated Ligand Binding Domain of the Ampa Receptor." 55th Annual Meeting of the Biophysical Society, Baltimore, Maryland. (March 8, 2011) With J. N. Taylor, A. Rambhadran, V. Jayaraman

 
 

"De-Noising Single Molecule Fret Trajectories using Wavelength and Bayesian Techniques." 54th Annual Meeting of the Biophysical Society, San Francisco, California. (February 20-24, 2010)

 
 

"When Complexity Meets Function: Enhanced Analysis of Noisy Single Aptamer Data." Gordon Research Conference on Single Molecule Approaches to Biology, Lucca, Italy. (June-July, 2010)

 
 Seminar Speaker
 

"In search of concurrence between biological and synthetic single molecule structure and function." Department of Chemistry, Texas A&M University, College Station, Texas. (November 24, 2009)

 
 Session Chair
 

Symposium Organizer.  "Multiscale Nanomaterials, Polymer and Biomolecular Dynamics." 239th National Meeting of the American Chemical Society, (March 20-26, 2010)

 
 Workshops
 

Symposium Organizer.  "From ultrafast electron transfer to single molecule spectroscopy: forces driving contemporary themes in physical chemistry." ACS Fall Meeting 2011, Denver, CO. (08/28-09/01/2011)

 
Editorial Positions
 Associate Editor, Royal Society Advances. (2015 - 2015)

 Member of the Editorial Board, ACS Nano. (2016 - 2016)

 Member of the Editorial Board, Royal Society Advances. (2014 - 2015)

Supervised Theses & Dissertations
 Ferandre Salatan, MS Single-molecule FRET Analysis of the Dynamics of AMPA Receptor. (2010) (Thesis Director)

 Carmen Reznik, Ph.D. Environmental Response, Mechanisms, and Orientation of Diffusing Molecular Ions in Polyelectrolyte Thin Films. (2011) (Thesis Director)

 Charlisa Daniels, Ph.D. Monitoring Transport at Interfaces of Tunable Soft Surfaces. (2012) (Thesis Director)

 Lydia Kisley, Ph.D. Single Molecule Studies of Ion-Exchange Chromatography. (2015) (Thesis Director)

 David Cooper, Ph.D. Conformational Dynamics of the Glutamate Receptors via Single Molecule Förster Resonance Energy Transfer . (2015) (Thesis Director)

 Chad Byers, Ph.D. Spectroelectrochemistry of Plasmonic Nanoantennas . (Thesis Director)

 Chad Byers, M.S. Surface plasmon based spectroelectrochemical tuning and sensing with gold nanoparticle dimers. (Thesis Director)

 James Nicholas Taylor, Ph.D. Objective Approaches to Single-Molecule Time Series Analysis. (Thesis Director)

Awards, Prizes, & Fellowships
 CAREER Award, National Science Foundation, National SCience Foundation (2011)

 ACS PRF Doctoral New Investigator Award, American Chemical Society (1/1/2010)