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Scholarly Interest Report
         
Mary Farach-Carson
Professor
Ralph and Dorothy Looney Professor of Biochemistry and Cell Biology
 
e-mail:farachca@rice.edu
 
  • B.S. Biology (1978) University of South Carolina, Columbia SC
  • Ph.D. Biochemistry (1982) Medical College of Virginia, Virginia Commonwealth Univ., Richmond VA
 
Primary Department
   Department of BioSciences
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Department Affiliations
 
  • Department of Bioengineering
  • Institute of Biosciences and Bioengineering
  •  
    Other Affiliations
     
  • Baylor College of Medicine
  • MD Anderson
  • University of Texas Medical School at Houston
  •  
     
    Research Areas
     The role of extracellular matrix in the progression of cancer; the use of proteoglycans in the engineering of connective and glandular tissues
     
    Research Statement
     

    Research in Dr. Farach-Carson's laboratory relates to the role of extracellular matrix in the progression of cancer following metastasis from primary sites, such as prostate or breast, to bone.  In many cases, primary tumors are fairly slow growing and do not become life-threatening until they form tumors in bone. The growth factors sequestered in bone matrix provide a very rich environment to promote the growth of cancer cells that invade there. Many of these growth factors are bound to a class of proteoglycans that contain heparan sulfate which regulate their bioactivity. Studies in the laboratory are aimed at identifying and isolating the growth factors responsible for cancer growth and progression with the long term aim of developing "molecular drugs" to combat cancer metastasis. Three dimensional models are used to study the behavior of cancer cells and to test their susceptibility to anti-cancer drugs that reduce cancer growth and progression. Industrial partnerships support the development of novel cancer diagnostics based on the principle that cancer biomarkers are created by cancer growth in bone.



    A multidisciplinary project involves the use of proteoglycans, particularly those bearing heparan sulfate chains such as perlecan, in engineering of connective tissues such as bone, cartilage or salivary gland.
    Cell and molecular engineering strategies are being developed that facilitate controlled tissue growth and differentiation. Growth factor binding and delivery by engineered proteoglycans is being used in oral surgery and orthopaedic applications. Several engineering partnerships both within and outside the university exist to support these studies.



    A trainee doing research in this laboratory would be exposed to a variety of techniques including cell culture, recombinant and natural protein purification and analysis, calcium imaging, cloning and molecular biology, microRNAs, immunodetection and immunohistochemistry, and various pre-clinical cancer models.

     
    Selected Publications
     Refereed articles
     

    Chung, S.W., Cooper, C.R., Farach-Carson, M.C., Ogunnaike, B.A. "Computational modeling and analysis of the TGF-β-induced ERK and SMAD pathways." Submitted

     
     

    Engel BJ, Constantinou PE, Sablatura LK, Doty NJ, Carson DD, Farach-Carson MC, Harrington DA, Zarembinski TI. Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures. Adv Healthc Mater. (2015)  4(11):1664-74

     
     

    Farach, A., Ding, Y., Rowley, D., Delk, N., Farach-Carson, M.C., Ayala, G.E. "Neuronal mimicry as a resistance phenotype in prostate cancer cells." In Revision

     
     

    Farach, A., Teh, B.S., Chang, J.C., Farach-Carson, M.C., Butler, B. "The role of combined radiation and immunotherapy in breast cancer treatment ." J Radiation Oncology, 4 (2015) : 347-354.

     
     

    Fong ELS, Wang X, Yang J, Morgado M, Mikos AG, Harrington DA, Navone NM, Farach-Carson MC. A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials. (2015) 77:164-172

     
     

    Fong, E.L.S., Wan, X., Yang, J., Morgado, M., Mikos, A.G., Harrington, D.A., Navone, N.M., Farach-Carson, M.C. "A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interaction." Biomaterials, 77 (2016 ) : 164-72.

     
     

    Grigore, A.D., Ben-Jacob, E., Farach-Carson, M.C. "Prostate Cancer and Neuroendocrine Differentiation: More Neuronal, Less Endocrine?." Frontiers in Oncology, 5 (2015) : 37.

     
     

    Grindel, B.J., Arnold, Rl, Li, Q., Zayzafoon, M., Muldoon, M., Stave, J., Chung, L.W.C., Petros, J., Farach-Carson, M.C. "Perlecan/HSPG2 and Matrilysin/MMP7 as indices of tissue invasion: Tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients." OncotargetIn Press

     
     

    Hubka, K.M., Wu, D., Harrington, D.A., Langer, J.C., Pocard, T., Jammayrac, O., Farach-Carson, M.C., Pradhan-Bhatt, S. "Dissociative and non-dissociative models for culture of human eccrine glands for toxicology testing and tissue engineering applications." Applied In Vitro Toxicology, 1 (2015) : 187-97.

     
     

    Lin, S., Farach-Carson, M.C., Satcher, R.L. "Sex differences in the adherence and growth of metastatic cells in bone." Clin. Orthopedics and Related Research (CORR). , Sex Differences in Musculoskeletal Disease and Science (Special Issue)

     
     

    Pan T, Fong EL, Martinez M, Harrington DA, Lin SH, Farach-Carson MC, Satcher RL. Three-dimensional (3D) culture of bone-derived human 786-O renal cell carcinoma retains relevant clinical characteristics of bone metastases.  Cancer Letters (2015) 365: 89-95.

     
     

    Warren, C.R., Kassir, E., Spurlin, J., Martinez, J., Putnam, N., Farach-Carson, M.C. "Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis ." PLoS One, 10(4) (2015) : e012578.

     
     

    Wijeratne, S.S., Martinez, J.R., Grindel, B.J., Frey, E.W., Li, J., Wang, L., Farach-Carson, M.C., Kiang, C.-W. "Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix." Matrix Biology (2015) : (ePub ahead of print).

     
     

    Xu X, Farach-Carson MC, Jia X. "Three-dimensional in vitro tumor models for cancer research and drug evaluation." Biotechnol Adv., 32(7) (2014) : 1256-68.


    doi: 10.1016/j.biotechadv.2014.07.009
     
     

    Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium, Forrest AR, Carninci P, Rehli M, Sandelin A. "An atlas of active enhancers across human cell types and tissues.." Nature, 507(7493) (2014) : 455-61.


    doi: 10.1038/nature12787
     
     

    Arner E, Forrest AR, Ehrlund A, Mejhert N, Itoh M, Kawaji H, Lassmann T, Laurencikiene J, Rydén M, Arner P; FANTOM Consortium "Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells. ." PLoS One, 9(3) (2014) : e80274.


    doi: 10.1371/journal.pone.0080274
     
     

    Chang MA, Patel V, Gwede M, Morgado M, Tomasevich K, Fong EL, Farach-Carson MC, Delk NA. "IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells."  J Cell Biochem., 115(12) (2014) : 2188-97.


    doi: 10.1002/jcb.24897
     
     

    Chang, M., Morgado, M., Warren, C., Hinton, C.V., Farach-Carson, M.C., Delk, N. "p62/SQSTM1 is required for cell survival of apoptosis-resistant metastatic prostate cancer cell lines." The Prostate, 74 (2014) : 149-163.

     
     

    Chu, G.C., Zhau, H.E., Wang, R., Rogatko, A., Feng, X., Zayzafoon, M., Liu, Y., Farach-Carson, M.C., You, S., Kim, J., Freeman, M.R., Chung, L. "RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization." Endocr. Relat. Cancer, 21(2) (2014) : 311-26.In Press

     
     

    Dicker, K.T., Gurski, L.A., Pradhan-Bhatt, S., Witt, R.L., Farach-Carson, M.C. Jia, X. "Hyaluronan: A simple polysaccharide with diverse biological function." Acta Biomater, 10(4) (2014) : 1558-70.


    doi: 10.1016/j.actbio.2013.12.019
     
     

    FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassman T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, et al. "A promoter-level mammalian expression atlas. ." Nature, 507(7493) (2014) : 462-70.


    doi: 10.1038/nature13182
     
     

    Farach-Carson MC, Warren CR, Harrington DA, Carson DD. "Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders.." Matrix Biol., 34 (2014) : 64-79.

     
     

    Fong, E.L.S., Martinez, M., Yang, J., Mikos, A.G., Navone, N.M., Harrington, D.A., Farach-Carson, M.C. "Hydrogel-based 3D model of patient-derived prostate xenograft tumors suitable for drug screening." Molecular Pharmaceutics, 11(7) (2014) : 2040-50.


    doi: 10.1021/mp500085p
     
     

    Fong, E.L.S., Santoro, M., Farach-Carson, M.C., Kasper, F.K., Mikos, A.G. "Tissue engineering perfusable cancer models."  Current Opinion in Chemical Engineering: Biological engineering, 3 (2014) : 112-117.

     
     

    Grindel, B.J., Martinez, J.R., Pennington, C.L., Muldoon, M., Stave, J., Chung, L.W. and Farach-Carson, M.C. "Matrilysin/Matrix Metalloproteinase-7 (MMP7) cleavage of perlecan/HSPG2 produces bioactive fragments that alter prostate cancer cell behavior." Matrix Biology, 36 (2014) : 64-76.

     
     

    Hasegawa Y, Tang D, Takahashi N, Hayashizaki Y, Forrest AR; FANTOM Consortium, Suzuki H. "CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes." Sci Rep., 4 (2014) : 5228.


    doi: 10.1038/srep05228
     
     

    Lowe, D.A., Lepori-Bui, N., Fomin, P.V., Sloofman, L.G., Zhou, X., Farach-Carson, M.C., Wang, L., Kirn-Safran, C.B. "Deficiency of perlecan/HSPG2 during cartilage growth plate development enhances osteogenesis and decreases quality of adult bone in mice." Calcified Tissue Int., 95(1) (2014) : 29-38.

     
     

    Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM Consortium "Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation." Proc Natl Acad Sci U S A., 111(14) (2014) : 5289-94.


    doi: 10.1073/pnas.1312717110
     
     

    Pradhan-Bhatt S., Harrington D.A., Duncan R.L., Farach-Carson, M.C., Jia X., Witt, R.L. "A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland” Laryngoscope." Laryngoscope, 124 (2014) : 456-461.

     
     

    Wang, B., Lai, X., Price, C., Thompson, W.R., Li, W., Quabili, T.R., Tseng, W-J., Liu, X., Zhang, H., Pan, J., Kirn-Safran, C.B., Farach-Carson, M.C., Wang, L. "Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canilicular system." J. Bone Min. Res., 29(4) (2014) : 878-91.

     
     

    Warren, C.R., Grindel, B.J., Carson, D.D., Farach-Carson, M.C. "Perlecan/HSPG2 increases in the desmoplastic prostate tumor microenvironment involve transcriptional activation by NFKB." J. Cellular Biochemistry, 115(7) (2014) : 1322-33.

     
     

    Xu, X., Sabanayagam, C.R., Harrington, D.A., Farach-Carson, M.C., Jia, X. "A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics." Biomaterials, 35 (2014) : 3319-3330.

     
     

    Bhatt, S.P., Harrington, D.A., Duncan, R.L., Jia, X., Witt, R.L. Farach-Carson, M.C. "Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters." Tissue Engineering, 9 (13-14) (2013) : 1610-1620.

     
     

    Chen, J., Lobachev, K.S., Grindel, B.J., Farach-Carson, M.C., Olivares-Navarrette, R., Doroudi, M., Boyan, B.D., Schwartz, Z. " Chaperone properties of Pdia3 participate in rapid plasma membrane associated actions of 1α,25-dihydroxyvitamin D3 ." Molecular Endocrinology, 27 (2013 Jul) : 1065-77.

     
     

    Farach, A., Ding, Y., Rowley, D., Farach-Carson, M.C., Ayala, G.E. "Neuronal mimicry as a resistance phenotype in prostate cancer cells." OncogeneIn Revision

     
     

    Fong, E.L.S., Lamhamedi-Cherradi, S.E., Burdett, E., Ramamoorthy, V., Lazar, A., Kasper, F.K., Farach-Carson, M.C., Vishwamitra, D., Demicco, E.G., Menegaz, B.A., Amin, H.M., Ludwig, J.A., Mikos, A. "Modeling Ewing's sarcoma tumors in vitro with 3D scaffolds ." Proc. Natl. Acad. Sci., 110 (2013 ) : 6500-6505.

     
     

    Chung, S.-W., Cooper, C.R., Farach-Carson, M.C., and Ogunnaike, B.A. "A control engineering approach to understanding the TGF-β paradox in cancer." Journal of the Royal Society Interface, 9(71) (2012) : 1389-97.

     
     

    Delk,N., Farach-Carson, M.C. "Interleukin-6: A bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells." Autophagy, 8(4) (2012)

     
     

    Gurski, L.A., Xu, X., Labrada, L.N., Nguyen, N.T., Xiao, L., van Golen, K.L., Jia, X., Farach-Carson, M.C. "Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels." PLoS One, 7(11) (2012) : e50075.

     
     

    Srinivasan, P.P., McCoy, S.Y., Jha, A.K., Yang, W., Jia, X., Farach-Carson, M.C. and Kirn-Safran, C.B. "Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis." Biomedical Materials, 7(2) (2012) : 024109.

     
     

    Xu, X., Gurski, L.A., Zhang, Z., Harrington, D.A., Farach-Carson, M.C., Jia, X. "Recreating the Tumor Microenvironment in a Bilayer, Hyaluronic Acid-Hydrogel Construct for Growth of Prostate Cancer Spheroids." Biomaterials, 33(35) (2012) : 9049-60.

     
     

    Xu, X., Jha, J., Harrington, D.A., Farach-Carson, M.C., Jia, X. "Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks." Soft Matter, 8(12) (2012) : 3280-3294.

     
     

    Boggs, M.E., Thompson, W.R., Farach-Carson, M.C., Duncan, R.L., Beebe. T.P. "Co-culture of osteocytes and neurons on a unique patterned surface." Biointerfaces, 6(4) (2011) : 200.

     
     

    Grindel, B.J., Rohe, B., Safford, S.E., Bennett, J.J., Farach-Carson, M.C. "Tumor necrosis factor-α treatment of HepG2 cells mobilizes a cytoplasmic pool of ERp57/1,25D₃-MARRS to the nucleus." J. Cell Biochem., 112(9) (2011) : 2606-15.

     
     

    Thompson, W.R., Majid, A.S., Czymmek, K.J., Ruff, A.L., Garcia, J., Duncan, R.L., Farach-Carson, M.C. "Association of the α2δ1 Subunit with Cav3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes." J. Bone Min. Research, 26(9) (2011) : 2125-39.

     
     

    Thompson, W.R., Modla, S., Grindel, B.J., Czymmek, K., Kirn-Safran, C.B., Wang, L. Duncan, R.L., Farach-Carson, M.C. "Perlecan/Hspg2 deficiency alters the pericellular space of the lacuno-canalicular system surrounding osteocytic processes in cortical bone." J. Bone Min. Research, 26(3) (2011) : 618-629. (Top 2% article by Faculty of 1000).

     
     

    Warren, C.R. Ali-Khan Catts, Z., Farach-Carson, M.C. "A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin." Exp. Cell Res., 317(15) (2011) : 2099-109.

     
     

    Zhang, C., Soori, M., Sikes, R.A., Carson, D.D., Chung, L.L.W., Farach-Carson, M.C. "Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells." The Prostate, 71(2) (2011) : 157-67.

     
     

    Gurski, L. A., Petrelli, N.J., Jia,X., Farach-Carson, M.C. "Three-dimensional matrices for anti-cancer drug testing and development." Association of Community Cancer Centers Oncology Issues: New Technologies, Jan/Feb (2010) : 20-25.

     
     

    Hartman, O. Zhang, C., Adams, E.L., Farach-Carson, M.C., Petrelli, N.J., Chase, B.D. Rabolt, J.F. "Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model." Biomaterials, 31(21) (2010) : 5700-18.

     
     

    Jha, A.K. Malik, M.S., Farach-Carson, M.C., Duncan, R.L., Jia, X. "Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks." Soft Matter, 6(20) (2010) : 5045-55.

     
     

    Pradhan, S. and Farach-Carson M.C. "Mining the extracellular matrix for tissue engineering applications." Regen Med., 5(6) (2010) : 961-70.

     
     

    Pradhan, S., Liu, C., Zhang, C., Jia, X., Farach-Carson, M.C., Witt, R. "Lumen formation in 3D cultures of salivary acinar cells." Otolaryngology & Head and Neck Surgery, 142(2) (2010) : 191-5.

     
     

    Richard C.L., Farach-Carson M.C., Rohe B., Nemere I., Meckling K.A. "Involvement of 1,25D3MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells." Exp. Cell Res., 316(5) (2010) : 695-703.

     
     

    Sisson, K., Zhang, C., Farach-Carson, M.C., Chase, D.B., Rabolt, J.F. "Fiber diameter controls osteoblastic cell migration and differentiation in electrospun gelatin." Journal of Biomedical Materials Research Part A, 94(4) (2010) : 1312-20.

     
     

    Sloofman L.G., Verdelis K., Spevak L., Zayzafoon M., Yamauchi M., Opdenaker L.M., Farach-Carson M.C., Boskey A.L., Kirn-Safran C.B. "Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth." Bone, 47(1) (2010) : 93-101.

     
     

    Wang, X. Gurski, L.A., Zhong, S. Xu, X., Pochan, D.J., Farach-Carson, M.C., Jia, X. "Amphiphilic block copolyesters bearing pendant cyclic ketal groups as nanocarriers for controlled release of camptothecin." Journal of Biomaterials Science: Polymer Edition , Epub ahead of print (2010)

     
     

    Wu W., Beilhartz G., Roy Y., Richard C.L., Curtin M., Brown L., Cadieux D., Coppolino M., Farach-Carson M.C., Nemere I., Meckling K.A. "Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFB in differentiating NB4 leukemia cells.." Exp. Cell Res., 316(7) (2010) : 1101-8.

     
     

    Zhang, C., Soori, M., Miles F.L., Sikes, R.A., Carson, D.D., Chung, L.L.W., Farach-Carson, M.C. "Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells." Prostate (2010 Jul 21)

     
     

    Alcorn, J.L., Merritt, T.M., Farach-Carson, M.C., Wang, H.H., Hecht, J.T. "Targeted reduction of mutant cartilage oligomeric matrix protein (COMP) using a COMP-specific ribozyme: a new strategy for gene therapy." RNA, 15 (2009) : 686-695.

     
     

    Chung, S.-W., Miles, F.L., Sikes, R.A., Cooper, C.R., Farach-Carson, M.C., and Ogunnaike, B.A. "Quantitative modeling and analysis of the transforming growth factor beta signaling pathway." Biophys J , 96 (2009) : 1733-1750.

     
     

    Gurski, L., Jha, A.K., Zhang, C., Jia, X., Farach-Carson, M.C. "Hyaluronic acid hydrogel as a scaffold for chemotherapeutic drug selection with poorly adherent cells." Biomaterials, 30 (2009) : 6076-6085.

     
     

    Hartman O, Zhang C, Adams EL, Farach-Carson MC, Petrelli NJ, Chase BD, Rabolt JF "Microfabricated electrospun collagen membranes for 3-D cancer models and drug screening applications." Biomacromolecules, 10 (2009 Aug 10) : 2019-32.

     
     

    Kirn-Safran, C., Farach-Carson, M.C., Carson, D.D. "Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans." Cellular and Molecular Life Sciences , 66 (2009) : 3421-3434.

     
     

    O'Connor, R.D., Zayzafoon, M., Farach-Carson, M.C., Schanen, N.C. "Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett Syndrome." Bone, 45 (2009) : 346-356.

     
     

    Opdenaker, L.M., Farach-Carson, M.C. "Rapamycin selectively reduces the association of transcripts containing complexes of 5' UTRs with the ribosome in prostate cancer cells ." J Cell Biochem, 107 (2009) : 473-481.

     
     

    Oristian, D.S., Sloofman, L.G., Zhou, X., Wang, L., Farach-Carson, M.C., Kirn-Safran, C.B. "Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice." J Orthop Res (cover), 27 (2009) : 28-35.

     
     

    Pradhan, S.S., Zhang, C., Jia, X., Carson, D.D., Witt, R.L., Farach-Carson, M.C. "Perlecan Domain IV Peptide Stimulates Salivary Gland Cell Assembly In Vitro." Tissue Engineering Part A (2009 November ) : 3309-3320.

     
     

    Shao, Y., Czymmek, K., Fomin, V., Duncan, R.L., Farach-Carson, M.C. "Fluorescence resonance energy transfer (FRET) reveals dynamic interactions between L-type voltage sensitive calcium channel (VSCC) Cav 1.2 (alpha1C) subunits and ahnak in osteoblastic cells." AJP-Cell Physiol 296 (2009) C1067-1078.

     
     

    Sisson, K., Zhang, C., Farach-Carson, M.C., Chase, D.B., Rabolt, J.F. "Evaluation of Cross-Linking Methods for Electrospun Gelatin on Cell Growth and Viability." Biomacromolecules, 10 (2009)

     
     

    Witt, R.L., Jia, X., Liu, C., Zhang, C., Farach-Carson, M.C., Pradhan, S. "Engineering an artificial salivary gland ." Otolaryngology - Head and Neck Surgery , 141 (2009 September ) : P50.

     
     

    Brown, A.J., Alicknavitch, M., D’Souza, S.S., Daikoku, T., Kirn-Safran, C., Marchetti, D., Carson, D.D., and Farach-Carson, M.C. "Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation." Bone, 43(4) (2008) : 689-699.

     
     

    D’Souza, S.S., Yang, W., Marchetti, D., Muir, C., Farach-Carson, M.C., and Carson, D.D. "HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses." J Cell Biochem, 105(5) (2008) : 1183-1193.

     
     

    Farach-Carson, M.C., and Grindel, B. "HSPG2 (heparan sulfate proteoglycan 2)." Atlas Genet Cytogenet Oncol Haematol (2008 October )

     
     

    Casper, C. L., Yang, W., Farach-Carson, M.C., Rabolt, J.F. "Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding ." Biomacromolecules, 8(4) (2007) : 1116-1123.

     
     

    Farach-Carson, M.C. and Carson, D.D. "Perlecan: A multifunctional extracellular proteoglycan scaffold in embryo implantation and placentation." Glycobiology, 17 (2007) : 897-905.

     
     

    Farach-Carson, M.C., Brown, A.J., Lynam, M., Safran, J.B., and Carson, D.D. "A novel peptide sequence in perlecan domain IV supports cell adhesion and spreading." Matrix Biology, 27 (2007) : 150-160.

     
     

    O’Connor, J.C., Farach-Carson, M.C., Schneider, C.J., and Carson, D.D. "Co-culture of bone marrow stromal cells with prostate cancer cells alters endoglin expression and attenuates TGF-β signaling in reactive bone stroma." Mol Cancer Res, 5(6) (2007) : 585-603.

     
     

    Huang, W.C., Wu, D., Xie, Z., Zhau, H.E., Nomura, T., Zayzafoon, M., Pohl, J., Hsieh, C.L., Weitzmann, M.N., Farach-Carson, M.C., Chung, L.W. "β2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis." Cancer Res, 66(18) (2006) : 9108-9116.

     
     Book chapters
     

    19. Zarembinski, T.I., Engel, B.J., Doty, N.J., Constantinou, P.E., Onorato, M.V., Erickson, I.E., Fong, E.L.S., Martinez, M., Milton, R.L., Danysh, B.P., Delk, N.A., Harrington, D.A., Farach-Carson, M.C., Carson, D.D. "HyStem®, a customizable hyaluronan-based hydrogel material for 3D cell culture." 3D Cell Culture: Technology and ApplicationIn Press

     
     

    Bhatt, S.P., Cannon, K., Zakheim, D., Harrington, D., Duncan, R.L., Jia, X., Witt, R.L. and Farach-Carson, M.C. "Salivary gland tissue engineering and repair." In Stem Cell Biology and Tissue Engineering in Dental SciencesIn Press

     
     

    O'Connor, R.D., Farach-Carson, M.C., Schanen, N.C. "Genetic and Epigenetic Aspects of Bone Development." Topics in Bone Biology, 6 (2010)

     
     

    Thompson, W.R., Farach-Carson, M.C. "Effects of 1,25-dihydroxyvitamin D3 on voltage sensitive calcium channels in osteoblast differentiation and morphology." Vitamin D, Third Edition (2010) In Press

     
    Presentations
     Invited Talks
     

    "Building a Translational Research Hub: The BioScience Research Collaborative at Rice University. Pancreatic Cancer Seminar Series, UT MD Anderson Cancer Center, Houston, TX 2014." (2014)

     
     

    “Hydrogel Co-Culture Systems for Growing Patient-Derived Xenografts: Use in Selective Drug Screening” FAST: Functional Analysis & Screening Technologies Conference: Screening and Functional Analysis of 3D Models (2nd conference), Boston, MA 2014

     
     

    “Two Sides of the Same Coin: Perlecan Functions in Health and Disease”, University of Texas-Health Science Center [UT-Health], Dept of Biochemistry & Molecular Biology, Houston, TX 2014

     
     

    “Two Sides of the Same Coin: Perlecan Functions in Health and Disease”, Baylor College of Dentistry, Texas A & M, Dallas, TX 2014

     
     

    "Two Sides of the Same Coin: Perlecan Functions in Health and Disease”, Cedars- Sinai Medical Center, Los Angeles, CA 2014

     
     

    "3D Hydrogel Systems for Cytotoxicity Testing in Prostate Cancer. TxSACT Conference on Advanced Models of Imaging Based Drug Screening, Houston, TX 2013." (2013)

     
     

    "Perlecan: Border Patrol in Skeletal (and some other) Tissues. Bone Club, Houston, TX, 2013." (2013)

     
     

    "Two Sides of the Same Coin: Perlecan Functions in Health and Disease. University of North Carolina, Chapel Hill, Chapel Hill, NC, 2013." (2013)

     
     

    "Two Sides of the Same Coin: Perlecan Functions in Health and Disease. University of Texas-Health Science Center  [UT-Health], Houston, TX 2013." (2013)

     
     

    "Marrow Stromal Paracrine Factors Regulating Neuroendocrine Differentiation ." Joint Meeting on Prostate Cancer Skeletal Metastases, Symposium sponsored by University of Michigan, Ann Arbor, MI. (2012)

     
     

    "Role of Heparan Sulfate Proteoglycans in Bone Metastasis of Prostate Cancer: Studies in 3D." Department of Genetics, MD Anderson Cancer Center, Houston, TX. (2012)

     
     

    "Building Interdisciplinary Collaboration in Translational Sciences." FASEB/HHMI Engaging Basic Scientists in Translational Research, Washington, D.C.. (2011)

     
     

    "Role of Heparan Sulfate Proteoglycans in Bone Metastasis of Prostate Cancer: Studies in 3D." University of Texas Medical Branch, Galveston, TX. (2011)

     
     

    "Role of Heparan Sulfate Proteoglycans in Bone Metastasis of Prostate Cancer: Studies in 3D." Queensland University, Brisbane, AU. (2011)

     
     

    "Scientific Discoveries Improving Healthcare." Houston Museum of Natural Sciences, International Year of Chemistry Lecture Series, Houston, TX. (2011)

     
     

    "Heparan Sulfate Dependent Interactions in Bony Metastases of Prostate Cancer." University of Washington, (2010)

     
     

    "Heparan Sulfate Proteoglycans and Bone Metastasis of Prostate Cancer: Studies in 3D." Cancer Biology Seminar Series, UTMDACC, (2010)

     
     

    "Heparan Sulfate Proteoglycans as Modulators of the Bone Cancer Microenvironment." Texas Children’s Hospital, (2010)

     
     

    "Heparan Sulfate Proteoglycans in Bone Metastasis of Prostate Cancer." Bone Program, Baylor College of Medicine/UTMDACC, (2010)

     
     

    "Heparan Sulfate Proteoglycans in Prostate Cancer Metastasis to Bone." Koch Seminar, M.D. Anderson Cancer Center, (2010)

     
     

    "Heparan Sulfate Proteoglycans in Prostate Cancer Metastasis to Bone." Prostate Cancer Series, Baylor College of Medicine, (2010)

     
     

    "Perlecan/HSPG2 Helps Maintain the Pericellular Space of the Lacuno-Canalicular System Surrounding Osteocytic Processes in Murine Cortical Bone." 11th Bone Fluid Flow Workshop, (2010) With William Thompson, graduate student

     
     

    "The Nexus of Research on Cancer, Radiation, and Supercomputing: Dawn of a Golden Age?." Joint Meeting of Rice University and MD Anderson Cancer Center, (2010)

     
     Keynote Speaker
     

    "How Collaboration and Innovation Can Transform Graduate Education." Annual Conference: HESI (Health and Environmental Sciences Institute), Washington, DC. (2015)

     
     

    "Translational Research: An Idea 150 Years in the Making. Keynote address, Regional Symposium for Undergraduate Research, Houston, TX 2013." (2013)

     
     

    "Building Translational Research at an Academic University without a Medical School." Annual meeting of the AAU Board Secretaries, Houston, TX. (2011)

     
     

    "Stepping Stones: I Got By With a Little (Lotta!) Help From My Friends." ADVANCE Workshop “Negotiating the Ideal Faculty Position”, (2010)

     
     Lectures
     

    "Guest Instructor, RUSP (1 lecture), Spring." (Spring 2012 - 13)

     
     

    "Lecturer, Rice University, Advances in Tissue Engineering." (1999 - present)

     
     Other
     

    "Discussant and Presenter, Texas CEO Forum in association with BioHouston, Houston, TX, 2013." (2013)

     
     

    "Moderator, Oral Poster Presentation: Basic ASBMR, Baltimore, MD, 2013." (2013)

     
     

    "Organizer, 3D Cell Culture Workshop." BRC, Rice University, Houston, TX. (2011)

     
     Panelist
     

    "Panel Discussion Leader, e-HRI Summit, Houston, TX, 2013." (2013)

     
     Seminar Speaker
     

    "Engaging Clinicians in Discovery-Based Research in Cancer and Tissue Engineering." Something New for Lunch, Rice University, Houston, TX. (2015)

     
     

    "Perlecan/HSPG2 and Border Patrol in Tissues: Applications to Tissue Engineering and Cancer Biology." Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY. (2015)

     
     

    "Perlecan/HSPG2 and Border Patrol in Tissues: Applications to Tissue Engineering and Cancer Biology." Institute for Molecular Medicine; University of Texas-Health Science Center, Houston, TX. (2015)

     
     

    "Perlecan/HSPG2 in Health and Disease: Two Sides of the Same Coin ." Keck Seminar Series, Houston, TX. (2015)

     
     

    "Use of Stem Cells in Salivary Gland Replacement: Restoring Function to Patients with Post-Radiation Xerostomia." Image Guided Therapies program, Houston Methodist Research Institute, Houston, TX. (2015)

     
     

    "Use of Stem Cells in Salivary Gland Replacement: Restoring Function to Patients with Post-Radiation Xerostomia” ." Regenerative Medicine at the Texas Medical Center, Houston, TX. (2015)

     
     

    "FASEB Forum on the Critical Role of Basic Scientists in the Translational Research Enterprise." Federation of American Societies for Experimental Biology, Chevy Chase, MD. (2011)

     
     Session Chair
     

    "Session Co-Chair (Bone, Cartilage, Connective Tissue Matrix and Development)." ASBMR, Minneapolis, Minnesota. (2012)

     
     Workshops
     

    "Toward Creation of an Artificial Salivary Gland: A Realistic Look at Progress and Challenges." : HA Biomaterials for Cell Therapy, TERMIS-NA, (2010)

     
    Editorial Positions
     Series Editor, Topics in Bone Biology, 7 volume reference book. Springer Verlag. (2003 - 2014)

     Member of the Editorial Board, Matrix Biology. (2010 - 2014)

     Member of the Editorial Board, Matrix Biology. (2016 - 2016)

    Supervised Theses & Dissertations
     Ariel Diaz, M.A. The Folding and Binding Partners of the Perlecan SEA module. (2012) (Thesis or Dissertation Director)

     Derek Shenefelt, M.A. FGFR4 and ß-Klotho in Metastatic Prostate Cancer. (2012) (Thesis or Dissertation Director)

     Lisa Gurski, Ph.D. Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels. (2012) (Thesis or Dissertation Director)

     Curtis Warren, Ph.D. Evolution of the Perlecan/HSPG2 gene and Regulation of its Expression by Inflammatory Cytokines in Normal Tissue Models and Cancer. (2014) (Thesis or Dissertation Director)

     Brian Grindel, Ph.D. Interplay of Perlecan and MMP-7/Matrilysin Regulates Metastatic Prostate Cancer Cell Behavior: Basic and Clinical Implications. (2015) (Thesis or Dissertation Director)

     Eliza Fong, Ph.D. Engineering Three-Dimensional in vitro Models of Bone Tumors for Drug Testing and Mechanistic Studies. (2015) (Co-Director)

    Awards, Prizes, & Fellowships
     AAAS Fellow, Section on Biological Sciences, 2011 - present

     Hearts of Gold Honoree, Honoring Women in Health Care, The Health Museum, Houston, Texas (2014)

     International Rett Syndrome Foundation, Scientific Review Board, (2011-present)

    Positions Held
     Adjunct Professor, University of Delaware. (2009 - 2014)

     Adjunct Professor, U. T. Houston School of Dentistry at Houston. (2012 - 2014)

     Strategic Advisor for Clinical & Basic Research, Texas Medical Center. (2014 - 2014)

     Adjunct Professor, U.T. M. D. Anderson Cancer Center. (2009 - 2014)

     Joint Professor, Rice University. (2008 - 2014)

     Adjunct Professor, Baylor College of Medicine. (2012 - 2014)