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Scholarly Interest Report
Herbert Levine
Karl Hasselmann Professor of Bioengineering, Professor of Physics, Professor of Biosciences
  • B.S. Physics (1976) Massachusetts Institute of Technology, Cambridge, MA
  • Ph.D. Physics (1979) Princeton University, Princeton, NJ
  • M.A. Physics (1977) Princeton University, Princeton, NJ
Primary Department
   Department of Bioengineering
Department Affiliations
  • Department of BioSciences
  • Department of Physics and Astronomy
     Rice Faculty Page
    Research Areas
     Theoretical Biological Physics
    Teaching Areas
     Biomechanics, physical biology
    Selected Publications
     Refereed articles

    Alexandru Dan Grigore, Mohit Kumar Jolly, Dongya Jia, Mary C Farach-Carson, Herbert Levine "Tumor Budding: The Name is EMT. Partial EMT.." 


    Arpan Bhowmik, Wouter-Jan Rappel, Herbert Levine "Excitable waves and direction-sensing in Dictyostelium discoideum: steps towards a chemotaxis model." 


    Brian A Camley, Juliane Zimmermann, Herbert Levine, Wouter-Jan Rappel "Collective signal processing in cluster chemotaxis: Roles of adaptation, amplification, and co-attraction in collective guidance." In Press


    Brian A Camley, Juliane Zimmermann, Herbert Levine, Wouter-Jan Rappel "Emergent collective chemotaxis without single-cell gradient sensing." 


    Brian A Camley, Yanxiang Zhao, Bo Li, Herbert Levine, Wouter-Jan Rappel "Crawling and turning in a minimal reaction-diffusion cell motility model: coupling cell shape and biochemistry." 


    David A Kessler, Herbert Levine "Nonlinear self-adapting wave patterns." 


    David S Li, Juliane Zimmermann, Herbert Levine "Modeling closure of circular wounds through coordinated collective motion." 


    Deborah Schwarcz, Herbert Levine, Eshel Ben-Jacob, Gil Ariel "Uniform modeling of bacterial colony patterns with varying nutrient and substrate." 


    Dongya Jia, Mohit Kumar Jolly, Satyendra Chandra Tripathi, Petra Den Hollander, Bin Huang, Mingyang Lu, Muge Celiktas, Esmeralda Ramirez-Pena, Eshel Ben-Jacob, Jose N Onuchic, Samir M Hanash, Sendurai A Mani, Herbert Levine "Distinguishing Mechanisms Underlying EMT Tristability." In Press


    Herbert Levine "Expanding the scale of molecular biophysics." 


    Jason A Somarelli, Samantha Shetler, Mohit K Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, Alexander J Hish, Shivee Gilja, William C Eward, Kathryn E Ware, Herbert Levine, Andrew J Armstrong, Mariano A Garcia-Blanco "Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2." 


    Jingchen Feng, Herbert Levine, Xiaoming Mao, Leonard M Sander "Nonlinear elasticity of disordered fiber networks." 


    Jingchen Feng, Stuart Sevier, Bin Huang, Dongya Jia, Herbert Levine "Modeling delayed processes in biological systems." 


    Juliane Zimmermann, Brian A Camley, Wouter-Jan Rappel, Herbert Levine "Contact inhibition of locomotion determines cell–cell and cell–substrate forces in tissues." 


    Marcelo Boareto, Mohit Kumar Jolly, Aaron Goldman, Mika Pietilä, Sendurai A Mani, Shiladitya Sengupta, Eshel Ben-Jacob, Herbert Levine, Onuchic Jose’N "Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype." 


    Mohit Kumar Jolly, Satyendra C Tripathi, Dongya Jia, Steven M Mooney, Muge Celiktas, Samir M Hanash, Sendurai A Mani, Kenneth J Pienta, Eshel Ben-Jacob, Herbert Levine "Stability of the hybrid epithelial/mesenchymal phenotype." 


    Ryan R Cheng, Olle Nordesjö, Ryan L Hayes, Herbert Levine, Samuel C Flores, José N Onuchic, Faruck Morcos "Connecting the sequence-space of bacterial signaling proteins to phenotypes using coevolutionary landscapes." 


    Satyendra C Tripathi, Haley L Peters, Ayumu Taguchi, Hiroyuki Katayama, Hong Wang, Amin Momin, Mohit Kumar Jolly, Muge Celiktas, Jaime Rodriguez-Canales, Hui Liu, Carmen Behrens, Ignacio I Wistuba, Eshel Ben-Jacob, Herbert Levine, Jeffrey J Molldrem, Samir M Hanash, Edwin J Ostrin "Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome." 


    Steven M Mooney, Mohit Kumar Jolly, Herbert Levine, Prakash Kulkarni "Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins." 


    Stuart A Sevier, David A Kessler, Herbert Levine "Mechanical Bounds to Transcriptional Noise." 


    Inbal Hecht, Sari Natan, Assaf Zaritsky, Herbert Levine, Ilan Tsarfaty, Eshel Ben-Jacob "The motility-proliferation-metabolism interplay during metastatic invasion." 


    B. A. Camley, Y. Zhang, Y. Zhao, B. Li, E. Ben-Jacob, H.Levine and W.-J. Rappel "Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns." PNAS, 111 (2014) : 14770.


    B. Hu, W.J. Rappel, H. Levine "How input noise limits biochemical sensing in ultrasensitive systems." Physical Review E, 90 (2014) : 032702.


    D. A. Kessler, R. H. Austin, and H. Levine "Resistance to Chemotherapy: Patient Variability and Cellular Heterogeneity." Cancer Research, 74 (2014) : 4663-70.


    D.A. Kessler, H. Levine "Scaling solution in the large population limit of the general asymmetric stochastic Luria-Delbruck evolution process." J. Statistical Physics (2014) In Press


    H. Levine "Learning physics of living systems from Dictyostelium." Physical Biology, 11 (2014) : 053011.


    J Zimmermann, M Basan, H Levine "An instability at the edge of a tissue of collectively migrating cells can lead to finger formation during wound healing." European Physical Journal, 223 (2014) : 1259.


    J. Zimmermann, R. L. Hayes, M. Basan, J. N. Onuchic, W.-J. Rappel, and H. Levine "Intercellular Stress Reconstitution from Traction Force Data." Biophysical Journal, 107 (2014) : 548.


    L. Sun, J.K. Noel, J.I. Sulkowska, H. Levine, J.N. Onuchic "Connecting Thermal and Mechanical Protein (Un) folding Landscapes." Biophysical Journal, 107 (2014) : 2941-52.


    M. Skoge, H. Yue, M. Erickstad, A. Bae, H Levine, A. Groisman, W.F. Loomis, W.-J. Rappel "Cellular memory in eukaryotic chemotaxis." PNAS, 111 (2014) : 14448-14453.


    M.K. Jolly, B. Huang, M. Lu, S.A. Mani, H. Levine, E. Ben-Jacob "Towards elucidating the connection between epithelial–mesenchymal transitions and stemness." J Royal Soc Interface, 11 (2014) : 20140962 .


    R. R. Cheng, F. Morcos, H. Levine, J. N. Onuchic "Toward rationally re-designing bacterial two-component signaling systems using coevolutionary information." PNAS, 111 (2014) : 563.


    A. Samuel, H. Levine, K. B. Blagoev, "Scientic priorities for the BRAIN Initiative", Nat. Meth. 10, 713 (2013)


    B. A. Camley, Y. Zhao, B. Li, H. Levine, W. J. Rappel, "Periodic migration in a physical model of cells on micropatterns", Phys. Rev. Lett. 111, 15810 (2013)


    D. Kessler and H. Levine, "Large population solution of the stochastic Luria- Delbruck evolution model", Proc. Nat. Acad. Sci. 110, 11682 (2013)


    H. Levine and W. J. Rappel, "The physics of eukaryotic chemotaxis"", Physics Today, Feb 2013, 24 (2013)


    J Feng, D.A. Kessler, E. Ben-Jacob, H. Levine, "Growth feedback as a basis for persister bistability", Proc, Nat. Acad. Sci 111, 544 (2013)


    M. Basan, J. Elgeti, E. Hannezo, W. J. Rappel and H. Levine. "Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing", Proc. Nat. Acad. Sci. 110(7):2452-9 (2013)


    M. Lu, M. K. Jolly, H. Levine, J. N. Onuchic, E. Ben-Jacob, ``MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination" Proc, Nat. Acad. Sci 110 18144 (2013)


    P. Ghosh, E. Ben-Jacob, H. Levine "Modeling cell-death patterning during biolm formation", Physical Biology 10, 066006 (2013)


    S. Yang, K. M. Ravikumar, H. Levine, "Energy Evaluation of beta-Strand Packing in a Fibril-Forming SH3 Domain, J. Phys. Chem B 117, 13051 (2013)


    B. Ho, D.A. Kessler, B-J Rappel, et al., "How input fluctuations reshape the dynamics of a biological switching system" Phys. Rev. E 86:061910; DOI:10.1103/PhysRevE.86.061910, 2012.


    D. Shao, H. Levine, W-J. Rappel, "Coupling actin flow, adhesion and morphology in a computational cell motility model," Proc. Natl. Acad. Sci. USA 109:6851-6856; DOI:10.1073/pnas.1203252109, 2012.


    E. Ben-Jacob, D.S. Coffey, H. Levine, "Bacterial survival strategies suggest rethinking cancer cooperativity," Trends in Microbiology 209:403-410; DOI:10.106/j.tim.2012.06.001, 2012.


    K. Takeda, D. Shao, M. Adler, et al., "Incoherent Feedforward Control Governs Adaptation of Activate Ras in a Eukaryotic Chemotaxis Pathway," Science Signaling 5, 2012.


    N. Bostani, D.A. Kessler, N.M. Scnerb, et al., "Noise effects in nonlinear biochemical signaling," Phys. Rev. E 85:011901; DOI:10.1103/PhysRevE85.011901, 2012.


    S. Nadkarni, T.M. Bartol, C.F. Stevens, et al., "Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal," Proc. Natl. Acad. Sci. USA, 109:14657-14662; DOI:10.1073/pnas.1211971109, 2012.


    Herbert Levine "Cell biophysics: How to eat on the go." 

     Invited Talks

    "APS March meeting, Denver." (Mar. 2014)


    "Biophysical Society annual meeting, San Francisco." (Feb. 2014)


    "CECAM meeting, EPFL Lausanne Switerland." (Aug. 2014)


    "ICAM meeing, UC Davis." (Jun. 2014)


    "ICBP, Beijing." (Jun. 2014)


    "NCI Physical Science Oncology program, ann. mtg.." (Mar. 2014)


    "Physcs of Living Systems, ann. mtg. Munich." (Jul. 2014)


    "Society of Mathematical Biology, Osaka, Japan." (Aug. 2014)


    "Systems biology workshop, Beijing." (Sept. 2014)


    "Invited talk, Perspectives in Nonlinear Dynamics, Hyderabad India." (July 2013)


    "Invited talk, meeting on Animal Swarms, Huleh valley, Israel." (March 2013)


    "NSF Cancer imaging workshop, Harvard Medical School, Boston." (Nov. 2013)


    "NSF Cell Decision-Making Workshop, Arlington VA." (June 2013)


    "Physics of Cancer, Physics of Living Systems meeting (Princeton)." (July 2013)


    "Bacterial colonies at two levels: Physical Formation and Functional Significance,." Workshop on the Physics of Bacterial Communities, Chicago, IL. (June 11)


    "Cell Motility--getting from the individual to collective tissue motion, ." 109th Statistical Mechanics Conference, Rutgers, NJ. (December)


    "Colonies of Chiral Bacteria,." American Physical Society Annual Meeting, Boston, MA. (March)


    "Directed Cell Motility,." Baylor College of Medicine, Houston, TX. (November)


    "Directed Cell Motility,." MD Anderson Systems Biology, Houston, TX. (October)


    "Multiscale Modeling of Biochemical Networks That Control Cell Polarization and Motility,." The Society for Mathematical Biology, Knoxville, TN. (July) With J. Allard, B. Holmes, A. Jilkine


    "Physics of Cancer,." KITP Physics of Cancer, Santa Barbara, CA. (July)


    "Presynaptic Plasticity due to Astrocytes,." Federation of European Neuroscience Societies, Barcelona, Spain. (July)


    "Spatiotemporal Dynamics of Eukaryotic Chemotaxis,." Vanzant Lecture Series, Rice University, Houston, TX. (December)

     Keynote Speaker

    "Integrative Cancer Biology Program, annual meeting, Methodist hopsital Houston." (Apr. 2014)


    "Physics of Cancer, keynote talk at Radiation Research Society." (Sept, 2013)


    "Plenary talk, Society of Critical Care Medicine, Puerto Rico." (Jan 2013)

     Seminar Speaker

    "Baylor College of Medicine, MCB seminar." (Feb. 2014)


    "Bioengineering seminar, Stanford." (Oct. 2014)


    "Biophysics seminar, Univ. of Maryland." (Nov, 2014)


    "Complex systems seminar, Northwestern Univ.." (Oct 2014)


    "LMU Munich biophysics seminar." (Jul 2014)


    "MD Anderson, Imaging group." (Dec. 2014)


    "Physics colloquium, Auburn Univ.." (Apr. 2014)


    "Physics colloquium, Oregon State Univ. ." (Oct. 2014)


    "Bacterial Interest Group, Baylor College of Medicine." (Oct 2013)


    "Neuroscience semimar, UTHSC Houston." (Oct. 2013)


    "Physics Colloquium, IISER Pune, India." (July 2013)


    "Physics Colloquium, RPI." (March 2013)


    "Physics Colloquium, UT Austin." (Feb 2013)


    "Physics colloquium, Univ. of Waterloo." (Oct. 2013)

    Editorial Positions
     Associate Editor, Cancer Convergence . (2016 - 2017)

     Associate Editor, Physical Review Letters. American Physical Society. (2014 - 2017)

     Editor in Chief, Physical Biology. Institute of Physics. (2014 - 2017)

     Member of the Editorial Board, Proceedings of the National Academy of Sciences USA. (2012 - 2017)

     Editor for Special Issue, Cancer Research. (2014 - 2014)

    Supervised Theses & Dissertations
     Dongya Jia, PhD Problems in biophysics. (Thesis Director)

     Jason George, MD/PhD Cancer drug resistance models. (Thesis Director)

     Mohit Jolly, PhD Quantitative systems biology of cancer. (Thesis Director)

     Stuart Sevier, PhD Analysis of transcriptional regulation. (Thesis Director)

     Yunsong Zhang, PhD Modeling cellular and multicellular motility. (Thesis Director)

     Arpan Bhowmik, PhD Wave induced motility in Dictyostelium. (Thesis Director)

     Jingchen Feng, PhD problems in biophysics. (Thesis Director)

    Awards, Prizes, & Fellowships
     Member, American Academy of Arts and Sciences (2012)