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Scholarly Interest Report
         
K.C. Nicolaou
Professor
Harry C. and Olga K. Wiess Professor of Chemistry
 
e-mail:kcn@rice.edu
 
  • Ph.D. (1972) University College, University of London, London, England
  • D.Sc. Chemistry (1994) University College, University of London, London, UK
  • B.Sc. (First Class Honors) (1969) Bedford College, University of London, London, England
 
Primary Department
   Department of Chemistry
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Department Affiliations
 
  • Institute of Biosciences and Bioengineering
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    Websites
     K.C. Nicolaou's Research Group Website
     
    Research Areas
     Research Areas: Total Synthesis of Natural and Designed Molecules, Chemical Biology, Bioorganic, Organic, Pharmaceutical
     

    Research Statement

     

    The advent of organic synthesis and the understanding of the structure of the molecule stand as two of the most profound developments of all time. Their advancement and exploitation led to the development of the molecular sciences including chemistry, biology and medicine. Total synthesis—the art of constructing the molecules of living nature in the laboratory—has played a crucial role in these developments by challenging and driving forward organic synthesis, thereby facilitating the drug discovery and development process, material sciences, biotechnology and nanotechnology, among other disciplines.


    Today the synthesis of biologically active molecules—natural or designed—is at the center of biomedical research, manifesting itself as a creative art and a precise science that enables biology and medicine as well as striving to advance itself to higher levels of sophistication and efficiency.


    In our laboratories we are pursuing both the advancement of synthesis and its application to chemical biology and pharmaceutical research. Thus, we strive to discover and develop new synthetic strategies and technologies and employ them in the synthesis of molecular complexity and diversity relevant to biology and medicine. Emphasis is placed on collaborative biomedical research with academic and industrial laboratories around the world.


    Current research programs include the synthesis and investigation of biologically active substances, including antitumor, antibacterial and antiviral agents, and marine neurotoxins, among others. Examples of past accomplishments from the group include the synthesis of the endiandric acids (plant secondary metabolites), amphotericin B (antifungal drug), calicheamicin γ1I (anticancer drug), rapamycin (immunosuppressive and anticancer drug), Taxol® (anticancer drug), brevetoxins B and A (marine neurotoxins), epothilones A and B (anticancer agents), vancomycin (antibiotic of last resort), azaspiracids (marine neurotoxins), and thiostrepton (veterinary antibiotic). We have also produced educational tools for graduate and undergraduate students such as the Classics in Total Synthesis series (I, II, and III) and Molecules That Changed the World.

     
    Selected Publications
     Refereed articles
     

    K. C. Nicolaou, A. A. Shah, H. Korman, T. Khan, L. Shi, W. Worawalai, E. A. Theodorakis "Total Synthesis and Structural Revision of Antibiotic CJ-16,264." Angew. Chem. Int. Ed., 54 (2015) : 9203-9208.

     
     

    K. C. Nicolaou, C. Nilewski, C. R. H. Hale, C. F. Ahles, C. A. Chiu, C. Ebner, A. ElMarrouni, L. Yang, K. Stiles, D. Nagrath "Synthesis and Biological Evaluation of Dimeric Furanoid Macroheterocycles: Discovery of New Anticancer Agents." J. Am. Chem. Soc., 137 (2015) : 4766-4770.

     
     

    K. C. Nicolaou, D. Rhoades, Y. Wang, S. Totokotsopoulos, R. Bai, E. Hamel "Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues, ." ChemMedChem (2015) : 10.1002/cmdc.201500401.

     
     

    K. C. Nicolaou, D. Vourloumis, S. Totokotsopoulos, A. Papakyriakou, H. Karsunky, H. Fernando, J. Gavrilyuk, D. Webb, A. F. Stepan "Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs." ChemMedChem (2015) : 10.1002/cmdc.201500510.

     
     

    K. C. Nicolaou, M. Lu, P. Chen, A. A. Shah "Practical Synthesis of p- and o-Amino- and Methoxyphenolic Anthraquinones." Angew. Chem. Int. Ed., 54 (2015) : 12687-12691.

     
     

    K. C. Nicolaou, Q. Cai, B. Qin, M. T. Peterson, R. J. T. Mikkelsen, P. Heretsch "Total Synthesis of Trioxacarcin DC-45-A2." Angew. Chem. Int. Ed., 53 (2015) : 3074–3078.

     
     

    K. C. Nicolaou, Z. Lu, R. Li, J. R. Woods, T. Sohn "Total Synthesis of Shishijimicin A." J. Am. Chem. Soc., 137 (2015) : 8716-8719.

     
     

    C. Cheng, Y. Liu, M. E. Balasis, T. P. Garner, J. Li, N. L. Simmons, N. Berndt, H. Song, L. Pan, Y. Qin, K. C. Nicolaou, E. Gavathiotis, S. M. Sebti, R. Li "Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim." Mar. Drugs, 12 (2014) : 4311–4325.

     
     

    K. C. Nicolaou "Academic–Industrial Partnerships in Drug Discovery and Development." Angew. Chem. Int. Ed., 53 (2014) : 4730–4731.

     
     

    K. C. Nicolaou "Advancing the Drug Discovery and Development Process." Angew. Chem. Int. Ed., 53 (2014) : 9128–9140.

     
     

    K. C. Nicolaou "Organic Synthesis: The Art of Replicating the Molecules of Living Nature and Others Like Them in the Laboratory." Proc. R. Soc. A, 470 (2014) : 20130690.

     
     

    K. C. Nicolaou "The Chemistry–Biology–Medicine Continuum and the Drug Discovery and Development Process in Academia." Chem. Biol., 21 (2014) : 1039-1045.

     
     

    K. C. Nicolaou, C. R. H. Hale, C. Nilewski, H. A. Ioannidou, A. ElMarrouni, L. G. Nilewski, K. Beabout, T. T. Wang, Y. Shamoo "Total Synthesis of Viridicatumtoxin B and Analogues Thereof: Strategy Evolution, Structural Revision, and Biological Evaluation." J. Am. Chem. Soc., 136 (2014) : 12137–12160.

     
     

    K. C. Nicolaou, L. Shi, M. Lu, M. R. Pattanayak, A. A. Shah, H. A. Ioannidou, M. Lamani "Total Synthesis of Myceliothermophins C, D and E." Angew. Chem. Int. Ed., 53 (2014) : 10970-10974.

     
     

    K. C. Nicolaou, P. Heretsch, A. ElMarrouni, C. R. H. Hale, K. K. Pulukuri, A. K. Kudva, V. Narayan, K. S. Prabhu "Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent." Angew. Chem. Int. Ed., 53: 10443-10447.

     
     

    K. C. Nicolaou, P. Heretsch, T. Nakamura, A. Rudo, M. Murata, K. Konoki "Synthesis and Biological Evaluation of QRSTUVWXYZA′ Domains of Maitotoxin." J. Am. Chem. Soc., 136 (2014) : 16444-16451.

     
     

    S. F. Ferreiro, N. Vilariño, M. C. Louzao, K. C. Nicolaou, M. O. Frederick, L. M. Botana "In Vitro Chronic Effects on hERG Channel Caused by the Marine Biotoxin Azaspiracid-2." Toxicon, 78 (2014) : 69-75.

     
     

    K. C. Nicolaou "The Emergence of the Structure of the Molecule and the Art of Its Synthesis." Angew. Chem. Int. Ed., 52 (2013) : 131-146.

     
     

    K. C. Nicolaou, C. Nilewski, C. R. H. Hale, H. A. Ioannidou, A. ElMarrouni, and L. G. Koch "Total Synthesis and Structural Revision of Viridicatumtoxin B." Angew. Chem. Int. Ed., 52 (2013) : 8736-8741.

     
     

    K. C. Nicolaou, C. R. H. Hale, C. Nilewski, and H. A. Ioannidou "Constructing Molecular Complexity and Diversity: Total Synthesis of Natural Products of Biological and Medicinal Importance." Chem. Soc. Rev., 41 (2012) : 5185-5238.

     
     

    K. C. Nicolaou, M. Lu, S. Totokotsopoulos, P. Heretsch, D. Giguère, Y. Sun, D. Sarlah, T. H. Nguyen, I. C. Wolf, D. F. Smee, C. W. Day, S. Bopp, and E. A. Winzeler "Synthesis and Biological Evaluation of Epidithio-, Epitetrathio- and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8'-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E and Haematocin and Discovery of New Antiviral and Antimalarial Agents." J. Am. Chem. Soc., 134 (2012) : 17320-17332.

     
     

    K. C. Nicolaou "Invigorating Education." Angew. Chem. Int. Ed., 50 (2011) : 63-74.

     
     

    K. C. Nicolaou and R. J. Aversa "Maitotoxin: An Inspiration for Synthesis." Isr. J. Chem., 51 (2011) : 359-377.

     
     

    K. C. Nicolaou, A. Ortiz, H. Zhang, and G. Guella "Total Synthesis and Structural Revision of Vannusals A and B: Synthesis of the True Structures of Vannusals A and B." J. Am. Chem. Soc., 132 (2010) : 7153-7176.

     
     

    K. C. Nicolaou, J. Wang, Y. Tang, and L. Botta "Total Synthesis of Sporolide B and 9-epi-Sporolide B." J. Am. Chem. Soc., 132 (2010) : 11350-11363.

     
     

    K. C. Nicolaou "Inspirations, Discoveries, and Future Perspectives in Total Synthesis." J. Org. Chem., 74 (2009) : 951-972.

     
     

    K. C. Nicolaou, D. Sarlah, T. R. Wu, and W. Zhan "Total Synthesis of Hirsutellone B." Angew. Chem. Int. Ed., 48 (2009) : 6870-6874.

     
     

    K. C. Nicolaou, J. S. Chen, H. Zhang, and A. Montero "Asymmetric Synthesis and Biological Properties of Uncialamycin and 26-epi-Uncialamycin." Angew. Chem. Int. Ed., 47 (2008) : 185-189.

     
     

    K. C. Nicolaou, B. A. Pratt, S. Arseniyadis, M. Wartmann, A. O'Brate, and P. Giannakakou "Molecular Design and Chemical Synthesis of a Highly Potent Epothilone." ChemMedChem, 1 (2006) : 41-44.

     
     

    K. C. Nicolaou, D. J. Edmonds, and P. G. Bulger "Cascade Reactions in Total Synthesis." Angew. Chem. Int. Ed., 45 (2006) : 7134-7186.

     
     

    K. C. Nicolaou "Joys of Molecules. 1. Campaigns in Total Synthesis." J. Org. Chem., 70 (2005) : 7007-7027.

     
     

    K. C. Nicolaou "Joys of Molecules. 2. Endeavors in Chemical Biology and Medicinal Chemistry." J. Med. Chem., 48 (2005) : 5613-5638.

     
     

    K. C. Nicolaou and S. A. Snyder "The Essence of Total Synthesis." Proc. Nat. Acad. Sci. USA, 101 (2004) : 11929-11936.

     
     

    K. C. Nicolaou, M. Zak, B. S. Safina, S. H. Lee, and A. A. Estrada "Total Synthesis of Thiostrepton, Part 2: Construction of the Quinaldic Acid-Containing Macrocycle and Completion of the Synthesis." Angew. Chem. Int. Ed., 43 (2004) : 5092-5097.

     
     

    K. C. Nicolaou, T. V. Koftis, S. Vyskocil, G. Petrovic, T. Ling, Y. M. A. Yamada, W. Tang, and M. O. Frederick "Structural Revision and Total Synthesis of Azaspiracid-1. Part 2: Definition of the ABCD Domain and Total Synthesis." Angew. Chem. Int. Ed., 43 (2004) : 4318-4324.

     
     

    K. C. Nicolaou and P. S. Baran "The CP Molecule Labyrinth: A Paradigm of How Endeavors in Total Synthesis Lead to Discoveries and Inventions in Organic Synthesis." Angew. Chem. Int. Ed., 41 (2002) : 2678-2720.

     
     

    K. C. Nicolaou, M. Bella, D. Y.-K. Chen, X. Huang, T. Ling, and S. A. Snyder "Total Synthesis of Diazonamide A." Angew. Chem. Int. Ed., 41 (2002) : 3495-3499.

     
     

    K. C. Nicolaou, H. J. Mitchell, N. F. Jain, N. Winssinger, R. Hughes, and T. Bando "Total Synthesis of Vancomycin." Angew. Chem. Int. Ed., 38 (1999) : 240-245.

     
     

    K. C. Nicolaou, H. J. Mitchell, R. M. Rodríguez, K. C. Fylaktakidou, and H. Suzuki "Total Synthesis of Everninomicin 13,384-1. Part 3. Synthesis of the DE Fragment and Completion of the Total Synthesis." Angew. Chem. Int. Ed., 38 (1999) : 3345-3350.

     
     

    K. C. Nicolaou, P. S. Baran, Y.-L. Zhong, K. C. Fong, Y. He, W. H. Yoon, and H.-S. Choi "Total Synthesis of the CP Molecules CP-263,114 and CP-225,917 - Part 2: Evolution of the Final Strategy." Angew. Chem. Int. Ed., 38 (1999) : 1676-1678.

     
     

    K. C. Nicolaou, Z. Yang, G.-Q. Shi, J. L. Gunzner, K. A. Agrios, and P. Gärtner "Total Synthesis of Brevetoxin A." Nature, 392 (1998) : 264-269.

     
     

    K. C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He, D. Vourloumis, Z. Yang, T. Li, P. Giannakakou, and E. Hamel "Synthesis of Epothilones A and B in Solid and Solution Phase." Nature, 387 (1997) : 268-272.

     
     

    K. C. Nicolaou, F. P. J. T. Rutjes, E. Theodorakis, J. Tiebes, M. Sato, and E. Untersteller "Total Synthesis of Brevetoxin B. 2. Completion." J. Am. Chem. Soc., 117 (1995) : 1173-1174.

     
     

    K. C. Nicolaou, Z. Yang, J. J. Liu, H. Ueno, P. G. Nantermet, R. K. Guy, C. F. Claiborne, J. B. Renaud, E. A. Couladouros, K. Paulvannan, and E. J. Sorensen "Total Synthesis of Taxol." Nature, 367 (1994) : 630-634.

     
     

    K. C. Nicolaou, T. K. Chakraborty, A. D. Piscopio, N. Minowa, and P. Bertinato "Total Synthesis of Rapamycin." J. Am. Chem. Soc., 115 (1993) : 4419-4420.

     
     

    K. C. Nicolaou, C. W. Hummel, E. N. Pitsinos, M. Nakada, A. L. Smith, K. Shibayama, and H. Saimoto "The Total Synthesis of Calicheamicin γ1I." J. Am. Chem. Soc., 114 (1992) : 10082-10084.

     
     

    K. C. Nicolaou, R. A. Daines, and T. K. Chakraborty, Y. Ogawa "Total Synthesis of Amphotericin B." J. Am. Chem. Soc., 109 (1987) : 2821-2822.

     
     

    K. C. Nicolaou, N. A. Petasis, and R. E. Zipkin "The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 4. 'Biomimetic' Approach to Endiandric Acids A-G. Total Synthesis and Thermal Studies." J. Am. Chem. Soc., 104 (1982) : 5560-5562.

     
    Presentations
     Invited Talks
     

    Invited Lecturer.  " Total Synthesis of Natural and Designed Molecules of Biological and Medicinal Importance." Second Torkil Holm Symposium 2014, Copenhagen, Denmark. (01/24/2014)

     
     

    Invited Lecturer.  " Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." COST Conference Epigenetics: From Bench To Bedside, Athens, Greece. (05/05/2014)

     
     

    Invited Guest Professorship.  "Lecture 1:  The Art and Science of Organic Synthesis and Its Impact on Science and Society." Rolf Sammet Guest Professorship, Goethe University, Campus Riedberg, Frankfurt, Germany. (05/12/14)

     
     

    Invited Guest Professorship.  "Lecture 2:  Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." Rolf Sammet Guest Professorship, Goethe University, Medical Campus, Frankfurt, Germany. (05/13/2014)

     
     

    Invited Guest Professorship.  "Lecture 3:  How Taxol Was Made in the Laboratory." Rolf Sammet Guest Professorship, Goethe, University, Campus Riedberg, Frankfurt, Germany. (05/14/2014)

     
     

    Invited Guest Professorship.  "Lecture 4:  Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." Rolf Sammet Guest Professorship, Sanofi Aventis, Frankfurt, Germany. (05/15/14)

     
     

    Invited Guest Professorship.  "Lecture 5:  Maitotoxin:  An Inspiration for Organic Synthesis and Biology." Rolf Sammet Guest Professorship, Goethe University, Campus Riedberg, Frankfurt, Germany. (05/16/2014)

     
     

    Invited Lecturer.  "Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance.." Qua Vadis Synthesis Meeting, Rome, Italy. (05/19/2014)

     
     

    Einstein Professorship.  "Lecture 1...." Institute of Chemistry, Chinese Academy of Sciences, Beijing, China. (09/09/2014)

     
     

    Einstein Professorship.  "Lecture 2...." Chongqing University, Chongqing, China. (09/11/2014)

     
     

    Einstein Professorship.  "Lecture 3...." Sichuan University, Chengdu, China. (09/12/2014)

     
     

    Einstein Professorship.  "Lecture 4...." Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China. (09/15/2014)

     
     

    Einstein Professorship.  "Lecture 5...." Lanzhou University, Lanzhou, China. (09/17/2014)

     
     

    Einstein Professorship.  "Lecture 6...." Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. (09/19/2014)

     
     

    Einstein Professorship.  "Lecture 7...." Shanghai Institute of Materia Medica , Shanghai, China. (09/19/2014)

     
     

    Nemitsas Foundation Prize Recipient.  "Prize Lecture...." Takis and Louki Nemitsas Foundation, Nicosia, Cyprus. (10/7/14)

     
     

    Invited Speaker/Induction into RSC as ForMem.  "New Fellow and Foreign Member Seminar." Royal Society of Chemistry, London, UK. (07/12/2013)

     
     Keynote Speaker
     

    "Keynote Lecture.  Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." Symposium on Organic and Natural Product Chemistry at the HZI, Braunchsweig, Germany. (7/24/2015)

     
     

    Keynote Speaker.  "Total Synthesis of Natural and Designed Molecules of Biological and Medical Importance." New Frontiers in Therapeutic Agents: Successes in Drugging the Undruggable Conference, BioScience Research Collaborative, Rice University, Houston, Texas. (04/17/2014)

     
     Lectures
     

    "Arnold O. Beckman Lecture.  Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." California Institute of Technology, Pasadena, California. (03/04/2015)

     
     

    "Jean Dreyfus Boissevain Lecture.  The Art and Science of Organic Synthesis and Its Impact on Science and Society." University of North Florida, Jacksonville, Florida. (03/27/2015)

     
     

    "Lemieux Lecture.  Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." University of Ottawa, Ottawa, Canada. (03/02/2015)

     
     

    "Plenary Lecture.  Total Synthesis of Rare Natural and Designed Molecules of Biological and Medical Importance." University of Cambridge, International Symposium: Synthesis in Organic Chemistry, Cambridge, UK. (7/22/2015)

     
    Editorial Positions
     Member of the Editorial Board, Bioorganic and Medicinal Chemistry Letters. (1992 - 2014)

     Other, Synthesis. (1990 - 2001)

     Member of the Editorial Board, Bioorganic and Medicinal Chemistry. (1993 - 2014)

     Member of the Editorial Board, Chemistry & Biodiversity. (2004 - 2015)

     Member of the Editorial Board, IDrug. (1998 - 2002)

     Member of the Editorial Board, Topics in Heterocyclic Chemistry (Series). (2004 - 2015)

     Member of the Editorial Board, Indian Journal of Chemistry Section-B. (2005 - 2007)

     Member of the Editorial Board, Perspectives in Drug Discovery and Design. (1994 - 2000)

     Member of the Editorial Board, Chemistry - A European Journal. (1994 - 2015)

     Member of the Editorial Board, Carbohydrate Letters. (1993 - 1999)

     Member of the Editorial Board, Tetrahedron Letters. (1992 - 2015)

     Member of the Editorial Board, Tetrahedron. (1992 - 2015)

     Member of the Editorial Board, International Journal of Oncology. (2007 - 2008)

     Member of the Editorial Board, Current Opinion in Chemical Biology. (1997 - 2005)

     Member of the Editorial Board, European Chemistry Chronicle. (1996 - 1998)

     Member of the Editorial Board, Accounts of Chemical Research. (1992 - 1995)

     Member of the Editorial Board, Prostaglandins Leukotrienes and Medicine. (1978 - 1988)

     Member of the Editorial Board, ChemistryOpen. (2011 - 2015)

     Member of the Editorial Board, Current Cancer Drug Targets. (2001 - 2015)

     Member of the Editorial Board, Current Organic Chemistry. (1998 - 2015)

     Other, Organic and Biomolecular Chemistry. (2003 - 2006)

     Other, Contemporary Organic Synthesis. (1994 - 1997)

     Other, Bulletin of the Chemical Society of Japan. (2005 - 2014)

     Other, Journal of the Chemical Society, Perkin Transactions I. (1991 - 1996)

     Other, Israel Journal of Chemistry. (2010 - 2015)

     Other, Chemistry - An Asian Journal. (2006 - 2015)

     Other, QSAR & Combinatorial Science. (2003 - 2009)

     Other, Journal of the Chemical Society, Perkins I. (1997 - 2002)

     Other, ChemBioChem. (2000 - 2010)

     Other, Organic Letters. (1998 - 2014)

     Other, Synlett. (1990 - 2001)

     Other, Chemistry and Biology. (1994 - 2015)

     Other, Angewandte Chemie. (1994 - 2013)

     Other, Journal of the Chemical Society, Chemical Communications. (1989 - 1997)

     Member of the Editorial Board, Index Chemicus. (1996 - 1997)

    Supervised Theses & Dissertations
     Derek Rhoades, Ph.D. Synthetic and Medicinal Chemistry Studies of Epothilone Natural Products. (2016) (Thesis Director)

     Ruocheng Yu, Ph.D. Synthesis of Anticancer Agents: Gukulenin A and 15-Deoxy-15alpha-fluoro-delta12-prostaglandin J3. (2017) (Thesis Director)

     Ruofan Li, Ph.D. TBD. (2018) (Thesis Director)

     Pengxi Chen, Ph.D. TBD. (2019) (Thesis Director)

     Marek Buchman, Ph.D. TBD. (2020) (Thesis Director)

     Samuel (Cody) Martin, Ph.D. TBD. (Thesis Committee Member)

     I-Che Li, Ph.D. TBD. (Thesis Committee Member)

     Han Lu, Ph.D. Structural  Study  On  Natural  Product  Biosynthesis  Enzymes  and  Natural product Structure Determination Method Development . (Thesis Committee Member)

     Fengbin (Jerry) Wang, Ph.D. Developing an Enzyme Toolbox for Anti-Tumor Natural Product Biosynthesis. (Thesis Committee Member)

     Sarah E. Knudsen, Ph.D. Rhodium(II) metallopeptides as specific and high-affinity ligands for SH3 domains. (Thesis Committee Member)

     Matthew Minus, Ph.D. Drug Development for STAT3 Oncoprotein. (Thesis Committee Member)

     Andrew Metzger, Ph.D. TBD. (Thesis Committee Member)

    Awards, Prizes, & Fellowships
     Phileleftheros Award, Phileleftheros Media Group, Cyprus (07/16/2015)

     Scientist of the Year, SPP Media, Cyprus (01/27/2015)

     MAN of the Year, SPP Media, Cyprus (01/27/2015)

     Nemitsas Prize, Takis and Louki Nemitsas Foundation (10/2014)

     Rolf Sammet Guest Professorship, Aventis Foundation (05/2014)

     Einstein Professorship, Chinese Academy of Sciences (09/2014)

     Member, The Academy of Medicine, Engineering & Science of Texas

     Foreign Member, Royal Society of London (2013)

     Member, American Chemical Society

     Member, German Chemical Society

     Member, European Chemical Society

     Member, Chemical Society of Japan