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Scholarly Interest Report
         
K. Jane Grande-Allen
Professor
Isabel C. Cameron Professor of Bioengineering
 
e-mail:grande@rice.edu
 
  • B.A. Mathematics and Biology (1991) Transylvania University, Lexington, KY
  • Ph.D. Bioengineering (1998) University of Washington, Seattle, WA
 
Primary Department
   Department of Bioengineering
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Department Affiliations
 
  • Institute of Biosciences and Bioengineering
  •  
    Websites
     http://bioengineering.rice.edu/faculty/Jane_Grande-Allen.aspx
     Grande-Allen Lab
     K. Jane Grande-Allen
     
    Research Areas
     Integrative biomechanics, biochemistry, pathology, & therapies of heart valve disease; extracellular matrix; proteoglycans, organ cultured & tissue engineered surrogates for studies of soft tissue biology & disease
     
    Research Statement
     

    Work in my laboratory uses the engineering analysis of tissue composition and behavior to investigate tissue and cellular responses to disease, using the cardiac valves as a paradigm for other soft tissues. These projects are interdisciplinary, innovative, medically and biologically applicable, and clinically relevant. Heart valve disease, whether presenting as a primary dysfunction requiring surgical repair or replacement, or as a secondary complication to another disease such as heart failure, affects the health of hundreds of thousands of Americans (and patients worldwide) every year. The overall focus of our research is to characterize and eventually to manipulate the structure-function-environment relationship of cardiac valves in an integrative fashion (cellular, tissue, organ, and clinical). The matrix composition and material properties of heart valves are believed to be determined by the load patterns imposed during valve function. Consequently, alterations to the normal tissue loading patterns will affect the cellular phenotypic production of extracellular matrix and transform the valve morphology, mechanics, and function. To relate tissue composition and mechanics in leaflets and chordae from normal and diseased mitral valves, our laboratory performs mechanical testing, biochemical measurements, and microstructural analysis of the extracellular matrix (especially glycosaminoglycans (GAGs) and proteoglycans) of these tissues. We then correlate these data with echocardiographically assessed cardiac functional parameters and clinical demographics. We are also using cells, organ cultures, and tissue engineering approaches to investigate valve disease from a more mechanistic angle. The main diseases that we study are myxomatous ("floppy") mitral valve disease and secondary remodeling of the heart valves in patients with heart failure, but this research may have implications and applications for other soft tissues. Our goal in characterizing the normal and pathological mechanisms of valvular remodeling is to derive novel surgical and medical therapies that can be used to treat patients earlier in the disease process.


    My current research projects include the following:



    • Understanding the extracellular matrix basis for the tissue mechanics of valves and other soft tissues, particularly with respect to proteoglycans

    • Identification, characterization, and mechanical/humoral/pharmaceutical control of valvular glycosaminoglycans and proteoglycans

    • Biochemical, biomechanical, and echocardiographic quantification of valvular remodeling in clinical congestive heart failure (a secondary valve disease) and myxomatous mitral valves (a primary valve disease)

    • Development of in vitro surrogates (via cell / organ culture and tissue engineering) and bioreactor systems to study disease and remodeling in valves and other soft tissues

    • Bioelectricity and contractility of valve cells in relation to valvular/cardiac disease

     
    Integrative Extracellular Matrix and Biomechanics Laboratory
     

    Work in my laboratory uses the engineering analysis of tissue composition and behavior to investigate tissue and cellular responses to disease, using the cardiac valves as a paradigm for other soft tissues. These projects are interdisciplinary, innovative, medically and biologically applicable, and clinically relevant. Heart valve disease, whether presenting as a primary dysfunction requiring surgical repair or replacement, or as a secondary complication to another disease such as heart failure, affects the health of hundreds of thousands of Americans (and patients worldwide) every year. The overall focus of our research is to characterize and eventually to manipulate the structure-function-environment relationship of cardiac valves in an integrative fashion (cellular, tissue, organ, and clinical). The matrix composition and material properties of heart valves are believed to be determined by the load patterns imposed during valve function. Consequently, alterations to the normal tissue loading patterns will affect the cellular phenotypic production of extracellular matrix and transform the valve morphology, mechanics, and function. To relate tissue composition and mechanics in leaflets and chordae from normal and diseased mitral valves, our laboratory performs mechanical testing, biochemical measurements, and microstructural analysis of the extracellular matrix (especially glycosaminoglycans (GAGs) and proteoglycans) of these tissues. We then correlate these data with echocardiographically assessed cardiac functional parameters and clinical demographics. We are also using cells, organ cultures, and tissue engineering approaches to investigate valve disease from a more mechanistic angle. The main diseases that we study are myxomatous ("floppy") mitral valve disease and secondary remodeling of the heart valves in patients with heart failure, but this research may have implications and applications for other soft tissues. Our goal in characterizing the normal and pathological mechanisms of valvular remodeling is to derive novel surgical and medical therapies that can be used to treat patients earlier in the disease process. My current research projects include the following:



    1. Understanding the extracellular matrix basis for the tissue mechanics of valves and other soft tissues, particularly with respect to proteoglycans

    2. Identification, characterization, and mechanical/humoral/pharmaceutical control of valvular glycosaminoglycans and proteoglycans

    3. Biochemical, proteomic, biomechanical, and echocardiographic quantification of valvular remodeling in clinical congestive heart failure (a secondary valve disease) and myxomatous mitral valves (a primary valve disease)

    4. Development of in vitro surrogates (via cell / organ culture and tissue engineering) and bioreactor systems to study disease and remodeling in valves and other soft tissues

     
    Teaching Areas
     Extracellular Matrix, Biomechanics, Numerical Methods, Statistics, Devices for Cardiac Surgery
     
    Selected Publications
     Abstracts
     

    Arevalos CA, Walborn A, Grande-Allen KJ: Valve interstitial cells act in a pericyte manner promoting angiogenesis and transdifferentiation by valve endothelial cells.  BMES, Seattle, WA, September 2013.

     
     

    Azimuddin AF, Connell PC, Grande-Allen KJ: Optimizing function of a mitral valve physiological flow loop bioreactor.  Society for Experimental Mechanics, Lombard, IL, June 2013.

     
     

    Fares H, Sapp MS, Grande-Allen KJ: Calcific aortic valve disease cell culture:  three dimensional models for cellular characterization of calcified valves. BMES, Seattle, WA, September 2013.

     
     

    Kreuz JM, Erskine KN, Blancas AA, Grande-Allen KJ: Age and regional dependence of collagen crimp in heart valves. Society for Experimental Mechanics, Lombard, IL, June 2013.

     
     

    Puperi DS, West JL Grande-Allen KJ: Hyaluronan hydrogels for biomimetic spongiosa layer of tissue engineered aortic valve.  Accepted to TERMIS-AM, Atlanta, GA, November 2013.

     
     

    Sapp MS, Fares H, Grande-Allen KJ: Three dimensional cell culture construct for the study of calcific aortic valve disease.  BMES, Seattle, WA, September 2013.

     
     

    Balaoing LR, Smith ER, Grande-Allen KJ: Colocalization of endothelial cell secreted thrombotic related proteins with subendothelial matrix in human aortic valves.  Southern Biomedical Engineering Conference, Arlington, TX, April 2011

     
     

    Jejelowo AO, Grande-Allen KJ: Tissue characterization of diseased aortic valve leaflets via micro-computed tomography.  Accepted to American Heart Association, 19th Annual NHLBI Cardiovascular Diversity Research Supplement Awardee Session, Orlando, FL, November 2011

     
     

    Tseng H, Kim E, Shah J, Grande-Allen KJ: Anisotropic hydrogel-fiber composites for heart valve tissue engineering.  TERMIS-NA 2011, Houston, TX, December 2011

     
     

    Tseng H, Souza G, Grande-Allen KJ: A three-dimensional two-cell co-culture model of the aortic valve using magnetic levitation.  SFB Biomaterials Day at Texas A&M University, College Station, TX, May 2011

     
     

    Wiltz DC, Kumar A, Grande-Allen KJ: Development of a scaffold-free, three-dimensional construct using aortic valve interstitial cells for use in valvular disease modeling.  Southern Biomedical Engineering Conference, Arlington, TX, April 2011

     
     

    Grande-Allen KJ, Ballinger ML, Dadlani H, Osman N, Marasco S, Dilley RJ, O'Brien KD, Little PJ: TGFβ1 promotes GAG elongation by valvular interstitial cells and enhances proteoglycan-LDL binding. Proceedings of the BMES, Pittsburgh, PA, October 2009

     
     

    Grande-Allen KJ, Stephens EH, McNeill M, de Jonge N: Stress-strain curve transition region demonstrates heart valve collagen fiber alignment. Proceedings of the SEM, Albuquerque, NM, June 2009

     
     

    Saltarrelli JG, Stephens EH, Pilling D, Baggett S, Gomer RH, Nandi I, Kuo JJ, Davis E, Davis AR, Grande-Allen KJ: Hypoxia, inflammatory cells, and hyaluronan homeostasis in aortic valve calcification. Proceedings of the AHA, Orlando, FL, November 2009

     
     

    Stephens EH, de Jonge N, McNeill MP, Durst CA, Grande-Allen KJ: Changes in material behavior of mitral and aortic valves with age and relation to matrix composition. Proceedings of the BMES, Pittsburgh, PA, October 2009

     
     

    Stephens EH, Nguyen TC, Itoh A, Ingels Jr NB, Miller DC, Grande-Allen KJ: The effects of mitral regurgitation alone are sufficient for leaflet remodeling. Circulation 118;S243-S249, 2008

     
     Stephens EH, Shangkuan J, Carberry KE, Kearney DK, Fraser CD, Grande-Allen KJ: Phenotype of VICs from normal and pathological pediatric valves: implications for a tissue engineered heart valve. Proceedings of the 3rd Biennial Meeting on Heart Valve Biology and Tissue Engineering, London UK, May 2008.
     
     

    Stephens EH, Timek TA, Daughters GT, Ingels NB, Miller DC, Grande-Allen KJ: Significant changes in mitral valve leaflet matrix composition and turnover with dilated cardiomyopathy. Proceeding of the AHA, New Orleans, LA, November 2008

     
     

    Stephens EH, Nguyen TC, Itoh A, Miller DC, Grande-Allen KJ "Mitral leaflet remodeling: response to isolated mitral regurgitation."  (Nov 2007) Submitted

     
     

    Peterson SB, Radovancevic B, Hernandez A, Radovancevic R, Droddy A, Carranza S, Stainback R, Bogaev RC, Gregoric I, Frazier OH "Diastolic dysfunction persists after unloading of the left ventricle by LVAD support."  (April 2006) Submitted

     
     

    Blevins TL, Grande-Allen KJ "Separation of valvular interstitial cell phenotypes in preparation for proteomic analysis." Proceedings of the Houston Society for Engineering in Medicine and Biology (2005)

     
     

    Blevins TL, Raza A, Grande-Allen KJ "Phenotypic characterization of isolated heart valve cell subpopulations." Society for Heart Valve Disease Biennial Meeting Astract Book (June 2005) : P. 218.

     
     

    Ferdous Z, Grande-Allen KJ "Role of decorin in engineering tissue mechanics." Proceedings of the Biomedical Engineering Society (September 2005)

     
     

    Grande-Allen KJ "Mitral valve remodeling in end-stage heart failure." Proceedings of the Houston Society for Engineering in Medicine and Biology (2005)

     
     

    Grande-Allen KJ "Overview of tissue engineered heart valves." Proceedings of the Houston Society for Engineering in Medicine and Biology (2005)

     
     

    Gupta V, Grande-Allen KJ "Proteoglycan detection in collagen gels seeded with mitral valve interstitial cells: relevance to myxomatous mitral valve disease." Society for Heart Valve Disease Biennial Meeting Abstract Book (June 2005) : P.325.

     
     

    Barzilla JE, Grande-Allen KJ: Can LVADs restore normal mitral valve mechanics in heart failure? Proceedings of the Society for Experimental Mechanics,PortlandOR, June 2005.

     
     

    Borowski AG, Popovic ZB, Sallach JA, Kassimatis K, Kamis S, Sigurdsson S, Grande-Allen KJ, McCarthy PM, Garcia M "Right ventricular function is preserved following left ventricular assist device insertion: a pump turndown study (poster)." Proceedings of the American Society of Echocardiography Annual Meeting (2004)

     
     

    Borowski AG, Popovic ZB, Troughton RW, Yeager ML, Thomas JD, Griffin BP, Garcia MJ, Starling RC, McCarthy PM, Grande-Allen KJ "Impact of LVAD unloading on mitral valve function (poster)." Proceedings of the American Society of Echocardiography Annual Meeting (2004)

     
     

    Grande-Allen KJ "Elucidating the mechanical functions of versican, decorin, biglycan, and hyaluronan in heart valves (poster)." Proceedings of the Gordon Research Conference on Proteoglycans (2004)

     
     

    Grande-Allen KJ "Fibrotic vs. myxomatous remodeling of mitral valves." Proceedings of the IEEE-Engineering in Medicine and Biology Society Annual Meeting (2004) : p. 382.

     
     

    Grande-Allen KJ "Heart valves demonstrate loading-modulated phenotypes of extracellular matrix." Houston Society for Engineering in Medicine and Biology Annual Meeting (2004)

     
     

    Grande-Allen KJ "Loading-modulated phenotypes of extracellular matrix in normal and diseased heart valves." Proceedings of the European Society for Biomechanics (July, 2004)

     
     

    Grande-Allen KJ "Mechanical modulation of glycosaminoglycan and proteoglycan production by valvular interstitial cells (poster)." Whitaker Foundation Annual Retreat Abstract Book (Aug, 2004)

     
     

    Grande-Allen KJ, Lawrence B, Gupta, V. "Tissue engineering tools for mechanical modulation of valvular extracellular matrix." Proceedings of the Society for Experimental Mechanics Annual Meeting (2004)

     
     

    McKenney AS, Grande-Allen KJ "Collagen upregulation and cell migration in long term static organ culture of heart valves." Proceedings of the Biomedical Engineering Society Annual Meeting (2004)

     
     

    McKenney AS, Grande-Allen KJ "Phenotypic analysis of long term static organ culture of heart valves: collagen upregulation and cell migration." Proceedings of Advances in Tissue Engineering and Biology of Heart Valves Symposium, (2004)

     
     

    Allison DD, Drazba J, Vesely I, Grande-Allen KJ "Localization of viability within valvular organ cultures." Proceedings of the 7th Annual Hilton Head Workshop on Engineering Tissues (Feb. 2003) : p. 49.

     
     

    Allison DD, Drazba J, Vesely I, Grande-Allen KJ "Localization of viable cells within long-term heart valve organ cultures." Proceedings of the Second Biennial Meeting of the Society for Heart Valve Disease (2003) : p. 136.

     
     

    Borowski AG, Troughton RW, Yeager ML, Thomas JD, Garcia MJ, Griffin BP, Starling RC, McCarthy PM, Grande-Allen KJ "Persistent mitral regurgitation in turndown echo evaluations of LVAD patients." Proceedings of the Heart Failure Society of America Annual Meeting (2003)

     
     

    Borowski AG, Troughton RW, Yeager ML, Thomas JD, Garcia MJ, Griffin BP, Starling RC, McCarthy PM, Grande-Allen KJ "Persistent mitral regurgitation in turndown echo evaluations of LVAD patients." The CCF 23rd Annual Research Day Abstract Book (2003)

     
     

    Corcoran JA, Grande-Allen KJ, Vesely I "Population and synthesis of glycosaminoglycans in mitral valve interstitial cell culture." Proceedings of the 55th Annual Eastern Colleges Science Conference (2001)

     
     

    Grande KJ, Barber JE, Griffin BP, Ratliff N, Cosgrove III D, Vesely I "Does myxomatous mitral valve disease selectively affect the chordae? A mechanical and biochemical analysis." Proceedings of the BMES-IEEE conference (1999) : p.38.

     
     

    Grande KJ, Barber JE, Griffin BP, Ratliff NB, Cosgrove DM, Vesely I "Mechanical and biochemical properties of myxomatous mitral valve chordae." World Symposium on Heart Valve Disease (1999) : p.48-49.

     
     

    Grande KJ, Cochran RP, Kunzelman KS "Variations in aortic root sinus dimensions: implications for stentless bioprostheses." Proceedings of the Workshop on Prosthetic Heart Valves: Future Directions, sponsored by Georgia Technological Institute (1998)

     
     

    Grande KJ, Cochran RP, Reinhall P, Kunzelman KS "Altered valve stresses in osteogenesis imperfecta." Ann Biomed Eng, 25(suppl. 1) (1997) : S-19.

     
     

    Grande KJ, Cochran RP, Reinhall P, Kunzelman KS "Dacron root replacement alters aortic valve stresses: finite element modeling." International Journal of Cardiovascular Medicine and Science, 1(1) (1997) : 37.

     
     

    Grande KJ, Cochran RP, Reinhall P, Kunzelman KS "Regional variations in aortic root and valve stresses in a finite element model." Artif Organs, 21(6) (1997) : 491.

     
     

    Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS "Effect of graft shape and material properties on aortic valve function in valve-sparing procedures." Ann Biomed Eng, 26(suppl. 1) (1998) : S-57.

     
     

    Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS "Influence of aging on aortic root and valve function." ASAIO J, 44(2) (1998) : 17A.

     
     

    Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier E "Porcine aortic valve leaflet dimensions." Proceedings of the 38th Annual Meeting of ASAIO (1992) : p. 33.

     
     

    Grande KJ, Kunzelman KS, Cochran RP, Richards TL, David TE, Verrier ED "Finite element modeling of the aortic root and valve." Ann Biomed Eng, 21(suppl. 1) (1993) : 22.

     
     

    Grande-Allen KJ "Loading-modulated phenotypes of extracellular matrix: lessons from heart valves." Proceedings of the Society for Experimental Mechanics Meeting on Biologically Inspired Materials (2003)

     
     

    Grande-Allen KJ "Material - mechanical relationships in heart valve tissues." Proceedings of the Society for Experimental Mechanics Annual Conference on Experimental and Applied Mechanics (2002) : p. 7.

     
     

    Grande-Allen KJ, Barber JE, Griffin BP, Vesely I "Mechanical and biochemical evidence for chordal remodeling in hearts with dilated cardiomyopathy." Circulation, 100(18 Suppl. 1) (1999) : I-460.

     
     

    Grande-Allen KJ, Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM "Altered material properties of mitral leaflets and chordae in end-stage heart failure: mechanical evidence for dysfunctional remodeling." Proceedings of the Second Biennial Meeting of the Society for Heart Valve Disease (2003) : p. 229.

     
     

    Grande-Allen KJ, Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM "Altered material properties of mitral leaflets and chordae in end-stage heart failure: mechanical evidence for dysfunctional remodeling." Circulation, 108(17 Suppl. 1) (2003) : IV-368.

     
     

    Grande-Allen KJ, Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM "Altered material properties of mitral leaflets and chordae in end-stage heart failure: mechanical evidence for dysfunctional remodeling." Proceedings of the Biomedical Engineering Society (2003)

     
     

    Grande-Allen KJ, Borowski A, Troughton R, Houghtaling P, DiPaola N, Moravec CS, Vesely I, Griffin BP "Is mitral regurgitation in congestive heart failure truly functional? Evidence for significant biochemical changes in the valvular extracellular matrix." J Am Coll Cardiol, 41(6 suppl. A) (2003) : 509A.

     
     

    Grande-Allen KJ, Borowski AG, Troughton RW, Yeager ML, Thomas JG, Garcia MJ, Griffin BP, Starling RC, McCarthy PM, Thomas JD "Persistent mitral regurgitation in turndown echo evaluations of LVAD patients." Proceedings of the Second Biennial Meeting of the Society for Heart Valve Disease (2003) : p. 222.

     
     

    Grande-Allen KJ, Corcoran JA, Reed L, Vesely I "Glycosaminoglycan production by cultured interstitial cells from mitral valve leaflets and chordae." Proceedings of the First Biennial Meeting of the Society of Heart Valve Disease (2001) : p. 69.

     
     

    Grande-Allen KJ, Griffin BP, Holcomb J, Vesely I "Biochemical and echocardiographic indicators of valvular dysfunction in failing hearts." The Cleveland Clinic Foundation 20th Annual Research Day Abstract Book (2000) : p. 19.

     
     

    Grande-Allen KJ, Griffin BP, Holcomb J, Vesely I "Correlation of biochemical and echocardiographic indicators of valvular dysfunction in dilated cardiomyopathy." Proceedings of the First Biennial Meeting of the Society of Heart Valve Disease (2001) : p. 325.

     
     

    Grande-Allen KJ, Griffin BP, Holcomb J, Vesely I "Correlation of biochemical and echocardiographic indicators of valvular dysfunction in dilated cardiomyopathy." J Am Coll Cardiol, 37(2 suppl. A) (2001) : 473A.

     
     

    Grande-Allen KJ, Griffin BP, Mills WR, Ratliff NB, Cosgrove DM III, Vesely I "Elevated glycosaminoglycan content of myxomatous mitral valve chordae is more severe in unileaflet than in bileaflet prolapse." Proceedings of the First Biennial Meeting of the Society of Heart Valve Disease (2001) : p. 177.

     
     

    Grande-Allen KJ, Griffin BP, Mills WR, Ratliff NB, Cosgrove DM III, Vesely I "Elevated glycosaminoglycan content of myxomatous mitral valves is more severe in unileaflet prolapse than in bileaflet prolapse." J Am Coll Cardiol, 37(2 suppl. A) (2001) : 487A.

     
     

    Grande-Allen KJ, Griffin BP, Ratliff NB, Cosgrove III DM, Vesely I "Altered glycosaminoglycan distribution in myxomatous mitral valves." J Am Coll Cardiol, 35(2 Suppl. A) (2000) : 527A-528A.

     
     

    Grande-Allen KJ, Griffin BP, Vesely I "The relationship between glycosaminoglycans and tensile vs. compressive loads in the mitral valve." Ann Biomed Eng, 28(suppl. 1) (2000) : S-4.

     
     

    Grande-Allen KJ, Griffin BP, Vesely I "The relationship between glycosaminoglycans and tensile vs. compressive loads in the mitral valve." Proceedings of the First Biennial Meeting of the Society of Heart Valve Disease (2001) : p. 132.

     
     

    Grande-Allen KJ, Gupta V, Hascall VC, Wight TN, Ratliff NB, Griffin BP, Cosgrove DM, Vesely I "Identification and localization of proteoglycans in normal and diseased valves and valvular cell cultures." Proceedings of the Second Biennial Meeting of the Society for Heart Valve Disease (2003) : p. 70.

     
     

    Grande-Allen KJ, Mako WJ, Calabro A, Ratliff NB, Vesely I "Explanted porcine bioprosthetic valves show disproportional losses of selective proteoglycans." Proceedings of the Second Biennial Meeting of the Society for Heart Valve Disease (2003) : p. 193.

     
     

    Grande-Allen KJ, Mako WJ, Ratliff NB, Vesely I "Loss of hyaluronan accompanies structural deterioration of porcine bioprosthetic valves." Proceedings, Workshop on Prosthetic Heart Valves: Future Directions, sponsored by Georgia Technological Institute (2002) : p. 40.

     
     

    Grande-Allen KJ, Mako WJ, Ratliff NB, Vesely I "Loss of hyaluronan accompanies structural deterioration of porcine bioprosthetic valves." Ann Biomed Eng, 29(suppl. 1) (2001) : S-4.

     
     

    Grande-Allen KJ, Ratliff NB, Griffin BP, Cosgrove DM III, Vesely I "Increased cellular production of glycosaminoglycans in myxomatous mitral valves." The Cleveland Clinic Foundation 19th Annual Research Day Abstract Book (1999) : p. 38.

     
     

    Grande-Allen KJ, Vesely I "Tensile vs. compressive glycosaminoglycan profiles in normal and myxomatous mitral valves." The 4th World Congress of Biomechanics (2002)

     
     

    Gupta V, Hascall VC, Wight TN, Ratliff NB, Griffin BP, Cosgrove DM, Vesely I, Grande-Allen KJ "Identification and localization of proteoglycans in normal and diseased valves and valvular cell cultures." Proceedings of the Biomedical Engineering Society (2003)

     
     

    Hulbert JL, Klatka K, Grande-Allen KJ, Barber JE, Griffin BP, Ratliff NB, Cosgrove DM, Houghtaling P, Vesely I "Mechanical significance of increased collagen in myxomatous mitral valves." The Cleveland Clinic 22nd Annual Research Day Abstract Book (2002) : p.14.

     
     

    Hulbert JL, Klatka K, Grande-Allen KJ, Barber JE, Griffin BP, Ratliff NB, Cosgrove DM, Houghtaling P, Vesely I "Mechanical significance of increased collagen in myxomatous mitral valves." Proceedings of 6th New Jersey Symposium on Biomaterials Science (2002) : p. 85.

     
     

    Knapp CF, Evans JM, Grande KJ, Murphy CD, Patwardhan AR "Spectral components of human cardiovascular responses to step changes in lower body negative pressure (LBNP) before and after 22 hr of 6 degree head down bed rest." Proceedings of the Aerospace Medical Association (1992)

     
     

    Kunzelman KS, Grande KJ, Cochran RP, David TE, Verrier ED "MRI analysis of aortic valve/root conformation - basis for finite element analysis of root replacements." Proceedings of the 39th Annual Meeting of ASAIO (1993) : p. 28.

     
     

    Lawrence BD, Vesely I, Grande-Allen KJ "Bioreactor system used for applying biaxial cyclic stretch on cells seeded upon an elastic substrate." Proceedings of the 6th New Jersey Symposium on Biomaterials Science (2002) : p. 89.

     
     

    Patwardhan AR, Brown DR, Levenhagen DK, Grande KJ, Evans JM, Knapp CF "Spectral components of resting cardiovascular variables in humans before and after 22 hours of 6 degree head down bed rest." Proceedings of the Aerospace Medical Association (1991)

     
     

    Ratliff NB, Grande KJ, Griffin BP, Barber JE, Cosgrove DM, Vesely I "Mechanical properties of myxoid mitral valve leaflets and chordae." Lab Invest, 80 (2000) : 53a.

     
     

    Ratliff NB, Grande-Allen J, Barber JE, Vesely I "Characterization of inflammatory reaction in xenograft and homograft replacement of cardiac valves." Proceedings of the First Biennial Meeting of the Society of Heart Valve Disease (2001) : p. 123.

     
     

    Sedransk K, Grande-Allen KJ, Vesely I "The biomechanics of chordal rupture in mitral valves." The Cleveland Clinic Foundation 19th Annual Research Day Abstract Book (1999) : p. 39.

     
     

    Sedransk K., Grande-Allen KJ, Vesely I "The biomechanics of chordal rupture in mitral valves." Proceedings of the AAAS Annual Meeting/American Junior Academy of Science (2001)

     
     

    Sedransk KL, Grande-Allen KJ, Vesely I "Failure mechanics of mitral valve chordae tendineae." Ann Biomed Eng, 29(suppl. 1) (2001) : S-59.

     
     

    Setola V, Hufeisen S, Grande-Allen J, Vesely I, Roth BL "How does fenfluramine (Fen/Phen) induce valvular heart disease?." Proceedings of the G-Protein Coupled Receptors Meeting (2001)

     
     Refereed articles
     

    Abu Saleh WK, Al Jabbari O, Grande-Allen J, Ramchandani M. Extracellular matrix scaffold as a tubular graft for ascending aorta aneurysm repair. J Card Surg. 2015 Aug;30(8):648-50. doi: 10.1111/jocs.12583. Epub 2015 Jun 4. PubMed PMID: 26044510.

     
     

    Arevalos CA, Walborn AT, Rupert AA, Grande-Allen KJ: Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors. Microvasc Res, 98:108-18, 2015. PMID: 25660064.

     
     

    Balaoing LR, Post AD, Lin AY, Tseng H, Moake JL, Grande-Allen KJ: Laminin peptide-immobilized hydrogels modulate valve endothelial cell hemostatic regulation. PLoS One, 10(6):e0130749, 2015. PMID: 26090873

     
     

    Blancas AA, Acosta FM, Grande-Allen KJ: Not just skin deep: Cosmetic and medical applications of injectable hyaluronan and fibrin.  Materials Technology, accepted, 2015.

     
     

    Chen Y, Terajima M, Yang Y, Sun L, An YH, Pankova D, Puperi DS, Kim MP, Blackmon SP, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams JS, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zai T, Grande-Allen KJ, Yamauchi M, Kurie JM: Lysyl hydroxylase 2 induces a collagen cross-link switch and promotes metastasis. J Clin Invest, 125(3):1147-62, 2015. PMID: 25664850.

     
     

    Connell PS, Azimuddin AF, Kim SE, Ramirez F, Jackson MS, Little SH, Grande-Allen KJ: Regurgitation hemodynamics alone cause mitral valve remodeling characteristic of clinical disease states in vitro. Ann Biomed Eng, in press, 2015.

     
     

    Fahrenholtz MM, Wen Y, Grande-Allen KJ: Development of a heart valve model surface for optimization of surface modifications. Acta Biomaterialia, in press, 2015.

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH: Emerging trends in heart valve engineering: Part I. Solutions for the future. Ann Biomed Eng, 43(4):833-43, 2015.

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH: Emerging trends in heart valve engineering: Part II. Current state-of-the-art. Ann Biomed Eng, 43(4):844-57, 2015.

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH: Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Ann Biomed Eng, 43(4):858-70, 2015.

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH: Emerging trends in heart valve engineering: Part IV. Computational modeling and experimental studies. Ann Biomed Eng, 43(10):2314-33, 2015.

     
     

    Maragiannis D, Jackson MS, Igo SR, Schutt RC, Connell P, Grande-Allen J, Barker CM, Chang SM, Reardon MJ, Zoghbi WA, Little SH: Replicating patient-specific severe aortic valve stenosis with functional 3D modeling. Circulation: Cardiovascular Imaging, accepted, 2015.

     
     

    Pankova D, Chen Y, Terajima M, Schliekelman MJ, Sun L, Baird BJ, Fahrenholtz MM, Vadakkan TJ, Kim MP, Ahn YH, Roybal JD, Creighton CJ, Gibbons DL, Hicks JM, Dickinson ME, Grande-Allen KJ, Hanash SM, Yamauchi M, Kurie JM: Cancer-associated fibroblasts induce a collagen cross-link switch in tumor stroma. Molecular Cancer Research, accepted, 2015.

     
     

    Puperi DS, Balaoing LR, O’ConnellRW, WestJL, Grande-Allen KJ:  3-dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model.  Biomaterials, 67:354-364, 2015.

     
     

    Sapp MS, Fares HJ, Estrada AC, Grande-Allen KJ: Multilayer 3D filter paper constructs for the culture and analysis of aortic valvular interstitial cells. Acta Biomaterialia, 13:199-206, 2015. PMID: 25463506.

     
     

    Scully BB, Fan C, Grigoryan B, Jacot JG, Vick GW III, Kim J, Fraser CD Jr, Grande-Allen KJ, Morales DLS: In vivo remodeling of an extracellular matrix patch into functional myocardium in an ovine model. J Biomat Mater Res B, accepted, 2015.

     
     

    Stephens EH, Connell PS, Fahrenholtz MM, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels NB Jr, Miller DC, Grande-Allen KJ:  Heterogeneity of mitral leaflet matrix composition and turnover correlates with regional leaflet strain. Cardiovasc Technol Eng, 6(2):141-150, 2015.

     
     

    Stephens EH, Fahrenholtz MM, Connell PS, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels NB Jr, Miller DC, Grande-Allen KJ: Cellular and extracellular matrix basis for heterogeneity in mitral annular contraction. Cardiovasc Technol Eng, 6(2):151-159, 2015.

     
     

     Stephens EH, Nguyen TC, Blazejewski JG, Vekilov D, Connell JP, Itoh A, Ingels NB, Miller DC, Grande-Allen KJ: Extracellular matrix remodeling in wound healing of critical size defects in the mitral valve leaflet. Heart and Vessels, accepted, 2015.

     
     

    Wong FF, Ho ML, Yamagami M, Lam M, Grande-Allen KJ, Suh J: Effective gene delivery to heart valve cells using adeno-associated virus serotypes 2 and 3.  Tissue Eng C, 21(8):808-15, 2015.  PMID: 25603445.

     
     

    Wu Y, Puperi DS, Grande-Allen KJ, West JL: Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. J Tiss Eng Regen Med, accepted, 2015.

     
     

    Zhang X, Xu B, Puperi DS, Wu Y, West JL, Grande-Allen KJ: Application of hydrogels in heart valve tissue engineering. J Long Term Eff Med Impl, 25(1–2): 105–134, 2015. PMID: 25955010.

     
     

    Zhang X, Xu B, Puperi DS, Yonezawa AL, Wu Y, Tseng H, Cuchiara ML, West JL, Grande-Allen KJ: Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering. Acta Biomaterialia, 14:11-21, 2015.

     
     

    Arevalos CA, Walborn AT, Rupert AA, Grande-Allen KJ "Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors." Microvasc ResSubmitted

     
     

    Balaoing LR, Post AD, Liu H, Minn KT, Grande-Allen KJ "Age-related changes in aortic valve hemostatic regulation." Arterioscler Thromb Vasc Biol, 34(1): 72-80.

     
     

    Barzilla JE, Collard CD, Moravec CS, Grande-Allen KJ "Effect of the left ventricular assist device on the hydration, cellularity, and collagen content of the mitral valve." J Am Coll CardiolSubmitted

     
     

    Blancas AA, Balaoing LR, Acosta F, Grande-Allen KJ "Valvular rhapsody: identifying behavioral phenotypes and heterogeneity in heart valve surface endothelium." Cardiovasc ResSubmitted

     
     

    Connell PS, Azimuddin AF, Kim SE, Ramirez F, Jackson MS, Little SH, Grande-Allen KJ "Modeling mitral valve prolapse and functional mitral regurgitation using a flow loop bioreactor." J Am Coll CardiolSubmitted

     
     

    Fahrenholtz MM, Liu H, Kearney DL, Wadhwa L, Fraser CD, Grande-Allen KJ "Characterization of dermal fibroblasts as a cell source for pediatric tissue engineered heart valves." J Cardiovasc Dev Dis, 1(2): 146-162.

     
     

    Kamel PI, Qu X, Geiszler AM, Nagrath D, Harmancey R, Taegtmeyer H, Grande-Allen KJ "Metabolic regulation of collagen gel contraction by porcine aortic valvular interstitial cells." J Royal Soc Interface, 11(101)

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH "Emerging trends in heart valve engineering: Part I. Solutions for the future." Submitted

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH "Emerging trends in heart valve engineering: Part II. Current state-of-the-art." Ann Biomed EngIn Press

     
     

    Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MK, Baaijens F, Canic S, Little SH "Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement." Ann Biomed EngIn Press

     
     

    Lafont AL, Tan FK, Tran-Fadulu V, Grande-Allen KJ, Estrera AL, Safi HJ, Geng YJ, Milewicz DM "Activation of ERK1/2 signaling and inactivation of GSK-3β in the aortic smooth muscle cells in patients with familial thoracic aortic aneurysms and dissections." Arterioscler Thromb Vasc BiolSubmitted

     
     

    Peterson SB, Radovancevic B, Hernandez A, Bogaev RC, Radovancevic R, Droddy A, Carranza S, Stainback R, Gregoric ID, Frazier OH, Grande-Allen KJ "Diastolic dysfunction persists after unloading by left ventricular assist device support." Artif OrgansSubmitted

     
     

    Sapp MS, Fares HJ, Estrada AC, Grande-Allen KJ "Multilayer 3D filter paper constructs for the culture and analysis of aortic valvular interstitial cells." Acta BiomaterialiaIn Press

     
     

    Scully BB, Fan C, Grigoryan B, Jacot JG, Vick GW III, Kim J, Fraser CD Jr, Grande-Allen KJ, Morales DLS "In vivo remodeling of an extracellular matrix patch into functional myocardium in an ovine model." J Biomat Mater Res BSubmitted

     
     

    Scully BB, Grigoryan B, Erskine KN, Fan C, Durst CA, Kwak M, Barzilla JE, Morales DLS, Grande-Allen KJ "A dynamic in vitro model of mitral valve repair: remodeling of a small intestinal submucosa patch seeded with mitral valve interstitial cells." Cardiovasc Technol EngSubmitted

     
     

    Scully BB, Morales DLS, Grande-Allen KJ, McCullough LB "Responsibly managing the clinical application of tissue-engineered scaffolds: how ontology may dictate ethics." Arch SurgSubmitted

     
     

    Srinivas VR, Lazaro LD, Grande-Allen KJ "Effects of differential glycosaminoglycan sulfation on tandem enzyme digestion and fragment size." Macromol BiosSubmitted

     
     

    Stephens EH, Connell PS, Fahrenholtz MM, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels NB Jr, Miller DC, Grande-Allen KJ "Heterogeneity of mitral leaflet matrix composition and turnover correlates with regional leaflet strain." Cardiovasc Technol Eng

     
     

    Stephens EH, Fahrenholtz MM, Connell PS, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels NB Jr, Miller DC, Grande-Allen KJ "Cellular and extracellular matrix basis for heterogeneity in mitral annular contraction." Cardiovasc Technol EngSubmitted

     
     

    Stephens EH, Nguyen TC, Blazejewski JG, Itoh A, Miller DC, Grande-Allen KJ "Acute injury to mitral leaflet elicits both local and global extracellular matrix remodeling." J Thorac Cardiovasc SurgSubmitted

     
     

    Tseng H, Balaoing LR, Grigoryan B, Raphael RM, Killian TC, Souza GR, Grande-Allen KJ "A three- dimensional co-culture model of the aortic valve using magnetic levitation." Acta Biomaterialia, 10(1): 173- 82.

     
     

    Tseng H, Kim EJ, Ayoub S, Shah JV, Puperi DS, Cuchiara ML, West JL, Grande-Allen KJ "Anisotropic poly(ethylene glycol)/polycaprolactone (PEG/PCL) hydrogel-fiber composites for heart valve tissue engineering." Tissue Eng AIn Press

     
     

    Wiltz DC, Han RI, Wilson RW, Kumar A, Morrisett JD, Grande-Allen KJ "Differential aortic and mitral valve interstitial cell mineralization and the induction of mineralization by lysophosphatidylcholine in vitro." Cardiovasc Eng Technol, 5(4): 371-383.

     
     

    Wong FF, Ho ML, Yamagami M, Grande-Allen KJ, Suh J "Effective gene delivery to heart valve cells using adeno-associated virus." Tissue Eng CIn Revision

     
     

    Zhang X, Xu B, Puperi DS, Wu Y, West JL, Grande-Allen KJ "Application of hydrogels in heart valve tissue engineering." J Long Term Eff Med ImplIn Press

     
     

    Zhang X, Xu B, Puperi DS, Yonezawa AL, Wu Y, Tseng H, Cuchiara ML, West JL, Grande-Allen KJ "Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering." Acta BiomaterialiaIn Press

     
     

    Connell PS, Han RI, Grande-Allen KJ: Differentiating the aging of the mitral valve from human and canine myxomatous degeneration.  J Vet Cardiol, 14(1):31-45, 2012. PMID: 22364720

     
     

    Gheewala N, Schwarz KA, Grande-Allen KJ: Organ culture of porcine mitral valves as a novel experimental paradigm. Cardiovasc Eng Technol, 4(2):139-150, 2013.

     
     

    Kumar A, Wiltz DC, Grande-Allen KJ: Gentamicin reduces calcific nodule formation by aortic valve interstitial cells in vitro. Cardiovasc Eng Technol, 4(1):16-25 and 98-100, 2013.

     
     

    Lafont AL, Tan FK, Tran-Fadulu V, Grande-Allen KJ, Estrera AL, Safi HJ, Geng YJ, Milewicz DM: Activation of ERK1/2 signaling and inactivation of GSK-3β in the aortic smooth muscle cells in patients with familial thoracic aortic aneurysms and dissections.  Arterioscler Thromb Vasc Biol, submitted

     
     

    Osman N, Grande-Allen KJ, Ballinger ML, Getachew R, Marasco S, O’Brien KD, Little PJ: Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.  Cardiovasc Pathol, 22(2):146-55, 2013.

     
     

    Scully BB, Morales DLS, Grande-Allen KJ, McCullough LB: Responsibly managing the clinical application of tissue-engineered scaffolds: how ontology may dictate ethics.  New Engl J Med, submitted

     
     

    Stephens EH, Kearney DL, Grande-Allen KJ: Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix.  Cardiovasc Pathol, 21(1):46-58, 2012. PMID: 21349746

     
     

    Stephens EH, Saltarrelli JG, Balaoing LR, Baggett LS, Nandi I, Anderson KM, Reardon MJ, Morrisett JD, Olmsted-Davis EA, Davis AR, Grande-Allen KJ: Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with endochondral ossification in calcified human aortic valves.  Pathol Res Pract, 208(11):642-50, 2012. 

     
     

    Tseng H, Cuciara ML, Durst CA, Cuchiara MP, Lin CJ, West JL, Grande-Allen KJ: Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations.  Ann Biomed Eng, 41(2):398-407, 2013.

     
     

    Tseng H, Kim EJ, Connell PS, Ayoub S, Shah JV, Grande-Allen KJ: The tensile and viscoelastic properties of aortic valve leaflets treated with a hyaluronidase gradient. Cardiovasc Eng Technol, accepted 2012

     
     

    Tseng H, Raphael RM, Killian TC, Grande-Allen KJ, Souza GR: Assembly of a three-dimensional multitype bronchiole co-culture model using magnetic levitation. Tissue Eng C, accepted 2012

     
     

    Durst CA, Cuchiara MP, Mansfield EG, West JL, Grande-Allen KJ: Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves. Acta Biomaterialia, 7(6):2467-76, 2011. PMID: 21329770

     
     

    Grande-Allen KJ, Liao J: The heterogeneous biomechanics and mechanobiology of the mitral valve: implications for tissue engineering.  Current Cardiology Reports, 13(2):113-20, 2011. PMID: 21221857

     
     

    Haldar S, Gheewala N, Grande-Allen KJ, Sutton MA, Bruck HA: Multi-scale mechanical characterization of Palmetto wood as a template for biologically inspired polymer composites.  Exp Mech, 51(4): 575-589, 2011

     
     

    Qu X, Jimenez-Vergara AC, Munoz-Pinto DJ, Ortiz D, McMahon RE, Cristancho D, Becerra-Bayona S, Guiza-Arguello V, Grande-Allen KJ, Hahn MS: Regulation of smooth muscle cell phenotype by glycosaminoglycan identity. Acta Biomater, 7(3):1031-9, 2011. PMID: 21094702

     
     

    Rajamannan NM, Evans F, Aikawa E, Grande-Allen KJ, Demer L, Heistad D, Simmons C, Masters KS, Mathieu P, O’Brien K, Schoen F, Towler D, Yoganathan A, Otto CM: Calcific aortic valve disease: not simply a degenerative process. A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group.  Circulation, 124:1783-1791, 2011.

     
     

    Scully BB, Fan C, Jacot JG, Vick GW, Kim J, Fraser CD, Grande-Allen KJ, Morales DLS.  In vivo remodeling of a small intestinal submucosa patch into functional myocardium.  Accepted to Congenital Heart Surgeon’s Society Annual Meeting, Chicago, IL.  October 2011

     
     

    Stephens EH, Durst CA, West JL, Grande-Allen KJ: Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region.  Acta Biomaterialia, 7;75–82, 2011. PMID: 20624493

     
     

    Stephens EH, Kearney DL, Grande-Allen KJ: Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix.  Cardiovasc Pathol, 21(1):46-58, 2012 PMID: 21349746

     
     

    Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, Davis AR, Olmsted-Davis EA, Reardon MJ, Morrisett JD, Grande-Allen KJ: Differential proteoglycan and hyaluronan distribution in calcified aortic valves.  Cardiovasc Pathol, 20(6):334-42, 2011. PMID: 21185747

     
     

    Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD Jr, Grande-Allen KJ: Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar cardiac valves, Cardiovasc Pathol, 20(5):e157-67, 2011. PMID: 20817569

     
     

    Tseng H, Grande-Allen KJ: Elastic fibers in the aortic valve spongiosa: a fresh perspective on their structure and role in overall tissue function.  Acta Biomaterialia, 7(5):2101-8, 2011. PMID: 21255691

     
     

    Barzilla JE, McKenney AS. Durst CA, Cowan AE, Grande-Allen KJ: Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture. Ann Biomed Eng, 38(10); 3280-3294, 2010.

     
     

    Durst CA, Grande-Allen KJ: Design and physical characterization of a synchronous multivalve aortic valve culture system.  Ann Biomed Eng, 38(2):319-325, 2010

     
     

    Ferdous Z, Peterson SB, Tseng H, Anderson DK, Iozzo RV, Grande-Allen KJ:  A role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts. J Biomed Mater Res Part A, 93(2):419-428, 2010

     
     

    Gheewala N, Grande-Allen KJ: Design and mechanical evaluation of a physiological mitral valve organ culture system, Cardiovasc Eng Technol, 1(2):123-131, 2010

     
     

    Haldar S, Gheewala N, Grande-Allen KJ, Sutton MA, Bruck HA: Multi-scale mechanical characterization of Palmetto wood as a template for biologically inspired polymer composites.  Exp Mech, accepted, 2010

     
     

    Liao J, Guo X, Grande-Allen KJ, Kasper FK, Mikos AG: Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering, Biomaterials, 31:8911-8920, 2010

     
     

    Stephens EH, Durst CA, Swanson JC, Grande-Allen KJ, Ingels, NB Jr, Miller DC: Functional coupling of valvular interstitial cells and collagen in the mitral leaflet.  Cell Mol Bioeng, accepted, 2010

     
     

    Stephens EH, Durst CA, West JL, Grande-Allen KJ: Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region.  Acta Biomaterialia, 7;75–82, 2011.

     
     

    Stephens EH, Huynh TN, Cieluch JD, Grande-Allen KJ: Fibronectin-based isolation of valve interstitial cell subpopulations: relevance to valve disease.  J Biomed Mater Res Part A, 92(1):340-9, 2010

     
     

    Stephens EH, Post AD, Laucirica DR, Grande-Allen KJ: Perinatal changes in mitral and aortic valve structure and composition. Ped Dev Pathol, 13(6):447-58, 2010.

     
     

    Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD Jr, Grande-Allen KJ: Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar cardiac valves, Cardiovasc Pathol, 20(5):e157-67, 2011.

     
     

    Stephens EH, de Jonge N, McNeill MP, Durst CA, Grande-Allen KJ: Age-related changes in material behavior of porcine mitral and aortic valves and correlation to matrix composition. Tissue Eng A, 16(3):867-78, 2010. PMID: 19814589

     
     

    Xu S, Grande-Allen KJ: The evolution of the field of biomechanics through the lens of Experimental Mechanics. Exp Mech, 50:667-682, 2010

     
     

    Xu S, Grande-Allen KJ: The role of cell biology and leaflet remodeling in the progression of heart valve disease. Methodist DeBakey Cardiovascular Journal, 6(1):2-7, 2010

     
     Allison DD, Braun KR, Wight TN, Grande-Allen KJ: Differential effects of exogenous and endogenous hyaluronan on contraction and strength of collagen gels. Acta Biomaterialia, accepted, 2008.
     
     Allison DD, Wight TN, Ripp NJ, Braun KR, Grande-Allen KJ: Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: implications for vascular and valvular disease. Biomaterials, 29:29692976, 2008.
     
     Blevins TL, Peterson SB, Lee EL, Bailey A, Frederick JD, Gupta V, Grande-Allen KJ: Mitral valvular interstitial cells demonstrate regional, adhesional, and synthetic heterogeneity. Cells Tissues Organs, 187(2):113-122, 2008.
     
     Ferdous Z, Lazaro LD, Iozzo RV, Hvvk M, Grande-Allen KJ: Influence of cyclic strain and decorin deficiency on 3-D cellularized collagen matrices. Biomaterials, 29:2740-8, 2008.
     
     

    Gupta V, Barzilla JE, Mendez JS, Stephens EH, Lee EL, Collard CD, Laucirica R, Weigel PH, Grande-Allen KJ: Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves. Cardiovasc Pathol, 18:191-197, 2009

     
     

    Gupta V, Lawrence BD, Grande-Allen KJ: Effect of cyclic mechanical strain on glycosaminoglycan and proteoglycan synthesis by heart valve cells. Acta Biomaterialia, 5:531–540, 2009. 

     
     Gupta V, Werdenberg JA, Lawrence BD, Stephens EH, Mendez JS, Grande-Allen KJ: Reversible secretion of glycosaminoglycans and proteoglycans by cyclically stretched valvular interstitial cells in 3D culture. Ann Biomed Eng, 36(7):1092-103, 2008.
     
     **Gupta V, Werdenberg JA, Mendez JS, Grande-Allen KJ: Influence of strain on proteoglycan synthesis by valvular interstitial cells in 3D culture. Acta Biomaterialia, 4(1):88-96, 2008
     
     Hahn MS, Jao CW, Faquin W, Grande-Allen KJ: Analysis of glycosaminoglycan composition of the vocal fold lamina propria in relation to function. Ann Otol Rhinol Laryngol, 117(5):371-81, 2008.
     
     Nistri S, Grande-Allen KJ, Noale M, Basso C, Maggi S, Thiene G: Aortic elasticity and size in bicuspid aortic valve syndrome, Eur Heart J, 29(4):472-9, 2008.
     
     Ofek G, Revell CM, Hu JC, Allison DD, Grande-Allen KJ, Athanasiou KA: Matrix development in self-assembly of articular cartilage. PLoS ONE, 3(7):e2795, 2008.
     
     Saraf A, Hacker MC, Sitharaman B, Grande-Allen KJ, Barry MA, Mikos AG: Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules, 9:818-827, 2008.
     
     Stephens EH, Huynh TN, Cieluch JD, Grande-Allen KJ: Fibronectin-based isolation of valve interstitial cell subpopulations: relevance to valve disease. J Biomed Mater Res Part A, accepted, 2008.
     
     Stephens EH, Nguyen TC, Itoh A, Ingels Jr NB, Miller DC, Grande-Allen KJ: The effects of mitral regurgitation alone are sufficient for leaflet remodeling. Circulation 118;S243-S249, 2008
     
     Stephens ES, Chu CK, Grande-Allen KJ: Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical loads, and age: relevance to an age-specific tissue engineered heart valve. Acta Biomaterialia, 4:1148-1160, 2008.
     
     Xu S, Grande-Allen KJ: Novel miniaturized collagen static tension tissue molds tested with cardiac aortic valve cells and decorin knocked-out fibroblasts, J Young Investigators, 8(4), 2008 [online].
     
     

    Allison DD, Braun KR, Vasco N, Wight TN, Grande-Allen KJ "The effect of endogenous overexpression of hyaluronan synthases on material, morphological and biochemical properties of uncrosslinked collagen biomaterials." Biomaterials (2007) In Press

     
     

    Ferdous Z, Wei VM, Iozzo RV, Hvvk M, Grande-Allen KJ "Decorin-TGF-beta interaction regulates matrix organization and mechanical characteristics of 3-D collagen matrices." J Biol Chem (2007) Submitted

     
     

    Ferdous Z., Grande-Allen KJ "Utility and control of proteoglycans in tissue engineering." Tissue Eng, 13(8) (2007) : 1893-1904.

     
     

    Grande-Allen KJ, Osman N, Ballinger ML, Dadlani H, Marasco S, Little PJ "Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease." Cardiovasc Res, 76(1) (2007) : 19-28.

     
     

    Gupta V, Lawrence BD, Grande-Allen KJ "Effect of cyclic mechanical strain and frequency on glycosaminoglycan and proteoglycan synthesis by heart valve cells. Tissue Eng."  (2007) Submitted

     
     

    Gupta V, Werdenberg J, Blevins TL, Grande-Allen KJ "Synthesis of glycosaminoglycans in differently loaded regions of collagen gels seeded with valvular interstitial cells." Tissue Eng, 13 (1) (2007) : 41-49.

     
     

    Nistri S, Grande-Allen KJ, Noale M, Basso C, Maggi S, Thiene G "Relations between aortic elastic properties and aortic size in bicuspid aortic valves." Eur Heart J (2007) Submitted

     
     

    Stephens ES, Carroll JL, Grande-Allen KJ "The use of collagenase III for the isolation of porcine aortic valvular interstitial cells: rationale and optimization." J Heart Valve Dis, 16 (2007) : 175-183.

     
     

    Stephens ES, Grande-Allen KJ "Age-related changes in collagen synthesis and turnover in porcine heart valves." J Heart Valve Dis (2007) In Press

     
     

    "The year in valvular heart disease." J Am Coll Cardiol, 49 (3) (2007) : 361-374.

     
     

    Grande-Allen KJ, Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM "Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation." J Thorac Cardiovasc Surg, 130(3):783-790 (2005)

     
     

    Grande-Allen KJ, Borowski A, Troughton R, Houghtaling P, DiPaola N, Moravec CS, Vesely I, Griffin BP "Apparently normal mitral valves in heart failure patients demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study." J Am Coll Cardiol, 45(1):54-61 (2005)

     
     

    Allison DD, Drazba JA, Vesely I, Kader KN, Grande-Allen KJ "Mapping cell viability within long-term heart valve organ cultures.." J Heart Valve Dis, 13(2) (2004) : 290-296.

     
     

    Blevins TL, Raza A, Grande-Allen KJ "Separation of valvular interstitial cell phenotypes." in preparation (2005)

     
     

    Grande-Allen KJ, Borowski A, Troughton R, Houghtaling P, DiPaola N, Moravec CS, Vesely I, Griffin BP "Apparently normal mitral valves in heart failure patients demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study." J Am Coll Cardiol (2004) In Press

     
     

    Grande-Allen KJ, Calabro A, Gupta V, Wight TN, Hascall VC, Vesely I "Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading." Glycobiology, 14(7) (2004) : 621-633.

     
     

    McKenney AS, Grande-Allen KJ "Phenotypic cell and matrix remodeling in static organ culture of heart valves.." in preparation (2005)

     
     

    Popovic ZB, Martin M, Fukamachi K, Borowski A, Inoue M, Doi K, Kwan J, Qin JX, Shiota T, Grande-Allen KJ, McCarthy PM, Thomas JD "Mitral annulus size links ventricular dilatation to functional mitral regurgitation: a clinical and experimental study." in preparation (2005)

     
     

    Grande KJ, Cochran RP, Reinhall PE, Kunzelman KD "Stress variations in the human aortic root and valve: the role of anatomic asymmetry." Ann Biomed Eng, 26(4) (1998) : 534-545.

     
     

    Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS "Mechanisms of aortic valve incompetence in aging: finite element modeling." J Heart Valve Dis, 8(2) (1999) : 149-156.

     
     

    Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS "Mechanisms of aortic valve incompetence in aortic root dilatation: finite element modeling." Ann Thorac Surg, 69(6) (2000) : 1851-1857.

     
     

    Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED "Porcine aortic leaflet arrangement may contribute to clinical xenograft failure." ASAIO J, 39 (1993) : 918-922.

     
     

    Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS "Mechanisms of aortic valve incompetence: finite element modeling of Marfan syndrome." J Thorac Cardiovasc Surg, 122 (2001) : 946-954.

     
     

    Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS "Simulation of aortic valve-sparing: influence of graft shape and stiffness." IEEE Trans Biomed Eng, 48(6) (2001) : 647-659.

     
     

    Grande-Allen KJ, Cochran RP, Reinhall PG, Verrier ED, Kunzelman KS "Re-creation of sinuses is important for aortic valve-sparing." J Thorac Cardiovasc Surg, 119(4 Pt 1) (2000) : 753-63.

     
     

    Grande-Allen KJ, Griffin BP, Calabro A, Ratliff NB, Cosgrove DM III, Vesely I "Myxomatous mitral valve chordae II: Selective increase of glycosaminoglycans." J Heart Valve Dis, 10(3) (2001) : 325-333.

     
     

    Grande-Allen KJ, Griffin BP, Ratliff NB, Cosgrove DM, Vesely I "Glycosaminoglycan profiles of myxomatous mitral leaflets and chordae parallel the severity of mechanical alterations." J Am Coll Cardiol, 42(2) (2003) : 271-7.

     
     

    Grande-Allen KJ, Mako WJ, Calabro A, Ratliff NB, Vesely I "Loss of chondroitin 6-sulfate and hyaluronan from failed porcine bioprosthetic valves." J Biomed Mater Res, 65A(2) (2003) : 251-259.

     
     

    Grande-Allen KJ, Ratliff N, Griffin B, Cosgrove DM, Vesely I "Outer sheath rupture may initiate chordal rupture in fibrotic mitral valve disease." J Heart Valve Dis, 10(1) (2001) : 90-93.

     
     

    Kunzelman KS, Grande KJ, David TE, Cochran RP, Verrier ED "Aortic valve and root relationships: impact on surgical repair." J Thorac Cardiovasc Surg, 107 (1994) : 162-170.

     
     

    Patwardhan AR, Brown DR, Levenhagen DK, Grande KJ, Evans JM, Knapp CF "Effect of 22 hours of 6 degree head down bed rest on spectral components of resting cardiovascular variables in humans." FASEB J, 75 (1991) : A1038.

     
     

    Patwardhan AR, Evans JM, Berk M, Grande KJ, Knapp CF "Spectral indices of cardiovascular adaptations to short term simulated microgravity exposure." Integr Physiol Behav Sci, 30(3) (1995) : 201-214.

     
     

    Sedransk K, Grande-Allen KJ, Vesely I "Failure mechanics of mitral valve chordae tendineae." J Heart Valve Dis, 11 (2002) : 644-650.

     
     

    Seidler DG, Breuer E, Grande-Allen KJ, Hascall VC, Kresse H "Core-protein dependence of epimerization on glucuronosyl residues in galactosaminoglycans." J Biol Chem, 277(44) (2002) : 42409-42416.

     
     

    Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Rothman RB, Roth BL "3,4-methylenedioxymethamphetamine, (MDMA, Ecstasy) has fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro." Mol Pharmacol, 63(6) (2003) : 1223-9.

     
     Articles
     

    Balaoing LR, Post AD, Minn KT, Grande-Allen KJ: Age-related changes in aortic valve hemostatic regulation.  Arterioscler Thromb Vasc Biol, submitted.

     
     

    Gheewala N, Schwarz KA, Grande-Allen KJ: Organ culture of porcine mitral valves as a novel experimental paradigm. Cardiovasc Eng Technol, 4(2):139-150, 2013.

     
     

    Kumar A, Wiltz DC, Grande-Allen KJ: Gentamicin reduces calcific nodule formation by aortic valve interstitial cells in vitro. Cardiovasc Eng Technol, 4(1):16-25 and 98-100, 2013.

     
     

    Osman N, Grande-Allen KJ, Ballinger ML, Getachew R, Marasco S, O’Brien KD, Little PJ: Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.  Cardiovasc Pathol, 22(2):146-55, 2013. PMID: 22999704.

     
     

    Stephens EH, Saltarrelli JG, Balaoing LR, Baggett LS, Nandi I, Anderson KM, Reardon MJ, Morrisett JD, Olmsted-Davis EA, Davis AR, Grande-Allen KJ: Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with endochondral ossification in calcified human aortic valves.  Pathol Res Pract;208(11):642-50, 2012. PMID: 23017666.

     
     

    Tseng H, Balaoing LR, Grigoryan B, Raphael RM, Killian TC, Souza GR, Grande-Allen KJ: A three-dimensional co-culture model of the aortic valve using magnetic levitation. Acta Biomaterialia, 10(1):173-82, 2014.

     
     

    Tseng H, Cuciara ML, Durst CA, Cuchiara MP, Lin CJ, West JL, Grande-Allen KJ: Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations.  Ann Biomed Eng, 41(2):398-407, 2013.

     
     

    Tseng H, Kim EJ, Ayoub S, Shah JV, Puperi DS, Cuchiara ML, West JL, Grande-Allen KJ: Anisotropic poly(ethylene glycol)/polycaprolactone (PEG/PCL) hydrogel-fiber composites for heart valve tissue engineering.  Tissue Eng A, submitted.

     
     

    Tseng H, Kim EJ, Connell PS, Ayoub S, Shah JV, Grande-Allen KJ: The tensile and viscoelastic properties of aortic valve leaflets treated with a hyaluronidase gradient. Cardiovasc Eng Technol, 4(20):151-160, 2013.

     
     

    Tseng H, Raphael RM, Killian TC, Grande-Allen KJ, Souza GR: Assembly of a three-dimensional multitype bronchiole co-culture model using magnetic levitation. Tissue Eng C, 19(9):665-75, 2013.

     
     

    Wiltz DC, Kumar A, Morrisett JD, Grande-Allen KJ: Differential aortic and mitral valve interstitial cell mineralization and the induction of mineralization by lysophosphatidylcholine in vitro. Cardiovasc Eng Technol, submitted.

     
     

    Barzilla JE, Acevedo FE, Grande-Allen KJ: Organ culture as a tool to identify early mechanisms of serotonergic valve disease. J Heart Valve Dis, 19:626-635, 2010. 

     
     

    Barzilla JE, McKenney AS, Cowan AE, Grande-Allen KJ: Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture. Ann Biomed Eng, 38(10); 3280-3294, 2010.

     
     

    Gheewala N, Grande-Allen KJ: Design and mechanical evaluation of a physiological mitral valve organ culture system, Cardiovasc Eng Technol, 1(2):123-131, 2010.

     
     

    Gupta V, Barzilla JE, Mendez JS, Stephens EH, Lee EL, Collard CD, Laucirica R, Weigel PH, Grande-Allen KJ: Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves.  Cardiovasc Pathol, 18:191-197, 2009

     
     

    Gupta V, Tseng H, Lawrence BD, Grande-Allen KJEffect of cyclic mechanical strain on glycosaminoglycan and proteoglycan synthesis by heart valve cells.  Acta Biomaterialia, 5:531-540, 2009.

     
     

    Srinivas VR, Lazaro LD, Grande-Allen KJ: Effects of differential glycosaminoglycan sulfation on tandem enzyme digestion and fragment size.  Macromol Bios, submitted, 2009

     
     

    Stephens EH, Carroll JL, Post AD, Kuo JJ, Grande-Allen KJFunctional characterization of fibronectin-separated value interstitial cell subpopulations in 3D culture, J Heart Valve Dis, submitted, 2009.

     
     

    Stephens EH, Timek TA, Daughters GT, Kuo JJ, Patton AM, Baggett LS, Ingels NB, Miller DC, Grande-Allen KJ: Significant changes in mitral valve leaflet matrix composition and turnover with tachycardia-induced cardiomyopathy.  Circulation 120;S112-S119, 2009

     
     

    Ferdous Z, Peterson SB, Tseng H, Anderson DK, Iozzo RV, Grande-Allen KJ: A role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts. J Biomed Mater Res Part A, 93(2):419-428, 2010. 

     
     

    Lafont AL, Tan FK, Tran-Fadulu V, Grande-Allen KJ, Estrera AL, Safi HJ, Geng YJ, Milewicz DM: Activation of ERK1/2 signaling and inactivation of GSK-3b in the aortic smooth muscle cells in patients with familial thoracic aortic aneurysms and dissections. Arterioscler Thromb Vasc Biol, Arterioscler Thromb Vasc Biol.

     
     

    Blevins TL, Carroll J, Raza A "Phenotypic characterization of isolated valvular interstitial cell subpopulations." J Heart Valve Dis, 15(6): (2006) : 815-22.

     
     

    Gupta V "Effects of static vs. cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells." Cardiovasc Res, 72(3) (2006) : 375-383.

     
     

    Allison DD, Grande-Allen KJ "Hyaluronan: a powerful tissue engineering tool." Tissue Engineering (2005) In Press

     
     Books
     

    Durst CA, Cuchiara MP, Mansfield EG, West JL, Grande-Allen KJ: Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves. Acta Biomaterialia, 7(6):2467-76, 2011.

     
     

    Srinivas VR, Lazaro LD, Grande-Allen KJ: Effects of differential glycosaminoglycan sulfation on tandem enzyme digestion and fragment size.  Macromol Bios, submitted, 2010

     
     

    Stephens EH, Kearney DL, Grande-Allen KJ: Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix.  Cardiovasc Pathol, 21(1):46-58, 2012. 

     
     

    Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Anderson KM, Reardon MJ, Morrisett JD, Olmsted-Davis EA, Davis AR, Grande-Allen KJ: Hyaluronan turnover and hypoxic brown adipocytes are co-localized with endochondral ossification in calcified human aortic valves.  Human Pathol, submitted, 2010

     
     

    Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, Davis AR, Olmsted-Davis EA, Reardon MJ, Morrisett JD, Grande-Allen KJ: Differential proteoglycan and hyaluronan distribution in calcified aortic valves.  Cardiovasc Pathol, 20(6):334-42, 2011. 

     
     

    Tseng H, Grande-Allen KJ: Elastic fibers in the aortic valve spongiosa: a fresh perspective on their structure and role in overall tissue function.  Acta Biomaterialia, 7(5):2101-8, 2011. 

     
     Book chapters
     

    Aikawa E, Grande-Allen KJ: Biology of mitral valve disease. In Cardiac Valvular Medicine (edited by N. Rajamannan), Springer-Verlag: London, 2013.

     
     

    Wiltz DC, Arevalos CA, Balaoing LR, Blancas AA, Sapp MS, Zhang X, Grande-Allen KJ: Extracellular matrix organization, structure, and function.  In Calcific Aortic Valve Disease (edited by E. Aikawa), ISBN: 978-953-51-1150-4, InTech (2013),  Available from: http://www.intechopen.com/books/calcific-aortic-valve-disease/extracellular-matrix-organization-structure-and-function

     
     

    Aikawa E, Grande-Allen KJ: Biology of mitral valve disease. In Cardiac Valvular Medicine (edited by N. Rajamannan), Springer-Verlag: London, 2013.

     
     

    Wiltz DC, Arevalos CA, Balaoing LR, Blancas AA, Sapp MS, Zhang X, Grande-Allen KJ: Extracellular matrix organization, structure, and function. In Calcific Aortic Valve Disease (edited by E. Aikawa), ISBN: 978-953-51-1150-4, InTech (2013),  Available from: http://www.intechopen.com/books/calcific-aortic-valve-disease/extracellular-matrix-organization-structure-and-function

     
     

    Tseng H, Grande-Allen KJ: Microstructure of the aortic valve: implications for valvular mechanics and function.  Advances in Cardiovascular Research, Volume 1, Nova Science Publishers, Inc.: Hauppauge, NY, 2010

     
     

    Tseng H, Grande-Allen KJ: Microstructure of the aortic valve: implications for valvular mechanics and function.  Invited submission to Heart Valves: Disorders, Repair, and Replacement, Nova Science Publishers, Inc.: Hauppauge, NY, 2010

     
     

    "Tissue engineering of heart valves." Biomedical Engineering Handbook, 3rd Edition (2006) : 57-1 – 57-19.

     
     

    Grande-Allen KJ "Tissue engineering of heart valves." Biomedical Engineering Handbook, 3rd Edition (2004) In Press

     
     Book reviews
     

    Barzilla JE, Blevins TL "Age-related structural changes in cardiac valves: implications for tissue engineered repairs." American Journal of Geriatric Cardiology, 15(5) (2006) : 311-5.

     
     Refereed conference papers
     

    Allison DD, Wight TN, Grande-Allen KJ "The role of HA in soft tissue mechanics." Proceedings of Hyaluronan 2007 (2007)

     
     Peterson SB, Radovancevic B, Hernandez A,
     
     

    Stephens EH, Blazejewski JG, Nguyen TC, Miller DC, Grande-Allen KJ "Ovine valvular changes after experimental mitral valve regurgitation. Proceedings of the Fourth Biennial Meeting of the Society for Heart Valve Disease."  (2007)

     
     Conference papers
     

    Kreuz JM, Erskine KN, Blancas AA, Grande-Allen KJ: Age and regional dependence of collagen crimp in heart valves. Proceedings of the Society for Experimental Mechanics, Lombard, IL, June 2013

     
     Barzilla JE, Grande-Allen KJ: Design of splashing bioreactor maintaining mitral valve structure in vitro. Proceedings of the Society for Experimental Mechanics, Orlando, FL, June
     
     Durst CA, Grande-Allen KJ: Design and development of an aortic valve culture system, Proceedings of the Society for Experimental Mechanics, Orlando FL, June 2008.
     
     Gheewala N, Grande-Allen KJ: Design of a pulsatile flow loop for sterile mitral heart valve organ culture. Proceedings of the Society for Experimental Mechanics, Orlando, FL, June 2008
     
     

    Stephens ES, Grande-Allen KJ "The porcine valve as a model for age-specific human heart valve disease: analysis of collagen turnover throughout development and aging.Proceedings of the American College of Surgeons Clinical Congress."  (2007)

     
     

    Barzilla JE, Grande-Allen KJ "Can LVADs restore normal mitral valve mechanics in heart failure?." Proceedings of the Scociety for Experimental Mechanics (June 2005) : p. 113.

     
     

    Grande-Allen KJ "Fibrotic vs. myxomatous remodeling of mitral valves." Proceedings of the IEEE-EMBS Annual Meeting (2004)

     
     

    Grande-Allen KJ, Lawrence BD, Gupta V "Tissue engineering tools for mechanical modulation of valvular extracellular matrix." Proceedings of the Society for Experimental Mechanics X International Congress & Exposition (2004)

     
     

    Grande-Allen KJ, Vesely I, Hascall VC "Identification, localization, and function of proteoglycans in normal and diseased valves and valvular cell cultures." Proceedings of Hyaluronan 2003 (2003)

     
     Other
     

    Peterson SB, Ferdous Z, Hvvk M, Grande-Allen KJ "Decorin deficient cells demonstrate increased proliferation and altered phenotypic properties. Proceedings of the ASME Summer Bioengineering Conference."  (June)

     
     

    Stephens EH, Grande-Allen KJ "Role of matrix turnover in porcine valve development and aging. Proceedings of the Fourth Biennial Meeting of the Society for Heart Valve Disease."  (2007)

     
     

    Stephens ES, Chu KC, Grande-Allen KJ "Age-related changes in the glycosaminoglycan composition of heart valves. Proceedings of the 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences."  (2007)

     
     

    Allison DD "Hyaluronan:a powerful tissue engineering tool." Tissue Eng, 12(8) (2006) : 2131-40.

     
     

    Brown EN, Peterson ML "Biological systems and materials: a review of the field of biomechanics and the role of the Society for Experimental Mechanics." Experimental Techniques, 30(2) (2006) : 21-30.

     
     

    Gupta V, Werdenberg JA, Lawrence BD "Inducible and reversible glycosaminoglycan synthesis by repeatedly stretched and relaxed valvular interstitial cells in 3D culture." Cardiovasc Res (2006) Submitted

     
     

    McKenney AS "Collagen upregulation and cell migration in long term static organ culture of heart valves." J Heart Valve Dis (2006) In Revision

     
     

    Stephens ES, Carroll JC "Optimization of valvular interstitial cell isolation." J Heart Valve Dis (2006) Submitted

     
    Presentations
     Conference Committee Member
     

    "Track 1: Mechanical and Microstructural Analyses of Biological Systems and Materials."

     
     

    "Glycosaminoglycans synthesis in uniaxial vs. biaxial regions of collagen gels." Houston Society for Engineering in Medicine and Biology, Houston TX. (February 2006) With Gupta V, Werdenberg JA

     
     Invited Papers
     

    Notre Dame University, Department of Aerospace and Mechanical Engineering, South Bend, IN, Spring 2010

     
     

    Stephens EH, Durst CA, Swanson J, Grande-Allen KJ, Ingels Jr NB, Miller DC: Functional coupling of valvular interstitial cells and collagen in the mitral leaflet. Proceedings of the 4th Biennial Heart Valve Biology and Tissue Engineering Meeting, Hilton Head, SC, March 2010

     
     

    Gordon Research Conference on Proteoglycans, Andover NH, July 2010.

     
     

    Stephens EH, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels Jr. NB, Miller DC, Grande-Allen KJ: Mitral valve remodeling in dilated cardiomyopathy, Baylor MD/PhD Conference, Houston, TX, August 2010

     
     

    Durst CA, Grande-Allen KJ: Phenotypic characterization of porcine aortic valves cultured in a synchronous multivalve culture system.  Proceedings of the 4th Biennial Heart Valve Biology and Tissue Engineering Meeting, Hilton Head, SC, March 2010

     
     Invited Talks
     

    "Inaugural Heart Valve Society Meeting, Monte Carlo, Monaco, May 2015.." (May 2015)

     
     

    "Kansas State University, Engineering in Medicine and Biology Society, Manhattan, KS, February 2015.." (February 2015)

     
     

    "Texas A&M University, Mechanical Engineering Graduate Seminar Series, College Station, TX, March 2015.." (March 2015)

     
     

    "University of Akron, Biomedical Engineering Seminar Series, Akron, OH, January 2015.." (January 2015)

     
     

    "University of Maryland Baltimore County, Department of Mechanical Engineering Seminar Series, September 2015.  ." (September 2015)

     
     

    Kansas State University, Engineering in Medicine and Biology Society, Manhattan, KS, February 2015.

     
     

    Heart Valve Society of America / Society for Heart Valve Disease Joint Conference, New York City, NY, May 2014.

     
     

    Texas A&M University, Mechanical Engineering Graduate Seminar Series, College Station, TX, March 2015.

     
     

    NYU/Brooklyn Polytech, Biomedical Engineering Program, New York City, NY, April 2014

     
     

    "Southwest Valve Summit." (May 2015)

     
     

    Auburn University, Department of Chemical Engineering, Auburn University, AL, February 2013.

     
     

    Boston University, Department of Biomedical Engineering, Boston, MA, April 2013.

     
     

    Florida International University, Department of Biomedical Engineering, Miami, FL, September 2013.

     
     

    Georgia Institute of Technology, Department of Biomedical Engineering, Atlanta, GA, February 2013.

     
     

    Gordon Research Conference on Biomaterials & Tissue Engineering, Plymouth, NH, July 2013.

     
     

    Mathematics Biology Institute:  Mathematics Guiding Bioartificial Heart Valve Design, Columbus, OH, October 2013

     
     

    ASME Emerging Technologies' 6th Frontiers in Biomedical Devices Conference & Exhibition, Irvine, CA, September 2011

     
     

    American College of Cardiology Symposium on Biology of Mitral Valve Disease: Degenerative and Rheumatic, New Orleans, LA, April 2011

     
     

    Baylor College of Medicine Medical Scientist Training Program, Biomedical Sciences Research Seminar, Houston, TX, October 2011

     
     

    Baylor College of Medicine Molecular Physiology and Biophysics Faculty Seminar Series, Houston, TX, November 2011

     
     

    Baylor College of Medicine, Cullen Trust for Higher Education Translational Research Symposium, Houston TX, January 2011

     
     

    McGill University Department of Mechanical Engineering, Montreal, QC, Canada, December 2011

     
     

    National Institutional Research and Academic Career Development Award Conference, Houston, TX, July 2011

     
     

    Rice University Institute of Biosciences and Bioengineering NSF/HHMI Seminar Series, Houston TX, June 2011

     
     

    University of Alabama at Birmingham Postdoctoral Association Seminar Series, Birmingham, AB, September 2011

     
     

    University of Kentucky Gill Heart Institute and Saha Cardiovascular Research Center’s Cardiovascular Seminar Series, Lexington, KY, February 2011

     
     

    University of Pittsburgh McGowan Center for Regenerative Medicine Seminar Series, Pittsburgh, PA, November 2011

     
     

    University of Texas – Houston, Institute of Molecular Medicine, Stem Cell Centre Seminar Series, Houston, TX, March 2011

     
     

    University of Texas Health Science Center, Division of Cardiology Grand Rounds, Houston, TX, September 2011

     
     

    American Heart Association Houston Board of Directors, Houston TX, September 2010

     
     

    Baylor College of Medicine Medical Scientist Training Program Interview Weekend Seminar Series, Houston TX, January 2010

     
     

    Rice University Institute of Biosciences and Bioengineering IGERT Seminar Series, Houston TX, July 2010

     
     

    Texas Heart Institute Cardiovascular Seminar, Houston TX, February 2010

     
     

    Rice University Institute of Biosciences and Bioengineering IGERT Seminar Series, Houston TX, June 2009

     
     

    Texas A&M University, Molecular and Cellular Medicine Seminar, College Station TX, April 2009.

     
     

    Re-Evolution Summit, Methodist DeBakey Heart and Vascular Center, Houston TX, March 2009

     
     

    "Heart valves, glycosaminoglycans, and tissue engineering." Technical University of Eindhoven Tissue Engineering Program, Eindhoven, The Netherlands. (2007)

     
     

    "Heart valves, glycosaminoglycans, and tissue engineering." University of Kentucky Center for Biomedical Engineering, Lexington KY. (2007)

     
     

    "Tissue engineered valves." INDO-US Workshop on Cardiovascular Prosthetic Devices: In Vitro Studies to Clinical Implantation, Trivandrum, India. (2007)

     
     

    "Valvular heart disease: bioengineering from bench to bedside." Methodist DeBakey Heart Center Research Conference, Houston TX. (2007)

     
     

    "Heart valves, glycosaminoglycans, and tissue engineering." Rice University Institute of Biosciences and Bioengineering IGERT Seminar Series, Houston TX. (June 2006)

     
     

    "Heart valves, glycosaminoglycans, and tissue engineering." Washington University in St. Louis Cell and Tissue Mechanics Seminar Series, St. Louis MO. (June 2006)

     
     

    "Tissue engineering approach to determine proteoglycan biomechanics." Texas A&M University Biomedical Engineering Seminar, College Station TX. (October 2006)

     
     

    "Tissue engineering models for proteoglycan biomechanics." Brown University Biomedical Engineering Seminar, Providence RI. (November 2006)

     
     

    "Tissue engineering tools for analyzing glycosaminoglycan and proteoglycan biomechanics." University of South Florida, Tampa FL. (January 2006)

     
     

    "Tissue engineering tools for analyzing glycosaminoglycan and proteoglycan biomechanics." Baylor College of Medicine Medical Scientist Training Program Seminar Series, Houston TX. (April 2006)

     
     

    "Tissue engineering, heart valves, and proteoglycans." Brown Medical School Cardiology Grand Rounds, Providence RI. (November 2006)

     
     

    "Valvular heart disease: bioengineering from bench to bedside." Rice University Board of Trustees, Houston TX. (September 2006)

     
     

    "Bioengineering analysis of heart valve disease." Texas Heart Institute Cardiology Grand Rounds, Houston TX. (April 2005)

     
     

    "Bioengineering analysis of heart valve disease." University of Houston Biomedical Engineering Program, Houston, TX. (March 2005)

     
     

    "Biomedical engineering, heart valves, and extracellular matrix mechanics." Department of Physics and Engineering, Murray State University, Murray KY. (October 2005)

     
     

    "Heart valves, cells, and gels." Rice Alumni College, Dallas, TX. (November, 2005)

     
     

    "The role of proteoglycans in the mechanics and structure of heart valves." Rice University Biophysics Group, Houston, TX. (January 2005)

     
     

    "Bioengineering analysis of heart valve disease." Texas Heart Institute Cardiology Grand Rounds, Houston, TX. (2005)

     
     

    "Bioengineering analysis of heart valve disease." Texas A&M University System Health Science Center / Institute of Biosciences and Technology, Houston, TX. (2004)

     
     

    "Bioengineering studies of heart valve disease." Rice University Institute of Biosciences and Bioengineering IGERT Seminar Series, Houston, TX. (2004)

     
     

    "Elucidating the mechanical function of versican, decorin, biglycan and hyaluronan in heart valves." Gordon Research Conference on Proteoglycans, Andover, NH. (2004)

     
     

    "Loading-modulated phenotypes of extracellular matrix in normal and diseased heart valves." European Society for Biomechanics, 's-Hertogenbosch, The Netherlands. (2004)

     
     

    "Valvular heart disease: bioengineering from bench to bedside." Sigma Xi Houston Chapter, Houston, TX. (2004)

     
     

    "Altered material properties of mitral leaflets and chordae in end-stage heart failure: mechanical evidence for dysfunctional remodeling." Biomedical Engineering Society, Nashville, TN. (October, 2003) With Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM

     
     

    "Biomedical engineering analysis of heart valves: the structure-function continuum." Department of Biomedical Engineering, Marquette University, Milwaukee, WI. (April 1999)

     
     

    "Cellular and molecular analysis of mitral valve proteoglycans." Department of Anesthesiology Research, Cleveland Clinic Foundation, Cleveland, OH. (January 2003)

     
     

    "Extracellular matrix alterations in mitral valve disease." Department of Anesthesiology Research, Cleveland Clinic Foundation, Cleveland, OH. (May 2001)

     
     

    "Finite element analysis of the aortic root and valve." Department of Physics, Reed College, Portland, OR. (November 1997)

     
     

    "Glycosaminoglycans and the mechanics of materials in normal and diseased mitral valves." International Society for Heart Research, Madison WI. (July 2002)

     
     

    "Material - mechanical relationships in heart valve tissues." Society for Experimental Mechanics, Milwaukee, WI. (June 2002)

     
     

    "Material - mechanical relationships in heart valve tissues." Department of Mechanical Engineering, Temple University, Philadelphia, PA. (November 2002)

     
     

    "Material - mechanical relationships in heart valve tissues." Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH. (December 2002)

     
     

    "Material - mechanical relationships in heart valve tissues." Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL. (December, 2002)

     
     

    "Material - mechanical relationships in heart valve tissues." Department of Biomedical Engineering, Wake Forest University, Winston-Salem, NC. (December 2002)

     
     

    "Tensile vs. compressive glycosaminoglycan profiles in normal and myxomatous mitral valves." IV World Congress of Biomechanics, Calgary, Canada. (August 2002)

     
     

    "The aortic root-aortic valve relationship in the normal, diseased, and surgically repaired states." Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH. (April 1998)

     
     

    "Valvular heart disease: bioengineering from bench to bedside." Department of Biomedical Engineering, University of Iowa, Iowa City, IA. (April 2003)

     
     

    "Valvular heart disease: bioengineering from bench to bedside." Department of Bioengineering, Rice University, Houston, TX. (March 2003)

     
     Keynote Speaker
     

    Keynote Speaker, 5th Biennial Heart Valve Biology & Tissue Engineering Meeting, London, UK, September 2014.

     
     

    Keynote Speaker, Biological Systems and Materials Symposium, Society for Experimental Mechanics, Greenville, SC, June 2014.

     
     

    Keynote Speaker, TERMIS-EU Symposium on Heart Valve Tissue Engineering, Genoa, Italy, June 2014.

     
     

    4th Biennial Heart Valve Biology & Tissue Engineering Meeting (Keynote Lecture), Hilton Head, SC, March 2010

     
     Lectures
     

    Connell PS, Azimuddin A, Grande-Allen KJ: Analysis of mitral valve prolapse using a flow loop bioreactor. BMES, Atlanta, GA, October 2012

     
     

    Balaoing LR, Post AD, Lin AY, Nolasco L, Turner NA, Moake JL, Grande-Allen KJ: Biomechanical stimuli effects on valve endothelial cell anti-thrombotic mechanisms. Heart Valve Biology and Tissue Engineering Biennial Conference, Mykonos, Greece, May 2012

     
     

    Grande-Allen KJ, Scully BB, Morales DLS: Cardiovascular Remodeling of a Small Intestinal Submucosa Patch In Vivo and In Vitro. Southern Biomedical Engineering Conference, Houston, TX, May 2012

     
     

    Kamel PI, Qu P, Grande-Allen KJ: Contraction of porcine aortic valvular interstitial cells in collagen and fibrin gels under various metabolic substrate conditions. Southern Biomedical Engineering Conference, Houston, TX, May 2012

     
     

    Connell PS, Azimuddin A, Grande-Allen KJ: Preliminary Validation of Heart Valve Disease Models in a Physiological Flow Loop.  Southern Biomedical Engineering Conference, Houston, TX, May 2012

     
     

    Tseng H, Kim E, Connell P, Grande-Allen KJ: Quantification of the role of glycosaminoglycans on the tensile and viscoelastic properties of the aortic valve leaflet. Heart Valve Biology and Tissue Engineering Biennial Conference, Mykonos, Greece, May 2012

     
     

    Zhang X, Xu B, Tseng H, Rowland M, West JL, Grande-Allen KJ: Tissue engineering of aortic valve leaflets using biomimetic composite poly(ethylene glycol) diacrylate hydrogels. Southern Biomedical Engineering Conference, Houston, TX, May 2012

     
     

    Oden M, Grande-Allen J, Igoshin O, Jacot J, Suh J, Saterbak A: Vertical integration of CATME as a peer evaluation tool for assessment of teams.  BMES, Atlanta, GA, October 2012

     
     

    Tseng H, Kim E, Shah J, Grande-Allen KJ: Anisotropic hydrogel-fiber composites for heart valve tissue engineering. TERMIS-NA 2011, Houston, TX, December 2011

     
     

    Liezl LR, Post AD, Lin A, Moake J, Grande-Allen KJ: Developing a Framework for Evaluating Valvular Endothelial Cell Response to Basal Lamina Peptides Immobilized onto PEGDA Hydrogel Scaffolds.  TERMIS-NA 2011, Houston, TX, December 2011

     
     

    Scully BB, Fan C, Jacot JG, Vick GW, Kim J, Fraser CD, Grande-Allen KJ, Morales DLS.  In vivo remodeling of a small intestinal submucosa patch into functional myocardium. Congenital Heart Surgeon’s Society Annual Meeting, Chicago, IL.  October 2011

     
     

    Jejelowo AO, Grande-Allen KJ: Tissue characterization of diseased aortic valve leaflets via micro-computed tomography. American Heart Association, 19th Annual NHLBI Cardiovascular Diversity Research Supplement Awardee Session, Orlando, FL, November 2011

     
     Other
     

    "Design of a pseudo-physiologic aortic valve culture system.." Proceedings of the HSEMB, Houston, TX. (February 2008) With Durst CD, Grande-Allen KJ

     
     

    "Unique protein expression profiles in normal and pathological pediatric valves: implications for a tissue engineered heart valve,." Proceedings of the Current Trends in Cardiothoracic Surgery Conference, Houston, TX. (May 2008) With Stephens EH, Huynh TN, Cieluch JD, Grande-Allen KJ

     
     

    "Contribution of TGF-beta to cell proliferation, matrix organization and tissue mechanics in decorin deficient collagen gels." Proceedings of the HSEMB, Houston TX. (February 2007) With Ferdous Z, Hook M

     
     

    "Effects of LVAD support on human failing hearts and valves." Proceedings of the HSEMB, ,, Houston TX. (February 2007) With Peterson SB, Barzilla JE, Radovancevic B, Hernandez A, Radovancevic R, Droddy A

     
     

    "Optimization of valvular interstitial cell isolation for investigations of valvular biology and tissue engineering." Proceedings of the HSEMB, Houston TX. (February 2007) With Stephens ES, Carroll JC

     
     

    "Ovine myocardial and valvular changes after experimental mitral valve regurgitation." Proceedings of the HSEMB, Houston TX. (February 2007) With Blazejewski JG, Nguyen TC, Miller DC

     
     

    "Physiological flow loop for mitral valve ex vivo organ culture." Proceedings of the HSEMB, Houston TX. (February 2007) With Gheewala N

     
     

    "Protein-based fibers, ropes, films, sheets, and baskets." Proceedings of the Texas Protein Folders Meeting, Navasota TX. (March 2007) With Bondos SE, Greer AM, Huang Z, Xu S, Matthews KS

     
     

    "Remodeling in an ovine mitral valve regurgitation model." Proceedings of the BMES, Los Angeles CA. (September 2007) With Stephens ES, Nguyen TC, Miller DC

     
     

    "Spectrum of extracellular matrix proteins, precursors, and turnover in fetal through aged porcine heart valves." Proceedings of the HSEMB, Houston TX. (February 2007) With Stephens ES, Smith AA

     
     

    "An in vitro model for myxomatous mitral valve disease." (2006) With Allison DD, Wight TN

     
     

    "An in vitro model for myxomatous mitral valve disease." Houston Society for Engineering in Medicine and Biology, Houston TX. (February 2006) With Allison DD, Wight TN

     
     

    "Can LVADs restore normal mitral valve composition in heart failure?." Chicago IL. (October 2006) With Barzilla JE

     
     

    "Can LVADs restore normal mitral valve composition in heart failure?." Biomedical Engineering Society, Chicago IL. (October 2006) With Barzilla JE

     
     

    "Decorin-TGF beta interplay in cell growth and contraction of collagen constructs." Biomedical Engineering Society, Chicago IL. (October 2006) With Ferdous Z, Höök

     
     

    "Decorin-TGF beta interplay in cell growth and contraction of collagen constructs." Chicago IL. (October 2006) With Ferdous Z, Höök M

     
     

    "Glycosaminoglycans synthesis in uniaxial vs. biaxial regions of collagen gels." Hilton Head, SC. (March 2006) With Gupta V, Werdenberg JA

     
     

    "Glycosaminoglycans synthesis in uniaxial vs. biaxial regions of collagen gels." (2006) With Gupta V, Werdenberg JA

     
     

    "Glycosaminoglycans synthesis in uniaxial vs. biaxial regions of collagen gels." Hilton Head SC. (March 2006) With Gupta V, Werdenberg JA

     
     

    "Hyaluronan: a molecular basis for altered tissue mechanics?." Chicago IL. (October 2006) With Allison DD, Wight TN

     
     

    "Hyaluronan: a molecular basis for altered tissue mechanics?." Biomedical Engineering Society, Chicago IL,. (October, 2006) With Allison DD, Wight TN

     
     

    "Inducible and reversible GAG and PG synthesis by cyclically stretched valvular cells in 3D culture." Chicago IL. (October 2006) With Gupta V, Werdenberg JA

     
     

    "Inducible and reversible GAG and PG synthesis by cyclically stretched valvular cells in 3D culture." Biomedical Engineering Society, Chicago IL. (October 2006) With Gupta V, Werdenberg JA,

     
     

    "Can LVADs restore normal mitral valve mechanics in heart failure." Society for Experimental Mechanics, Portland OR. (June 2005) With Barzilla JE

     
     

    "Mitral valve remodeling in end-stage heart failure." Houston Society for Engineering in Medicine and Biology Annual Meeting, Houston TX. (February 2005)

     
     

    "Overview of tissue engineered heart valves." HSEMB Annual Meeting, Houston TX. (February 2005)

     
     

    "Role of decorin in engineered tissue mechanics." Biomedical Engineering Society, Baltimore MD. (September 2005) With Ferdous Z

     
     

    "Separation of valvular interstitial cell phenotypes in preparation for proteomic analysis." Houston Society for Engineering in Medicine and Biology Annual Meeting, Houston TX. (February 2005) With Blevins TL

     
     

    "Collagen upregulation and cell migration in long term static organ culture of heart valves." Biomedical Engineering Society, Philadelphia, PA. (2004) With McKenney AS

     
     

    "Extracellular matrix biomechanics considerations for tissue engineering." Advances in Tissue Engineering Short Course, Houston, TX. (2004)

     
     

    "Fibrotic vs. myxomatous remodeling of mitral valves." The IEEE-Engineering in Medicine and Biology Society Annual Meeting, San Francicso, CA. (2004)

     
     

    "Heart valves demonstrate loading-modulated phenotypes of extracellular matrix." Houston Society for Engineering in Medicine and Biology Annual Meeting, Houston, TX. (2004)

     
     

    "Localization of proteoglycans within normal and myxomatous mitral valves." John Carroll University 3rd Annual Celebration of Science, University Heights, OH. (2004) With Olshavsky NA

     
     

    "Phenotypic analysis of long term static organ culture of heart valves: collagen upregulation and cell migration." Advances in Tissue Engineering and Biology of Heart Valves Symposium, Florence, Italy. (2004) With McKenney AS

     
     

    "Tissue engineering tools for mechanical modulation of valvular extracellular matrix." Society for Experimental Mechanics Annual Meeting, Costa Mesa, CA. (2004) With Lawrence B, Gupta V

     
     

    "Altered material properties of mitral leaflets and chordae in end-stage heart failure: mechanical evidence for dysfunctional remodeling." American Heart Association Scientific Sessions 2003, Orlando, FL. (November 2003) With Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM

     
     

    "Altered material properties of mitral leaflets and chordae in end-stage heart failure: mechanical evidence for dysfunctional remodeling." Second Biennial Meeting of the Society for Heart Valve Disease, Paris, France. (June 2003) With Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM

     
     

    "Altered valve stresses in Osteogenesis Imperfecta." Biomedical Engineering Society, San Diego, CA. (October 1997) With Cochran RP, Reinhall P, Kunzelman KS

     
     

    "Bioengineering and tissue engineering tools for studying remodeling in normal and diseased heart valves." Rice Alliance 3rd Annual Biotechnology / Life Sciences Technology Innovation Forum, Houston, TX. (2003)

     
     

    "Correlation of biochemical and echocardiographic indicators of valvular dysfunction in dilated cardiomyopathy." First Biennial Meeting of the Society of Heart Valve Disease, London. (June 2001) With Griffin BP, Holcomb J, Vesely I

     
     

    "Dacron root replacement alters aortic valve stresses: finite element modeling." First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mechanics, Washington, DC. (June 1997) With Cochran RP, Reinhall P, Kunzelman KS

     
     

    "Does myxomatous mitral valve disease selectively affect the chordae? A mechanical and biochemical analysis." BMES-IEEE conference, Atlanta. (November 1999) With Barber JE, Griffin BP, Ratliff N, Cosgrove III D, Vesely I

     
     

    "Elevated glycosaminoglycan content of myxomatous mitral valve chordae is more severe in unileaflet than in bileaflet prolapse." First Biennial Meeting of the Society of Heart Valve Disease, London. (June 2001) With Griffin BP, Mills WR, Ratliff NB, Cosgrove DM III, Vesely I

     
     

    "Elevated glycosaminoglycan content of myxomatous mitral valves is more severe in unileaflet prolapse than in bileaflet prolapse." 50th Annual Scientific Sessions of the American College of Cardiology, Orlando, FL. (March 2001) With Griffin BP, Mills WR, Ratliff NB, Cosgrove DM III, Vesely I

     
     

    "Extracellular matrix alterations in mitral valve disease." Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH. (May 2001)

     
     

    "Failure mechanics of mitral valve chordae tendineae." Biomedical Engineering Society, Durham, NC. (October 2001) With Sedransk KL, Vesely I

     
     

    "Finite element modeling of the aortic root and valve." Biomedical Engineering Society, Memphis, TN. (October 1993) With Kunzelman KS, Cochran RP, Richards TL, David TE, Verrier ED

     
     

    "Glycosaminoglycan production by cultured interstitial cells from mitral valve leaflets and chordae." First Biennial Meeting of the Society of Heart Valve Disease, London. (June 2001) With Corcoran JA, Reed L, Vesely I

     
     

    "How does fenfluramine (Fen/Phen) induce valvular heart disease?." G-Protein Coupled Receptors Meeting, Montreal. (October 2001) With Setola V, Hufeisen S, Vesely I, Roth BL

     
     

    "Identification and localization of proteoglycans in normal and diseased valves and valvular cell cultures." Second Biennial Meeting of the Society for Heart Valve Disease, Paris, France. (June 2003) With Gupta V, Hascall VC, Wight TN, Ratliff NB, Griffin BP, Cosgrove DM, Vesely I

     
     

    "Loading-modulated phenotypes of extracellular matrix: lessons from heart valves." Society for Experimental Mechanics Meeting on Biologically Inspired Materials, Springfield, MA. (October 2003)

     
     

    "Loss of hyaluronan accompanies structural deterioration of porcine bioprosthetic valves." Workshop on Prosthetic Heart Valves: Future Directions, sponsored by Georgia Technological Institute, Hilton Head Island, SC. (2002) With Mako WJ, Ratliff NB, Vesely I

     
     

    "Loss of hyaluronan accompanies structural deterioration of porcine bioprosthetic valves." Biomedical Engineering Society, Durham, NC. (October 2001) With Mako WJ, Ratliff NB, Vesely I

     
     

    "Mechanical and biochemical properties of myxomatous mitral valve chordae." World Symposium on Heart Valve Disease, London. (June 1999) With Barber JE, Griffin BP, Ratliff NB, Cosgrove DM, Vesely I

     
     

    "Mitral valve dysfunction in heart failure." Heart Failure Research Group, Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH. (December 2002)

     
     

    "Mitral valve remodeling and response with LVAD support in patients with heart failure." Imaging Research Rounds, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH. (March 2003) With Borowski AG

     
     

    "Persistent mitral regurgitation in turndown echo evaluations of LVAD patients." Second Biennial Meeting of the Society for Heart Valve Disease, Paris, France. (June 2003) With Borowski AG, Troughton RW, Yeager ML, Thomas JG, Garcia MJ, Griffin BP, Starling RC, McCarthy PM, Thomas JD

     
     

    "Porcine aortic leaflet dimensions." University of Washington, Division of Cardiothoracic Surgery, First Annual Visiting Scholar Research Forum, Seattle, WA. (May 1992) With Kunzelman KS, Cochran RP, David TE, Verrier ED

     
     

    "Re-creation of sinuses is important for aortic valve-sparing." University of Washington, Division of Cardiothoracic Surgery Seventh Annual Visiting Scholar Research Forum, Seattle, WA. (May 1998) With Cochran RP, Reinhall PG, Verrier ED, Kunzelman KS

     
     

    "Regional variations in aortic root and valve stresses in a finite element model." University of Washington, Division of Cardiothoracic Surgery Sixth Annual Visiting Scholar Research Forum, Seattle, WA. (May 1997) With Cochran RP, Reinhall PG, Kunzelman KS

     
     

    "The relationship between glycosaminoglycans and tensile vs. compressive loads in the mitral valve." Biomedical Engineering Society, Seattle, WA. (October 2000) With Griffin BP, Vesely I

     
     

    "The relationship between glycosaminoglycans and tensile vs. compressive loads in the mitral valve." First Biennial Meeting of the Society of Heart Valve Disease, London. (June 2001) With Griffin BP, Vesely I

     
     

    "Variations in aortic root sinus dimensions: implications for stentless bioprostheses." Workshop on Prosthetic Heart Valves: Future Directions, sponsored by Georgia Technological Institute, Hilton Head Island, SC. (February 1998) With Cochran RP, Kunzelman KS

     
     Posters
     

    Puperi DS, Balaoing LR, West JL, Grande-Allen KJ: 3D spatially organized PEG-based hydrogels as an aortic valve co-culture model to study valve disease. BMES, San Antonio, TX, October 2014.

     
     

    Fahrenholtz MM, Dixit N, Grande-Allen KJ: Development of a model surface for bioprosthetic heart valves. Society for Biomaterials, Denver, CO, April 2014.

     
     

    Wiltz DC, Kumar A, Morrisett JD, Grande-Allen KJ: Presence of ryanodine receptor isoforms 2 and 3 and the mineralization action of lysophosphatidylcholine through the ryanodine receptor in valvular interstitial cells. ISACB, Cleveland, OH, April 2014.

     
     

    Balaoing LR, Post AD, Liu H, Minn KT, Grande-Allen KJ: Age-related changes in aortic valve hemostatic protein regulation.  BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014 

     
     

    Balaoing LR, Post AD, Liu H, Minn KT, Grande-Allen KJ: Age-related changes in aortic valve hemostatic protein regulation.  BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014 

     
     

    Wu Y, Puperi DS, Grande-Allen KJ, West JL: Ascorbic acid promotes valve interstitial cell-mediated extracellular matrix deposition in hydrogel scaffolds. Society for Biomaterials, Denver, CO, April 2014 (poster).

     
     

    Sapp MS, Fatora G, Grande-Allen KJ: Design of a hypoxic incubator for the study of calcific aortic valve disease. BMES, San Antonio, TX, October 2014.

     
     

    Blancas AA, Acosta F, Grande-Allen KJ: Developing a natural fiber scaffold for pediatric heart valve tissue engineering. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014

     
     

    Chang AJ, Han M, Statham EE, Igo SR, Grande-Allen KJ: Developing a transmedia archival exhibit for artificial hearts: genuine stories. BMES, San Antonio, TX, October 2014.

     
     

    Han RI, Li L, Rosenblatt KL, Morrisett JD, Grande-Allen KJ: Differential protein expression and biological pathways in calcified human aortic valves. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014

     
     

    Krishnamurthy VK, Stout A, Lim K, Grande-Allen KJ: Effect of exogenous TGFβ and its inhibitors on ECM synthesis in porcine aortic valve interstitial cells. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014 

     
     

    Wong FF, Ho ML, Yamagami M, Suh J, Grande-Allen KJ: Effective gene delivery to heart valve cells using adeno-associated virus.  BMES, San Antonio, TX, October 2014.

     
     

    Wong FF, Ho ML, Yamagami M, Suh J, Grande-Allen KJ: Engineered glycosaminoglycan toolkit for heart valve applications.  ASMB, Cleveland, OH, October 2014.

     
     

    Puperi DS, West JL, Grande-Allen KJ: Hyaluronan hydrogels for biomimetic spongiosa layer of tissue engineered aortic valve. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014 

     
     

    Puperi DS, West JL, Grande-Allen KJ: Hyaluronan hydrogels for biomimetic spongiosa layer of tissue engineered aortic valve. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014 

     
     

    Tatara AM, Shah SR, Puperi DS, Watson BM, Wong MEK, Grande-Allen KJ, Mikos AG, Kasper FK:. Mitigation of biofilm formation with an elastomeric barrier membrane system. Society for Biomaterials, Denver, CO, April 2014.

     
     

    Sapp MS, Fares H, Grande-Allen KJ: Multilayer 3D filter paper constructs for the culture and analysis of aortic valvular interstitial cells. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014 

     
     

    Wong FF, Ho ML, Yamagami M, Suh J, Grande-Allen KJ: Regulation of heart valve glycosaminoglycan biosynthesis. BCM Cardiovascular Research Institute Symposium, Houston, TX, April 2014

     
     

    Balaoing LR, Tseng H, Grigoryan B, Raphael RM, Killian TC, Souza GR, Grande-Allen KJ: A three-dimensional co-culture model of the aortic valve using magnetic levitation. Society for Biomaterials, Boston, MA, April 2013. (poster)

     
     

    Connell PS, Azimuddin A, Ramirez F, Jackson M, Little S, Grande-Allen KJ: Analysis of mitral valve prolapse using a flow loop bioreactor.  Baylor College of Medicine Cardiovascular Research Institute Symposium, Houston, TX, April 2013 (poster).

     
     

    Kim SE, Connell PS, Azimuddin AF, Jackson MS, Little SH, Grande-Allen KJ: Creation and validation of a functional mitral regurgitation model in a physiological flow loop bioreactor. 2013 Advances in Tissue Engineering Short Course, Houston, TX, August 2013 (poster).

     
     

    Fahrenholtz MM, Liu H, Kearney DL, Wadhwa L, Frzser CD, Grande-Allen KJ: Dermal fibroblasts as a cell source for tissue engineered heart valves in pediatric patients2013 Advances in Tissue Engineering Short Course, Houston, TX, August 2013 (poster).

     
     

    Zhang X, Xu B, Tseng H, Cuchiara ML, West JL, Grande-Allen KJ: Fabrication of advanced poly(ethylene glycol) diacrylatehydrogels for heart valve tissue engineering. Society for Biomaterials, Boston, MA, April 2013 (poster).

     
     

    Wong FF, Ho M, Yamagami M, Suh J, Grande-Allen KJ: Regulation of glycosaminoglycan structure in heart valves. 2013 Advances in Tissue Engineering Short Course, Houston, TX, August 2013 (poster).

     
     

    Dang S, Puperi DS, Connell PS, Grande-Allen KJ: The effects of cryopreservation on mechanical properties of porcine mitral valve leaflets. 2013 Advances in Tissue Engineering Short Course, Houston, TX, August 2013 (poster).

     
     

    Sapp MC, Estrada AC, Grande-Allen KJ: 3D cell culture construct for the analysis of valvular interstitial cells in a hypoxic environment. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Grigoryan B, Balaoing LR, Tseng H, Raphael RM, Killian TC, Souza GR, Grande-Allen KJ: A 3D co-culture model of the aortic valve using magnetic levitation. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Balaoing LR, Post AD, Moake JL, Grande-Allen KJ: Age-related changes in cardiac valve endothelial cell hemostatic behavior. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Fahrenholtz M, Liu H, Kearney D, Fraser C, Grande-Allen KJ: Characterization of dermal fibroblasts as a cell source for tissue engineered heart valves. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Kamel PI, Qu X, Harmancey R, Taegtmeyer H, Nagrath D, Grande-Allen KJ: Collagen gel contraction assay for evaluation of porcine aortic valve interstitial cell glycolytic metabolism. ISACB, London, UK, September 2012 (poster)

     
     

    Sapp MS, Estrada AC, Grande-Allen KJ: Construction of Stacked Paper Arrays for High-Throughput 3D Culturing and Analysis of Valvular Interstitial Cells. TCH Surgical Research Day, Houston, TX, June 2012 (poster)

     
     

    Sapp MS, Estrada AC, Grande-Allen KJ: Construction of Stacked Paper Arrays for High-Throughput 3D Culturing and Analysis of Valvular Interstitial Cells. Southern Biomedical Engineering Conference, Houston, TX, May 2012 (poster)

     
     

    Fahrenholtz M, Dixit N, Grande-Allen KJ: Development of a model surface for investigation of glutaraldehyde-fixed heart valve surface modification. SFB Biomaterials Day, Houston, TX, July 2012 (poster)

     
     

    Ayoub S, Tseng H, Grande-Allen KJ: Investigating electrospinning as a method to induce anisotropic mechanical behavior in hydrogels used for heart valve tissue engineering. SFB Biomaterials Day, Houston, TX, July 2012 (poster)

     
     

    Arevalos CA, Walborn A, Grande-Allen KJ: Investigating the potential therapeutic effect of ROCK inhibition on pathological aortic valve endothelial cell angiogenesis network formation. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Arevalos CA, Martinez J, Farach-Carson MC, Grande-Allen KJ: Investigating the role of perlecan in modulating pathological angiogenesis in calcific aortic valve disease.  ISACB, London, UK, September 2012 (poster)

     
     

    Wiltz DC, Morrisett JD, Grande-Allen KJ: Lysophosphatidylcholine alters valvular interstitial cell mineralization.  Heart Valve Biology and Tissue Engineering Biennial Conference, Mykonos, Greece, May 2012 (poster).

     
     

    Arevalos CA, Walborn A, Rupert A, Grande-Allen KJ: Modulating neoangiogenesis of heart valve endothelial cells:  a platform for the development of an interventional treatment for CAVD and for pediatric heart valve tissue engineering. Southern Biomedical Engineering Conference, Houston, TX, May 2012 (poster)

     
     

    Arevalos CA, Walborn A, Rupert A, Grande-Allen KJ: Modulating neoangiogenesis of heart valve endothelial cells:  a platform for the development of an interventional treatment for CAVD and for pediatric heart valve tissue engineering. TCH Surgical Research Day, Houston, TX, June 2012 (poster)

     
     

    Yonezawa A, Zhang X, Grande-Allen KJ: Modulation of activity of valvular interstitial cells by in-vitro culture with biomimetic poly(ethylene glycol) diacrylate hydrogels. SFB Biomaterials Day, Houston, TX, July 2012 (poster)

     
     

    Yonezawa A, Zhang X, Grande-Allen KJ: Modulation of valvular interstitial cell activity by in-vitro culture with biomimetic poly(ethylene glycol) diacrylate hydrogels. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Xu B, Zhang X, West JL, Grande-Allen KJ: Modulation of valvular interstitial cells using biomimetic poly(ethylene glycol) diacrylate hydrogels for heart valve tissue engineering application.  2012 Advances in Tissue Engineering Short Course, Houston, TX, August 2012 (poster)

     
     

    Grigoryan B, Scully BB, Fan C, Jacot JG, Vick GW, Kim J, Fraser CD, Grande-Allen KJ, Morales DLS: Myocardial remodeling of an ECM patch in an ovine model.  SFB Biomaterials Day, Houston, TX, July 2012 (poster)

     
     

    Connell PS, Azimuddin A, Grande-Allen KJ: Preliminary Validation of Heart Valve Disease Models in a Physiological Flow Loop.  TCH Surgical Research Day, Houston, TX, June 2012 (poster)

     
     

    Tseng H, Saltarrelli JG, Balaoing LR, Wirth JA, Nandi I, Desai PK, Souza GR, Raphael RM, Killian TC. Grande-Allen KJ: The development of a 3D co-culture model of the aortic valve for the study of the effect of shear stress on biglycan production and structure. World Biomaterials Congress, Chengdu, China, June 2012 (poster)

     
     

    Tseng H, Saltarrelli JG, Balaoing LR, Wirth JA, Nandi I, Desai PK, Souza GR, Raphael RM, Killian TC, Grande-Allen KJ: The development of a 3D co-culture model of the aortic valve for the study of the effect of shear stress on biglycan production and structure.  Southern Biomedical Engineering Conference, Houston, TX, May 2012 (poster)

     
     

    Sapp MS, Estrada AC, Grande-Allen KJ: Three dimensional cell culture construct for the study of hypoxia in valvular interstitial cells.  2012 Advances in Tissue Engineering Short Course, Houston, TX, August 2012 (poster)

     
     

    Estrada AC, Sapp M, Grande-Allen KJ: Three-dimensional cell culture construct for the study of hypoxia and calcification in valvular interstitial cells. BMES, Atlanta, GA, October 2012 (poster)

     
     

    Zhang X, Xu B, Tseng H, Cuchiara ML, West JL, Grande-Allen KJ: Tissue engineering of aortic valve leaflets using biomimetic composite poly(ethylene glycol) diacrylate hydrogels. ISACB, London, UK, September 2012 (poster)

     
     

    Sapp M, Mondragon E, Grande-Allen KJ: Construction of stacked paper arrays for high-throughput 3D culturing and analysis of valvular interstitial cells. 2011 Advances in Tissue Engineering Short Course, Houston, TX, August 2011 (poster)

     
     

    Connell PS, Azimuddin A, Grande-Allen KJ: Effects of chordal positioning on the remodelling of the mitral valve using a physiological flow loop – preliminary work. 2011 Advances in Tissue Engineering Short Course, Houston, TX, August 2011 (poster)

     
     

    Kumar A, Wiltz DC, Grande-Allen KJ: In vitro modeling of the effect of gentamicin on aortic valve interstitial cell calcification. Accepted to TERMIS-NA 2011, Houston, TX, December 2011

     
     

    Scully BB, Fan C, Jacot JG, Vick GW, Kim J, Fraser CD, Grande-Allen KJ, Morales DLS: Promising in vivo remodeling of a small intestinal submucosa patch into functional myocardium: an ovine model.  Baylor College of Medicine 11th Annual James K. Alexander Research Symposium, Houston, TX, March 2011 (poster)

     
     

    Balaoing LR, Post AD, Lin AY, Grande-Allen KJ: Valvular endothelial cell hemostatic response to various biomechanical stimuli in vitro. 2011 Advances in Tissue Engineering Short Course, Houston, TX, August 2011 (poster)

     
     

    Arevalos CA, Grande-Allen KJ: Quantification of the angiogenic potential of aortic valve endothelial cells. 2011 Advances in Tissue Engineering Short Course, Houston, TX, August 2011 (poster)

     
     

    Scully BB, Grande-Allen KJ, Jacot JG, Morales DLS: In vivo evaluation of a small intestinal submucosa patch in an ovine model.  TCH Surgical Research Day, Houston, TX, May 2010 (poster).

     
     

    Stephens EH, de Jonge N, McNeill MP, Durst CA, Fraser CD Jr., Grande-Allen KJ: Age-related changes in material behavior of porcine mitral and aortic valves and correlation to matrix composition. TCH Surgical Research Day, Houston, TX, May 2010 (poster).

     
     

    Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD Jr., Grande-Allen KJ: Alterations in valve composition and structure in congenitally diseased aortic and pulmonic valves, Proceedings of the American College of Surgeons, Washington D.C., Oct 2010 (poster).

     
     

    Scully BB, Morales DL, Barzilla JE, Grande-Allen KJ: Can matrix degrading enzymes improve remodeling in vitro? Pepsin degradation of a SIS cardiac patch.  Proceedings of the BMES, Austin, TX, Oct 2010 (poster)

     
     

    Durst CA, Cuchiara MP, Fraser CD Jr., West JL, Grande-Allen KJ:  Cell seeded PEGDA gels adapted for tissue engineered heart valve leaflets. TCH Surgical Research Day, Houston, TX, May 2010 (poster)

     
     

    Gheewala N, Grande-Allen KJ: Design and mechanical evaluation of a physiological mitral valve organ culture system. TCH Surgical Research Day, Houston, TX, May 2010 (poster)

     
     

    Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD Jr., Grande-Allen KJ: Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar valves, Advances in Tissue Engineering, Houston, TX, August 2010 (poster)

     
     

    Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD Jr., Grande-Allen KJ: Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar valves. TCH Surgical Research Day, Houston, TX, May 2010 (poster)

     
     

    Durst CA, Cuchiara MP, Mansfield EG, West JL, Grande-Allen KJ: Flexural evaluation of cell-encapsulated PEGDA hydrogels for use in a tissue engineered heart valve leaflet, Advances in Tissue Engineering, Houston, TX, August 2010 (poster)

     
     

    Durst CA, Grande-Allen KJ: Phenotypic characterization of porcine aortic valves cultured in a synchronous multivalve culture system. TCH Surgical Research Day, Houston, TX, May 2010 (poster)

     
     

    Stephens EH, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels Jr. NB, Miller DC, Grande-Allen KJ: Mitral annular ultrastructural changes in dilated cardiomyopathy correspond with regional geometric remodeling. Proceedings of the 4th Biennial Heart Valve Biology and Tissue Engineering Meeting, Hilton Head, SC, March 2010 (poster)

     
     

    Stephens EH, Carroll J, Kuo JJ, Post AD, Grande-Allen KJ: Collagen gel contraction by fibronectin-separated valve interstitial cell subpopulations. Proceedings of the BMES, Pittsburgh, PA, October 2009 (poster)

     
     

    Stephens EH, Post AD, Laucirica D, Grande-Allen KJ: Perinatal changes in mitral and aortic valve composition. Proceedings of the BMES, Pittsburgh, PA, October 2009 (poster)

     
     

    Tseng H, Grande-Allen KJ: The elastin mesostructure of the aortic valve leaflet and its role in tissue mechanics. Proceedings of the BMES, Pittsburgh, PA, October 2009 (poster)

     
     

    "Characterizing tandem enzyme digestion approach for glycosaminoglycan degradation.." Proceedings of the HSEMB, Houston, TX. (February 2008) With Srinivas VR, Grande-Allen KJ:

     
     

    "Heterogeneous mitral annular segment motion correlates with matrix turnover and valve cell activation.." Proceedings of the BMES,, St Louis, MO. (September 2008) With Stephens EH, Timek TA, Daughters GT, Ingels NB, Miller DC

     
     

    "LVAD effect on mitral valve cellularity and glycosaminoglycan content.." Proceedings of the BMES,, St Louis, MO. (September 2008) With Barzilla JE

     
     

    "Mitral valve cell proliferation due to serotonergic drug exposure.." Proceedings of the BMES, St Louis, MO. (September 2008) With Barzilla JE

     
     

    "Mitral valve exposure to serotonergic agents.." Proceedings of the 3rd Biennial Meeting on Heart Valve Biology and Tissue Engineering, London UK. (May 2008) With Barzilla JE, Roth BL

     
     

    "Organ culture of the mitral valve using a splashing bioreactor.." Proceedings of the 3rd Biennial Meeting on Heart Valve Biology and Tissue Engineering, London UK. (May 2008) With Barzilla JE, Cowan A

     
     

    "Phenotype of VICs from normal and pathological pediatric valves: implications for a tissue engineered heart valve.." Proceedings of the 3rd Biennial Meeting on Heart Valve Biology and Tissue Engineering, London UK. (May 2008) With Stephens EH, Shangkuan J, Carberry KE, Kearney DK, Fraser CD

     
     

    "Strategies for valvular endothelial cell isolation and phenotyping.." Proceedings of the HSEMB, Houston, TX. (February 2008) With Saltarrelli JG, Grande-Allen KJ

     
     

    "Utilization of fibronectin for the isolation of specific valve cell subpopulations: application for the study of mitral valve diseases.." Proceedings of the 3rd Biennial Meeting on Heart Valve Biology and Tissue Engineering, London UK. (May 2008) With Stephens EH, Huynh TN, Cieluch J

     
     

    "Validation of a novel splashing bioreactor for use in mitral valve organ culture.." Proceedings of the BMES, St Louis, MO. (September 2008) With Barzilla JE, Cowan A

     
     

    "Wound healing in ovine mitral valves involve significant leaflet remodeling.." Proceedings of the Current Trends in Cardiothoracic Surgery Conference, Houston, TX. (May 2008) With Stephens EH, Nguyen TC, Blazejewski JG, Itoh A, Ingels NB Jr., Miller DC, Grande-Allen KJ:

     
     

    "Age-specific glycosaminoglycan composition for tissue-engineered heart valves." Proceedings of the BMES, Los Angeles CA. (September 2007) With Stephens ES, Chu CK

     
     

    "Changes in extracellular matrix production by valvular interstitial cells with aging.." Proceedings of the HSEMB, Houston TX. (February 2007) With Stephens ES, Mendenhall M

     
     

    "Deficiency and restoration of decorin in engineered tissues modulates material strength and modulus." Proceedings of the BMES, Los Angeles CA. (September 2007) With Ferdous Z, Wei VM, Hook, M

     
     

    "TGF Beta enhances gel contraction in decorin deficient engineered tissues." Proceedings of the BMES, Los Angeles CA. (September 2007) With Ferdous Z, Hook, M

     
     

    "The effect of passive left ventricular restraint on mitral valve leaflet remodeling following myocardial infraction." Houston TX. (February 2007) With Sen P, Nguyen TC, Blazejewski J, Cheng A, Ingels NB, Miller DC

     
     

    "Understanding global sequence complexity of glycosaminoglycans: a tandem enzyme digestion approach." Proceedings of the HSEMB, Houston TX. (February 2007) With Srinivas VR

     
     

    "An in vitro model for myxomatous mitral valve disease." Hilton Head, SC. (March 2006) With Allison DD, Wight TN

     
     

    "An in vitro model for myxomatous mitral valve disease." Hilton Head SC. (March 2006) With Allison DD, Wight TN

     
     

    "Glycosaminoglycan and proteoglycan synthesis in uniaxial vs. biaxial regions of collagen gels." Biomedical Engineering Society, Chicago IL. (October 2006) With Gupta V, Werdenberg JA

     
     

    "Glycosaminoglycan and proteoglycan synthesis in uniaxial vs. biaxial regions of collagen gels." Chicago IL. (October 2006) With Gupta V, Werdenberg JA

     
     

    "Harnessing proteoglycans and glycosaminoglycans in tissue engineering." Boston MA. (July 2006) With Gupta V, Ferdous Z, Allison DD

     
     

    "Regional heterogeneity of porcine mitral valve interstitial cells." Hilton Head SC. (March 2006) With Blevins TL, Bailey A, Lee EL, Gupta V

     
     

    "Regional heterogeneity of porcine mitral valve interstitial cells." Hilton Head, SC. (March 2006) With Blevins TL, Bailey A, Lee EL, Gupta V

     
     

    "Role of decorin in engineered tissue mechanics." (2006) With Ferdous Z

     
     

    "Role of decorin in engineered tissue mechanics." Houston Society for Engineering in Medicine and Biology, Houston TX. (February 2006) With Ferdous Z

     
     

    "Tension-induced synthesis of glycosaminoglycans and proteoglycans in mitral valve tissue surrogates." Gordon Research Conference on Proteoglycans, Andover NH,. (July 2006) With Gupta V, Werdenberg J

     
     

    "Cellularity of aortic valves from failed hearts." Rice Undergraduate Research Symposium, Houston TX. (April 2005) With Maniar S

     
     

    "Evaluation of reverse remodeling of the mitral valve in hearts supported by left ventricular assist devices (LVADs)." American Heart Association Research Symposium, Dallas, TX. (November, 2005) With Borowski AG, Barzilla JE, Peterson SB

     
     

    "Phenotypic characterization of isolated heart valve cell subpopulations." Society for Heart Valve Disease Biennial meeting, Vancouver, Canada. (June 2005) With Blevins TL, Raza A

     
     

    "Proteoglycan detection in collagen gels seeded with mitral valve interstitial cells: relevance to myxomatous mitral valve disease." Society for Heart Valve Biennial Meeting, Vancouver, Canada. (June 2005) With Gupta V

     
     

    "Explaining proteoglycans to undergraduates: a senior elective in extracellular matrix." Gordon Research Conference on Proteoglycans, Andover, NH. (2004)

     
     

    "Impact of LVAD unloading on mitral valve function." American Society of Echocardiography Annual Meeting, San Diego, CA. (2004) With Borowski AG, Popovic ZB, Troughton RW, Yeager ML, Thomas JD, Griffin BP, Garcia MJ, Starling RC, McCarthy PM

     
     

    "Mechanical modulation of glycosaminoglycan and proteoglycan production by valvular interstitial cells." Whitaker Foundation Annual Retreat, La Jolla, CA. (2004)

     
     

    "Right ventricular function is preserved following left ventricular assist device insertion: a pump turndown study." American Society of Echocardiography Annual Meeting, San Diego, CA. (2004) With Borowski AG, Popovic ZB, Sallach JA, Kassimatis K, Kamis S, Sigurdsson S, Grande-Allen KJ, McCarthy PM, Garcia M

     
     

    "Altered glycosaminoglycan distribution in myxomatous mitral valves." 49th Annual Scientific Sessions of the American College of Cardiology, Anaheim, CA. (March 2000) With Griffin BP, Ratliff NB, Cosgrove III DM, Vesely I

     
     

    "Biochemical and echocardiographic indicators of valvular dysfunction in failing hearts." The Cleveland Clinic Foundation 20th Annual Research Day, Cleveland, OH. (October 2000) With Griffin BP, Holcomb J, Vesely I

     
     

    "Bioreactor system used for applying biaxial cyclic stretch on cells seeded upon an elastic substrate." The 6th New Jersey Symposium on Biomaterials Science, New Jersey. (October 2002) With Lawrence BD, Vesely I

     
     

    "Characterization of inflammatory reaction in xenograft and homograft replacement of cardiac valves." First Biennial Meeting of the Society of Heart Valve Disease, London. (June 2001) With Ratliff NB, Barber JE, Vesely I

     
     

    "Correlation of biochemical and echocardiographic indicators of valvular dysfunction in dilated cardiomyopathy." 50th Annual Scientific Sessions of the American College of Cardiology, Orlando, FL. (March 2001) With Griffin BP, Holcomb J, Vesely I

     
     

    "Effect of graft shape and material properties on aortic valve function in valve-sparing procedures." Biomedical Engineering Society, Cleveland, OH. (October 1998) With Cochran RP, Reinhall PG, Kunzelman KS

     
     

    "Explanted porcine bioprosthetic valves show disproportional losses of selective proteoglycans.." Second Biennial Meeting of the Society for Heart Valve Disease, Paris. (June 2003) With Mako WJ, Calabro A, Ratliff NB, Vesely I

     
     

    "Identification and localization of proteoglycans in normal and diseased valves and valvular cell cultures." Biomedical Engineering Society, Nashville, TN. (October 2003) With Gupta V, Hascall VC, Wight TN, Ratliff NB, Griffin BP, Cosgrove DM, Vesely I

     
     

    "Identification, localization, and function of proteoglycans in normal and diseased valves and valvular cell cultures." Hyaluronan 2003, Cleveland, OH. (October 2003) With Vesely I, Hascall VC

     
     

    "Increased cellular production of glycosaminoglycans in myxomatous mitral valves." The Cleveland Clinic Foundation 19th Annual Research Day, Cleveland, OH. (October 1999) With Ratliff NB, Griffin BP, Cosgrove DM III, Vesely I

     
     

    "Influence of aging on aortic root and valve function." ASAIO, New York, NY. (April 1998) With Cochran RP, Reinhall PG, Kunzelman KS

     
     

    "Is mitral regurgitation in congestive heart failure truly functional? Evidence for significant biochemical changes in the valvular extracellular matrix." The American College of Cardiology 52nd Annual Scientific Session, Chicago, IL. (March 2003) With Borowski A, Troughton R, Houghtaling P, DiPaola N, Moravec CS, Vesely I, Griffin BP

     
     

    "Localization of viability within valvular organ cultures." 7th Annual Hilton Head Workshop on Engineering Tissues, Hilton Head Island, SC. (February-March 2003) With Allison DD, Drazba J, Vesely I

     
     

    "Localization of viability within valvular organ cultures." Engineering Tissue Growth Conference, Pittsburgh, PA. (March 2003) With Allison DD, Drazba J, Vesely I

     
     

    "Localization of viable cells within long-term heart valve organ cultures." Second Biennial Meeting of the Society for Heart Valve Disease, Paris, France. (June 2003) With Allison DD, Drazba J, Vesely I,

     
     

    "MRI analysis of aortic valve/root conformation - basis for finite element analysis of root replacements." ASAIO, New Orleans, LA. (May 1993) With Kunzelman KS, Cochran RP, David TE, Verrier ED

     
     

    "Mechanical and biochemical evidence for chordal remodeling in hearts with dilated cardiomyopathy." 72nd Scientific Sessions of the American Heart Association, Atlanta. (November 1999) With Barber JE, Vesely I

     
     

    "Mechanical significance of increased collagen in myxomatous mitral valves." The Cleveland Clinic Foundation 22nd Annual Research Day, Cleveland, OH. (October 2002) With Hulbert JL, Klatka K, Barber JE, Griffin BP, Ratliff NB, Cosgrove DM, Houghtaling P, Vesely I

     
     

    "Mechanical significance of increased collagen in myxomatous mitral valves." The 6th New Jersey Symposium on Biomaterials Science, New Jersey. (October 2002) With Hulbert JL, Klatka K, Barber JE, Griffin BP, Ratliff NB, Cosgrove DM, Houghtaling P, Vesely I

     
     

    "Persistent mitral regurgitation in turndown echo evaluations of LVAD patients." The Cleveland Clinic Foundation 23rd Annual Research Day, Cleveland, OH. (November 2003) With Borowski AG, Troughton RW, Yeager ML, Thomas JD, Garcia MJ, Griffin BP, Starling RC, McCarthy PM

     
     

    "Persistent mitral regurgitation in turndown echo evaluations of LVAD patients." Heart Failure Society of America Annual Meeting, Las Vegas, NV. (September 2003) With Borowski AG, Troughton RW, Yeager ML, Thomas JD, Garcia MJ, Griffin BP, Starling RC, McCarthy PM

     
     

    "Population and synthesis of glycosaminoglycans in mitral valve interstitial cell culture." 55th Annual Eastern Colleges Science Conference, Wilkes-Barre, PA. (2001) With Corcoran JA, Vesely I

     
     

    "Porcine aortic valve leaflet dimensions." ASAIO, Nashville, TN. (May 1992) With Kunzelman KS, Cochran RP, David TE, Verrier E

     
     

    "Regional variations in aortic root and valve stresses in a finite element model." International Society of Artificial Organs, Providence, RI. (June 1997) With Cochran RP, Reinhall P, Kunzelman KS

     
     

    "The biomechanics of chordal rupture in mitral valves." AAAS Annual Meeting/American Junior Academy of Science, San Francisco, CA. (February 2001) With Sedransk K., Vesely I

     
     

    "The biomechanics of chordal rupture in mitral valves." The Cleveland Clinic Foundation 19th Annual Research Day, Cleveland, OH. (October 1999) With Sedransk K, Vesely I

     
     Session Chair
     

    Society for Experimental Mechanics (SEM)

     
     

    Biomedical Engineering Society (BMES)

     
     

    4th Biennial Heart Valve Biology and Tissue Engineering Meeting

     
     

    "Heart Valves 2."

     
     Workshops
     

    "Tissue engineering of heart valves." Advances in Tissue Engineering, Houston, TX. (August 2005)

     
    Editorial Positions
     Associate Editor, Annals of Biomedical Engineering. (2013 - 2013)

     Associate Editor, Cardiovascular Engineering and Technology. (2013 - 2014)

     Other, Circulation. (2004 - 2014)

     Other, Arteriosclerosis, Thrombosis, and Vascular Biology. (2005 - 2014)

     Other, Annals of Biomedical Engineering. (2004 - 2014)

     Other, American Journal of Physiology – Heart and Circulatory Physiology. Journal of Biomaterials Applications. (2012 - 2014)

     Other, Acta Biomaterialia. International Journal of Cardiology. (2012 - 2014)

     Other, National Center Bioengineering and Biotechnology Review Group. AHA. (2012 - 2012)

     Other, Tissue Engineering. (2012 - 2012)

     Other, National Center Bioengineering and Biotechnology Review Group. (2013 - 2013)

     Other, Biomaterials. (2014 - 2014)

     Other, Matrix Biology. (2014 - 2014)

     Other, Nanomedicine. (2014 - 2014)

     Other, Pediatric Research. (2014 - 2014)

     Associate Editor, Experimental Techniques . (2013 - 2013)

     Associate Editor, Annals of Biomedical Engineering. (2012 - 2014)

     Associate Editor, Cardiovascular Engineering and Technology. (2012 - 2012)

     Associate Editor, Experimental Techniques. (2012 - 2012)

     Associate Editor, BMC Biotechnology. (2012 - 2012)

     Member of the Editorial Board, Tissue Engineering. (2013 - 2013)

     Member of the Editorial Board, Journal of Heart Valve Disease. (2013 - 2014)

     Other, Cardiovascular Engineering and Technology. (2014 - 2014)

     Other, BMC Biotechnology. (2014 - 2014)

     Other, Biomaterials. (2014 - 2014)

     Other, Biochimica et Biophysica Acta – General Subjects. (2014 - 2014)

     Other, Journal of Thoracic and Cardiovascular Surgery. (2014 - 2014)

     Other, Journal of the Royal Society Interface. (2014 - 2014)

     Other, Journal of Tissue Engineering and Regenerative Medicine. (2014 - 2014)

     Other, Journal of Molecular and Cellular Cardiology. (2014 - 2014)

     Other, Journal of Heart Valve Disease. (2014 - 2014)

     Other, Journal of Biomedical Materials Research. (2014 - 2014)

     Other, Journal of Biomechanics. (2014 - 2014)

     Other, Journal of Biomaterials Applications. (2014 - 2014)

     Other, International Journal of Cardiology. (2014 - 2014)

     Other, Connective Tissue Research. (2014 - 2014)

     Other, Circulation Research. (2014 - 2014)

     Other, Cell Biochemistry and Biophysics. (2014 - 2014)

     Other, Cardiovascular Research. (2014 - 2014)

     Other, Cardiovascular Pathology. (2014 - 2014)

     Other, 16th International Conference for Experimental . (2014 - 2014)

     Other, Wound Repair and Regeneration. (2014 - 2014)

     Other, Tissue Engineering. (2014 - 2014)

     Other, Journal of Biomechanical Engineering. (2003 - 2003)

     Other, American Journal of Hypertension. (2005 - 2005)

     Other, Journal of Thoracic and Cardiovascular Surgery. (2003 - 2003)

     Other, Anatomical Record. (2005 - 2005)

     Other, Experimental Mechanics. (2004 - 2004)

     Other, Journal of Biomechanics. (2004 - 2004)

     Other, Circulation. (2003 - 2003)

     Other, Tissue engineering. (2004 - 2004)

     Other, Cell Biochemistry and Biophysics. (2005 - 2005)

     Other, Experimental Techniques. (2005 - 2005)

     Other, Journal of Biomechanical Engineering. (2004 - 2004)

     Other, Journal of Heart Valve Disease. (2004 - 2004)

     Other, Journal of Thoracic and Cardiovascular Surgery. (2004 - 2004)

    Supervised Theses & Dissertations
     Vishal Gupta, Doctoral Mechanical modulation of glycosaminoglycan and proteoglycan production by valvular interstitial cells. (2002) (Thesis or Dissertation Director)

     Janet Barzilla, Doctoral Matrix and mechanics of heart valves in congestive heart failure. (2003) (Thesis or Dissertation Director)

     Lakeshia Taite, Doctoral Ph.D. Dissertation. (2003) (Committee Member)

     Adam AufderHeide, Doctoral Ph.D. Dissertation. (2003) (Committee Member)

     Solitaire DeLong, Doctoral Ph.D. Dissertation. (2003) (Committee Member)

     Adam AufderHeide, Doctoral Ph.D. Dissertation, Bioengineering. (2004) (Committee Member)

     Nikhil Gheewala, Doctoral Physiological flow loop bioreactor for mitral valves. (2004) (Thesis or Dissertation Director)

     Greg Bowden, Doctoral Improvement of biomineralization, matrix, and osteogenic development using a dynamic flow bioreactor. (2004) (Co-Director)

     David Allison, Doctoral Hyaluronan contributions to matrix mechanics. (2004) (Thesis or Dissertation Director)

     Zannatul Ferdous, Doctoral Small leucine-rich proteoglycan contributions to matrix mechanics. (2004) (Thesis or Dissertation Director)

     Janet Barzilla, Doctoral Matrix and mechanics of heart valves in congestive heart failure. (2004) (Thesis or Dissertation Director)

     Vishal Gupta, Doctoral Mechanical modulation of glycosaminoglycan and proteoglycan production by valvular interstitial cells. (2004) (Thesis or Dissertation Director)

     Masters Masters Dissertation (External Evaluator). (2004) (Committee Member)

     Beth Ray, Doctoral Ph.D. Dissertation, Biochemistry and Cell Biology. (2004) (Committee Member)

     Jeff Triffo, Doctoral Ph.D. Dissertation, Bioengineering. (2004) (Committee Member)

     Brandon Bucklen, Doctoral Ph.D. Dissertation, Bioengineering. (2004) (Committee Member)

     Zarana Patel, Doctoral Ph.D. Dissertation, Bioengineering. (2004) (Committee Member)

     Solitaire DeLong, Doctoral Ph.D. Dissertation, Bioengineering. (2004) (Committee Member)

     Lakeshia Taite, Doctoral Ph.D. Dissertation, Bioengineering. (2004) (Committee Member)

     Zarana Patel, Doctoral PhD. Dissertation Bioengineering. (2005) (Committee Member)

     Sergey Paramonov, Doctoral Ph.D. Dissertation Chemistry. (2005) (Committee Member)

     Adam AufderHeide, Doctoral Phd. Dissertation Bioengineering. (2005) (Committee Member)

     Brandon Bucklen, Doctoral Ph.D Dissertation Bioengineering. (2005) (Committee Member)

     Jeff Triffo, Doctoral Ph.D Dissertation Bioengineering. (2005) (Committee Member)

     April Smith, Doctoral PhD. Dissertation Bioengineering. (2005) (Committee Member)

     James Jaehyun Moon, Doctoral PhD. Dissertation Bioengineering. (2005) (Committee Member)

     Lakeshia Taite, Doctoral PhD. Dissertation Bioengineering. (2005) (Committee Member)

     Beth Ray, Doctoral Ph.D Dissertation Biochemistry and Cell Biology. (2005) (Committee Member)

     Quynh Pham, Doctoral PhD. Dissertation Bioengineering. (2005) (Committee Member)

     Sheila Moore, Doctoral PhD. Dissertation Bioengineering. (2005) (Committee Member)

     Vishal Gupta, M.S Bioengineering, Rice University, Mechanical modulation of glycosaminoglycan and proteoglycan production by valvular interstitial cells. (2007) (Thesis or Dissertation Director)

     Lesley R O'Leary, Ph.D. Chemistry. (2011) (Committee Member)

     Jeffrey Crawford, Ph.D. Biochemistry and Cell Biology. (2011) (Committee Member)

     Nikhil Gheewala, Ph.D. Mitral valve organ culture provides a novel experimental paradigm. (2011) (Thesis or Dissertation Director)

     Eric Raborn, Ph.D. Bioengineering. (2011) (Committee Member)

     Paschalia Mountziaris, Ph.D. Bioengineering. (2011) (Committee Member)

     Vince Willard, Ph.D. Bioengineering. (2011) (Committee Member)

     Christopher Durst, Ph.D. Novel dynamic bioreactor and PEGDA hydrogel scaffolds for investigation and engineering of aortic valve tissues. (2011) (Thesis or Dissertation Director)

     Magdalena Walkiewicz, Ph.D. Biochemistry and Cell Biology. (2011) (Committee Member)

     Anu Maharjan, Ph.D. Biochemistry and Cell Biology. (2011) (Committee Member)

     Johannah Sanchez-Adams, Ph.D. Bioengineering. (2011) (Committee Member)

     Daniel Gould, Ph.D. Bioengineering. (2011) (Committee Member)

     Maude Rowland, Ph.D Bioengineering. (2011) (Committee Member)

     Hubert Tseng, The characterization of the microstructure of the aortic valve for tissue engineering applications. (2012) (Thesis or Dissertation Director)

     Brandi Scully, In Vivo and In Vitro Remodeling of a Small Intestinal Submucosa Extracellular Matrix Cardiac Patch in an Ovine Model and Splashing Bioreactor. (2012) (Thesis or Dissertation Director)

     Dena Wiltz, Calcific Aortic Valve Disease: Underlying Mechanisms and Novel 3D In Vitro Models. (2013) (Thesis or Dissertation Director)

     Liezl Balaoing, Valvular Endothelial Hemostasis and the Recruitment of an Anti-Thrombotic Endothelium on Tissue Engineered Valves. (2014) (Thesis or Dissertation Director)

     Alex Arevalos, Angiogenic behavior of valvular endothelial cells. (2015) (Thesis or Dissertation Director)

     Patrick Connell, Remodeling in in vitro models of mitral regurgitation. (2015) (Thesis or Dissertation Director)

     Matthew Sapp, Development of models for investigating valvular interstitial cell response to hypoxia. (2015) (Thesis or Dissertation Director)

     Andy Geiszler, Metabolic behavior of valvular interstitial cells. (2015) (Thesis or Dissertation Director)

     Monica Fahrenholtz, Development of an endothelial layer on implanted pediatric cardiovascular devices. (2015) (Thesis or Dissertation Director)

     Yan Wu, Advanced hydrogel structures for valve tissue engineering. (2016) (Thesis or Dissertation Director)

     Fergus Wong, Manipulation of GAG structure via gene delivery for valve tissue engineering. (2016) (Thesis or Dissertation Director)

     Dan Puperi, Advanced hydrogel structures for valve tissue engineering. (2016) (Thesis or Dissertation Director)

     Tao Jin, Civil and Environmental Engineering. (Committee Member)

     Steven Lu, Bioengineering. (Committee Member)

     Patrick Spicer, Bioengineering. (Committee Member)

     Clark Needham, Bioengineering. (Committee Member)

     David Ryan, Bioengineering . (Committee Member)

     Alex Tatara, Bioengineering. (Committee Member)

     Bagrat Grigoryan, Bioengineering . (Committee Member)

     Sydney Gibson, Bioengineering . (Committee Member)

     Chris Tsao, Bioengineering. (Committee Member)

     Marci Kang, Chemistry. (Committee Member)

     Amanda Moore, Chemistry . (Committee Member)

     Kelsea Hubka, Bioengineering . (Committee Member)

     Rajoshi Biswas, Electrical and Computer Engineering. (Committee Member)

     Samantha Paulsen, Bioengineering . (Committee Member)

     Charles Puelz, Computational and Applied Mathematics . (Committee Member)

     Tawana Robinson, Chemistry. (Committee Member)

     Mariane Martinez, Bioengineering . (Committee Member)

     James Spurlin, Biochemistry and Cell Biology . (Committee Member)

     Tiffany Vo, Bioengineering . (Committee Member)

     Johnny Lam, Bioengineering . (Committee Member)

     Linlin Cao, Materials Science and Nanoengineering. (Committee Member)

     Mayra Hernandez, Chemistry. (Committee Member)

     Krista Sider, Mechanical and Industrial Engineering, U. Toronto. (Committee Member)

     Steven Higbee, Bioengineering. (Committee Member)

     Richard Thibault, Bioengineering. (Committee Member)

     Christine Caneba, Bioengineering. (Committee Member)

     Liang Gao, Ph.D. Bioengineering. (Committee Member)

     Jacob Albritton, Bioengineering. (Committee Member)

     Erica Levorson, Bioengineering. (Committee Member)

    Awards, Prizes, & Fellowships
     Invited Protégé, The Academy of Medicine, Science, and Engineering of Texas

     Co-Chair, Bioengineering Basic Science Peer Review Panel, American Heart Association,

     Fellow, Society for Experimental Mechanics,

     Fellow, American Association for the Advancement of Science, (2015)

     Appointed Deputy Editor-in-Chief, Annals of Biomedical Engineering, (2015)

     Fellow, American Heart Association

     George R. Brown Award for Superior Teaching, Rice University

     Invited Protégé, The Academy of Medicine, Science, and Engineering of Texas

     Graduate Student Association Teaching and Mentoring Award, Rice University

     Co-Chair, Bioengineering Basic Science Peer Review Panel, American Heart Association,

     Fellow, Biomedical Engineering Society,

     Established Investigator Award, American Heart Association

     Award for Editorial Excellence, Annals of Biomedical Engineering

     Fellow, American Institute for Medical and Biological Engineering

     Outstanding Associate Award, Hanszen College,

     A.J. Durelli Award, Society for Experimental Mechanics

     Appointed to Editorial Board, Journal of Heart Valve Disease

     Excellence in Advising Award, Office of Academic Advising, Rice University

     Characterization of age-specific matrix and mechanics of valves, NHLBI Kirchstein NRSA Predoctoral Fellowship (F30) (07/01/08-06/30/11)

     Appointed as Associate Editor, Experimental Techniques

     Appointed as Associate Editor, Cardiovascular Engineering and Technology

     REU: Bioreactor organ cultures: in vitro models of valvular remodeling and biology, National Science Foundation REU Supplement (06/01/08-08/31/08)

     Hertz Foundation Graduate Fellowship, (2006-2011)

     Presidential Award for Mentoring, Rice University

     Distinguished Faculty Associate Award, Hanszen College, Rice University

     Runner-up, HSEMB Student Poster Competition, (2007)

     NIH Biotechnology Training Grant Graduate Fellowship, (2006-2008)

     Distinguished Faculty Associate Award, Hanszen College, Rice University, (2007)

     Goldwater Scholarship, (2007)

     Hertz Foundation Graduate Fellowship, (2006-2011)

     Honorable Mention, Bioengineering Graduate Student Poster Contest, (2007)

     Alliance for NanoHealth Scholarship for Summer Nanomedicine Workshop, (2007)

     IBB Mary Frances Dunham Morse Graduate Fellowship Award, (2007)

     Rice Insstitute for Biosciences and Bioengineering Medical Innovation Award, (2007)

     Poster Competition, (2006)

     Graduate Student Award, (2006)

     Bioengineering Recruitment Weekend Graduate Student Poster Contest, (2006)

     NIH Biotechnology Training Grant Graduate Fellowship, (2006-2008)

     Brown Foundation Teaching Grant, (2006)

     Outstanding Young Scientist Award, HSEMB (2005)

     Ralph E. Power Junior Faculty Development Award, Oak Ridge Associated Universities (2005)

     Pfizer Atorvastatin Research Award, (2005)

     Rice Institute for Biosciences and Bioengineering, Hamill Innovation Award (2005)

     Distinguished Faculty Associate Award, Hanszen College, Rice University (2005)

     Student Award: Sherket Peterson, Rice University (2004)

     Student Award: Martin Bost, Rice University (2004)

     Student Award: Martin Bost, Rice University (2004)

     Student Award: Sherket Peterson, Rice University (2004)

     Student Award: Janet Barzilla, Rice University (2004-2006)

     Regional Merit Scholarship, Deans List, and Judicial Board, Transylvania University (1987-1991)

     Scientist Development Grant, National American Heart Association (2002)

     Student Award: Julie Ann Corcoran, 55th Annual Eastern Colleges Science Conference (2001)

     Student Award: Brian Lawrence, AHA (2002)

     Student Award: Brian Lawrence, 6th New Jersey Symposium on Biomaterials Science (2002)

     Student Award: Jamie Hulbert, AHA (2002)

     Student Award: Jamie Hulbert, 6th New Jersey Symposium on Biomaterials Science (2002)

     Student Award: David Allison, NSF (2002)

     Student Award: Sophie McKenney, NSF (2003)

     Student Award: Nick Olshavsky, AHA (2003)

     Student Award: Adrienne Fleurke, Northeastern Ohio Science & Engineering Fair (2000)

     Student Award: Adrienne Fleurke, US Army (2000)

     Student Award: Adrienne Fleurke, Buckeye Science and Engineering Fair (2000)

     Student Award: Adrienne Fleurke, Hathaway Brown School (2001)

     Student Award: Kate Goddard, Cleveland Regional Counsel of Science Teachers (2001)

     Student Award: Kate Goddard, NEOSEF (2002)

     Student Award: Erin Levendorf, Northeastern Ohio Science and Engineering Fair (2000)

     Student Award: Kyra Sedransk, Ohio State Science Day (1999)

     Student Award: Kyra Sedransk, Hathaway Brown School (1999)

     Student Award: Kyra Sedransk, Northeastern Ohio Science and Engineering Fair (NEOSEF) (1999)

     Student Award: Kyra Sedransk, CCF-Cardiology and CWRU-Biology, NEOSEF (2001)

     Student Award: Kyra Sedransk, US Air Force and American Statistical Association, NEOSEF (2002)

     Student Award: Kyra Sedransk, Siemens Westinghouse Competition (2002)

     Student Award: Kyra Sedransk, Intel Science Talent Search (2003)

     Student Award: Kyra Sedransk, Buckeye Science and Engineering Fair (2003)

     Student Award: Kyra Sedransk, Intel International Science and Engineering Fair (2003)

     Student Award: Abha Tewari, Siemens Westinghouse Scholarship competition (2002)

     Student Award: Abha Tewari, Northeastern Ohio Science and Engineering Fair (2003)

     Invited Speakers Award, Vanderbilt University Medical Center (Oct 2003)

     Magna Cum Laude, Mathematics & Biology, Transylvania University (1991)

     Space Grant Graduate Fellowship in Bioengineering, NASA (1991-1993)

     Fellowship Travel Award, ASAIO (1992)

     Scholarship, Mortar Board Tolo Alumni Association (1996)

     Student Honorarium, International Society for Artificial Organs (ISAO) (1997)

     Biomedical Engineering Student Fellowship Award, ASAIO (1998)

     Postdoctoral Fellowship, CCF Lerner Research Institute (1998)

     Postdoctoral Fellowship, NIH NRSA (2000)

     Biomedical Engineering Grant, Whitaker Foundation (2002)

     Outstanding Mentor, Siemens Westinghouse Competition (2003)

     Student Award: Melody Hu, AHA (2001)

    Positions Held
     Member, Society for Biomaterials. (2004 - 2014)

     Executive Board, International Society for Applied Cardiovascular Biology. (2014 - 2014)

     Member, American Society for Artificial Internal Organs (ASAIO). (2004 - 2014)

     Member, Biomedical Engineering Society (BMES). (2004 - 2014)

     Member, American Association for the Advancement of Science (AAAS). (2004 - 2014)

     Member, Society for Heart Valve Disease. (2004 - 2014)

     Elected to Board of Directors, Biomedical Engineering Society (BMES). (2009 - 2009)

     Reviewer, South Carolina Experimental Program to Stimulate Competitive Research and Institutional Development Awards (EPSCoR/IDeA). (2009 - 2009)

     Reviewer, Natural Sciences and Engineering Research Council of Canada Discovery Grants. (2009 - 2009)

     Member, NIH NHLBI Working Group on Basic and Translational Research in Calcific Aortic Stenosis. (2009 - 2009)

     Graduate Research Fellowship Bioengineering 2 Review Panel, NSF. (2009 - 2009)

     Reviewer - Special Emphasis Panel, K99/R00 Pathway to Independence Award, NIH . (2009 - 2009)

     National Center Bioengineering and Biotechnology Peer Review, AHA. (2009 - 2009)

     Session Chair, Society for Experimental Mechanics (SEM). (2011 - 2011)

     Scientific Co-Chair, Tissue Engineering and Regenerative Medicine International Society (TERMIS) – North American Chapter. (2011 - 2011)

     Program Committee; Session Organizer and Chair, 28th Southern Biomedical Engineering Conference. (2012 - 2012)

     Board of Directors, Biomedical Engineering Society. (2011 - 2011)

     Pre-conference workshop co-chair , Tissue Engineering for Pediatric Applications. (2011 - 2011)

     Executive Board, Society for Experimental Mechanics . (2011 - 2011)

     Executive Board, Society for Experimental Mechanics . (2013 - 2014)

     Board of Directors, Biomedical Engineering Society. (2013 - 2014)

     Abstract reviewer; session chair, Biomedical Engineering Society. (2013 - 2013)

     Session chair, Society for Experimental Mechanics (SEM). (2013 - 2013)

     Session organizer, US National Congress on Computational Mechanics. (2013 - 2013)

     Session Chair, 5th Biennial Meeting on Heart Valve Biology and Tissue Engineering. (2012 - 2012)

     Abstract reviewer, Society for Biomaterials. (2013 - 2013)

     Ad Hoc Grant Referee, UK Shared Business Services. (2013 - 2013)

     Ad Hoc referee, British Heart Foundation. (2013 - 2013)

     Ad Hoc referee, Ireland Health Research Board. (2013 - 2013)

     Ad Hoc referee, University of Padua, Research Grants Projects. (2013 - 2013)

     Referee, NSERC of Canada Discovery Grants . (2013 - 2013)

     Session Chair; abstract reviewer, Biomedical Engineering Society. (2012 - 2012)

     Member, American Society for Engineering Education (ASEE) . (2014 - 2014)

     Member, American Society for Matrix Biology (ASMB) . (2014 - 2014)

     Member, Society for Glycobiology. (2014 - 2014)

     Member, International Society of Hyaluronan Sciences (ISHAS) . (2014 - 2014)

     Member, International Society for Applied Cardiovascular Biology (ISACB) . (2014 - 2014)

     Board of Directors, Heart Valve Society . (2014 - 2014)

     Chair of review group, American Heart Association. (2014 - 2014)

     Member, IEEE Engineering in Medicine & Biology Society (EMBS). (2014 - 2014)

     Member, Institute of Electrical & Electronics Engineers (IEEE) . (2014 - 2014)

     Member, Houston Society for Engineering in Medicine and Biology. (2014 - 2014)

     Grant Referee, Wound Repair and Regeneration. (2014 - 2014)

     Member, American Heart Association. (2004 - 2014)

     Member, Society for Experimental Mechanics (SEM). (2002 - 2002)

     Member, Society for Experimental Mechanics (SEM). (2003 - 2003)

     Member, Society for Experimental Mechanics (SEM). (2004 - 2004)

     Assistant Professor, Department of Bioengineering, Rice University. (2005 - 2005)

     Adjunct Assistant Professor, Michael E. DeBakey Department of Surgery. (2006 - 2006)

     Member, American Association for the Advancement of Science (AAAS). (2003 - 2003)

     Member, American Association for the Advancement of Science (AAAS). (2002 - 2002)

     Adjunct Assistant Professor, Department of Cardiology. (2006 - 2006)

     Adjunct Assistant Professor, Department of Cardiology, University of Texas Health Science Center. (2005 - 2005)

     Assistant Professor, Department of Bioengineering, Rice University. (2006 - 2006)

     Member, Society for Heart Valve Disease. (2002 - 2002)

     Member, Society for Heart Valve Disease. (2003 - 2003)

     Member, American Heart Association. (2002 - 2002)

     Member, American Heart Association. (2003 - 2003)

     Contributing Lecturer. (2006 - 2006)

     Mentor. (2006 - 2006)

     Member, Society for Biomaterials. (2002 - 2002)

     Member, Society for Biomaterials. (2003 - 2003)

     Member, American Society for Artificial Internal Organs (ASAIO). (2002 - 2002)

     Seminar Coordinator. (2006 - 2006)

     Member, American Society for Artificial Internal Organs (ASAIO). (2003 - 2003)

     Member, Biomedical Engineering Society (BMES). (2003 - 2003)

     Instructor. (2006 - 2006)

     Member, Biomedical Engineering Society (BMES). (2002 - 2002)

     Member, American Society for Engineering Education (ASEE). (2004 - 2004)

     President, UW Bioengineering Student Association. (2003 - 2003)

     President, UW Bioengineering Student Association. (2002 - 2002)

     Contributing Lecturer. (2006 - 2006)

     Contributing Lecturer. (2006 - 2006)

     Member, Transylvania University Holleian Society (liberal arts honorary) and Science Honorary. (2002 - 2002)

     Member, International Society for Applied Cardiovascular Biology (ISACB). (2004 - 2004)

     Member, Transylvania University Holleian Society (liberal arts honorary) and Science Honorary. (2003 - 2003)

     Member, IEEE Engineering in Medicine & Biology Society (EMBS). (2004 - 2004)

     Instructor. (2006 - 2006)

     Organizer, Annual Mareb Hoke Research Symposium. (2003 - 2003)

     Chairperson and Funding Coordinator of Organizing Committee, University of Washington. (2003 - 2003)

     Member, Houston Scociety for Engineering in Medicine and Biology (HSEMB). (2004 - 2004)

     Contributing Lecturer. (2006 - 2006)

     Session Chair, Cardiovascular I: Heart Valves, HSEMB. (2004 - 2004)

     Contributing Instructor. (2006 - 2006)

     Conference Organizing Committee Member and Scientific Session Chair, Society for Experimental Mechanics Meeting on Biologically Inspired Materials. (2003 - 2003)

     Conference Organizing Committee Member, Session Organizer, and Session Chair, Novel Methods and Materials for Orthopaedics; Biomaterials Characterization, SEM Annual Meeting. (2004 - 2004)

     Contributing Instructor. (2006 - 2006)

     Session Organizer and Chair, IEEE-EMBS Meeting. (2004 - 2004)

     Session Co-Chair, Heart Valve Cell & Tissue Function, BMES Annual Fall Meeting. (2004 - 2004)