Rice
FIS

FIS image header
  •  
  •  
  •  
  •  
  •  
Download 
Scholarly Interest Report
         
Kathleen M. Beckingham
Professor
Professor of Biochemistry and Cell Biology
 
e-mail:kate@rice.edu
 
  • M.A. Biochemistry (1972) University of Cambridge, England
  • B.A. Biochemistry (1967) University of Cambridge, England
  • Ph.D. Biochemistry (1972) University of Cambridge, England
 
Primary Department
   Department of BioSciences
Picture
 
Department Affiliations
 
  • Institute of Biosciences and Bioengineering
  •  
     
    Research Areas
     Drosophila molecular genetics, biological applications of nanotube infrared fluorescence
     
    Research Statement 2009
     

    1. Molecular mechanisms of calcium signaling Calcium undergoes complex, intricate movements within cells in response to external stimuli. These calcium mobilization events change cellular activity as a result of calcium binding to "sensor" proteins which then mediate activation of downstream targets. We are using the fly Drosophila melanogaster to investigate calcium signaling in processes within the whole organism. Currently we are focused on two major aspects of calcium signaling; beckingham_figure i) analysis of developmental processes mediated by the ubiquitous calcium sensor calmodulin and ii) investigation of a new testis-specific calcium sensor protein which we have identified and termed Androcam. The sophisticated genetic methodologies available in Drosophila provide unique opportunities for these functional studies. 2. Molecular mechanisms of gravitational sensing Little is understood of the mechanisms by which animals sense and respond to gravity. To identify the pathways involved in gravitational responses, we are isolating mutants of Drosophila melanogaster that show aberrant gravitaxic behavior. Our work has identified genes with roles in molecular signaling pathways and in neuronal circuitry that are involved in gravitaxic responses.

     
    Teaching Areas
     Endocrinology, Freshman Writing Seminar
     
    Selected Publications
     Abstracts
     

    Beckingham, K.M. "A proper sense of gravity: graviperception in insects." Grav. Space Biol. Bull., 18 (2004) : 3.

     
     Refereed articles
     

    Chen, D., Qu, C., Bjorum, S.M., Beckingham, K.M., Hewes, R.S. "Neuronal remodeling during metamorphosis regulated by the alan shepard (shep) gene in Drosophila melanogaster." Genetics, 197 (2014) : 1267-1284.

     
     

    Taylor K, Kleinhesselink K, George MD, Morgan R, Smallwood T, Hammonds AS, Fuller PM, Saelao P, Alley J, Gibbs AG, Hoshizaki DK, von Kalm L, Fuller CA, Beckingham KM, Kimbrell DA "Toll mediated infection response is altered by gravity and spaceflight in Drosophila ." PLOS ONE, 9(1) (2014) : e86485.


    doi: 10.1371/journal.pone.0086485
     
     

    Bjorum, S.M., Simonette, R.A., Alanis, R., Wang, J.E., Lewis, B.M., Trejo, M.H., Hanson, K.A., Beckingham, K.M. "The Drosophila BTB domain protein Jim Lovell has roles in multiple larval and adult behaviors." PLOS ONE, 8(4) (2013) : e61270. doi:10.1371.

     
     

    Joshi, M.K., Moran, S.T., Beckingham, K.M. and K.R.MacKenzie "The structure of androcam supports specialized interactions with myosin VI." Proceedings of the National Academy of Sciences, USA, 109 (2012 Aug 14) : 13290-13295.

     
     

    Texada, M.J., Deery, W. J., Simonette, R. A. and K.M. Beckingham “ Tropomyosin is a direct interaction partner of the Drosophila coiled coil protein Yuri Gagarin.” Experimental Cell Research, 317, 474-487, 2011.

     
     

    Beckingham, K.M. "Synergy between stresses: an interaction between spaceflight-associated conditions and the microgravity response." Molecular Ecology, 19 (2010) : 4105-4107.

     
     

    Ghosh, S., Bachilo, S. M., Simonette, R.A., Beckingham. K. M., Weisman, R. B. "Oxygen doping modifies near-infrared band gaps in fluorescent single-walled carbon nanotubes ." Science, 330: 1656-1659, 2010. (Chosen for mention in “This week in Science”, p.1583, with a figure from the paper displayed)

     
     

    Kracklauer, M.P., Wiora, H.M., Chen, X., Deery, W.J., Bolival, B. Jr., Romanowicz, D., Simonette, R.A., Fuller, M.T., Fischer, J.A., and Beckingham, K.M. "The Drosophila SUN protein Dspag4 cooperates with the coiled-coil protein Yuri Gagarin to position the basal body on the spermatid nucleus." J Cell Science, 123: 2763-2772, 2010. (Chosen to provide the cover photo and for special mention in “In This Issue”, journal editorial comment page, J Cell Sci 123, e1603).

     
     

    Texada, M.J., Simonette, R.A., Johnson, C.B., Deery, W.J., and Beckingham, K.M. "Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis." J. Cell. Sci., 121 (2008) : 1926-1936.

     
     

    Texada, M.J., and Beckingham, K.M. "Tropomyosin is a direct interaction partner of Drosophila coiled coil protein yuri gagarin." Molecular Biology of the Cell (2008) In Revision

     
     

    Baker, D.A., Beckingham, K.M., and Armstrong, J.D. "Functional dissection of the neural substrates for gravitaxic maze behavior." Journal of Comparative Neurology, 501 (2007) : 756-764.

     
     

    Leeuw, T.K., Reith, R.M., Simonette, R.A., Harden, M., Cherukuri, P., Tsyboulski, D., Beckingham, K.M., and Weisman, R.B. "Single-walled nanotubes in the intact organism: Detection and biocompatibility studies in Drosophila." Nanoletters, 7 (2007) : 2650-2654.

     
     

    Armstrong, J. D., Texada, M. J., Munjaal, R.V., Baker, D.A., and Beckingham, K. "Gravitaxis in Drosophila: A forward genetic screen." Genes, Brain and Behavior, 5 (2006) : 222-239.

     
     

    Frank, D.J., Martin, S.R., Gruender, B.N.T., Lee, Y-SR., Simonette, R. A., Bayley, P.M., Miller, K.G., and Beckingham, K.M. "Androcam is a tissue-specific light chain for myosin VI in the Drosophila testis." Journal of Biological Chemistry, 281 (2006) : 24728-24736.

     
     

    Pavlik, P., Konduri, V., Massa, E., Simonette, R., and Beckingham, K.M. "A dicistronic gene pair within a cluster of "EF hand" protein genes in the genomes of Drosophila species." Genomics, 88 (2006) : 347-359.

     
     

    Beckingham, K.M., Armstrong, J.D., Texada, M.J., Munjaal, R., and Baker, D. "Drosophila melanogaster: The model organism of choice for the complex biology of multi-cellular rganisms." Gravitational and Space Biology, 18 (2005) : 1-13.

     
     

    Beckingham, K.M., Texada, M.J, Baker, D.A., Munjaal, R. and Armstrong, J.D. "Graviperception in animals." Advances in Genetics, 55 (2005) : 106-145.

     
     

    Andruss, B.F., Bolduc, C., and Beckingham, K. "Transfer of calmodulin between cells of different tissue types in an intact organism." Genesis, 38 (2004) : 93-103.

     
     

    Beckingham, K.M., Texada, M.J, Baker, D.A., Munjaal, R., and Armstrong, J.D. "Genetics of graviperception in animals." Advances in Genetics, Elsevier Holland (2004) In Revision

     
     

    Douglas, J.D., Texada, M.J., Munjaal, R., Baker, D., and Beckingham, K.M. "Drosophila melanogaster: the model organism of choice for complex biology in complex organisms." Gravitational and Space Biology Bulletin (2004) In Press

     
     

    Wang, B., Martin, S.R., Newman, R.A., Hamilton, S.L., Shea, M. A., Bayley, P. M., and Beckingham, K. "Biochemical properties of V91G Calmodulin: a mutant calmodulin that deregulates muscle contraction in Drosophila." Protein Science, 13 (2004) : 3285-3297.

     
     

    Munjaal, R.P., Texada, M.J., Armstrong, J.D., and Beckingham, K. "Studies of Drosophila mutants with altered gravitaxic behavior." Gravitational and Space Biology Bulletin, 17 (2003) : 60.

     
     

    Wang, B., Sullivan, K. M. C. and Beckingham, K. "Drosophila calmodulin mutations with specific defects in the musculature or nervous system." Genetics, 165 (2003) : 1340-1356.

     
     

    Kimbrell, D. A., Hice, C., Bolduc, C., Kleinhesselink, K. and Beckingham, K. "The Dorothy enhancer has Tinman binding sites and drives hopscotch-induced tumor formation." Genesis, 24 (2002) : 23-28.

     
     

    Shen, Y., Lee, Y-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M. and Tang, W-J. "Physiological calcium concentrations regulate calmodulin binding and catalytic activity of adenylyl cyclase exotoxins." EMBO J., 21 (2002) : 6721-6732.

     
     

    Wang, B., Bolduc, C., and Beckingham, K. "Calmodulin UAS-constructs and the in vivo roles of calmodulin: Analysis of a muscle-specific phenotype." Genesis, 34 (2002) : 86-90.

     
     

    Lee, S-J, Beckingham, K. and Stull, J.T. "Calcium Independent Activity of Nitric oxide Synthase." Biochem. Biophys. Res. Comm., 284 (2001) : 526-530.

     
     

    Rodney, G.G., Krol, J., Williams, B., Beckingham, K. and Hamilton, S.L. "The Carboxy-terminal Calcium Binding Sites of Calmodulin Control Calmoldulin's Switch from an Activator to an Inhibitor of RYR1." Biochemistry, 40 (2001) : 12430-12435.

     
     Articles
     

    Hetrick, G., Miller, C. S. and Beckingham, K. "Role of the antennae in gravity sensing by Drosophila melanogaster." Gravitational and Space Biology Bulletin, 16 (2002) : 20.

     
     Book chapters
     

    Beckingham, K. "Dwarfism." in Encyclopedia of Genetics, Eds. S. Brenner and J.H. Miller, Academic Press (2001)

     
     

    Beckingham, K. "Genetic Diseases." in Encyclopedia of Genetics, Eds. S. Brenner and J.H. Miller, Academic Press (2001)

     
     

    Beckingham, K. "Hunter's Syndrome." in Encyclopedia of Genetics, Eds. S. Brenner and J.H. Miller, Academic Press (2001)

     
     Other
     

    Armstrong, J.D., Texada, M.J., Carter, E.L., Kuo, E.S., Nadorff, C.M. and Beckingham, K. "Gravitaxic Behavior in Drosophila melanogaster." Gravitational and Space Biology Bulletin, 14 (2000) : 23.

     
     

    Drum, C. L., Yan, S-Z., Sarac, R., Mabuchi, Y., Beckingham, K., Bohm, A., Grabarek, Z., and Tang, W-J. "An Extended Conformation of Calmodulin Induces Interactions Between the Structural Domains of Adenylyl Cyclase from Bacillus anthracis to Promote Catalysis." J. Biol. Chem., 275 (2000) : 36334-36340.

     
     

    Guptaroy, B., Marwaha, N., Pla, M., Wang, Z., Nelson, H. B., Beckingham, K. and Griffith, L. C. "Alternative Splicing of Drosophila Calcium/Calmodulin-dependent Protein Kinase II Regulates Substrate Specificity and Activation." Mol. Brain Res., 80 (2000) : 26-34.

     
     

    Lee, S-J, Beckingham, K., and Stull, J.T. "Mutations at Lysine 525 of Inducible Nitric Oxide Synthase Affect its Ca2+ Independent Activity." J. Biol.Chem., 275 (2000) : 36067-36072.

     
     

    Lu, A.Q., and Beckingham, K. "Androcam, a Drosophila Calmodulin-related Protein, Is Expressed Specifically in the Testes and Decorates Loop Kl-3 of the Y Chromosome." Mech. Development, 94 (2000) : 171-181.

     
     

    Markesich, D.C., Gajewski, K.M., Nazimiec, M.E. and Beckingham, K. "Bicaudal Encodes the Drosophila beta NAC Homolog, a Component of the Ribosomal Translational Machinery." Development, 127 (2000) : 559-572.

     
     

    Rodney, G.G, Williams, B.Y., Strasburg, G.M., Beckingham, K. and Hamilton, S.L. "Regulation of RYR1 Activity by Ca2+ and Calmodulin." Biochemistry, 39 (2000) : 7807-7812.

     
     

    Bohni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B.F., Beckingham, K., and Hafen, E. "Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1-4." Cell, 97 (1999) : 865-875.

     
     

    Fanger, C.M., Ghanshani, S., Logsdon, N.J., Rauer, H., Kalman, K., Zhou, J., Beckingham, K., Chandy, K.G., Cahalan, M.D. and Aiyar, J. "Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel, IKCa1." J. Biol. Chem., 274 (1999) : 5746-5754.

     
     

    Martin, S.R., Lu, A.Q., Xiao, J., Beckingham, K. and Bayley, P.M. "Conformational and Metal-binding Properties of Androcam, a Testis-specific, Calmodulin-related Protein from Drosophila." Protein Science, 8 (1999) : 2444-2454.

     
     

    Stitzinger, S.M., Pellicena-Palle, A., Albrecht, E.B., Gajewski, K.M., Beckingham, K.M., and Salz, H.K. "Mutations in the Predicted Aspartyl tRNA Synthetase of Drosophila Are Lethal and Function as Dosage-sensitive Maternal Modifiers of the Sex Determination Gene Sex-lethal." Mol. Gen. Genet., 261 (1999) : 142-151.

     
     

    Arredondo, L., Nelson, H.B., Beckingham, K., and Stern, M. "Increased Transmitter Release and Aberrant Synaptic Morphology in a Drosophila Calmodulin Mutant." Genetics, 150 (1998) : 265-274.

     
     

    Beckingham, K., Bolduc, C. and Miettinen, S. "Identification of Gravitaxis Mutant in Drosophila." Gravitational and Space Biology Bulletin, 12 (1998) : 66.

     
     

    Beckingham, K., Lu, A.Q., and Andruss, B.F. "Calcium Binding Proteins and Development." Biometals, 11 (1998) : 359-373.

     
     

    Krueger, J.K., Bishop, N.A., Blumenthal, D.K., Zhi, G., Beckingham, K., Stull, J.T., and Trewhella, J. "Calmodulin Binding to Myosin Light Chain Kinase Begins at Substoichiometric Ca2+ Concentrations: A Small-angle Scattering Study of Binding and Conformational Transitions." Biochemistry, 37 (1998) : 17810-17817.

     
     

    Magidin, M., and Beckingham, K. "Use of GFP-Based Calcium and Calcium/calmodulin Sensors to Investigate Mechanical Stimulation." Gravitational and Space Biology Bulletin, 12 (1998) : 13.

     
     

    Zhu, T., Beckingham, K., and Ikebe, M. "High Affinity Ca2+ Binding Sites of Calmodulin Are Critical for the Regulation of Myosin 1b Motor Function." J. Biol. Chem., 273 (1998) : 20481-20486.

     
    Presentations
     Invited Talks
     

     Invited talk at 227th Meeting of The Electrochemical Society (Chicago, Illinois) May 28, 2015.  “Developing Short-Wave Infrared Fluorescent Immunoprobes Based on Single-Walled Carbon            Nanotubes,” R.B.Weisman, K.M. Beckingham, M. Vu, C.-W. Lin, and R.C. Bast.

     
     

    "Novel SWCNT-based Immunoprobes for Spectrally Multiplexed Detection and Imaging in Biomedical Applications." 225th ECS Meeting , Orlando, Florida. (May 2014 ) With Michael Vu, Ching-Wei Lin, Ada Williams, Robert C. Bast, and R. Bruce Weisman

     
     

    "Androcam - a tale of unexpected discovery and productive collaborations." Washington University, St. Louis, MO. (March 27th, 2013)

     
     

    "Astronaut genes: novel cellular functions from mutants with defects in gravity responses." St Louis University School of Medicine, St. Louis, MO. (March 26th, 2013)

     
     

    "Novel SWCNT bases immunoprobes for spectrally multiplexed detection and imaging in biomedical applications." Electrochemical Society 223rd Meeting, Toronto, Canada. (May12-17, 2013) With M. Trejo, S. Ghosh, M. Vu, J. K. Streit, R. B. Weisman

     
     

    "Single-walled Carbon Nanotubes: Biomedical Applications for SWCNT-based immunoprobes." MDAnderson Cancer Center Ovarian Cancer Group, Houston,TX. (August 5th, 2013)

     
     

    "Development of novel nanoprobes with multiple applications in biology and medicine." Johnson Space Center Nanoforum, Houston, TX. (May 18)

     
     

    "The Drosophila SUN protein Dspag4 recruits dynein to the nuclear periphery and cooperates with Yuri Gagarin to position the basal body on the spermatid nucleus." 51st Annual Drosophila Research Conference, Washington D.C.. (April 9)

     
     

    "A genetic approach to understanding gravity responses in Drosophila." Symposium on Gravity Sensing Mechanisms, 16th Annual Union of Physiological Sciences, Kyoto, Japan. (July 27-August 1)

     
     

    "Summary on pipeline approaches to animal behavior." Virtual Fly Brain Behavior Workshop, Magdalen College, Oxford, UK. (September 21-23)

     
     

    "Single-walled Carbon Nanotubes: Physical Properties and Biomedical Applications." HHMI Seminar Series, Harvey Mudd College, Claremont, California. (2008) With R.B. Weisman

     
     

    "Isolation of Gravitaxis Mutants of Drosophila." Mechanosensory Transduction Gordon Conference, University of New England, Biddeford, Maine. (July 22-27, 2007)

     
     

    "Publish or perish: the mechanics of academic publication." RUSP Program, Rice University. (October 30, 2007)

     
     

    "yuri gagarin, alan shepard, john glenn -- Genes with Roles in Drosophila Gravitaxis." Neurofly Meeting, Leuven, Belgium. (September 5, 2006)

     
     

    "Calcium Signaling and Miranda in the Drosophila Testis." University of Oregon, Eugene, Oregon. (June 27, 2006)

     
     

    "Studies of john glenn (jog) and alan shepard (alan), two Drosophila Genes with Roles in Gravitaxis." 22nd Annual Meeting of the American Society for Gravitational and Space Biology, Washington, D.C.. (November 5, 2006)

     
     

    "Using Genetics to Investigate Gravity Responses in the Fruit Fly Drosophila melanogaster." University of Oklahoma, Norman, Oklahoma. (March 1, 2006)

     
     

    "Analysing the Complexities of Calcium Signaling in the Whole Organism." TX-UK Collaborative Research Initiative - Post Receptor Events in Cell Signaling and Disease Workshop, Dundee, Scotland, UK. (September 14, 2005)

     
     

    "Androcam -- A Testis-specific Calcium Sensor Protein of Drosophila." National Institute for Medical Research, Mill Hill, London, UK. (September 16, 2005)

     
     

    "Gravitaxic Mutants of Drosophila melanogaster." Gordon Research Conference on Mechanotransduction and Gravity Signaling in Biological Systems, Biddeford, Maine. (July 25, 2005)

     
     

    "Using Fruit Flies to Investigate Responses to Gravity." USRA Division of Space Life Sciences, Houston, Texas. (November 17, 2005)

     
     

    "Drosophila melanogaster: the model organism of choice for studies of complex biology in complex organisms." 20th Annual Meeting, American Society for Gravitation and Space Biology, New York, New York. (November 2004)

     
     

    "A genetic approach to gravity perception: studies with Drosophila melanogaster." Department of Entomology, University of Illinois, Urbana-Champaign, Illinois. (June 2004)

     
     

    "A proper sense of gravity - using the humble fruit fly." Society of Rice University Women, Houston, Texas. (November 2004)

     
     

    "A proper sense of gravity; investigating graviperception with the fruit fly Drosophila melanogaster." Department of Biochemistry and Molecular Biology, U.T. Health Science Center, Houston, Texas. (October 2004)

     
     

    "Exploring gravity perception with Drosophila mutants." Department of Biology, Trinity University, San Antonio, Texas. (February 2004)

     
     

    "A Genetic Approach to Calcium Signaling; Studies of Two Calcium Sensor Proteins in Drosophila." Dept. Biological Sciences, Univ. Nevada at Las Vegas, Las Vegas, Nevada. (September 2003)

     
     

    "A Molecular Genetic Approach to Calcium Signaling and Gravity Sensing in Flies." Frontiers of Biology" Mini-Symposium on Interdisciplinary Biology, Rice University, Houston, Texas. (June 2003)

     
     

    "Drosophila Gene Expression and Behavior in Hyper-gravity and Micro-gravity." NASA Ames Research Center, Moffat Field, California. (December 2003)

     
     

    "A Cluster of Putative Calcium Sensors Expressed Specifically in the Drosophila Testis." Baylor College of Medicine, Houston, Texas. (April 25, 2002)

     
     

    "Exploring Gravitaxis in Drosophila with a Genetic Approach." Department of Biological Sciences, University of Iowa, Iowa City, Iowa. (February 15, 2002)

     
     

    "Gravity Sensing in Drosophila." NASA Ames Research Center, Mountain View, California. (November 22, 2002)

     
     Other
     

    "Defects in the Individualization Step of Spermatogenesis Produced by Depression of Androcam Expresion with RNAi." 48th Annual Drosophila Research Conference, Philadelphia, Pennsylvania. (March 7-11, 2007) With Lee, R.Y.S., Simonette, R.A., and Deery, W.J.

     
     

    "Aberrant Calcium Release and Re-uptake in Drosophila Muscle Caused by Calmodulin Mutations." 42nd Annual Dosophila Research Conference, Washington, D.C.. (March, 2001) With with B. Wang

     
     

    "Androcam, a Potential Testis-specific Calcium Sensor." 42nd Annual Drosophila Research Conference, Washington, D.C.. (March 2001) With with P. Cornwell

     
     

    "Characterization of yuri: A Gravitaxis Mutant in Drosophila." invited talk, European Drosophila Research Conference, (September 2001) With with J.D. Armstrong and M. Texada

     
     

    "Genetics of Gravitational Perception in Drosophila melanogaster." 42nd Annual Drosophila Research Conference, Washington, D.C.. (March 2001) With with M. Texada, J.D. Armstrong, E. Carter, E. Kuo and C. Nadorff

     
     

    "Gravitaxic Behavior in Drosophila." invited Talk, 9th Biennial Drosophila Neurobiology, Cole Spring Harbor, New York. (October 2001)

     
     

    "In vivo Studies of Calmodulin in Drosophila." Invited seminar, Dept. Biology, University of Toronto, Toronto, Canada. (September 2000)

     
     

    "A Genetic Approach to Calmodulin Function in Drosophila." Invited seminar, Dept. Molecular Genetics, MD Anderson Cancer Center, Houston, Texas. (April 2000)

     
     

    "Calmodulin Function as Studied by a Genetic Approach." Invited seminar, Dept. Pharmacology and Cancer Biology, Duke University, Durham, North Carolina. (April 2000)

     
     

    "Drosophila Muscle and Neuronal Disorders Caused by Calmodulin Mutations." Platform presentation, 41st Annual Drosophila Meeting, Pittsburgh, Pennsylvania. (March 2000) With with B. Wang

     
     

    "Gravitaxic Behavior in Drosophila." Invited talk, 16th Annual Meeting of the American Society for Gravitational and Space Biology, Montreal, Canada. (October 2000) With with J.D. Armstrong

     
     

    "Gravitaxic Mutants of Drosophila melanogaster." Invited seminar, NASA Ames Research Center, Moffett Field, California. (November, 2000)

     
     

    "Sex, Flies, and Videotape." Invited seminar, Studies in Women Gender Program, Rice University, Houston, Texas. (November 2000) With with J.D. Armstrong

     
     

    "Transfer of Calmodulin between Cells, Calmodulin Dependence of Nurse Cell Dumping and Embryonic Cleavage Division." 41st Annual Drosophila Meeting, Pittsburgh, Pennsylvania. (March 2000) With with B.F. Andruss, C. Bolduc, and D.C. Markesich

     
     

    "Unusual Insights into Calmodulin Function from in vivo Genetic Studies." Invited talk, Gordon Conference, Second Messengers and Protein Phosphorylation, Kimbrell Academy, New Hampshire. (June 2000)

     
     

    "A Search for Gravitaxic Mutants in Drosophila." 40th Annual Drosophila Research Conference, Seattle, Washington. (March, 1999) With with Bolduc, C., and Miettinen, S

     
     

    "Androcam - A Testis-specific Calmodulin-related Protein of Drosophila." 40th Annual Drosophila Research Conference, Seattle, Washington. (March, 1999) With with Lu, A., Bishop, N., and Green, B

     
     

    "Calmodulin Function in vivo by a Genetic Approach." invited talk, Vollum Institute, Portland, Oregon. (March 29, 1999)

     
     

    "Cell-to-cell Transfer of Calmodulin in Tissues of an Intact Organism." Abstract for 11th Annual International Symposium on Calcium-binding proteins and Calcium Function in Health and Diseases, Kisarazu, Japan. (October 19-23, 1999) With with Andruss, B., and Bolduc, C.

     
     

    "Dissection of Calmodulin Function in vivo." invited seminar, Texas A&M University. (November 2, 1999)

     
     

    "Gravitaxic Mutants of Drosophila." Neurobiology of Drosophila Meeting, Cold Spring Harbor, New York. (October 6-10, 1999) With with Bolduc, C., Miettinen, S., and Gamse, A

     
     

    "Transfer of Calmodulin Between Cells in Both the Ovary and the Embryonic CNS." 40th Annual Drosophila Research Conference, Seattle, Washington. (March, 1999) With with Andruss, B., and Bolduc, C

     
     Posters
     

    Poster presentation at 56th Annual Drosophila Meeting, Chicago, IL, March 4th-8th , 2015.  Failure to burrow while wandering: an indication of tracheal damage in mutants of the jim lovell (lov) gene. K. Beckingham, F. Zhou, K. Qiang, Y. Yuan, P. Yun, R. Dibbs, T. Ghanayem, R. Mohan, P. Frasse, N. Sankoorikkal.

     
     

    "A novel behavioral phenotype reveals a new function for the Drosophila transcription factor Lov." 2014 Neurofly Meeting, Hersonissos, Crete, Greece. (October 2014) With Fanli Zhou and Karen Qiang

     
     

    "Roles for jim lovell in larval feeding behavior and embryonic development ." 55th Annual Drosophila Meeting, San Diego, California. (March 2014) With Fanli Zhou and Cheng Wang

     
     

    "jim lovell regulates behavior through roles in the CNS and PNS." 54th Annual Drosophila Meeting, Washington DC. (April 3 - 7, 2013) With S. Bjorum, R.A. Simonette, R. Alanis, B. Lewis, M. Trejo, and K. Hanson

     
     

    "Androcam: a tissue specific light chain for Myosin VI." 18th International Symposium on Calcium and Calcium binding proteins in health and disease, Kiruna, Sweden. (June 30 - July 4, 2013) With M.K. Joshi, S. Moran, and K.R. MacKenzie

     
     

    "jim lovell - a transcription factor with two distinct embryonic expression patterns that can negatively regulate broad" , 53rd Annual Drosophila Meeting March 7-11th, 2012, Chicago, IL, with Sonia Bjorum, Rebecca A. Simonette, Raul Alanis and Benjamin Lewis.

     
     

    "jim lovell - a gene with roles in neural development and behavior." 51st Annual Drosophila Research Conference, Chicago, IL. (April 7-11) With Sonia M. Bjorum

     
     

    "jim lovell, a neural transcription factor with roles in multiple behavioral responses." Neurofly 2010, Manchester, UK. (Sept 1-5) With Sonia Bjorum, Rebecca Simonette, Raul Alanis, James Liu, Darin Carabenciov

     
     

    "Yuri Gagarin protein regulates F-Actin formation and interacts with the F-Actin stabilizing protein Tropomyosin." 50th Annual Drosophila Research Conference, Chicago, IL. (March 4-8) With K.M. Beckingham, M.J. Texada, R.A. Simonette, W.J. Deery

     
     

    "jim lovell - a gene with structural and functional similarities to fruitless." 50th Annual Drosophila Research Conference, Chicago, IL. (March 4-8) With S.M. Bjorum, K.M. Beckingham

     
     

    "john glenn (jog), a gene implicated in gravitaxis, may function downstram of the Drosophila ortholog of the beta-amyloid precursor protein." 50th Annual Drosophila Research Conference, Chicago, IL. (March 4-8) With C.B. Johnson, V.Konduri, S. Hueslsmann, N. Brown, K.M. Beckingham

     
     

    "john glenn (jog), a gene iplicated in gravitaxis, may be involved in axon outgrowth and function downstream of APP (APPL)." 49th Annual Drosophila Conference, San Diego, California. (April 2-6, 2008) With C.B. Johnson, V. Konduri, S. Huelsmann, and N. Brown

     
     

    "yuri gagarin is required for actin, tubulin and basal body functions in spermatogenesis"." 49th Annual Drosophila Conference, San Diego, California. (April 2-6, 2008) With M. Texada, R.P. Munjaal, R.A. Simonette, C.B. Johnsn, and W.J. Deery

     
     

    "Androcam: a testis-specific calcium sensor." Biophysical Discussions Meeting. Calmodulin modulation of ion channels., Asilomar, California. (October 30-November 2, 2008) With R.A. Simonette, W. Deery, and R.Y.-S. Lee

     
     

    "Targeting of single-walled carbon nanotubes to a specific tissue type for near-IR imaging in vivo." Carbon Nanotube in Biology, Medicine & Toxicology Conference, Montpellier, France. (June 28, 2008) With R. Divers, T. Leeuw, and R.B. Weisman

     
     

    "What's Lov got to do with it? A role for jim lovell in Drosophila courtship." 49th Annual Drosophila Conference, San Diego, California. (April 2-6, 2008) With S. Bjorum

     
     

    "Characterization of mutants for jog, a gene with a role in gravity perception in Drosophila." 48th Annual Drosophila Conference, Philadelphia, Pennsylvania. (March 7-11, 2007) With Konduri, V.

     
     

    "Effects of SWNT Feeding on Drosophila Growth, Development and Longevity." 233rd ACS National Meeting, Chicago, Illinois. (March 25-29, 2007) With Weisman, R.B., Reith, R.M., and Harden, M.E.

     
     

    "The Gravitaxis-affecting Protein YURI Interacts with the Actin Cytoskeleton." 48th Annual Drosophila Conference, Philadelphia, Pennsylvania. (March 7-11, 2007) With Texada, M., Johnson, C.B., and Simonette, R.A.

     
     

    "Two Genes Affecting Gravitaxis." 48th Annual Drosophila Conference, Philadelphia, Pennsylvania. (March 7-11, 2007) With Bjorum, S.

     
     

    "A Role of Miranda in Calcium Signaling in the Drosophila Testis?." 47th Annual Drosophila Research Conference, Houston, Texas. (March 29-April 2, 2006) With Lee, Y.-S.R. and Simonette, R.A.

     
     

    "Characterization of Mutants Affecting Gravity Responses in Drosophila." 47th Annual Drosophila Research Conference, Houston, Texas. (March 29-April 2, 2006) With Konduri, V.

     
     

    "Characterization of the Gravitaxis-related Protein Yuri." 47th Annual Drosophila Research Conference, Houston, Texas. (March 29-April 2, 2006) With Texada, M.J., Munjaal, R.P., and Simonette, R.A.

     
     

    "Identifing the Neuronal Basis of Graviperception in Drosophila melanogaster." 22nd Annual Meeting of the American Society for Gravitational and Space Biology, Washington, D.C.. (November 2-5, 2006) With Johnson, C.J., Texada, M.J., and Simonette, R.A.

     
     

    "Yuri gagarin -- A Gene with a Role in Gravitaxic Responses." 46th Annual Drosophila Research Conference, San Diego, California. (March 30-April 3, 2005) With R.P. Munjaal, M.J. Texada, R.A. Simonette and F. Sultan

     
     

    "Androcam - A Light Chain for Myosin VI in the Drosophila Testis?." 46th Annual Drosophila Research Conference, San Diego, California. (March 30-April 3, 2005) With D.J. Frank, S.R. Martin, B.N.T. Gruender, Y-S.R. Lee, R.A. Simonette, P.M. Bayley and K.G. Miller

     
     

    "Characterization of Mutations in yuri, a Drosophila Gravitaxis Related Gene." Gordon Research Conference on Mechanotransduction and Gravity Signaling in Biological Systems, Biddeford, Maine. (July 24-29, 2005) With R.P. Munjaal, M.J. Texada and R.A. Simonette

     
     

    "Conservation of the Androcam Gene Cluster and its Unusual Dicistronic Transcript in other Drosophila Species." 46th Annual Drosophila Research Conference, San Diego, California. (March 30-April 3, 2005) With V. Konduri and P. Pavlik

     
     

    "Protein Interaction Partners of the Calcium Sensor Protein Androcam in the Drosophila Testis." 46th Annual Drosophila Research Conference, San Diego, California. (March 30-April 3, 2005) With Y-S.R. Lee and R.A. Simonette

     
     

    "Protein Interaction Partners of the Calcium Sensor Protein Androcam in the Drosophila Testis." 46th Annual Drosophila Research Conference, San Diego, California. (March 30-April 3, 2005) With Y-S.R Lee and R.A. Simonette

     
     

    "Androcam: a testis-specific, putative calcium sensor is expressed from a cluster of Androcam-like genes." 45th Annual Drosophila Research Conference, Washington, DC. (March 2003) With P. Cornwell and E. Massa

     
     

    "Yuri, a gene affecting Drosophila gravitaxis." 45th Annual Drosophila Research Conference, Washington, DD. (March 2004) With M.J. Texada, R.P. Munjaal and J.D. Armstrong

     
     

    "Genes with Roles in Gravity Perception." 44th Annual Drosophila Research Conference, Chicago, Illinois. (March 2003) With Texada, M.J., Munjaal, R.P., and Armstrong, J.D.

     
     

    "Polycistronic Transcription in a Cluster of Genes Encoding Testis-specific Putative Calcium Sensors." 44th Annual Drosophila Research Conference, Chicago, Illinois. (March 2003) With Cornwell, P., and Massa, E.

     
     

    "Studies of Drosophila Mutants with Altered Gravitaxic Behavior." 19th Annual ASGSB Meeting, Huntsville, Alabama. (November 2003) With Munjaal, R.P., Texada, M.J., and Armstrong, J.D.

     
     

    "Yuri Gagarin - a Gene with Functions in Gravitaxic Responses." Drosophila Neurobiology Meeting, Cold Spring Harbor, New York. (October 2003) With Texada, M., Armstrong, J.D., and Munjaal, R.P.

     
     

    "Analysis of Various Larval Behaviors and Developmental Phenotypes by Different Mutations to the Single Drosophila Calmodulin Gene." 43rd Annual Drosophila Research Conference, San Diego, California. (April 2002) With B. Wang

     
     

    "Androcam, a Potential Testis-specific Calcium Sensor." 43rd Annual Drosophila Research Conference, San Diego, California. (April 2002) With P. Cornwell

     
     

    "Drosophila Mutants with Altered Gravitaxic Behavior." 9th European Symposium on Drosophila Neurobiology, Dijon, France. (September 2002) With J.D. Armstrong and M.J. Texada

     
     

    "Identification of Genes Involved in Gravitaxis in Drosophila." 43rd Annual Drosophila Research Conference, San Diego, California. (April 2002) With M.J. Texada, J.D. Armstrong, and R.P. Munjall

     
     

    "Role of the Antennae in Gravity Sensing by Drosophila melanogaster." 18th Annual Meeting of the ASGSB Society, Orlando, Florida. (November 2002) With G. Hetrick and C.S. Miller

     
     Seminar Speaker
     

    "Astronaut genes: novel cellular functions from mutants with defective gravity responses."   Invited Seminar Brandeis University, November 5th, 2012.

     
     Workshops
     

    "GFP-based Sensors for in vivo Imaging of Calcium." TX-UK-IBB Workshop, Rice University, Houston, Texas. (February 16, 2006)

     
    Editorial Positions
     Member of the Editorial Board, Nature Scientific Reports. (2015 - 2018)

     Member of the Editorial Board, Journal of Biological Chemistry. (2007 - 2007)

     Member of the Editorial Board, Journal of Biological Chemistry. (2006 - 2006)

     Member of the Editorial Board, Journal of Biological Chemistry. (2000 - 2000)

     Member of the Editorial Board, Journal of Biological Chemistry. (2005 - 2005)

     Member of the Editorial Board, Journal of Biological Chemistry. (2004 - 2004)

     Member of the Editorial Board, Journal of Biological Chemistry. (2002 - 2002)

     Member of the Editorial Board, Journal of Biological Chemistry. (2008 - 2008)

     Member of the Editorial Board, Journal of Biological Chemistry. (2003 - 2003)

    Supervised Theses & Dissertations
     Breanna Ullmann, Ph.D. Identification and Characterization of Yeast Genes Involved in Defense against Oxidative Stress Induced by Macrophages. (1993) (Thesis Committee Member)

     Ph.D. Control of Perineurial Glial Growth in Drosophila melanogaster. (2002) (Thesis Committee Member)

     Ph.D. The Drosophila melanogaster Gene, bemused, Is a New Allele of pumilio: Insights into Understanding the Role of Translational Regulation in the Maintenance of Proper Neuronal Excitability. (2002) (Thesis Committee Member)

     M.A. The Arabidospis sugar-insensitive2 (sis2) Mutant Displays a Novel Combination of Altered Sugar and Phytohormone Responses. (2002) (Thesis Committee Member)

     Ph.D. Analysis of Physiological Roles of Drosophila Calmodulin Through in vivo Genetic and in vitro Structure/Function Studies. (2002) (Thesis Director)

     Ph.D. Heparanase and Platelet Factor-4 Induce Smooth Muscle Cell Proliferation and Migration via Basic Fibroblast Growth Factor Release from the Extracellular Matrix: Implications in the Testenosis Process. (2002) (Thesis Committee Member)

     Veronica Hall-O'Connell, Ph.D. Broad-Complex, a Mediator of Ecdysone Induced Stress Response in Drosophila melanogaster. (2004) (Thesis Committee Member)

     Samuel Campos, Ph.D. Metabolic Biotinylation of the Adenoviral Capsid: Avidin-Based Applications and Studies of Ligand-Targeted Gene Delivery. (2005) (Thesis Committee Member)

     Jeff VanKomen, Ph.D. Regulatory Elements of Sso1p and Their Effect on SNARE Mediated Membrane Fusion. (2005) (Thesis Committee Member)

     Yong Zhou, Ph.D. Effect of Nonsteroidal Anti-inflammatory Drugs on the Mechanical and Electrical Stability of Phospholipid Membranes. (2006) (Thesis Committee Member)

     Jinhua Pan, Ph.D. Structural and Functional Studies on Birnavirus RNA Polymerases - Insights into the Protein-priming Mechanism and Evolution of RNA Viruses. (2007) (Thesis Committee Member)

     Wiriya Chiranand, Ph.D. Regulation of Nitrosative Stress Response in the Fungal Pathogen Candida albicans by CTA4, a DNA-Binding Protein Transcription Factor. (2007) (Thesis Committee Member)

     Leighan Sullivan, Ph.D. Molecular and Genomic Analyses in Clostridium acetobutylicum. (2008) (Thesis Committee Member)

     Michael Texada, Ph.D. Characterization of the Drosophila Gene ‘yuri gagarin,’ Which Is Required for Mechanosensation and Male Fertility. (2008) (Thesis Director)

     Adina Maximiuc, Ph.D. Structural Basis for Calmodulin-mediated Regulation of the Ryanodine Receptor. (2008) (Thesis Committee Member)

     Augustina Rodriguez-Granillo, PhD Copper as a Biological Yin-Yang Element: Structural Dynamics, Protein-Protein Interactions and Transfer Mechanisms of Copper Transport Proteins. (2010) (Thesis Committee Member)

     Wenjie Zheng, Ph.D. Structural and functional studies on the infectious salmon anemia virus nucleoprotein. (2013) (Thesis Committee Member)

     Ye Chen, PhD Multi-strain synthetic biology: Design and construction of genetically controlled micro-ecosystems. (Thesis Committee Member)

    Awards, Prizes, & Fellowships
     Attendee, 42nd Annual Drosophila Research Conference, Washington, D.C., (March 21-25, 2001)

     Member, Society for Developmental Biology

     Member, Genetics Society of America

     Attendee, 9th Biennial Neurobiology of Drosophila Meeting, Cold Spring Harbor, New York, (October 3-7, 2001)

     Member, American Society for Biological Chemists

     Member, American Society for Cell Biology

     Member, Genetics Society of America

     Member, American Society for Biological Chemists

     Member, American Society for Cell Biology

     Attendee, 16th Annual Meeting, American Society for Gravitational and Space Biology, Montreal, Canada (October 25-28,2000)

     Attendee, 41st Annual Drosophila Research Conference, Pittsburg, Pennsylvania (March 22-26, 2000)

     Attendee, Gordon Conference, Second Messengers and Protein Phorphorylation, Kimbrell Academy, NH (June 2000)

     Member, Society for Developmental Biology

     Attendee, Neurobiology of Drosophila Meeting, Cold Spring Harbor, New York (October 6-10, 1999)

     Attendee, 40th Annual Drosophila Research Conference, Seattle, Washington (March 24-28, 1999)

     Attendee, Welch Foundation, 43rd Conference on Chemical Research, Houston, Texas (October 24-26, 1999)