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Scholarly Interest Report
         
Oleg Igoshin
Associate Professor
Associate Professor in Bioengineering
 
e-mail:Oleg.Igoshin@rice.edu
 
  • Ph.D. Physics (2004) UC Berkeley, Berkeley, CA
  • MSc Chemical Physics (2000) Weizmann Institute of Science, Israel
  • BSc Physics (1998) Novosibirsk State University, Russia
 
Primary Department
   Department of Bioengineering
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Department Affiliations
 
  • Department of BioSciences
  • Institute of Biosciences and Bioengineering
  • Ken Kennedy Institute for Information Technology
  •  
    Websites
     Igoshin Lab
     Oleg A.Igoshin
     
    Research Areas
     Computational systems biology, evolutionary design principles, characterization of biochemical networks, pattern formation in bacterial biofilms, and genetic networks in bacterial and stem cell development.
     
    Research Statement
     

    The Igoshin group specializes in computational systems biology with emphasis in evolutionary design principles and the characterization of biochemical networks, pattern formation in bacterial biofilms, and genetic networks in bacterial and stem cell development. This includes:



    • Modeling of microbiological self-organization
      Myxococcus xanthus is one of the most intriguing microbes known for its multicellular lifestyle. Under appropriate conditions, bacterial cells self-organize to form complex fruiting body structures that contain environmentally resistant spores. The Igoshin Research Group and their collaborators seek to quantitatively characterize and mechanistically understand M. xanthus and other bacterial self-organization phenomena. In addition to traditional experimental research, they use computational biophysics and engineering approaches to understand the genetic mechanisms involved in pattern formation.

    • Noise and feedback regulation in bacterial genetic networks
      Transcriptional feedbacks are abundant in bacterial gene regulation, but their physiological role is not always well understood. The Igoshin Group investigates the role transcriptional feedback plays in shaping signal response and the characteristics of master-level regulation of bacterial gene expression. They focus on major classes of bacterial signaling systems – two-component signal transduction cascades as well as circuits responsible for bacterial sporulation. They are specifically interested in the stochastic nature of these processes, which allows isogenic bacteria to achieve different responses in identical environmental conditions.

    • Feedback architectures of transcriptional regulation in hematopoietic stem cells
      Transcriptional regulation of multipotent mammalian stem-cell lines is significantly more complex than bacterial regulation and therefore contains more complicated functional network motifs. The Igoshin Group uses mathematical modeling to study how the architecture of these motifs affects their physiological function.

    • Diffusive-kinetic theories of enzymatic reaction networks
      Recent single-molecule experiments have demonstrated that catalytic enzymes often display slow conformational fluctuations that affect their kinetic properties. As a result, macroscopic rate laws describing the enzymatic reaction may deviate from classical biochemical kinetics. The Igoshin Group investigates how fluctuation may affect the kinetics of coupled biochemical reaction networks.

     
    Selected Publications
     Refereed articles
     

    Balagam, R., Litwin, D.B., Czerwinski, F., Sun, M., Kaplan, H.B., Shaevitz, J.W., Igoshin, O.A. "Myxococcus xanthus gliding motors are coupled elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility." PLoS Comp Biol, 10:e1003619 (2014)

     
     

    Datta, P., Hancioglu, B., Igoshin, O.A., Gennaro, M. "The phage shock protein response of Mycobacterium tuberculosis maintains envelope integrity and sensing of surface-stress signals."  (2014) Submitted

     
     

    Judd, J., Ho, M.L., Tiwari, A., Gomez, E.J., Dempsey, C., Van Vliet. K., Igoshin, O.A., Silberg, J.J. , Agbandje-McKenna, M., Suh, J. "Tunable Protease-Activatable Virus nanonodes programmed to compute proteolytic signatures." ACS Nano, 8 (2014) : 4740-4746.

     
     

    Lee, J., Tiwari*, A., Shum, V., Mills, G.B., Mancini, M.A., Igoshin, O.A., Balazsi, G. "Unraveling the regulatory connections between two controllers of breast cancer cell fate." Nucleic Acid Research, 42 (2014) : 6839-6849.

     
     

    Narula, J., Kuchina, A., Fujita, M., SŁel, G.M. and. Igoshin, O.A. "Chromosomal locations of phosphorelay genes controls the Bacillus subtilis response to starvation."  (2014) Submitted

     
     

    Narula*, J., Williams* CJ, Tiwari* A., Marks-Bluth J., Pimanda J.E. and Igoshin, O.A., Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence, Developmental Biology (2013) 379: 258–269 [* - equal contribution] M.

     
     

    Vishnoi* M, Narula* J, Devi SN, Dao HA, Igoshin† O, Fujita† M., Triggering sporulation in Bacillus subtilis with artificial two-component systems reveals the importance of proper Spo0A activation dynamics, Mol Microbiol (2013)  90, 181–194 [† co-corresponding authors, * - equal contribution] 

     
     

    Narula, J., Devi, SN, J., Fujita, M. and Igoshin, O.A., Ultrasensitivity of B. subtilis sporulation decision, (2012) Proc Natl Acad Sci U S A, 109: 20196–20197 and E3513–E3522.

     
     

    Ray, J.C.J. and Igoshin, O.A., Interplay of Noisy Gene Expression and Ultrasensitive Dynamics Influences Bacterial Operon Organization, PLoS Comp Bio (2012), 8:e1002672

     
     

    Tiwari, A., and Igoshin, O.A., Coupling between feedback loops in autoregulatory networks affects bistability range, open-loop gain and switching times, Physical Biology (2012) Phys. Biol. 9: 055003.

     
     

    Vishnoi M, Narula J, Devi SN, Dao HA, Igoshin O, Fujita M., Triggering sporulation in Bacillus subtilis with artificial two-component systems reveals the importance of proper Spo0A activation dynamics, Mol Microbiol (2013)  90, 181–194.

     
     

    Zhang, H., Vaksman, Z., Litwin D., Shi P., Kaplan H., Igoshin, O.A The Mechanistic Basis of Myxococcus xanthus Rippling Behavior and Its Physiological Role during Predation, PLoS Comp Biology (2012), 8: e1002715.

     
     

     Ray, J.C.J., Tabor, J.J. and Igoshin, O.A., Non-transcriptional regulation shapes relationships between bacterial network structure and function, Nature Reviews Microbiology, 9(2011) 817-828

     
     

    Ray, J.C.J. and Igoshin, O.A., Interplay of Noisy Gene Expression and Biochemical Dynamics Influences Bacterial Operon Organization, PLoS Comp Bio (2012), 8:e1002672.

     
     

    Tiwari, A., Ray, J.C.J., Narula, J., and  Igoshin, O.A., Bistable responses in bacterial genetic networks: designs and dynamical consequences, Mathematical Bioscience, 231(2011) : 76-89

     
     

    Xie S., Zhang, H., Shimkets, L. and Igoshin, O.A. , Statistical image analysis reveals features affecting fates of Myxococcus xanthus developmental aggregates, Proceedings of the National Academy of Sciences 108 (2011), 5915-5920

     
     

     Zhang, H., Angus, S., Tran, M., Xie S., Igoshin*, O.A. and Welch*, R.D , Quantifying aggregation dynamics during Myxococcus xanthus development, J Bacteriol., 193 (2011): 5164-70

     
     

    Chaudhury, S. and Igoshin, O.A., Dynamic disorder in rapid-equilibrium enzymatic system, PLoS One,5(8) (2010): e12364

     
     

    Eswaramoorthy, P, Dinh, D, Dunn, D., Igoshin, O.A. and Fujita, M., Single cell measurement of the levels and distributions of the phosphorelay components in a population of sporulating Bacillus subtilis cells, Microbiology , 156 (8) (2010): 2294 - 2304

     
     

    Narula, J., Smith, A.M. Gottgens B., Igoshin, O.A., Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate, Comp Biol 6(5) (2010): e1000771.

     
     

    Narula, J., and Igoshin, O.A. "Thermodynamic models of combinatorial gene regulation by distant regulatory elements, ." IET System Biology, 4: 393-408.

     
     

    Ray, J.C.J. and Igoshin, O.A., Adaptable Functionality of Transcriptional Feedback in Bacterial Two-Component Systems, PLoS Comp Biol , 6(2) (2010): e1000676

     
     

    Tiwari, A., Balazsi, G., Gennaro, M.L. and Igoshin, O.A., Interplay of Multiple Feedbacks with Post-Translational Kinetics Results in Bistability of Mycobacterial Stress-Response Network, Phys. Biol. 7 (2010) 036005

     
     

    Chaudhury, S. and Igoshin, O.A., Dynamic disorder-driven substrate inhibition and bistability in a simple enzyme catalysis reaction, J Phys Chem B, 113 (2009): 13421-8

     
     

    Ray, J.C.J. and Igoshin, O.A "Adaptable Functionality of Transcriptional Feedback in Bacterial Two-Component Systems." PLoS Comp BiolIn Press

     
     

    Igoshin, O.A., Alves, R. and Savageau, M.A., Hysteretic and graded responses in bacterial two-component signal transduction, Molecular Microbiology, 68 (2008): 1196-1215

     
     

    Veening, J-W, Igoshin, O.A., Eijlander, R.T., Hamoen, L.W., Nijland, R. and Kuipers, O.P. Transient heterogeneity in extracellular protease production by Bacillus subtilis, Molecular Systems Biology, 4:184

     
     

    Igoshin, O.A., Brody, M.S., Price, C.W., Savageau, M.A. "Distinct topologies of partnerswitching signaling networks correlate with their physiological roles." J Mol Biol, 369 (2007) : 1333-52.

     
     Books
     

    Igoshin, O.A, Integral Encounter Theory of Photochemical Transfer Reactions: Formalism and Applications, LAP Lambert Academic Publishing AG&Co, Koln, Germany, 2009, ISBN: 978-3-8383-0101-3

     
     Book chapters
     

    Harvey, C.W., Igoshin, O.A., Welch R.D., Alber M. and Shimkets L.J. "Computational Biology: From Observation to Statistical Image Analysis to Modeling and Back to Biology, in Myxobacteria: Genomics, Cellular and Molecular Biology." 

     
     

    Balazsi, G., Igoshin, O.A. and Gennaro, M.L. , The transcriptional regulatory network of Mycobacterium tuberculosis, in Bacterial Gene Regulation and Transcriptional Networks, ed. M.M. Babu, Caister Academic Press, 2013; ISBN: 978-1-908230-14-0

     
     

    Harvey, C.W., Igoshin, O.A.,  Welch R.D.,  Alber M. and Shimkets L.J., Computational Biology: From Observation to Statistical Image Analysis to Modeling and Back to Biology, in Myxobacteria: Genomics, Cellular and Molecular Biology, ed. Z. Pang and P.I. Higgs, Caister Academic Press, 2014 ISBN: 978-1-908230-34-8

     
     

    1.     Balazsi, G., Igoshin, O.A. and Gennaro, M.L. , The transcriptional regulatory network of Mycobacterium tuberculosis, in Bacterial Gene Regulation and Transcriptional Networks, ed. M.M. Babu, Caister Academic Press, 2013; ISBN: 978-1-908230-14-0

     
    Presentations
     Invited Talks
     

    Mechanismof cell alignment in M. xanthus groups, 41st International Conference on the Biology of Myxobacteria, Frejus, France

     
     

    Ph.D. Program in Systems, Synthetic and Physical Biology (SSPB) at Rice University: Challenges, solutions and perspectives, UK/US Synthetic Biology Workshop, Chicago, IL

     
     

    Slowdown of cell growth acts as the signal triggering cellular differentiation, The 8th Annual q-bio Conference on Cellular Information Processing, Santa Fe, NM

     
     

    Slowdown of cell growth acts as the signal triggering cellular differentiation, 9th International Conference on Bioinformatics of Genome Regulation and structure\Systems Biology, Novosibirsk, Russia

     
     

    Uncovering evolutionary design principles of bacterial differentiation decisions Northwestern University, Molecular Biophysics Colloquium, Evanston, IL

     
     

    Biophysical analysis of mechanical intercellular interactions discriminates between alternative models of A-motility, 40h Annual International 

     
     

    Design principles of Bacillus subtilis sporulation decision network,  NSF/RU Cell Decision Making Workshop, Arlington, VA

     
     

    Design principles of information processing in the Bacillus subtilis sporulation network, Investigative Workshop on Systems and Synthetic Microbiology, NIMBioS at the University of Tennessee, Knoxville, TN

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks,  Departmental Colloquium, Department of Computational and Applied Mathematics and Statistics, Notre Dame University, South Bend, IN

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Science at the Edge Seminar, Michigan State University, East Lansing, M

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Departmental Colloquium, Department of Microbiology, University of Georgia, Athens, GA

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks,  Center of Quantitative Biology colloquium, Peking University, Beijing, China

     
     

    Uncovering design principles of Bacillus subtilis sporulation network, Computational and Integrative Biomedical Research Center Seminar, Baylor College of Medicine, Houston, TX

     
     

    Uncovering the mechanisms behind Bacillus subtilis sporulation decisions, Frontiers in Systems and Synthetic Biology ’13 (FSSB’13), Atlanta, GA

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks,  Public Health Research Institute Center, UMDNJ - New Jersey Medical School, Newark, NJ 12/10/2012

     
     

    Ultrasensitivity and stochasticity of the Bacillus subtilis sporulation decision, International Conference on Stochastic Processes in Systems Biology, Genetics & Evolution, Houston, TX 08/23/2012

     
     

    Peng Shi, Christopher Cotter, Lawrence J. Shimkets and Oleg A. Igoshin, Clustering of Myxococcus xanthus genotypes based on spatial patterns of self-organization, 39th International Conference on the Biology of the Myxobacteria, Chicago, IL [talk]

     
     

    Interplay of Gene Expression Noise and Ultrasensitive Dynamics Influences Bacterial Operon Organization, 8th International Conference on Bioinformatics of Genome Regulation and structure\Systems Biology, Novosibirsk, Russia [talk]

     
     

    Interrogating Bacillus subtilis Sporulation Network, Losick Lab, Harvard, Boston, MA

     
     

    Interrogating Bacillus subtilis Sporulation Network, Suel Lab, UT Southwestern, Green Center for Systems Biology, Dallas, TX

     
     

    Mechanisms of Self-Organization in Myxococcus Xanthus Biofilms: Aggregation and Rippling, Bacterial Interest Group (BIG), Texas Medical Center, Houston, TX

     
     

    Reverse-engineering mechanisms of multicellular self-organization with mathematical modeling and statistical image processing, MD Andersen, Systems Biology Department, Houston, TX

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Department of Bioengineering, University of Texas at Dallas, Dallas, TX

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Systems Biology Theory Lunch, Department of Systems Biology, Harvard Medical School, Boston, MA

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Mathematical Biology Seminar, UC Davis, Davis, CA

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Department of Physics/Bioinformatics Group, Boston University, Boston, MA

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks, Integrative BioSystems Institute, GeorgiaTech, Atlanta, GA

     
     

    Stochasticity & Ultrasensitivity In Bacterial Networks,  Systems Biology Seminar, University of Washington, Seattle, WA 12/04/2012

     
     

    Engineering Approaches to Computational Systems Biology: Research Overview, Department of Systems Biology Retreat, MD Anderson 10/12/2011

     
     

    Interplay of Noisy Gene Expression and Dynamics Explains Patterns of Bacterial Operon Organization, APS March Meeting 2011, Dallas, TX 03/22/2011

     
     

    The Interplay of Noisy Gene Expression and Biochemical Dynamics Explains Patterns of Bacterial Operon Organization, XII International Congress on Molecular Systems Biology (ICMSB2011), Universitat de Lleida (Spain), 05/10/2011

     
     

    Bacterial Operon Patterns Reduce Biochemical Noise, Workshop and Symposium “From Networks to Pattern Formation – Evolution of Biological Function”, Houston, TX,[talk]

     
     

    Bistability and low-pass filtering in the network module determining blood stem cell fate, 7th International Conference on Bioinformatics of Genome Regulation and structure\Systems Biology, Novosibirsk, Russia 06/23/2010

     
     

    Jatin Narula, Abhinav Tiwari and Oleg A. Igoshin, Controlled comparison of peroxide stress response in E. coli and B. subtilis, Texas Branch ASM Spring Meeting 2010, New Braunfels, TX, [talk] 04/09/2010

     
     

    Design Principles of bacterial stress-response circuits, Bacterial Interest  Group (BIG), Texas Medical Center, Houston, TX 06/02/2010

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Gene organization in bacterial chromosomes guides post-translational network dynamics, AAAS-SWARM 85th annual meeting, Houston, TX, [talk] 04/08/2010

     
     

    Abhinav Tiwari, Gábor Balázsi and Oleg A. Igoshin, Interplay of Multiple Feedbacks with Post-Translational Kinetics Results in Bistability of Mycobacterial Stress-Response, Texas Branch ASM Spring Meeting, New Braunfels, TX, [talk] 04/09/2010

     
     

    Interplay of Multiple Feedbacks with Post-Translational Kinetics in Mycobacterial Stress-Response Network, Invited Guest lecture, World Tuberculosis Day Symposium, Public Health Research Institute New Jersey Medical School, Newark, NJ 03/23/2010

     
     

    Mathematical Modeling in Systems Biology: Introduction and Examples,  Invited guest lecture, University of Houston-Downtown, Houston, TX 03/22/2010

     
     

    Reverse engineering self-organization of bacterial biofilms, K2I institute member luncheon seminar, Rice University 04/09/2010

     
     

    Uncovering the physiological implications of transcriptional feedback in bacterial genetic circuit, Interdisciplinary cluster on Networks, University of Houston, Houston, TX 02/26/2010

     
     

    Multiple positive feedbacks lead to bistability and low-pass filtering in gene regulatory network module controlling hematopoiesis, Workshop 2: Signal transduction and gene regulatory networks, Ohio Mathamatical Biosciences Institute, Columbus, OH [talk] 11/03/2009

     
     

    Quantifying, modeling and analyzing self-organization patterns in M. xanthus swarms, 36th Annual International Conference on the Biology of the Myxobacteria, Boston, MA [talk] 07/08/2009

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Surprising dynamic flexibility in bacterial two-component systems with transcriptional feedback, Molecular Genetics of Bacteria and Phages Conference, Madison, WI, [talk] 08/09/2009

     
     

    Transcriptional feedback in bacterial signaling and mammalian development: uncovering its physiological implications with mathematical modeling, Colloquium at University of Connecticut Health Center, Farmington, CT 09/17/2009

     
     

    "Uncovering its physiological implications of transcriptional feedback with mathematical modeling." Seminar at Computational Science and Mathematics Division, Pacific Northwest national Lab Richland, WA . (11/12/2009)

     
     

    "Feedback regulation and bistability in bacterial two-component systems. ." ICAM workshop "Evolutionary Design Principles of Biological Networks" 4th Computational and Theoretical Biology Symposium, Rice University. (12/06/2008)

     
     

    "Uncovering design principles of bacterial biochemical networks." Colloquium at symposium Modeling and Analysis of Biological networks, University of Houston. (05/16/2008)

     
     

    "Uncovering design principles of bacterial biochemical networks and biofilm self-organization." Colloquium at Cambridge Computational Biology Institute, Cambridge, UK. (09/18/2008)

     
     

    "Uncovering design principles of biochemical networks." Department Colloquium, Syracuse University, Department of Biology. (02/15/2008)

     
     

    "Uncovering design principles of biochemical networks." Biocomplexity Seminar Series, Department Colloquium, Notre Dame University. (02/11/2008)

     
     Lectures
     

    Structure-function relationships in bacterial gene regulatory networks, 2011 Computational Cell Biology Summer School, Cold Spring Harbor, NY 06/17/2011

     
     

    Dynamical Properties of gene regulatory networks: bistability, feedback and Stochasticity, Molecular systems Biology Module for PDBEB, University of Coimbra, Coimbra, Portugal 11/18/2011

     
     Other
     

    Abhinav Tiwari and Oleg A. Igoshin, Coupled Feedback Loops Govern Possible Persistance 'Switch' in Tuberculosis Bacteria, APS March Meeting, Dallas, TX, [talk] 03/24/2011

     
     

    Haiyang Zhang, Zalman Vaksman, Heidi Kaplan and Oleg A. Igoshin, Mechanism and Physiological Role of Predatory Ripples in Myxococcus xanthus Swarms, Bacteria Locomotion and Signal Transduction XI Meeting, New Orleans, LA, [talk] 01/16/2011

     
     

    Haiyang Zhang, Zalman Vaksman, Heidi Kaplan and Oleg A. Igoshin, Mechanism and Physiological role of Predatory Ripples in Myxococcus xanthus Swarms, The 38th Annual Conference on the Biology of the Myxobacteria, Mount Kisco, NY, [talk] 07/20/2011

     
     

    Jatin Narula, Masaya Fujita, and Oleg A. Igoshin, Sporulation commitment in Bacillus subtilis, Molecular Genetics of Bacteria and Phages, The 62nd Molecular Genetics of Bacteria and Phages Meeting, Madison, WI [talk] 08/03/2011

     
     

    Priya Rao, Jatin Narula and Oleg A. Igoshin, Variability of cell growth and its effects on population dynamics, UBM South Regional Conference, University of Houston-Downtown, Houston, TX, [talk] 10/28/2011

     
     

    "Design principles of graded and bistable switches in bacterial signaling networks." Bioinformatics Gordon Conference, Andover, NH. (07/17/2007)

     
     

    "Graded and bistable switches in bacterial signaling networks." Stochastic Gene Transcription & Signaling Workshop, Rice University. (06/22/2007)

     
     

    "Graded and hysteretic responses in bacterial signaling networks: mechanisms and design principles." The First International q-bio Conference on Cellular Information, Santa Fe, NM. (08/15/2007)

     
     Posters
     

    Slow-down of cell growth acts as stress signal triggering sporulation in Bacillus subtilis, Microbial Stress-response GRC, Mount Holyoke, MA

     
     

    Mechanisms of Self-Organization in Myxococcus Xanthus Biofilms: Aggregation and Rippling, 4th ASM Conference on Prokaryotic Cell Biology and Development, Montreal, QE, Canada [poster]

     
     

    Baris Hancioglu, Pratik Datta, Eduardo Sontag, Maria Laura Gennaro, and Oleg A. Igoshin, Network Architectures Compatible with the Nonmonotonic Dynamics of Central Metabolism Genes under Hypoxic Stress in M. tuberculosis, q-bio Conference 2012, St. John's College, Santa Fe, NM, [spotlight talk-poster]

     
     

    Pattern Formation in Myxococcus xanthus, Growth and patterns: pattern formation in Biology, Aspen Center for Physics, Aspen, CO [poster]

     
     

    Ultrasensitivity of B. subtilis sporulation decision, 4th ASM Conference on Prokaryotic Cell Biology and Development, Montreal, QE, Canada [poster]

     
     

    Abhinav Tiwari and Oleg A. Igoshin, Controlled Comparison Uncovers Dynamic Differences in Networks with Coupled Feedback Loops, The 5th Annual q-bio Conference on Cellular Infomation Processing, Santa Fe, NM, [poster] 08/12/2011

     
     

    Abhinav Tiwari, Gabor Balazsi, Maria L. Gennaro and Oleg A. Igoshin, Modeling of Stress-Response Network in Mycobacteria Reveals Possible Persistence Switch, The 62nd Molecular Genetics of Bacteria and Phages Meeting, Madison, WI, [poster] 08/03/2011

     
     

    Jatin Narula, Massaya Fujita and Oleg A. Igoshin, Noisy dynamics of the sporulation initiation network in Bacillus subtilis, Stochastic Physics in Biology, Gordon Research Conference, Ventura, CA [poster] 01/26/2011

     
     

    Oleg A. Igoshin, Patterns of bacterial operon organization reduce network noise,_Stochastic Physics in Biology, Gordon Research Conference, Ventura, CA [poster] 01/24/2011

     
     

    Jatin Narula, Massaya Fujita and Oleg A. Igoshin, Understanding the kinase threshold that controls sporulation in Bacillus subtilis, Workshop 2: Stochastic Processes in Cell and Population Biology, Mathematical Biosciences Institute, Columbus, OH, [poster] 10/25/2011

     
     

    Haiyang Zhang and Oleg A. Igoshin, Modeling Traveling Density Waves in Myxococcus Xanthus Biofilms, Texas Branch ASM Spring Meeting, New Braunfels, TX, [poster]

     
     

    Abhinav Tiwari, Gábor Balázsi and Oleg A. Igoshin, Interplay of Multiple Feedback Loops with Post-Translational Kinetics Results in Bistability of Mycobacterial Stress Response, The Fourth Annual q-bio Conference on Cellular Information Processing, Santa Fe, NM, [poster] 08/12/2010

     
     

    Abhinav Tiwari, Gábor Balázsi and Oleg A. Igoshin, Interplay of Multiple Feedback Loops with Post-Translational Kinetics Results in Bistability of Mycobacterial Stress Response, “From Networks to Pattern Formation –Evolution of Biological Function”, Houston, TX, [poster]

     
     

    Jatin Narula, Aileen M. Smith, Berthold Gottgens and Oleg A. Igoshin, Mathematical Model Predicts Master-regulatory Role of Hematopoietic Stem Cell Network Module, BMES, Austin, TX, [poster]

     
     

    Haiyang Zhang, Zalman Vaksman, Heidi Kaplan and Oleg A. Igoshin, Mechanism and Physiological Role of Predatory Ripples in Myxococcus xanthus Swarms, From Networks to Pattern Formation - Evolution of Biological Function, Workshop and Symposium, Rice University, Houston, TX, [poster] 12/04/2010

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Patterns of Bacterial Operon Organization Reduce Post-Transcriptional Noise, Physics of Evolution Summer School, San Diego, CA, [poster] 09/02/2010

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Patterns of Bacterial Operon Organization Reduce Post-Transcriptional Noise, The Fourth Annual q-bio Conference on Cellular Information Processing, Santa Fe, NM, [poster] 08/12/2010

     
     

    Jatin Narula, Aileen M. Smith, Berthold Gottgens and Oleg A. Igoshin, Phosphorelay Architecture Determines the Essential Dynamics of Sporulation, Workshop and Symposium: “From Networks to Pattern Formation – Evolution of Biological Function”, Houston, TX [poster] 12/04/2010

     
     

    Priya Rao, Jatin Narula and Oleg A. Igoshin, Positive and Negative Effects of Gene Regulation on Cellular Growth Rate, “From Networks to Pattern Formation – Evolution of Biological Function”, Houston, TX [poster] 12/04/2010

     
     

    Chunyan Xie, Haiyang Zhang, Lawrence Shimkets and Oleg A. Igoshin, Statistical Image Analysis Reveals Features Affecting Fates of Myxococcus Xanthus Developmental Aggregates, Workshop and Symposium: “From Networks to Pattern Formation – Evolution of Biological Function”, Houston, TX [poster]12/04/2010

     
     

    J. Christian J. Ray and Oleg A. Igoshin, The Interplay of Noisy Gene Expression and Biochemical Dynamics Explains Patterns of Bacterial Operon Organization, From Networks to Pattern Formation - Evolution of Biological Function, Workshop and Symposium, Rice University, Houston, TX, [poster] 12/04/2010

     
     

    Uncovering its physiological implications of transcriptional feedback in bacterial stress-response circuits, Microbial Stress Response Gordon Conference, Mount Holyoke College, South Hadley, MA [poster] 10/06/2010

     
     

    Haiyang Zhang and Oleg A. Igoshin, Agent-based modeling of self- organized behavior in Myxococcus xanthus biofilms, 36th Annual International Conference on the Biology of the Myxobacteria, Boston, MA, [poster] 07/08/2009

     
     

    Jatin Narula and Oleg A. Igoshin, Design principles of the Scl-Gata2-Fli1 regulatory module in the hematopoietic differentiation network, The Third International q-bio Conference on Cellular Information Processing, Santa Fe, NM, [poster] 08/06/2009

     
     

    S. Chaudhury and Oleg A. Igoshin, Dynamic disorder driven substrate inhibition and bistability in simple enzymatic reaction, The Third International q-bio Conference on Cellular Information Processing, Santa Fe, NM, [poster] 08/06/2009

     
     

    Jatin Narula and Oleg A. Igoshin, Dynamic modeling of a core blood stem cell regulatory network reveals bistability and low-pass noise filtering, 19th Keck Center Annual Research Conference, Houston, TX, [poster] 10/30/2009

     
     

    Jatin Narula and Oleg A. Igoshin, Dynamic modeling of a core blood stem cell regulatory network reveals bistability and low-pass noise filtering, 5th Computational and Theoretical Biology Symposium,  Houston, TX, [poster]

     
     

    Abhinav Tiwari, Gabor Balazsi and Oleg A. Igoshin, Feedbacks in mycobacterial stress-response network lead to bistability, 5th Computational and Theoretical Biology Symposium,  Houston, TX, [poster]

     
     

    Abhinav Tiwari, Gabor Balazsi and Oleg A. Igoshin, Feedbacks in mycobacterial stress-response network lead to bistability, 19th Keck Center Annual Research Conference,Houston, TX , [poster] 10/30/2009

     
     

    Chunyan Xie and Oleg A. Igoshin, Image processing methods to reverse-engineer self-organization of Myxococcus xanthus biofilms, 5th Computational and Theoretical Biology Symposium,  Houston, TX, [poster]

     
     

    Haiyang Zhang and Oleg A. Igoshin,  Mathematical model of travelling density waves in Myxococcus xanthus  biofilms, 5th Computational and Theoretical Biology Symposium,  Houston, TX, [poster]

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Relating bacterial chromosome organization to dynamics in simple biochemical networks. 19th Keck Center Annual Research Conference, Houston, TX, [poster]

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Relating bacterial chromosome organization to dynamics in simple biochemical networks, 5th Computational and Theoretical Biology Symposium,  Houston, TX, [poster]

     
     

    J. Christian J. Ray and Oleg A. Igoshin, Surprising dynamic flexibility in bacterial two-component systems with transcriptional feedback, 5th Annual IBB Symposium,Houston, TX , 2009, [poster] 07/15/2009

     
     

    Understanding Feedback Architectures in Two-Component Systems Signaling, 3rd ASM Conference on Prokaryotic Development, Cambridge, MA [poster] 07/02/2009

     
     

    "Design principles of bacterial chromosome organization." The Second International q-bio Conference on Cellular Information Processing, Santa Fe, NM. (08/05/2008)

     
     

    "Feedback regulation and bistability in bacterial two-component systems." Microbial Stress Response Gordon Conference,, Mount Holyoke College, South Hadley, MA. (07/08/2008)

     
     

    "Lifestyle-Optimized Transcriptional Feedback in Bacterial Signaling." 18th Keck Center Annual Research Conference, UT M. D. Anderson. (10/04/2008) With Christian Ray

     
     

    "Lifestyle-Optimized Transcriptional Feedback in Bacterial Signaling." ICAM workshop "Evolutionary Design Principles of Biological Networks", 4th Computational and Theoretical Biology Symposium, Rice University. (12/06/2008) With Christian Ray

     
     

    "Positive and Negative Modes of Gene Regulation: Coupling with Growth Rate." ICAM workshop "Evolutionary Design Principles of Biological Networks", 4th Computational and Theoretical Biology Symposium, Rice University. (12/06/2008) With Jatin Narula

     
     

    "Reverse-Engineering Self-Organization Behavior in Myxococcus Xanthus Biofilms: Predatory Waves and Aggregation Distribution"." ICAM workshop "Evolutionary Design Principles of Biological Networks", 4th Computational and Theoretical Biology Symposium, Rice University. (12/06/2008) With Haiyang Zhang

     
     Seminar Speaker
     

    Stochasticity and ultrasensitivity in bacterial network, Department of Biomedical sciences Colloquium, University of Coimbra, Coimbra, Portugal 11/18/2011

     
     

    Uncovering self-organization mechanisms in Myxococcus xanthus swarms with modeling and image processing, Mathematical Biology Seminar, University of British Columbia, BC, Canada 03/03/2011

     

     
     

    Stochasticity and ultrasensitivity in bacterial network, Department of Bioengineering, Johns Hopkins University, Baltimore, MD , 12/14/2011

     
     

    "Bacterial development: Insights from Mathematical Modeling." CAAM Colloquium, Rice University. (04/23/2007)

     
     

    "Design principles of graded and bistable responses in bacterial signaling switches." Biophysics Seminar, Rice University. (04/19/2007)

     
     

    "Design principles of graded and bistable switches in signaling networks." MD Andersen, Systems Biology Department. (09/05/2007)

     
     

    "Uncovering design principles of bacterial gene regulation." Department Colloquium Biochemistry and Cell Biology Department Rice University. (10/12/2007)

     
     

    "Uncovering design principles of bacterial gene regulation with mathematical modeling." University of Houston, Biology Department. (09/19/2007)

     
     Workshops
     

    Contact-based Signaling Explains the Emergent Properties and Physiological Role of Traveling Waves Formed during Myxococcus xanthus Predation, 4th ASM Conference on Cell-Cell Communication in Bacteria, Miami, FL 11/09/2011

     
     

    Reverse-engineering of self-organization mechanisms in Myxococcus xanthus swarms, The 5th Annual q-bio Conference on Cellular Information Processing, Santa Fe  08/12/2011

     
     

    Statistical image analysis reveals features affecting the fates of Myxococcus xanthus developmental aggregates, 38th Annual International Conference on the Biology of the Myxobacteria, Mt Kisco, NY [talk] 07/19/2011

     
    Editorial Positions
     Other, Physical Biology. (2014 - 2014)

     Other, Journal of Bacteriology. (2014 - 2014)

     Other, Mathematical Biosciences. (2013 - 2014)

     Other, Journal of Theoretical Biology. (2013 - 2014)

     Other, Bulletin of Mathematical Biology. (2013 - 2014)

     Other, Science. (2013 - 2014)

     Other, Archives of Microbiology. (2013 - 2014)

     Other, Molecular Microbiology. (2013 - 2014)

     Other, PLoS Computational Biology. (2013 - 2014)

     Other, PLoS Genetics. (2013 - 2014)

     Other, PNAS. (2013 - 2014)

     Other, Biophysical Journal. (2013 - 2014)

    Supervised Theses & Dissertations
     Enrique M. Tavera, PhD Statistical Mechanics of quasi-species theories of molecular evolution. (2008) (Committee Member)

    Awards, Prizes, & Fellowships
     Institute of Engineering and Technology (IET) Premium Award in Systems Biology, Institute of Engineering and Technology (IET) (November 2011)

     John C Dunn Foundation Collaborative Research Award, (September )

     NSF CAREER Award, (February)

     International Collaboration Travel Award, Rice University (09/2008)

    Positions Held
     Co-Organizer, From Motors to Morphogenesis: George Oster-Inspired Research. (2009 - 2009)

     Journal Reviewer, Science. (2009 - 2009)

     Journal Reviewer, Molecular Microbiology. (2009 - 2009)

     Journal Reviewer, Archives of Microbiology. (2009 - 2009)

     Journal Reviewer, Biophysical Journal. (2009 - 2009)

     Journal Reviewer, Journal of Theoretical Biology. (2009 - 2009)

     Journal Reviewer, PLoS Biology. (2009 - 2009)

     Discussion Leader, I2CAM Workshop on "Soft Active Matter: from Granular Rods to Flocks, Cells and Tissues". (2009 - 2009)

     Journal Reviewer, Bulletin of Mathematical Biology. (2009 - 2009)

     Session Chair, Bioinformatics Workshop, 26th Annual Houston Conference on Biomedical Engineering Research. (2009 - 2009)

     Journal Reviewer, PNAS. (2009 - 2009)

     Journal Reviewer, PLoS Computational Biology. (2009 - 2009)

     Journal Reviewer, Mathematical Biosciences. (2009 - 2009)