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Scholarly Interest Report
         
Jeffrey D. Hartgerink
Professor
Professor of Chemistry and Professor of Bioengineering
 
e-mail:jdh@rice.edu
 
  • A. B. Chemistry and Biology (1993) Washington University, St. Louis, MO
  • Ph.D. Molecular and Cellular Structure and Chemistry (1999) The Scripps Research Institute, La Jolla, CA
 
Primary Department
   Department of Chemistry
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Department Affiliations
 
  • Department of Bioengineering
  • Institute of Biosciences and Bioengineering
  • Rice Quantum Institute
  • Smalley Institute for Nanoscale Science and Technology
  •  
    Websites
     Hartgerink Group Web Page
     Hartgerink Research Group
     
    Research Areas
     Supramolecular Chemistry, Peptide Structure, Collagen and Biomaterials
     
    Research Statement
      Supramolecular chemistry is an emerging sub-discipline of chemistry that primarily concerns itself with non-covalent intermolecular interactions. These relatively weak forces are used in large number to create nanometer sized objects in a massively parallel fashion. The inspiration for this area of research comes primarily from advances in our understanding of biological systems and the miraculous structures found therein. Great strides have been made to mimic both the structures found in biological systems and the approaches that biology uses to create these structures. Although many of these advances are truly remarkable, and many may find practical application in the future, a situation has arisen where we are able to produce materials which have no easy method of manipulation or organization into higher order structures. It is analogous to being able to produce a wheel and an axle and having no way to connect them to one another, let alone to a cart. Alternatively one could compare this stage of supramolecular chemistry to traditional organic synthesis of a century ago when the number of chemical transformation and protecting groups were severely limited. In order to bring supramolecular chemistry to a new level of sophistication methods by which two or more supramolecular objects can be coupled or organized must be developed.

    My research is directed at solving this problem by employing a second step of self-assembly, covalent capture and / or mineralization to create complex and functional assemblies. Three projects are starting in my lab which address this. The first uses the self-assembly of ?coiled-coils? (a pair of alpha-helical peptides wound around one another) as a framework for the secondary self-assembly of a conductive organic matrix to form wires with nanometer dimensions. These wires, unlike most other approaches to nanoscale electronics, may be able to organize themselves in neural networks that can readily interface with traditional electronics. The second project is geared toward the synthesis of an artificial extracellular matrix (ECM) for use as a drug and cell delivery vehicle and tissue regeneration therapies. This biomimetic material will be prepared through two steps of self-assembly followed by covalent capture. The third project targets the synthesis of novel catalysts and magnetic materials. The preparation of these materials uses the mechanisms involved in biomineralization that allow biology to create an amazing diversity of inorganic and composite materials such as shells, teeth and bone.
     
    Hartgerink Research in Supramolecular Chemistry
      Research in my laboratory is focused on supramolecular chemistry - the interplay of groups of molecules through weak, non-covalent interactions such as electrostatics, hydrogen bonding, the hydrophobic effect and π-π stacking. Specifically we are interested in how these forces can be used to construct nanostructured organic materials through self-assembly.
    In the past century synthetic organic chemistry has developed into an extremely precise science in which nearly any molecule can be crafted with atomic precision. However, these traditional methods are limited to relatively small molecules with sizes generally below two nanometers. If one wants to produce molecules above this threshold there is no clear path to produce them because of the diminishing total yield on a long series of reactions. However, nature has shown us one method of producing such materials through the self-assembly of smaller, relatively easily prepared, subunits into large complex arrays. This type of synthesis can be seen in virtually every biological system including the assembly of lipids into the cell membrane, the assembly of proteins into viruses such as the beautiful cylindrical motif of the tobacco mosaic virus, the ubiquitous assembly of two complementary strands of DNA into a double helix, as well as the assembly of actin filaments, collagen fibers and microtubules. The synthesis of molecules and materials in this difficult size regime, from two nanometers to hundreds of nanometers, promises to have an enormous impact on drug delivery, tissue engineering, regenerative medicine, and cancer therapy as this is the size scale of the cellular machinery. Being able to intimately understand and interact with these structures will likely require making ones of similar scale. At the same time materials of this size scale, which are far smaller that those that are able to be produced by standard lithographic methods, are highly desirable for the miniaturization of machines and electronics in the growing area of nanotechnology.
    To address these challenges and opportunities my laboratory is focused on preparing a variety of nanostructured organic materials using self-assembly. The projects can be divided into three groups, although there is overlap between each of the three areas. The first project utilizes the well known coiled-coil motif, which is found in a large number of natural proteins, to control the self-assembly of a number of important nanostructured materials. We would like to be able to self-assemble short alpha-helices into much longer coiled-coils and yet maintain control over the length of this supramolecular polymerization. Although many groups have been working with one-dimensional self-assembled materials an important objective of controlling the length of these materials has not yet been achieved and we feel that our system will be able to solve this problem by using a molecular vernier approach. Also, utilizing coiled-coil systems we are attempting to mimic a variety of important fibrous proteins such as the intermediate filaments (laminin, karatin, etc.) and myosin II. The second project is to prepare mimics of extracellular matrix proteins and to use these synthetic materials as novel biomimetic scaffolds for tissue engineering and regeneration. The first molecules we have targeted for synthesis are collagen and elastin. They will be prepared by a combination of self-assembly and covalent capture. Both molecules are critical for the structural organization and mechanical properties of tissues and we believe that synthetic versions of these materials will be extremely valuable to the advancement of tissue engineering. Finally, the third project utilizes nanostructured organic scaffolds prepared by self-assembly (for example the collagen fibers described above) as a template for biomimetic mineralization to prepare composite organic-inorganic materials for applications ranging from hard tissue (bone and teeth) engineering to novel catalysts, and optical, electronic and magnetic materials.
     
    Teaching Areas
     Supramolecular Chemistry, Organic Chemistry
     
    Selected Publications
     Refereed articles
     

    A. M. Acevedo-Jake, A. A. Jalan, J. D. Hartgerink “Comparative NMR Analysis of Collagen Triple Helix Organization from N- to C-Termini” Biomacromolecules, 2015, 16, 145-155. DOI: dx.doi.org/10.1021/bm501281a.

     
     

    A. Moore, R. N. D'Souza, J. D. Hartgerink, J. Colombo "Ex Vivo Modeling of Multidomain Peptide Hydrogels with Intact Dental Pulp" J. Dental Res. 2015, 0022034515600380. DOI: 10.1177/0022034515600380.

     
     

    N. C. Wickremasinghe, V. A. Kumar, S. Shi, and J. D. Hartgerink "Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels" ACS Biomaterials Sci. Eng. 2015, 1, 845-854. DOI: 10.1021/acsbiomaterials.5b00210.

     
     

    V. A. Kumar, N. C. Wickremasinghe, S. Shi, and J. D. Hartgerink “Nanofibrous Snake Venom Hemostat” ACS Biomaterials Sci. Eng. 2015, 1, 1300-1305. DOI: 10.1021/acsbiomaterials.5b00356.

     
     

    V. A. Kumar, N. L. Taylor, S. Shi, B. K. Wang, A. A. Jalan, M. K. Kang, N. C. Wickremasinghe, J. D. Hartgerink “Highly Angiogenic Peptide Nanofibers” ACS Nano, 2015, 9, 860-868. DOI: 10.1021/nn506544b.

     
     

    V. A. Kumar, N. L. Taylor, S. Shi, N. C. Wickremasinghe, R. N. D'Souza and J. D. Hartgerink "Self-assembling multidomain peptides tailor biological responses through biphasic release" Biomaterials 2015, 52, 71-78.

     
     

    V. A. Kumar, S. Shi, B. K. Wang, I. Li, A. A. Jalan, B. Sarkar, N. C. Wikremasinghe and J. D. Hartgerink, "Drug-Triggered and Cross-Linked Self-Assembling Nanofibrous Hydrogels" J. Am. Chem. Soc. 2015, 137 4823-4830. DOI: 10.1021/jacs.5b01549.

     
     

    A. A. Jalan, K. A. Jochim, J. D. Hartgerink “Rational Design of a Non-canonical “Sticky-ended”  ABC-Collagen Triple Helix” J. Am. Chem. Soc., 2014, 136, 7535-7538. DOI: dx.doi.org/10.1021/ja5001246.

     
     

    Amanda M. Acevedo-Jake, Abhishek A. Jalan, and Jeffrey D. Hartgerink “Comparative NMR Analysis of Collagen Triple Helix Organization from N- to C-Termini” Biomacromolecules, 2014 available online. DOI: dx.doi.org/10.1021/bm501281a.

     
     

    B. Sarkar, L. E. R. O’Leary, J. D. Hartgerink “Self-Assembly of Fiber-Forming Collagen Mimetic Peptides Controlled by Triple-Helical Nucleation” J. Am. Chem. Soc., 2014, 136, 14417-14424. DOI: dx.doi.org/10.1021/ja504377s.

     
     

    J. S. Colombo, A. N. Moore, J. D. Hartgerink, R. N. D’Souza “Scaffolds to Control Inflammation and Facilitate Dental Pulp Regeneration” J. Endodontics, 2014, 40, S6-S12. DOI: dx.doi.org/10.1016/j.joen.2014.01.019.

     
     

    M. K. Kang, J. Colombo, R.N. D'Souza, J. D. Hartgerink “Sequence effects of self-assembling MultiDomain Peptide Hydrogels on encapsulated SHED cells” Biomacromolecules, 2014, 15, 2004-2011. DOI:dx.doi.org/10.1021/bm500075r.

     
     

    N. C. Wickremasinghe, V. A. Kumar, J. D. Hartgerink “Two-Step Self-Assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release” Biomacromolecules, 2014 15, 3587-3595. DOI: dx.doi.org/10.1021/bm500856c.

     
     

    V. A. Kumar, N. L. Taylor, A. A. Jalan, L. K. Hwang, B. K. Wang, Jeffery D. Hartgerink “A Novel Synthetic Collagen Mimic for Hemostasis” Biomacromolecules 2014, 15, 1484−1490. DOI: dx.doi.org/10.1021/bm500091e.

     
     

    A. A. Jalan, B. Demeler, J. D. Hartgerink "Hydroxyproline-Free Single Composition ABC Collagen." J. Am. Chem. Soc., 135 (2013) : 6014-6017.

     
     

    A. A. Jalan, J. D. Hartgerink "Pairwise interactions in collagen and the design of heterotrimeric helices." Curr. Opin. Chem. Biol., 17 (2013) : 960-967.

     
     

    A. A. Jalan, J. D. Hartgerink "Simultaneous Control of Composition and Register of an AAB-Type Collagen Heterotrimer." Biomacromolecules, 14 (2013) : 179-185.

     
     

    E. L. Bakota, O. Sensoy, B. Ozgur, M. Sayar, J. D. Hartgerink "Self-Assembling Multidomain Peptide Fibers with Aromatic Cores." Biomacromolecules, 14 (2013) : 1370-1378.

     
     

    F. Wei, J. A. Fallas, J. D. Hartgerink "Sequence Position and Side Chain Length Dependence of Charge Pair Interactions in Collagen Triple Helices." Macromol. Rapid Commun., 33 (2012) : 1445-1452.

     
     

    J. A. Fallas and J. D. Hartgerink "Computational design of self-assembling register-specific collagen heterotrimers." Nat. Commun., 3 (2012) : 1087.

     
     

    J. A. Fallas, J. Dong, Y. J. Tao, and J. D. Hartgerink "Structural Insights into Charge Pair Interactions in Triple Helical Collagen-like Proteins." J. Biol. Chem., 287 (2012) : 8039-8047.

     
     

    J. A. Fallas, M. A. Lee, A. A. Jalan, and J. D. Hartgerink "Rational Design of Single-Composition ABC Collagen Heterotrimers." J. Am. Chem. Soc., 134 (2012) : 1430-1433.

     
     

    K. M. Galler, J. D. Hartgerink, A. C. Cavender, G. Schmalz, and R. N. D'Souza "A Customized Self-Assembling Peptide Hydrogel for Dental Pulp Engineeering." Tissue Eng. Part A, 18 (2012) : 176-184.

     
     

    E. L. Bakota, L. Aulisa, K. M. Galler and J. D. Hartgerink "Enzymatic Cross-Linking of a Nanofibrous Peptide Hydrogel." Biomacromolecules, 12 (2011) : 82-87.

     
     

    E. L. Bakota, Y. Wang, F. R. Danesh and J. D. Hartgerink "Injectable Multidomain Peptide Nanofiber Hydrogel as a Delivery Agent for Stem Cell Secretome." Biomacromolecules, 12 (2011) : 1651-1657.

     
     

    K. M. Galler, R. N. D'Souza, J. D. Hartgerink, and G. Schmalz "Scaffolds for Dental Pulp Tissue Engineering." Adv. Dent. Res., 23 (2011) : 333-339.

     
     

    L. E. R. O'Leary, J A. Fallas, E. L. Bakota, M. K. Kang and J. D. Hartgerink "Multi-hierarchical self-assembly of a collagen mimetic peptide fro triple helix to nanofiber and hydrogel." Nat. Chem., 3 (2011) : 821-828.

     
     

    L. E. R. O'Leary, J. A. Fallas and J. D. Hartgerink "Positive and Negative Design Leads to Compositional Control in AAB Collagen Heterotrimers." J. Am. Chem. Soc., 133 (2011) : 5432-5443.

     
     

    W. C. Pomerantz, V. M. Yuwono, R. Drake, J. D. Hartgerink, N. L. Abbott and S. H. Gellman "Lyotropic Liquid Crystals Formed from ACHC-Rich β-Peptides." J. Am. Chem. Soc., 133 (2011) : 13604-13613.

     
     

    Y. Wang, E. Bakota, B. H. J. Chang, M. Entman, J. D. Hartgerink, and F. R. Danesh "Peptide Nanofibers Preconditioned with Stem Cell Secretome Are Renoprotective." J. Am. Soc. Nephrology, 22 (2011) : 704-717.

     
     

    J. A. Fallas, L. E. R. O'Leary and J. D. Hartgerink "Synthetic collagen mimics: self-assembly of homotrimers, heterotrimers and higher order structures." Chem. Soc. Rev., 39 (2010) : 3510-3527.

     
     

    K. M. Galler, L. Aulisa, K. R. Regan, R. N. D'Souza and J. D. Hartgerink "Self-assembling Multidomain Peptide Hydrogels: Designed Susceptibility to Enzymatic Cleavage Allows Enhanced Cell Migration and Spreading." J. Am. Chem. Soc., 132 (2010) : 3217-3223.In Press

     
     

    K. M. Galler, R. N. D'Souza and J. D. Hartgerink "Biomaterials and their Potential Applications for Dental Tissue Engineering." J. Mater. Chem., 20 (2010) : 8730-8746.

     
     

    L. E. Russell, J. A. Fallas and J. D. Hartgerink "Selective Assembly of a High Stability AAB Collagen Heterotrimer." J. Am. Chem. Soc., 132 (2010) : 3242-3243.

     
     

    D. Zhang, O. Neumann, H. Wang, V. M. Yuwono, A. Barhoumi, M. Perham, J. D. Hartgerink, P. Wittung-Stafshede and N. J. Halas "Gold Nanoparticles Can Induce the Formation of Protein-based Aggregates at Physiological pH" Nano Lett., 9 (2009) : 666-671.

     
     

    E. L. Bakota, L. Aulisa, D. A. Tsyboulski, R. B. Weisman and J. D. Hartgerink "Multidomain Peptides as Single-Walled Carbon Nanotube Surfactants in Cell Culture." Biomacromolecules, 10 (2010) : 2201-2206.

     
     

    J. A. Fallas, V. Gauba and J. D. Hartgerink "Solution structure of an ABC collagen heterotrimer reveals a single-register helix stabilized by electrostatic interactions" J. Biol. Chem., 284 (2009) : 26851-26859.

     
     

    L. Aulisa, H. Dong and J. D. Hartgerink "Self-Assembly of Multidomain Peptides: Sequence Variation Allows Control over Cross-Linking and Viscoelasticity" Biomacromolecules, 10 (2009) : 2694-2698.

     
     

    L. Aulisa, N. Forraz, C. McGuckin, J. D. Hartgerink "Inhibition of Cancer Cell Proliferation by Designed Peptide-Amphiphiles." Acta Biomater., 5 (2009) : 842-853.

     
     

    C. L. Pizzey, W. C. Pomerantz, B.-J. Sung, V. M. Yuwono, S. H. Gellman, J. D. Hartgerink, A. Yethiraj, N. L. Abbott "Characterization of nanofibers formed by self-assembly of beta-peptide oligomers using small angle x-ray scattering." J. Chem. Phys., 129 (2008) : 095103.

     
     

    D. Tsyboulski, E. Bakota, L. Witus, J-D. Rocha, J. D. Hartgerink, R. B. Weisman "Self-Assembling Peptide Coatings Designed for Highly Luminescent Suspensions of Single-Walled Carbon Nanotubes." J. Am. Chem. Soc., 130 (2008) : 17134-17140.

     
     

    F. Wei, D. Zhang, N. J. Halas and J. D. Hartgerink "Aromatic amino acids provide characteristic motifs in the Raman and SERS spectroscopy of Peptides." J. Phys. Chem. B, 113 (2008) : 9158-9164.

     
     

    H-W. Jun, S. E. Paramonov, H. Dong, N. Forraz, C. McGuckin, and J. D. Hartgerink "Tuning the mechanical and bioresponsive properties of peptide-amphiphile nanofiber networks." J. Biomater. Sci. Polymer Edn., 19 (2008) : 665-676.

     
     

    H. Dong, S. E. Paramonov and J. D. Hartgerink "Self-assembly of alpha-helica coiled-coil nanofibers." J. Am. Chem. Soc., 130 (2008) : 13691-13695.

     
     

    K. M. Galler, A. Cavender, V. Yuwono, H. Dong, S. Shi, G. Schmalz, J. D. Hartgerink and R. N. D'Souza "Self-Assembling Peptide Amphiphile Nanofibers as a Scaffold for Dental Stem Cells." Tissue Eng., 14 (2008) : 2051-2058 .

     
     

    V. Gauba and J. D. Hartgerink "Synthetic Collagen Heterotrimers: Structural Mimics of Wild Type and Mutant Collagen Type I." J. Am. Chem. Soc., 130 (2008) : 7509-7515.

     
     

    W. C. Pomerantz, V. M. Yuwono, C. L. Pizzey, J. D. Hartgerink, N. L. Abbott, S. H. Gellman "Nanofibers and Lyotropic Liquid Crystals from a Class of Self-Assembling Beta-Peptides." Angew. Chem. Int. Ed., 47 (2008) : 1241-1244.

     
     

    H. Dong and J. D. Hartgerink "The role of hydrophobic clusters in the stability of alpha-helical coiled coils and their conversion to amyloid-like beta-sheets." Biomacromolecules, 8 (2007) : 617-623.

     
     

    H. Dong, S. E. Paramonov, L. Aulisa, E. L. Bakota and J. D. Hartgerink "Self-assembly of Multi-domain Peptides: Balancing Molecular Frustration Controls Conformation and Nanostructure." J. Am. Chem. Soc., 129 (2007) : 12468-12472.

     
     

    J. Yang, L. B. Alemany, J. Driver, J. D. Hartgerink, A. R. Barron "Fullerene-derivatized amino acids: Synthesis, characterization, antioxidant properties, and solid-phase peptide synthesis." Chem. Eur. J., 13 (2007) : 2530-2545.

     
     

    L. S. Witus, J-D. R. Rocha, V. M. Yuwono, S. E. Paramonov, R. B. Weisman, J. D. Hartgerink "Peptides that noncovalently functionalize single-walled carbon nanotubes to give controlled solubility characteristics." J. Mater. Chem., 17 (2007) : 1909-1915.

     
     

    M. B. Murphy, J. D. Hartgerink, A. Goepferich, and A. G. Mikos "Synthesis and In Vitro Hydroxyapatite Binding of Peptides Conjugated to Calcium-Binding Moieties." Biomacromolecules, 8 (2007) : 2237-2243.

     
     

    V. Gauba and J. D. Hartgerink "Self-Assembled heterotrimeric collagen triple helices directed through electrostatic interactions." J. Am. Chem. Soc., 129 (2007) : 2683-2690.

     
     

    V. Gauba and J. D. Hartgerink "Surprisingly High Stability of Collagen ABC Heterotrimer: Evaluation of Side Chain Charge Pairs." J. Am. Chem. Soc., 10 (2007)

     
     

    V. M. Yuwono and J. D. Hartgerink "Peptide amphiphile nanofibers template and catalyze silica nanotube formation." Langmuir, 23 (2007) : 5003-5038.

     
     

    C. S. Levin, B. G. Janesko, R. Bardhan, G. E. Scuseria, J. D. Hartgerink, and N. J. Halas "Chain-Length-Dependent Vibrational Resonances in Alkanethiol Self-Assembled Monolayers Observed on Plasmonic Nanoparticle Substrates." Nanoletters 6, 11 (2006) : 2617-2621.

     
     

    H-W Jun, S. E. Paramonov, J. D. Hartgerink "Biomimetic Self-assembled Nanofibers." Soft Matter, 2 (2006) : 177-181.

     
     

    H. Dong and J. D. Hartgerink "The role of hydrophobic clusters in the stability of a-helical coiled coils and their conversion to amyloid-like b-sheets." BiomacromoleculesIn Press

     
     

    H. Dong, J. D. Hartgerink "Short Homodimeric and Heterodimeric Coiled Coils." Biomacromolecules, 7 (2006) : 691-695.

     
     

    M. J. Pender, L. A. Sowards, J. D. Hartgerink, M. O. Stone, R. R. Naik "Peptide-Mediated Formation of Single-Wall Carbon Nanotube Composites." Nanoletters 6, 1 (2006) : 40-44.

     
     

    S. E. Paramonov, H-W. Jun, J. D. Hartgerink "Modulation of Peptide-Amphiphile Nanofibers via Phospholipid Incusions." Biomacromolecules, 7 (2006) : 24-26.

     
     

    S. E. Paramonov, H-W. Jun, J. D. Hartgerink "Self-assembly of peptide-amphiphile nanofibers: the roles of hydrogen bonding and amphiphilic packing." J. Am. Chem. Soc., 128 (2006) : 7219-7298.

     
     

    H-W Jun, V. Yuwono, S. E. Paramonov, J. D. Hartgerink "Enzyme Mediated Degradation of Peptide-Amphiphile Nanofiber Networks." Adv. Mater., 17 (2005) : 2612-2617.

     
     

    S. E. Paramonov, V. Gauba, J. D. Hartgerink "Synthesis of Collagen-like Peptide Polymers via Native Chemical Ligation." Macromol, 38 (2005) : 7555-7561.

     
     

    K. L. Niece, J. D. Hartgerink, J. J. J> M. Donners and S. I. Stupp "Self-assembly Combining Two Bioactive Peptide-amphiphile Molecules into Nanofibers by Electrostatic Attraction." J. Am. Chem. Soc., 125,24 (2003) : 7146-7147.

     
     Articles
     

    J. D. Hartgerink "Covalent Capture: A Natural Complement to Self-Assembly." Curr. Opin. Chem. Biol., 8(6) (2004) : 604-609.

     
     

    S. I. Stupp, E. Beniash, J. D. Hartgerink and E. D. Sone "Self-assembling and Biomimetic Biomaterials." Bio-Implant Interface (2003) : 393-406.

     
     Book chapters
     

    V. Gauba and J. D. Hartgerink "Recent Advances in Supramolecular Polymers." Physical Properties of Polymers Handbook, 2nd Ed (2007) : 715-722.

     
     

    S. E. Paramonov, J. D. Hartgerink "The Structure of Collagen and Nanostructured Collagen Mimics in Tissue Engineering." Nanofabrication Towards Biomedical Applications (2005)

     
     Other
     

    H.-A. Klok, J. J. Hwang, Hartgerink, J. D., and S. I. Stupp "Self Assembling Biomaterials: L-Lysine Dendron substituted Cholesteryl-(L-lactic acid)n." Macromolecules, 35 (2002) : 6101-6111.

     
     

    Hartgerink, J. D., E. Beniash, S. I. Stupp "Peptide-Amphiphile Nanofibers: A versatile scaffold for the preparation of self-assembling materials.." PNAS, 99 (2002) : 5133-5138.

     
     

    J. D. Hartgerink, E. Beniash, and S. I. Stupp "Self-Assembly and Mineralization of Peptide Amphiphile Nanofibers." Science, 294 (2001) : 1685-1688.

     
     

    J. D. Hartgerink, E. R. Zubarev, and S. I. Stupp "Supramolecular One Dimensional Objects." Cur. Op. Solid State Mat. Sci., 5 (2001) : 355-361.

     
     

    H. S. Kim, J. D. Hartgerink and M. R. Ghadiri "Oriented Self-Assembly of Cyclic Peptide Nanotubes." JACS, 120 (1998) : 4417-4424.

     
     

    J. D. Hartgerink, T. D. Clark and M. R. Ghadiri "Peptide Nanotubes and Beyond." Chem. Eur. J., 4 (1998) : 1367-1372.

     
     

    J. D. Hartgerink, J. R. Granja, R. A. Milligan and M. R. Ghadiri "Self-Assembling Peptide Nanotubes." JACS, 118 (1996) : 43-50.

     
     

    P. Kast, J. D. Hartgerink, M. Asif-Ullah and D. Hilvert "Electrostatic Catalysis of the Claisen Rearrangement: Probing the Role of Glu78 in Bacillus subtilis Chorismate Mutase by Genetic Selection." JACS, 118 (1996) : 181-188.

     
    Presentations
     Invited Talks
     

    Gordon Research Conference on Protein Folding and Dynamics, January 2016, talk entitled, “Design Criteria for Collagen-like Triple Helices”.

     
     

    23rd annual short course on Advances in Tissue Engineering, Rice University, August 2015, talk entitled, “Self-assembled Multidomain Peptides for Cell and Protein Delivery”.

     
     

    "Axial Charge Pair Interactions Control Collagen Triple Helix Composition, Register and Higher Order Assembly." 6th Alpbach Workshop on Coiled-Coils, Collagen & Fibrous Proteins, Alpbach, Austria. (September, 2013)

     
     

    "Design and Self-Assembly of Collagen-Like Triple Helices and Nanofibrous Hydrogels." Gordon Research Conference on Self-Assembly and Supramolecular Chemistry, Les Diablerets, Switzerland. (May, 2013)

     
     

    "Design and Self-assembly of Collagen-like Triple Helices and Nano-fibrous Hydrogels." Gordon Research Conference on Collagen, New London, New Hampshire. (July, 2013)

     
     

    "Self-assembled Multidomain Peptides for Cell and Protein Delivery." Advances in Tissue Engineering Short Course , Rice University, Houston, Texas. (August, 2013)

     
     

    "Self-assembly of Collagen Triple Helices and Beta-Sheet Nanofibers." 37th Annual Macro Symposium, University of Michigan, Ann Arbor, Michigan. (October, 2013)

     
     

    "Self-assembly of Collagen Triple Helices and Beta-Sheet Nanofibers." Department of Chemistry, University of Utah, Salt Lake City, Utah. (November, 2013)

     
     

    "Collagen Triple Helices and Beta-Sheet Nanofibers." NanoPeptide 2012, Manchester, United Kingdom. (November, 2012)

     
     

    "Design and Self-assembly of Collagen Triple Helices, Nanofibers and Hydrogels." Department of Chemistry, Hope College, Holland, Michigan. (September, 2012)

     
     

    "Design and Self-assembly of Collagen Triple Helices, Nanofibers and Hydrogels." Materials Research Society Fall Meeting, Boston, Massachusetts. (November, 2012)

     
     

    "Design and Self-assembly of Collagen Triple Helices, Nanofibers and Hydrogels." Department of Chemistry, Calvin College, Grand Rapids, Michigan. (September, 2012)

     
     

    "Designed charged pair interactions control multi-hierarchical self-assembly of collagen mimetic peptides." 13th Dresden Polymer Discussion "Molecular Bioengineering Meets Polymer Science", Dresden, Germany. (April 2, 2012)

     
     

    "Multi-hierarchial assembly of collagen: from peptides to triple helices to nanofibers to hydrogels." Institute for BioNanotechnology in Medicine, Northwestern University, Evanston, Illinois. (November, 2011)

     
     

    "Multi-hierarchial self-assembly of a collagen mimetic: from peptide to triple helix to nanofiber and hydrogel." 67th Southwest Regional Meeting of the American Chemical Society, Austin, Texas. (November 9-11, 2011)

     
     

    "Self-assembly and structure of collagen AAB and ABC heterotrimers." Department of Chemistry, Stony Brook University, Stony Brook, New York. (April, 2011)

     
     

    "Self-assembling Multidomain Peptide Nanofibers: Applications in Cell Scaffolding and Drug Delivery." Alliance for Nanohealth Investigators 2010 Meeting, Houston, Texas. (February 23, 2010)

     
     

    "Self-assembling multidomain peptide nanofibers: Applications in cell scaffolding and drug delivery." Pacifichem 2010 International Chemical Congress of Pacific Basin Societies, (December 15-20, 2010)

     
     

    "Self-assembling multidomain peptide nanofibers: Applications in cell scaffolding and drug delivery." 239th National Meeting of the American Chemical Society, San Francisco, California. (March 21-25, 2010)

     
     

    "Self-assembly and Structure of Collagen AAB and ABC Heterotrimers." Department of Chemistry, Purdue University, West Lafayette, Indiana. (September 21, 2010)

     
     

    "Self-assembly of Multidomain Peptides into Nanofibrous Hydrogels for Cell Delivery." 2010 American Chemical Society Southwest Regional Meeting, New Orleans, Louisiana. (December 3, 2010)

     
     

    speaker.  "ABC nanofibers." Materials Research Society National Meeting, San Francisco, CA. (April 2007)

     
     

    speaker.  "Design & Synthesis of Collagen Triple Helices." Dept. of Chemistry Northwestern Univ., Evanston, IL. (September 2007)

     
     

    Speaker.  "Design & Synthesis of Collagen Triple Helices." Dept. of Chemistry, U. Chicago, Chicago, IL. (October 2007)

     
     

    speaker.  "Gelating nanofibers for tissue engineering." Materials Research Society National Meeting, Boston, MA. (November 2007)

     
     

    Speaker.  "Multi-domain peptides - orthogonal control over nanofiber assembly." ACS National Meeting, Chicago, IL. (March 2007)

     
     

    speaker.  "Peptide Self-Assembly: Collagen Triple Helices and Beta-Sheet Nanofibers." Dept. of Chemistry Missouri State Univ., Missouri. (October 2007)

     
     

    Speaker.  "Peptide Self-Assembly: Collagen Triple Helices and Beta-Sheet Nanofibers." Dept. of Chemistry, U.C. Irvine, Irvine, CA. (December 2007)

     
     

    Speaker.  "Peptide Self-Assembly: Collagen Triple Helices and Beta-Sheet Nanofibers." Dept. of Chemistry, U.C. Los Angeles, Los Angeles, CA. (December 2007)

     
     

    speaker.  "Peptide Self-Assembly: Collagen Triple Helices and Beta-Sheet Nanofibers." Dept of Chemistry, Trinity Univ., San Antonio, TX. (October 2007)

     
     

    speaker.  "Self-assembled Nanofibers - Towards the Tissue Engineering of Teeth." Gordon Research Conference on Tissue Repair and Regeneration, New London, NH. (June 2007)

     
     

    speaker.  "Self-assembly of A-B-C nanofibers and their applications." ACS National Meeting, Boston MA. (August 2007)

     
     

    speaker.  "Surprising Stability of Collagen Heterotrimers." Dept. of Chemistry, U. Wisconsin, Madison, WS. (Septmeber 2007)

     
     

    speaker.  "Synthesis and Stability of Collagen Heterotrimers." IBB Symposium, Houston, TX. (July 2007)

     
     Advances in Tissue Engineering-2006 Conference
     
     

    Presenter.  "Self-assembled alpha-helical Nanofibers." ACS Southwest Regional Meeting, Houston TX. (October 2006)

     
     Nanocomposit Education for Students and Teachers (NEST)
     
     

    speaker.  "Chemistry of supramolecules and assemblies." Gordon Research Conference, Waterville, ME. (June 2005)

     
     

    Speaker.  "Nanostructured Biomaterials through Self-assembly." US-Japan NSF Exchange Program on Nano-Biotechnology, Northwestern University, Evanston, IL. (March 8, 2005)

     
     

    Speaker.  "Nanostructured Biomaterials through Self-assembly." US-Japan NSF Exchange Program on Nano-Biotechnology, Tokyo and Osaka Japan. (12/8-14/2005)

     
     

    Speaker.  "Peptide Based Approaches to Anticancer Drugs and Tissue Engineering Scaffolds." Texas-United Kingdom Collaborative Research Initiative, Texas Medical Center, Houston, TX. (February 28,2005)

     
     

    Speaker.  "Supramolecular Chemistry: Building Big and Small." Rice University Alumni College, Houston, TX. (February 26, 2005)

     
     

    Speaker.  "pH-Controlled self-assembly of alpha-helical nanofibers." ACS National Meeting, San Diego, CA. (March 16, 2005) With He Dong

     
     

    Speaker.  "Rationally Designed Nanostructured Materials Through Self-Assembly." Engineering and Regenerative Medicine Workshop, London, England. (March 29-30, 2004)

     
     

    Speaker.  "Synthetic Approaches to Extracellular Matrix Mimics." Texas A&M Center for Extracellular Matrix Biology, College Station, TX. (October 20, 2004)

     
     

    Speaker.  "Synthetic Approaches to Nanomaterials from Biomolecules." Dept. of Chemistry, Univ. of New Orleans, New Orleans, LA. (November 5, 2004)

     
     

    Speaker.  "Synthetic Approaches to Nanomaterials from Biomolecules." Nanotechnology in Biology, Biotechnology and Medicine, 5th CAMD Summer Workshop, Louisiana State Univ. , Baton Rouge LA. (May 31-June 4, 2004)

     
     

    Speaker.  "Synthetic Approaches to Nanomaterials from Biomolecules." University of Texas, SPRING2 2004, Austin, TX. (November 22, 2004)

     
     

    speaker.  "Biomimitic Scaffolds for Tissue Engineering." Advances in Tissue Engineering-2003, Houston, TX. (August 2003)

     
     

    "Peptide-amphiphile nanofibers as a novel scaffold for tissue engineering." 20th Annual Houston Conference on Biomedical Engineering Research, Houston, TX. (April 2003)

     
     

    "Preparation of Nanostructured Materials through Self-assembly." 2003 Nano Summit, Houston, TX. (July 2003)

     
     Keynote Speaker
     

    "Collagen triple helices and beta-sheet nanofibers." Undergraduate Research Symposium, Rice University, Houston, Texas. (October, 2011)

     
     Other
     

    "Design and testing of a heterotrimeric collagen presenting an integrin binding site." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April, 2013) With A. Anan

     
     

    "Enhancing the properties of nanofibrous multidomain peptide hydrogels through amino acid modification." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April, 2013) With M. Kang

     
     

    "Fibrilogenesis of collagen mimetic peptides." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April, 2013) With L. O'Leary, B. Sarkar

     
     

    "Self-assembled multidomain peptide hydrogels for cell and protein delivery." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April, 2013)

     
     

    "Self-assembly of collagen-like biomimetic fibers: Designed sticky-ends through complementary charge pairs." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April, 2013) With B. Sarkar

     
     

    "Unraveling pairwise amino acid interactions in the collagen triple helex." 245th National Meeting of the American Chemical Society, New Orleans, Louisiana. (April, 2013)

     
     

    Contributed Talk.  "Self-assembly and structure of collagen-like AAB and ABC heterotrimers." 239th National Meeting of the American Chemical Society, San Francisco, California. (March 21-25, 2010)

     
     Lockheet Martin/Rice University Short Course on Nanotechnology
     
     Lockheed Martin / Rice University Short Course on Nanotechnology
     
     

    "pH Controlled Self-Assembly and Reversible Covalent Capture of Peptide-Amphiphile Nanofibers." Materials Research Society, Boston, MA. (November 2001)

     
     Panelist
     

    "Rice CAREER Award Workshop." (2012)

     
     

    "National Science Foundation Biomaterials Review Panel." Arlington, Virginia. (February, 2010)

     
     Posters
     

    "Design of Register Specific ABC Type Collagen Mimetic Heterotrimers." Gordon Research Conference on Collagen, New London, New Hampshire. (July, 2011) With J. Fallas

     
     

    "Hierachial Self-Assembly of Designed Synthetic Collagen Triple Helices into Organized Nanofiber Hydrogels." Gordon Research Conference on Collagen, New London, New Hampshire. (July, 2011) With L. R. O'Leary

     
     

    Presenter.  "Self-Assembly of Peptides into Controlled Length Super Helices." Materials Research Society, (12/1/03) With William C. Meddaugh, Sergey Paramonov and Jeffrey D. Hartgerink

     
     

    Presenter.  "Steps toward ex-vivo collagen synthesis." Materials Research Society, (12/1/03) With Sergey Paramonov, Jeffrey Hartgerink

     
     

    "Toward Controlled Length 1-Dimensional Self-assembling Systems." Gordon Research Conference Polymers (East), South Hadley, MA. (June 2003)

     
     Seminar Speaker
     

    speaker.  "Self-assembly of nanostructured fibers for tissue regeneration." Hope College Departmental Seminar, Holland, MI. (March 2007)

     
     

    Speaker.  "Self-assembly of peptides and peptide derivatives into nanofibrous scaffolds." Emory University, Chemistry Dept., Atlanta, GA. (September 2006)

     
     Session Chair
     

    "Biologically Related Molecules & Processes." 239th National Meeting of the American Chemical Society, San Francisco, California. (March, 2010)

     
     

    "Synthesis and Self-Assembly Approaches to Nanostructured Materials." 239th National Meeting of the American Chemical Society, San Francisco, California. (March, 2010)

     
    Editorial Positions
     Member of the Editorial Board, Biomacromolecules. (2015 - 2015)

     Other, Biomacromolecules. (2010 - 2014)

     Member of the Editorial Board, Biomacromolecules. (2010 - 2010)

     Member of the Editorial Board, Biomacromolecules. (2012 - 2012)

    Supervised Theses & Dissertations
     Cristin Erin Moran, Ph. D. Fabrication of Optically Active Nanostructers by Chemical Methods. (2003) (Thesis Committee Member)

     Huahua Jain, Ph. D. Synthetic Approaches to Molecular Motors and Conjugated Oligomer Libraries. (2004) (Thesis Committee Member)

     Francisco Maya, Ph. D. Synthesis and Analysis at the Chemical Interface of Novel Oligomers as Candidates for Molecular Electronics. (2004) (Thesis Committee Member)

     Corey Wilson, Ph.D. Experimental and Theoretical Approaches to Protein Folding, Stability, and Assembly. A Thorough Assessment of Complex Behavior. (2005) (Thesis Committee Member)

     Sergery E. Paramonov, Ph. D. Self-assembling Biomimetic Materials. (2006) (Thesis Director)

     He Dong, Ph.D. Self-Assembly of Alpha-Helical and Beta-Sheet Nanofibers. (2008) (Thesis Director)

     Varun Gauba, Ph.D. Design, Self-Assembly and Applications of Heterotrimeric Collagen Mimics. (2009) (Thesis Director)

     Carly S. Levin, Ph.D. Influence of Varying Analyte Concentration, Environment, and Composition on Nanoshell-based SERS. (2009) (Thesis Committee Member)

     Abhishek Anan Jalan, Ph.D. Design of Heterotrimeric Collagen Triple Helices. (2014) (Thesis Director)

     Biplab Sarkar, Ph.D. Nanofiber Formation by Collagen Mimetic Peptides: Elucidation of Supramolecular Principles and Application of Retrosynthetic Analysis. (2015) (Thesis Director)

     Marci Kang, Ph.D. Self-Assembling MultiDomain Peptides as Scaffolds for Tissue Engineering. (2015) (Thesis Director)

     Lesley R O'Leary, Ph.D. Multi-Hierarchical Self-Assembly of Collagen Mimetic Peptides into AAB Type Heterotrimers, Nanofibers and Hydrogels Driven by Charged Pair Interactions. (Thesis Director)

     Jorge Fallas, Ph.D. Design and Structural Characterization of Self-Assembling Triple Helical Heterotrimers. (Thesis Director)

     Erica L Bakota, Ph.D. Multidomain Peptides: Sequence-Nanostructure Relationships and Biological Applications. (Thesis Director)

    Awards, Prizes, & Fellowships
     McDonald Fund Award,

     IBB Hamill Innovation Award , (2014)

     Camille-Dreyfus Teacher Scholar Award, Camille & Henry Dreyfus Foundation (2007-2010)

     International Association for Dental Research GlaxoSmithKline Innovation in Oral Care Award, International Association for Dental Research (2009-2010)

     Institute of Biosciences and Bioengineering Collaborative Award, Institute of Biosciences and Bioengineering, Rice University (2008)

     Camille-Dreyfus Teacher Scholar Award, Dreyfus Foundation (July 2007)

     NSF CAREER Award, National Science Foundation (2007)

     Hamill Innovation Award, Institute of Biosciences and Bioengineering, Rice University (April 2007)

     Searle Scholar Award, Kinship Foundation (June 2004)

    Positions Held
     Review Panel Member, NSF DMR / BMAT Review Panel. (2014 - 2014)