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Scholarly Interest Report
         
Rosa Uribe
Assistant Professor
Assistant Professor
 
e-mail:Rosa.Uribe@rice.edu
 
  • B.S. Cell and Molecular Biology (2006) San Francisco State University, San Francisco, CA
  • Ph.D. Molecular Cell and Developmental Biology (2012) University of Texas, Austin, Texas
 
Primary Department
   Department of BioSciences
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Research Areas
 Developmental Biology, Zebrafish, Neuron, Cancer
 
Research Interests 18-JAN-2018
 

The Uribe lab research focuses on  deciphering the genetic, cellular and signaling level mechanisms of neural crest stem cell proliferation, migration and cell -type differentiation during embryogenesis.  Neural crest cells are a group of multipotent stem cell that migrate to various locations and give rise to many diverse cell types in the vertebrate body —such as pigment cells of the skin, cartilage, and neurons of the peripheral nervous system.  Currently, among various derivatives of the neural crest, we study how the largest division of the peripheral nervous system, the Enteric Nervous System (ENS), develops from the neural crest.  During development, neural crest stem cells are specified and migrate ventrally away from the neural tube (precursor to central nervous system) and enter the primitive foregut tissue.  They then migrate along the rostrocaudal extent of the gut in chains until they eventually reach the hindgut. These enteric neural crest cells (ENC) ultimately give rise to a diverse array of neurons and glia that make up the mature ENS, regulating such processes as gut peristalsis, water balance and hormone secretions.  To investigate these processes in vivo, we utilize the model organism zebrafish, danio rerio, and a combination of genetic manipulations, drug studies, transgenesis, molecular biology, and live confocal and light sheet imaging. Currently, our research goals are to increase understanding of the signaling and genetic mechanisms that regulate the cell-fate specification and migration of neural crest cells during peripheral nervous system development.  Ultimately, it is our overarching goal to enhance basic knowledge on the mechanisms that direct neural crest stem cell development and diversification in a tissue-specific context, leading to treatments for neural crest-derived diseases and cancers, affecting both children and adults world-wide.


 


 

 
Teaching Areas
 Developmental Biology, Zebrafish, Neuron, Cancer
 
Selected Publications
 Refereed articles
 

Uribe, R.A.*, Hong, S.S. and Bronner, M.E. "Retinoic Acid orchestrates colonization of the gut by vagal neural crest cells." Developmental Biology, 433: 17-32.Accepted

 
Presentations
 Seminar Speaker
 

Presenter.  "“Probing how the Vitamin A derivative Retinoic Acid regulates peripheral nervous system formation from neural crest stem cells”.." Department of Genetics at the University of Texas M.D. Anderson Cancer Center, Houston, TX. (03/2018)

 
 

Presenter.  "“What we can learn about early enteric nervous system formation using the optically transparent model organism, zebrafish”." Center for Theoretical Biological Physics (CTBP) Seminar Series, Houston, TX. (02/2018)

 
 

Presenter.  "“Unraveling how the peripheral nervous system forms from neural crest stem cells”." Biosciences Department Retreat, Rice University, Houston, TX. (08/2017)