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Scholarly Interest Report
         
Xue Gao
Assistant Professor
Assistant Professor
 
e-mail:Xue.Gao@rice.edu
 
  • M.S. Chemical Engineering (2007) Tianjin University, Tianjin, China
  • B.S. Chemical Engineering (2005) Tianjin University, Tianjin, China
  • Ph.D. Chemical and Biomolecular Engineering (2013) Univ. of CA - Los Angeles, Los Angeles, CA
 
Primary Department
   Department of Chemical and Biomolecular Engineering
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Department Affiliations
 
  • Department of Chemical and Biomolecular Engineering
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    Websites
     gaolab
     
    Research Areas
     Small molecules and genome editing agents discovery and their applications to human health, agriculture, and energy.
     
    Selected Publications
     Refereed articles
     

    Wang, M., Zuris, J. A., Meng, F., Rees, H., Sun, S., Deng, P., Han, Y., Gao, X., Pouli, D., Wu, Q., Georgakoudi, I., Liu, D. R., Xu, Q. "“Efficient Delivery of Genome-Editing Proteins using Bioreducible Lipid Nanoparticles.”." Proc. Natl. Acad. Sci. USA, 113 (2016) : 2868-73.

     
     

    Jiménez-Osés, G.†, Osuna S.†, Gao, X.†, Sawaya, M.R.; Gilson, L.; Collier, S.J.; Huisman, G.W., Yeates, T.O., Tang, Y., Houk, K.N., ""The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics"." Nat. Chem. Biol., 6 (2014) : 431-436.

     
     

    Gao, X., Jiang, W, Jiménez-Osés, G, Choi S. M., Houk K.N., Yi Tang, Walsh C.T., "“An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins"." Chem. Biol., 20 (2013) : 870-878.

     
     

    Haynes, S.W., Gao, X., Tang, Y., Walsh, C.T. "“Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: a Two Enzyme Pathway to the Hexacyclic MDR Export Pump Inhibitor Ardeemin.”." ACS Chem. Biol., 19 (2013) : z741-8.

     
     

    Haynes, S.W., Gao, X., Tang, Y., Walsh, C.T. "“Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: a Two Enzyme Pathway to the Hexacyclic MDR Export Pump Inhibitor Ardeemin.”." ACS Chem. Biol., 19 (2013) : 741-8.

     
     

    Walsh, C.T., Haynes, S.W., Ames, B.D., Gao, X., Tang, Y. "“Short Pathways to Complexity Generation: Fungal Peptidyl Alkaloid Multicyclic Scaffolds from Anthranilate Building Blocks.”." ACS Chem. Biol., 19 (2013) : 1366-82.

     
     

    Wang, P., Bashiri, G., Sawaya, M.R., Gao, X., Yeates T.O., Tang, Y. "“Uncovering the Enzymatic Basis of the Final Steps in Oxytetracycline Biosynthesis.”." J. Am. Chem. Soc., 135 (2013) : 7138-7141.

     
     

    Gao, X., Haynes, S.W., Ames, B.D., Wang, P., Vien, L.P., Walsh, C.T., Tang, Y. "“Cyclization of fungal nonribosomal peptides by a terminal condensation-Like domain.”." Nat. Chem. Biol., 8 (2012) : 823-830.

     
     

    Haynes, S.W., Gao, X., Tang, Y., Walsh, C.T. "“Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.”." J. Am. Chem. Soc., 134 (2012) : 17444-17447.

     
     

    Wang, P, Gao, X., Tang, Y. "“Complexity generation during natural product biosynthesis using redox enzmyes.”." Curr. Opin. Chem. Biol., 16 (2012) : 362-369.

     
     

    Wang, P., Kim, W., Pickens, L.B., Gao, X., Tang, Y. "“Heterologous expression and manipulation of three tetracycline biosynthetic pathways.”." Angew. Chem. Int. Ed. Engl., 51 (2012) : 11136-11140.

     
     

    Ames, B. D., Haynes, S. W., Gao, X., Tang, Y., Walsh, C.T. "“Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.”." Biochemistry, 50 (2011) : 8392-8406.

     
     

    Gao, X., Chooi, Y., Ames, B.D., Wang, P., Walsh, C. T., Tang, Y. "“Fungal quinazoline alkaloid biosynthesis: Genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.”." J. Am. Chem. Soc., 133 (2011) : 2729-2741.

     
     

    Haynes, S.W., Ames, B.D., Gao, X., Tang, Y., Walsh, C.T. "“Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.”." Biochemistry, 50 (2011) : 5668-5679.

     
     

    Wang, P., Gao, X., Deng, Z., Tang, Y. "“Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in Streptomyces rimosus.”." Microbiology, 157 (2011) : 2401-2409.

     
     

    Yang, J., Yang, S., Gao, X., Yuan, Y.J. "“Integrative investigation of lipidome and signal pathways in human endothelial cells under oxidative stress.”." Mol. Biosyst., 7 (2011) : 2448-40.

     
     

    Gao, X., Wang, P., Tang, Y. "“Engineered polyketides biosynthesis and biocatalysis in Escherichia coli.”." Appl. Microbiol. Biotechnol., 88 (2010) : 1233-1242.

     
     

    Gao, X.†, Xie, X.†, Pashkov, I., Sawaya, R.M., Laidmen, J., Zhang, W., Cacho, R., Yeates, T.O., Tang, Y. "“Directed evolution and structural characterization of a simvastatin synthase.”." Chem. Biol., 16 (77009) : 1064-1074.

     
     

    Xie, X., Pashkov, I., Gao, X., Guerrero, J., Yeates, T.O., Tang, Y. "“Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.”." Biotechnol. Bioeng., 102 (2009) : 20-28.

     
    Awards, Prizes, & Fellowships
     ACS Dan Su Travel Award, Harvard University (2014)

     Harry M. Showman Prize, UCLA (2013)

     AIChE WIC Travel Grant Award, UCLA (2012)

     UCLA Dissertation Year Fellowship, UCLA (2012)

     2012 Presidential Green Chemistry Challenge Award, (2012)

     Procter and Gamble Seminar Competition Award, UCLA (2012)

     The Most Outstanding Student of Tianjin University, Tianjin University (2004)

     Triple-A Student Award of Tianjin University, Tianjin University (2004)

     Triple-A Student Award of Tianjin University, Tianjin University (2003)

     First-Class Fellowship of China Petroleum, Tianjin University (2003)

     Triple-A Student Award of Tianjin University, Tianjin University (2002)