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Scholarly Interest Report
         
Lon J. Wilson
Professor
Professor of Chemistry
 
e-mail:durango@rice.edu
 
  • Ph.D. (1971) University of Washington, Seattle, Washington
  • B.S. (1966) Iowa State University, Ames, Iowa
 
Primary Department
   Department of Chemistry
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Department Affiliations
 
  • Laboratory for Biochemical and Genetic Engineering
  • Smalley Institute for Nanoscale Science and Technology
  •  
    Websites
     Wilson Research Group Website
     http://www.ruf.rice.edu/~ljwgroup/
     
    Research Areas
     Fullerene, Metallofullerene and Carbon Nanotube Nanotechnology for Medical Applications, Metal Ions in Medicine and Biology, Coordination Chemistry, Radiochemistry of the Lanthanides and Actinides.
     

    Lon J Wilson Research Statement

     

    Professor Wilson's research program involves bringing carbon nanotechnology to the fields of biology and medicine. The nanoparticle "building blocks" of this program are fullerenes (C60), endohedral metallofullerenes (M@C60), and ultra-short (20 nm long) single-walled carbon nanotube capsules (US-tubes). Externally, these carbon nanostructures are being chemically derivatized to make them biocompatible and cell-specific through peptide and antibody targeting. Internally, the nanostructures are being loaded with materials of medical interest for diagnostic and therapeutic medicine. Materials of interest include Fe2O3 and Gd3+ ions for magnetic resonance imaging (MRI), I2 molecules for X-ray computed tomography (CT) imaging and alpha-particle radionuclides (Ac3+-225 and At-211) for alpha-radioimmunotherapy of single-cell cancers. Cancer therapies are also being developed that take advantage of superparamagnetic nanostructures, such as Gd3+@US-tubes, that are simultaneously diagnostic (MRI-guided) and therapeutic (magnetic hyperthermia) agents in a single package. All these carbon nanostructures, with their medical cargos, are designed to be among the first intracellular agents, since the future of medicine will involve the early detection of disease at the cellular level when it is most treatable. Nanoengineered materials promise great advances in medicine, and, working with colleagues at various medical centers, our goal is to bring key, high-performance materials to the clinic as soon as possible.

     
    Selected Publications
     Refereed articles
     

    A. Gizzatov, M. Hernandez-Rivera, V. Keshishian, Y. Mackeyev, J. J. Law, R. Sethi, F. Qu, R. Muthupillai, M. Cabreira-Hansen, J. T. Willerson, E. C. Perin, Q. Ma, R. G. Bryant, L. J. Wilson, "Surfactant-Free Gd3+-ion-containing Carbon Nanotube MRI Contrast Agents for Stem Cell Labeling." Nanoscale, 7, 12085-1209L (2015).

     
     

    B. D. Holt, J. J. Law, L. J. Wilson, K. N. Dahl, M. F. Islam, "Sub-cellular Partitioning and Analysis of Gd3+-loaded Ultra-short Single-walled Carbon Nanotubes." ACS Applied Material Interfaces, 7 (27), 14593-14602 (2015).

     
     

    J. Kolosnjaj-Tabi, J. Just, K.B. Hartman, Y. Laoudi, S. Boudjemaa, D. Alloyeau, H. Szwarc, L. J. Wilson, F. Moussa, "Anthropogenic Carbon Nanotubes Found in the Airways of Parisian Children," EBioMedicine (2015), doi: 10.1016/jebiom.2015.10.012

     
     

    M. L. Matson, C. H. Villa, J. S. Ananta, J. J. Law, D. A. Scheinberg, L. J. Wilson, "Encapsulation of Alpha-particle Emitting Actinium - 225 Ions within Carbon Nanotubes." Journal of Nuclear Medicine, 9, 409-412 (2015).

     
     

    S. Corr, M. Raoof, B. Cisneros, A. Orbaek, M. Cheney, J. Law, N. Lara, A. Barron, L. Wilson, S. Curley, "Radiofrequency Electric-field Heating Behaviors of Highly Enriched Semiconducting and Metallic Single-walled Carbon Nanotubes." Nano Res., 8, 2859-2870 (2015).

     
     

    S. J. Corr, S. Shamsudeen, L. A. Vergara, J. C.-S. Ho, M. J. Ware, V. Keshishian, K. Yokoi, D .J. Savage,I. M. Meraz, W. Kaluarachchi, B. T. Cisneros, M. Raoof, D. T. Nguyen, Y. Zhang, L. J. Wilson, H. Summers, P. Rees, S. A. Curley, R. E. Serda, "A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia." PLoS One,  10, e013682 (2015) 10.1371/journal.pone.0136382).

     
     

    A. Gizzatov, V. Keshishian, A. Guven, A. M. Dimiev, F. Qu, R. Muthupillai, P. Decuzzi, R. G. Bryant, J. M. Tour and L. J. Wilson "Enhanced MRI Relaxivity of Aquated Gd3+ Ions by Carboxyphenylated Water-dispersed Graphene Nanoribbons." Nanoscale, 6 (2014) : 3059-3063.

     
     

    Ayrat Gizzataov, Jaehong Key, Santosh Aryal, Jeyarama Ananta, Antonio Cervadoro, Anna Lisa Palange, Matteo Fasano, Cinzia Stigliano, Meng Zhong, Daniele Di Mascalo, Adem Guven, Eliodoro Chiavazzo, Pietro Asinari, Xuewu Liu, Mauro Ferraro, Lon J. Wilson and Paolo Decuzzi "Hierarchically structured magnetic nanoconstructs with enhanced relaxivity and cooperative tumor accumulation." Advanced Functional Materials, 24 (2014) : 4584-4594.

     
     

    Ayrat Gizzatov, Cinzia Stigliano, J.S. Ananta, Richa Sethi, Rong Xu, Adem Guven, Maricela Ramirez, Haifa Shen, Anil Sood, Mauro Ferrari, Lon J. Wilson, Xuewu Liu and Paolo Decuzzi. "Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer." Cancer Letters 352 (2014): 97-101. 

     
     

    B. T. Cisneros, J. J. Law, M. L. Matson, A. Azhdarinia, E. M. Sevick-Muraca and L. J. Wilson "Stable Confinement of Positron Emission Tomography and Magnetic Resonance Agents within Carbon Nanotubes for Bimodal Imaging." Nanomedicine, 9 (16) (2014): 2499-2509. 

     
     

    J. J. Law, A. Guven, and L. J. Wilson "Relaxivity enhancement of aquated Tris(β-diketonate)gadolinium (III) chelates by confinement within ultrashort single-walled carbon nanotubes." Contrast Media & Mol. Imaging, 9 (2014): 409-412. 

     
     

    Lesa Tran, Mayra Hernandez-Rivera, Ari N. Berlin, Yi Zheng, Luiz Sampaio, Christina Bove, Maria de Graca Cabreira-Hansen, James T. Willerson, Emerson C. Perin, Lon J. Wilson "The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty." Biomaterials, 35 (2014) : 720-726.

     
     

    Mustafa Raoof, Cihui Zhu, Brandon T. Cisneros, Heping Liu, Stuart J. Corr, Lon J. Wilson and Steven A. Curley. "Hyperthermia Inhibits Recombination Repair of Gemcitabine-stalled Replication Forks." Journal of the National Cancer Institute, Aug 15;106(8) (2014). 

     
     

    Stuart J. Corr, Mustafa Raoof, Cihiu Zhu, Sophia Phounsavath, Brandon T. Cisneros, Warna D. Kaluarachchi, Lon J. Wilson, and Steven A. Curley. "Gold nanoparticles and Radiofrequency in Experimental Models for Hepatoceullar Carcinoma." Nanomedicine: Nanotechnology, Biology and Medicine 10 (6), 1121-1130 (2014). 

     
     

    A. M. Dimiev, A. Gizzatov, L. J. Wilson and J. M. Tour "Stable aqueous colloidal solutions of intact surfactant-free graphene nanoribbons and related graphitic nanostructures." Chem. Commun., 49 (2013) : 2613-2615.

     
     

    E. J. Rivera, L. A. Tran, M. Hernández-Rivera, D. Yoon, A. G. Mikos, I. A. Rusakova, B. Y. Cheong, M. G. Cabreira-Hansen, J. T. Willerson, E. C. Perin and L. J. Wilson "Bismuth@US-tubes as a potential contrast agent for X-ray imaging applications." J. Mater. Chem. B, 1 (2013) : 4792-4800.

     
     

    F. Huang, Y. Mackeyev, E. Watson, M. A. Cheney, L. J. Wilson and J. Suh "Evidence for nuclear internalisation of biocompatible [60]fullerene." Eur. J. Nanomed., 5 (2013) : 51-55.

     
     

    M. Raoof, B. T. Cisneros, A. Guven, S. Phounsavath, S. J. Corr, L. J. Wilson, S. A. Curley "Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields." Biomaterials, 34 (2013) : 1862-1869.

     
     

    Q. Ma, M. Jebb, M. F. Tweedle and L. J. Wilson "The Gadonanotubes: Structural Origin of Their High-Performance MRI Contrast Agent Behavior." J. Mater. Chem. B, 1 (2013) : 5791-5797.

     
     

    S. J. Corr, M. Raoof, B. T. Cisneros, O. Kuznetsov, K. Massey, W. D. Kaluarachchi, M. A. Cheney, W. E. Billups, L. J. Wilson, S. A. Curley "Cytotoxiciy and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells." Nanoscale Res. Lett., 8 (2013) : 1-10.

     
     

    Y. Choi, Y. Ye, Y. Mackeyev, M. Cho, L. J. Wilson, J. Lee, W. Choi, J. Lee "C60 aminofullerene-magnetite nanocomposite designed for efficient visible light photocatalysis and magnetic recovery." Carbon (2013) In Press

     
     

    A. Gizzatov, A. Dimiev, Y. Mackeyev, J. M. Tour and L. J. Wilson "Highly water soluble multi-layer graphene nanoribbons and related honey-comb carbon nanostructures." Chem. Commun., 48 (2012) : 5602-5604.

     
     

    A. Guven, I. A. Rusakova, M. T. Lewis, L. J. Wilson "Cisplatin@US-tube carbon nanocapsules for enhanced chemotherapeutic delivery." Biomaterials, 33 (2012) : 1455-1461.

     
     

    E. J. Rivera, R. Sethi, F. Qu, R. Krishnamurthy, R. Muthupillai, M. Alford, M. A. Swanson, S. S. Eaton, G. R. Eaton, and L. J. Wilson "Nitroxide Radicals@US-Tubes: New Spin Labels for Biomedical Applications." Adv. Funct. Mater., 22 (2012) : 3691-3698.

     
     

    H. Kim, W. Kim, Y. Mackeyev, G.-S. Lee, H.-J. Kim, T. Tachikawa, S. Hong, S. Lee, J. Kim, L. . Wilson, T. Majima, P. Alvarez, W. Choi, J. Lee "Selective Oxidative Degradation of Organic Pollutants by Singlet Oxygen-Mediated Photosensitization: Tin Porphyrin versus C60 Aminofullerene Systems." Environ. Sci. Technol., 46 (2012) : 9606-9613.

     
     

    J. T. Rosenberg, M. Matson, B. T. Cisneros, M. Sokoll, A. Sachi-Kocher, F. C. Bejarano. L. J. Wilson and S. C. Grant "Gadolinium and dysprosium single-walled ultra-short carbon nanotubes for MR microscopy at 11.75 and 21.1 T."  (2012) Submitted

     
     

    M. Raoof, C. Zhu, B. T. Cisneros, H. Liu, S. J. Corr, L. J. Wilson, S. A. Curley "Hyperthermia Inhibits Recombination Repair of Gemcitabine-stalled Replication Forks in Liver Cancer."  (2012) Submitted

     
     

    M. Raoof, S. J. Corr, W. D. Kaluarachchi, K. L. Massey, K. Briggs, C. Zhu, M. A. Cheney, L. J. Wilson, S. A. Curley "Stability of directionally conjugated gold nanoparticles in endolysosomal microenvironment: Implications in non-invasive radiofrequency base cancer therapy." Nanomed. Nanotechnol. Biol. Med, 8 (2012) : 1096-1105.

     
     

    M. Raoof, Y. Mackeyev, M. A. Cheney, L. J. Wilson, S. A. Curley "Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex." Biomaterials, 33 (2012) : 2952-2960.

     
     

    R. Sethi, J. S. Ananta, C. Karmonik, M. Zhong, S. H. Fung, X. Liu, K. Li, M. Ferrari, L. J. Wilson, and P. Decuzzi "Enhanced relaxivity of Gd3+-based contrast agents geometrically confined within porous nanoconstructs." Contrast Media Mol. Imaging, 7 (2012) : 501-508.

     
     

    R. Sethi, Y. Mackeyev, and L. J. Wilson "The Gadonanotubes Revisited: A New Frontier in MRI Contrast Agent Design." Inorg. Chim. Acta, 393 (2012) : 165-172.

     
     

    S. J. Corr, M. Raoof, Y. Mackeyev, S. Phounsavath, M. A. Cheney, B. T. Cisneros, M. Shur, P. J. McNally, L. J. Wilson, and S. A. Curley "Citrate-Capped Gold Nanoparticle Electrophoretic Heat Production in Response to a Time-Varying Radio-Frequency Electric Field." J. Phys. Chem. C, 116 (2012) : 24380-24389.

     
     

    A. Grattoni, D. Fine, E. Zabre, A. Ziemys, J. Gill, Y. Mackeyev, M. A. Cheney, D. C. Danila, S. Hosali, L. J. Wilson, F. Hussain and M. Ferrari "Gated and Near-Surface Diffusion of Charged Fullerenes in Nanochannels." ACS Nano, 5 (2011) : 9382-9391.

     
     

    A. M. Tang, J. S. Ananta, H. Zhao, B. T. Cisneros, E. Y. Lam, S. T. Wong, L. J. Wilson and K. K. Wong "Cellular uptake and imaging studies of gadolinium-loaded single-walled carbon nanotubes as MRI contrast agents." Contrast Media & Mol. Imaging, 6 (2011) : 93-99.

     
     

    C. S. Berger, J. W. Marks, R. D. Bolskar, M. G. Rosenblum and L. J. Wilson "Cell Internalization Studies of Gadofullerene–(ZME-018) Immunoconjugates into A375m Melanoma Cells." Translational Oncology, 4 (2011) : 350-354.

     
     

    J. Lee, S. Hong, Y. Mackeyev, C. Lee, E. Chung, L. J. Wilson, J.-H. Kim and P. J. J. Alvarez "Photosensitized Oxidation of Emerging Organic Pollutants by Tetrakis C(60) Aminofullerene-Derivatized Silica under Visible Light Irradiation." Environ. Sci. Technol., 45 (2011) : 10598-10604.

     
     

    L. A. Tran, L. J. Wilson "Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer." Breast Cancer Research, 13 (2011) : 303-304.

     
     

    M. van der Zande, B. Sitharaman, X. F. Walboomers, L. Tran, J. S. Ananta, A. Veltien, L. J. Wilson, J. I. Alava, A. Heerschap, A. G. Mikos, and J. A. Jansen "In Vivo Resonance Imaging of the Distribution Pattern of Gadonanotubes Released from a Degrading Poly(Lactic-Co-Glycolic Acid) Scaffold." Tissue Eng., 17 (2011) : 19-26.

     
     

    A. A. Hassan, B. Chan, K. B. Hartman, J. S. Ananta, Y. Mackeyev, L. Hu, R. G. Pautler, L. J. Wilson and A. V. Lee "Serine-Derivatized Gadonanotubes as Magnetic Nanoprobes for Intracellular Labeling." Contrast Media Mol. Imaging, 5 (2010) : 34-38.

     
     

    B. Sitharaman, M. van der Zande, J. S. Ananta, X. Shi, A. Veltien, X. F. Walboomers, L. J. Wilson, A. G. Mikos, A. Heerschap, J. A. Jansen "Magnetic Resonance Imaging Studies on Gadonanotube Reinforced Polymer Nanocomposites." J. Biomed. Mater. Res., 93A (2010) : 1454-1462.

     
     

    J. Kolosnjaj-Tabi, K. B. Hartman, S. Boudjemaa, J. S. Ananta, G. Morgant, H. Szwarc, L. J. Wilson, F. Moussa "In Vivo Behavior of Large Doses of Ultra-Short and Full-Length Single-Walled Carbon Nanotubes after Oral and Intraperitoneal Administration to Swiss Mice." ACS Nano, 4 (2010) : 1481-1492.

     
     

    J. S. Ananta, B. Godin, R. Sethi, L. Moriggi, X. Liu, R. E. Serda, R. Kishnamurthy, R. Muthupillai, R. D. Bolskar, L. Helm, M. Ferrari, L. J. Wilson, P. Decuzzi "Geometrical Confinement of Gadonanotube Based Contrast Agents in Nanoporous Particles Enhances T1 Contrast." Nat. Nanotechnol., 5 (2010) : 815-821.

     
     

    L. A. Tran, R. Krishnamurthy, R. Muthupillai, M. G. Cabreira-Hansen, J. T. Willerson, E. C. Perin, L. J. Wilson "Gadonanotubes as Magnetic Nanolabels for Stem Cell Detection." Biomaterials, 31 (2010) : 9482-9491.

     
     

    M. Cho, J. Lee, Y. Mackeyev, L. J. Wilson, P. J. J. Alvarez, J. B. Hughes and J.-H. Kim "Visible Light Sensitized Inactivation of MS-2 Bacteriophage by a Cationic Amine-Functionalized C60 Derivative." Environ. Sci. Technol., 44 (2010) : 6685-6691.

     
     

    M. Matson and L. J. Wilson "Nanotechnology and MRI contrast enhancement." Future Med. Chem., 2 (2010) : 491-502.

     
     

    S. Corr, S. Phounsavath, P. McNally, S. Curley, L. J. Wilson "Silver Nanoparticles as Thermal Agents for Capacitively-Coupled Radiofrequency Heating." Nano Lett.Submitted

     
     

    A. A. Hassan, B. Chan, K. B. Hartman, J. S. Ananta, Y. Mackeyev, L. Hu, R. G. Pautler, L. J. Wilson, and A. V. Lee "Serine-Derivatized Gadonanotubes as Magnetic Nanoprobes for Intracellular Labeling." Contrast Media Molecular Imaging (2009) In Press

     
     

    B. Sitharaman, M. van der Zande, J. S. Ananta, X. Shi, A. Veltier, X. F. Walboomers, L. J. Wilson, A. G. Mikos, A. Heerschap, J. A. Jansen "Magnetic Resonance Imaging Studies on Gadonanotube Reinforced Biodegradable Polymer Nanocomposites." J. Biomed. Mater. Res. (2009) In Press

     
     

    C. A. Ambros, I. R. G. Peralta, J. Mika, G. R. Gogla, E. Johnson, L. K. Culton, M. Condron, L. J. Wilson "In Vivo Testing of a Bone-Selective Fullerene: Preliminary Safety and Efficacy Testing." J. Controlled Release (2009) Submitted

     
     

    J. Ananta, M. Matson, A. Tang, T. Mandal, S. Lin, K. Wong, S. Wong, L. J. Wilson "Single-Walled Carbon Nanotube Materials as T2-weighted MRI Contrast Agents." J. Phys. Chem. C, 113 (2009) : 19369-19372.

     
     

    J. Lee, Y. Mackeyev, M. Cho, D. Li, J.-H. Kim, L. J. Wilson, and P. J. J. Alvarez "Photochemical and Antimicrobial Properties of Novel C60 Deriatives in Aqueous Systems." Environ. Sci. Technol., 43 (2009) : 6604-6610.

     
     

    J. Tabi, K. B. Hartman, S. Boudjemaa, J. A. Ananta, G. Morgant, H. Szwarc, L. J. Wilson and F. Moussa "In Vivo Behavior of Large Doses of Ultra-Short and Full-Length SWNTs after Oral and Intraperitoneal Administration to Swiss Mice." ACS Nano (2009) In Press

     
     

    K. K. Wong, A. M. Tang, J. S. Ananta, I. Muradyan, E. Y. Lam, S. Patz, L. J. Wilson, S. T. Wong "Molecular Imaging in Low Field MRI via Gadolinium Single-Walled Carbon Nanotubes." J. Magn. Reson. Med. (2009) Submitted

     
     

    Y. Mackeyev, K. B. Hartman, J. S. Ananta, A. V. Lee, L. J. Wilson "Catalytic Synthesis of Amino Acid- and Peptide-Derivatized Gadonanotubes." J. Am. Chem. Soc., 131 (2009) : 8342-8343.

     
     

    B. Sitharaman, T. Zakharian, A. Saraf, P. Misra, J. Ashcroft, S. Pan, Q. P. Pham, A. G. Mikos, L. J. Wilson and D. A. Engler "Water-Soluble Fullerene (C60) Derivatives as Non-Viral Gene-Delivery Vectors." Molecular Pharmaceutics, 5 (2008) : 567-578.

     
     

    B. Sitharaman, X. Shi, F. Walboomers, H., Liao, V. Cuijpers, L. J. Wilson, A. G. Mikos, and J. A. Jansen "In Vivo Biocompatibility of Ultra-Short Single Walled Carbon Nanotube/Biodegradable Polymer Nanocomposites for Bone Tissue Engineering." Bone, 43 (2008) : 362-370.

     
     

    K. B. Hartman, L. J. Wilson, M. G. Rosenblum "Detecting and Treating Cancer with Nanotechnology." Mol. Diag. Ther., 12 (2008) : 1-14.

     
     

    K. B. Hartman, S. Laus, R. D. Bolskar, R. Muthupillai, L. Helm, E. Toth, A. E. Merbach, and L. J. Wilson "Gadonanotubes as Ultrasensitive pH-Smart Probes for Magnetic Resonance Imaging." Nano Lett., 8 (2008) : 415-419.

     
     

    X. Shi, B. Sitharaman, Q. P. Pham, P. P. Spicer, J. L. Hudson, L. J. Wilson, J. M. Tour, R. M. Raphael, A. G. Mikos "In vitro cytotoxicity of single-walled carbon nanotube/biodegradable polymer nanocomposites." J. Biomed. Mater. Res. Part A, 86A (2008) : 813-823.

     
     

    B. Sitharaman, L. A. Tran, Q. P. Pham. R. D. Bolskar, R. Muthupillai, S. D. Flamm, A. G. Mikos, L. J. Wilson "Gadofullerenes as Nanoscale Magnetic Labels for Cellular MRI." Contrast Media and Molecular Imaging, 2 (2007) : 139-146.

     
     

    B. Sitharaman, X. Shi, L. A. Tran, P. P. Spicer, I. Rusakova, L. J. Wilson and A. G. Mikos "Injectable in Situ Cross-linkable Nanocomposites of Biodegradable Polymers and Carbon Nanostructures for Bone Tissue Engineering." J. Biomater. Sci., 18 (2007) : 655-671.

     
     

    E. Toth, R. D. Bolskar, L. Helm, L. J. Wilson and A. E. Merbach "Understanding Paramagnetic Relaxation Phenomenon for Water-soluble Gadofullerenes." J. Phys. Chem. C, 111 (2007) : 5633-5639.

     
     

    J. M. Ashcroft, K. B. Hartman, K. R. Kissell, Y. Mackeyev, S. Pheasant, S. Young, P. A. van der Heide, A. G. Mikos and L. J. Wilson "Single-molecule I2@US-tube Nanocapsules: A New X-ray Contrast Agent Design." Adv. Mater., 19 (2007) : 573-576.

     
     

    K. B. Hartman, D. K. Hamlin, D. S. Wilbur, L. J. Wilson "211AtCl@US-tube Nanocapsules: A New Concept in Radiotherapeutic Agent Design." Small, 3 (2007) : 1496-1499.

     
     

    Y. Mackeyev, S. Bachilo, K. B. Hartman and L. J. Wilson "The Purification of HiPCo SWCNTs with Liquid Bromine at Room Temperature." Carbon, 45 (2007) : 1013-1017.

     
     

    B. Sitharaman and L. J. Wilson "Gadonanotubes as New High Performance MRI Contrast Agents." Intl J of Nanomedicine, 1 (2006) : 291-295.

     
     

    J. M. Ashcroft, D. A. Tsyboulski, K. B. Hartman, T. Y. Zakharian, J. W. Marks, R. B. Weisman, M. G. Rosenblum and L. J. Wilson "Fullerene (C60) immunoconjugates: interaction of water-soluble C60 derivatives with the murine anti-gp240 melanoma antibody." Chem. Commun. (2006) : 3004-3006.

     
     

    J. M. Ashcroft, K. B. Hartman, Y. Mackeyev, C. Hofmann, S. Pheasant, L. . Alemany and L. J. Wilson "Functionalization of Individual Ultra-Short Single-Walled Carbon Nanotubes." Nanotechnology, 17 (2006) : 5033-5037.

     
     

    K. R. Kissell, K. B. Hartman, P. van der Heide, and L. J. Wilson "Preparation of I2@SWNTs: Synthesis and Spectroscopic Characterization of I2-loaded SWNTs." J. Phys. Chem. B, 110 (2006) : 17425-17429.

     
     

    B. Sitharaman, K. R. Kissell, K. B. Hartman, L. A. Tran, A. Baikalov, I. Rusakova, Y. Sun, H. A. Khant, S. J. Ludtke, W. Chiu, S. Laus, ¿. T¿th, L. Helm, A. E. Merbach, and L. J. Wilson "Superparamagnetic Gadonanotubes Are High-Performance MRI Contrast Agents." Chem. Commun., 31 (2005) : 3915-3917.

     
     

    E. Toth, R. D. Bolskar, A. Borel, G. Gonzalez, L. Helm, A. E. Merbach, B. Sitharaman and L. J. Wilson "Water-Soluble Gadofullerenes: Toward High-Relaxivity, pH-Responsive MRI Contrast Agents." J. Am. Chem. Soc., 127 (2005) : 799-805.

     
     

    S. Laus, B. Sitharaman, ¿. T¿th, R. D. Bolskar, L. Helm, S. Asokan, M. S. Wong, L. J. Wilson and A. E. Merbach "Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10." J. Am. Chem. Soc., 127 (2005) : 9368-9369.

     
     

    T. Y. Zakharian, A. Seryshev, B. Sitharaman, B. E. Gilbert, V. Knight, and L. J. Wilson "A Fullerene-Paclitaxel Chemotherapeutic: Synthesis, Characterization, and Study of Biological Activity in Tissue Culture." J. Am. Chem. Soc., 127 (2005) : 12508-12509.

     
     

    Y. A. Mackeyev, J. W. Marks, M. G. Rosenblum, and L. J. Wilson "Stable Containment of Radionuclides on the Nanoscale by Cut Single-Wall Carbon Nanotubes." J. Phys. Chem. B, 109 (2005) : 5482-5484.

     
     

    B. Sitharaman, S. Asokan, I. Rusakova, M. S. Wong, and L. J. Wilson "Nanoscale Aggregation Properties of Neuroprotective Carboxyfullerene (C3) in Aqueous Solution." Nano. Lett., 4 (2004) : 1759-1762.

     
     

    C. M. Sayes, J. D. Fortner, W. Guo, D. Lyon, A. M. Boyd, K. D. Ausman, Y. J. Tao, B. Sitharaman, L. J. Wilson, J. B. Hughes, J. L. West, and V. L. Colvin "The Differential Cytotoxicity of Water Soluble Fullerenes." Nano Lett., 4 (2004) : 1881-1887.

     
     

    L. O. Husebo, B. Sitharaman, K. Furukawa, T. Kato and L. J. Wilson "Fullerenols Revisited as Stable Radical Anions." J. Am. Chem. Soc., 126 (2004) : 12055-12064.

     
     

    R. D. Bolskar, A. F. Benedetto, L. O. Husebo, R. E. Price, E. F. Jackson, S. Wallace, Wilson, L. J. and J. M. Alford "First Soluble M@C60 Derivatives Provide Enhanced Access to Metallofullerenes and Permit in Vivo Evaluation of Gd@C60[C(COOH)2]10 as a MRI Contrast Agent." J. Am. Chem. Soc., 125 (2003) : 5471-5478.

     
     

    A. L. Mirakyan and Wilson, L. J. "Functionalization of C60 with Diphosphonate Groups: A Route to Bone-Vectored Fullerenes." J. Chem. Soc. Perkin Trans. II (2002) : 1173-1176.

     
     

    K. A. Gonzalez, Wilson, L. J., W. Wu and G. H. Nancollas "Synthesis and In Vitro Characterization of a Tissue-Selective Fullerene: Vectoring C60(OH)16AMBP to Mineralized Bone." Bioorg. Med. Chem., 10 (2002) : 1991-1997.

     
     

    T. Wharton and Wilson, L. J. "Highly-iodinated Fullerene as a Contrast Agent for X-ray Imaging." Bioorg. Med. Chem., 10 (2002) : 3545-3554.

     
     

    T. Wharton and Wilson, L. J. "Toward Fullerene-based X-ray Contrast Agents: Design and Synthesis of Non-ionic, Highly-iodinated Derivatives of C60." Tetrahedron Lett., 43 (2002) : 561-564.

     
     

    Boping Xie, Lon J. Wilson and David M. Stanbury "Cross-Electron-Transfer Reactions of the [CuII/I(bite)]2+/+ Redox Couple ." Inorg. Chem., 40 (2001) : 3606-3614.

     
     

    Thomas P. Thrash and Lon J. Wilson "Zn(II), Ni(II), Cu(II), and Fe(III) Complexes of Potentially-Bimetallating Tris(Pyridine- and Imidazole-Appended) Picket Fence Naphthylporphyrins with Benzyl Ether Spacers: Implications for Cytochrome c Oxidase Active-Site Modeling." Inorg. Chem., 40 (2001) : 4556-4562.

     
     

    Tim Wharton, Vinay U. Kini, Rachel A. Mortis, and Lon J. Wilson "New Non-Ionic, Highly Water-Soluble Derivatives of C60 Designed for Biological Compatibility." Tetrahedron Lett., 42 (2001) : 5159-5162.

     
     

    D. W. Cagle, S. J. Kennel, S. Mirzadeh, J. M. Alford and L. J. Wilson "In Vivo Studies of Fullerene-Based Materials Employing Endohedral Metallofullerene Radiotracers." Proc. Nat. Acad. Sci. USA, 96 (1999) : 5182-5187.

     
     

    D. W. Cagle, S. J. Kennel, S. Mirzadeh, J. M. Alford and L. J. Wilson "In Vivo Studies of Fullerene-Based Materials Employing Endohedral Metallofullerene Radiotracers." Proc. Nat. Acad. Sci. USA, 96 (1999) : 5182-5187.

     
     

    L. J. Wilson, D. W. Cagle, T. P. Thrash, S. J. Kennel, S. Mirzadeh, J. M. Alford and G. J. Ehrhardt "Metallofullerene Drug Design." Coord. Chem. Rev., 190-192 (1999) : 199-207.

     
     

    L. J. Wilson, D. W. Cagle, T. P. Thrash, S. J. Kennel, S. Mirzadeh, J. M. Alford and G. J. Ehrhardt "Metallofullerene Drug Design." Coord. Chem. Rev., 190-192 (1999) : 199-207.

     
     

    T. P. Thrash, D. W. Cagle, J. M. Alford, G. J. Ehrhardt, S. Mirzadeh and L. J. Wilson "Toward Fullerene-Based Radiopharmaceuticals: High Yield Neutron Activation of Endohedral 165Ho Metallofullerenes." Chem. Phys. Lett., 308 (1999) : 329-336.

     
     

    J. E. Bradshaw, K. A. Gillogly, L. J. Wilson, K. Kumar, X. Wan, M. F. Tweedle, G. Hernandez and R. G. Bryant "New Non-ironic Water-Soluble Porphyrins: Evaluation of Manganese(III) Polyphydoxylamide Porphyrins as MRI Contrast Agents." Inorg. Chim. Acta., 275-276 (1998) : 106-116.

     
     Articles
     

    Lon J. Wilson (as reported by Eric Berger) "New way to battle anthrax." Houston Chronicle (4/17/03)

     
     

    Lon J. Wilson (as reported by Jade Boyd) "Rice chemist uses buckyballs to reinvent 'antibiotic of last resort'." Rice News, 12/30 (4/24/03) : 3.

     
     

    A. L. Mirakyan and Wilson, L. J. "Design of Water-Soluble Bone-Vectored Fullerenes." The Exciting World of Nanocages and Nanotubes, 12 (2002) : 407-413.

     
     

    A. L. Mirakyan, Wilson, L. J., R. D. Bolskar and M. Alford "Exploring Holmium Metallofullerenes for Medical Applications." The Exciting World of Nanocages and Nanotubes, 12 (2002) : 390-397.

     
     

    R. D. Bolskar, J. M. Alford, A. F. Benedetto, L. O. Husebo and Wilson, L. J. "Development of Gd@C60 Based MRI Contrast Enhancing Agents." The Exciting World of Nanocages and Nanotubes, 12 (2002) : 398-406.

     
     

    Wilson, L. J. as reported by Ron Dagani "Cagey Chemistry." C&EN, June 17 (2002) : 34.

     
     

    Wilson, L. J. as reported by editor "New Ions for Better Living." Medical Imaging, January (2002) : 64.

     
     Book chapters
     

    Michael L. Matson, Jeyarama S. Ananta, Lon J. Wilson "Carbon-Based Nanomedicine." Nanobiomaterials Handbook (2011) : 5-1:5-24.

     
     

    J. Ananta, L. J. Wilson "Gadonanostructures as MRI Contrast Agents." Chemistry of Carbon Nanocarbons (2009) In Press

     
     

    K. B. Hartman and L. J. Wilson "Carbon Nanostructures as a New High-Performance Platform for MR Molecular Imaging." Bio-Applications of Nanoparticles, 620 (2007) : 74-84.

     
     

    K. B. Hartman and L. J. Wilson "Carbon Nanostuctures as a New High-performance Platform for MR Molecular Imaging." Nanostructures for Biomedical Applications (2006) In Press

     
     Conference papers
     

    Q. Ma, M. Jebb, M. F. Tweedle and L. J. Wilson "X-ray absorption spectroscopy study of Gd3+-loaded ultra-short carbon nanotubes." J. Phys. Conf. Ser., 403 (2013) : 012085.

     
     

    Andrey L. Mirakyan and Lon J. Wilson "Derivatization of C60 with Diphosphonate Groups." Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials, 13 (2001) : 270-276.

     
     Other
     

    L. J. Wilson "Buckyball Antibiotics." Technology Review, October (2003) : 14.

     
     

    John M. Alford and Lon J. Wilson "Fullerene Contrast Agent for Magnetic Resonance Imaging and Spectroscopy." International Patent Application Publication Number WO 01/24696 A1 (April 12, 2001)

     
     

    L. J. Wilson (reported by editor) "Advances in Drug Delivery Systems." Modern Drug Discovery , 4 (2001) : 49-50, 52.

     
     

    L. J. Wilson (reported by editor) "Buckyballs May Treat Cancer." Popular Mechanics (January, 2001) : 22.

     
     

    G. J. Ehrhardt and L. J. Wilson "Fullerene Radiopharmaceuticals." Nuclear and Radiation Chemical Approaches to Fullerene Science (2000) : 174-177.

     
     

    L. J. Wilson (reported by C. Wu) "Altered Buckyballs Go Straight to Bone ." Science News, 155 (1999) : 292.

     
     

    L. J. Wilson (reported by Todd Ackerman) "Buckyball set to make mark in market." Houston Chronicle (Sunday, November 26, 2000) : 37A, 40A.

     
     

    L. J. Wilson and U. Sagman "Fullerene-Based X-ray Contrast Agent for Diagnostic Imaging." 

     
     

    L. J. Wilson, U. Sagman and K. A. Gonzalez "Fullerene-Based Drugs Targeted to Bone ." 

     
     

    R. Bruce Weisman and Lon J. Wilson "Undergraduate Experiments in Fullerene Electrochemistry and Photophysics ." Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials, 2000-12 (2000) : 7-15.

     
     

    Tim Wharton, J. Michael Alford, Lars O. Husebo, and Lon J. Wilson "Paramagnetic Malono-diamide Derivatives of C60 as MRI Contrast Agent Precursors ." Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials, 9 (2000) : 258-266.

     
     

    D. W. Cagle, J. M. Alford and L. J. Wilson "Metallofullerene Sample Analysis by Mass Spectrometry (LD-TOF MS), Neutron-Activation Analysis (NAA) and Inductively-Coupled Plasma Atomic Emission Spectroscopy (ICP-AE)." Fullerenes: Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials, 5 (1999) : 250-255.

     
     

    L. J. Wilson "Medical Applications of Fullerenes and Metallofullerenes." Interface, 8 (1999) : 24-28.

     
    Presentations
     Invited Talks
     

    "Cytoxicity and Biocompatibility of Highly Water-Soluble Graphene Nanoribbons Derivitized with p-Carboxyphenyldiazonium Salt." 224th Spring Meeting of the Electrochemical Society, Orlando, Florida (May 2014). With S. Corr, A. Gizzatov, B. Cisneros, S. Curley. 

     
     

    "Enhancing MRI Relaxitivity of the Gd3+ Ions Coordinated to Carboxylated Highly Water-soluble Graphene Nanoribbons." 224th Spring Meeting of the Electrochemical Society, Orlando, Florida (May 2014). With A. Gizzatov and P. Decuzzi. 

     
     

    "Cytotoxicity and Biocompatibility of Highly Water-Soluble Graphene Nanoribbons Derivitized with p-Carboxyphenyldiazonium Salt ." 223rd Spring Meeting of the Electrochemical Society, Toronto, Canada. (May, 2013) With S. Corr, A. Gizzatov, B. Cisneros, S. Curley

     
     

    "Insights to Nano-Confinement and Its Effect on Relaxivity of Gadolinium Based Contrast Agents." 223rd Spring Meeting of the Electrochemical Society, Toronto, Canada. (May, 2013) With J. Law, C. Jeu

     
     

    "Radiofrequency Electric-Field Interactions with Purified Metallic and Semiconducting Single-Walled Carbon Nanotubes for Applications in Non-Invasive Cancer Hyperthermia ." 223rd Spring Meeting of the Electrochemical Society, Toronto, Canada. (May, 2013) With S. Corr, M. Raoof, B. Cisneros, M. Cheney, S. Curley

     
     

    "Toxicity and Fate of Gadonanotubes After Intravenous Administration in Mice." 223rd Spring Meeting of the Electrochemical Society, Toronto, Canada. (May, 2013) With E. Dhemaied, C. Sébrié, M. Matson, T. Baati, M. Abderrabba, L. Darrasse, F. Mousa

     
     

    "Absorption of Radiofrequency Energy by Gold Nanoparticles and Gd3+ loaded Ultra-short Carbon Nanotubes for Applications in Non-invasive Radiofrequency Hyperthermia Cancer Treatment." 221st Spring Meeting of The Electrochemical Society, Seattle, Washington. (May 8, 2012) With S. Corr, S. Phounsavath, and S. Curley

     
     

    "Early Response of Pig Mesenchymal Progenitor Cells to Intracellular Incorporation of Gadonanotubes Resembles Anoikis Resistance." 10th Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan. (June 13-16, 2012) With M. G. Cabreira-Hansen, L. A. Tran, T. M. Robinson, L. J. Wilson, J. T. Willerson, E. C. Perin

     
     

    "Enhanced Cardiac Stem Cell Engraftment with Magnetic Gadonanotubes." American Heart Association Scientific Sessions 2012, Los Angeles, California. (November 6, 2012) With L. A. Tran, M. Hernandez-Rivera, L. Sampaio, Y. Zheng, C. Bove, G. Silva, E. C. Perin

     
     

    "Multimodal Imaging Agents of Carbon Nanotube Design." Ensysce Science Day, Houston, Texas. (February 22, 2012) With M. Matson

     
     

    "Nanoparticle-facilitated Magnetization of Tumor Cells." 221st Spring Meeting of The Electrochemical Society, Seattle, Washington. (May 10, 2012) With M. Jebb, W. Wei, G. Villares, and M. T. Lewis

     
     

    "The Gadonanotubes: A New Cell-labeling Nanotechnology for MRI." International Society for Magnetic Resonance in Medicine Scientific Workshop on MRI-Based Cell Tracking, Miami Beach, Florida. (January 31, 2012)

     
     

    "Multimodal Imaging Agents of Carbon Nanotube Design." Contrast Media Research 2011, Galveston, Texas. (October 30, 2011) With M. Matson, B. T. Cisneros, A. Azhdarinia, E. M. Sevick-Muraca

     
     

    "On the Stability of Gadonanotubes." Contrast Media Research 2011, Galveston, Texas. (October 31, 2011) With K. Kumar, M. Matson, M. F. Tweedle

     
     

    "Ultra-short Single-walled Carbon Nanotubes (US-Tubes) as 'Smart' Activatable Drug Delivery Platform ." 4th International Congress of Molecular Medicine, Istanbul, Turkey. (June, 2011) With A. Guven, I. Rusakova

     
     

    "Ultra-short Single-walled Carbon Nanotubes (US-tubes) as 'Smart' Delivery Nanocapsules for Chemotherapeutics." 219th Spring Meeting of The Electrochemical Society, Montreal, Canada. (May 2-5, 2011) With A. Guven

     
     

    "Carbon Nanotube Capsules for Medical Imaging and Therapy." 8th World Congress on Trauma, Shock, Inflammation and Sepsis (TSIS 2010), Munich, Germany. (March 10, 2010)

     
     

    "Fullerene Immunoconjugates for Cancer Imaging and Treatment." 217th Spring Meeting of The Electrochemical Society, Vancouver, British Columbia, Canada. (April 27, 2010)

     
     

    "Nanotubes as radiopharmaceuticals for cancer imaging and therapy." 240th National Meeting of The American Chemical Society, Boston, Massachusetts. (August 26, 2010) With Y. Mackeyev, I. Tworowska

     
     

    "Non-Invasive Radio-Frequency Field Induced Thermal Destruction of Malignant Cells in Human Hepatocellular Cancer." National Cancer Institute Site Visit, University of Texas M D Anderson Cancer Center, Houston, Texas. (September 23, 2010)

     
     

    "Radiofrequency Induced Heating of Single-Walled Carbon Nanotubes/Materials." 217th Spring Meeting of The Electrochemical Society, Vancouver, British Columbia, Canada. (April 28, 2010)

     
     

    "Gadonanotubes as MRI Nanolabels for In Vivo Stem Cell Trafficking." 215th Spring Meeting of The Electrochemical Society, San Francisco, California. (May 26, 2009)

     
     

    "Nanotechnology in Cellular and Molecular Imaging." Cellular and Molecular Imaging Course for the 17th Scientific Meeting - International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii. (April 18, 2009)

     
     

    "Single-Walled Carbon Nanotube Nanocapsules for Medical Applications." Ensysce Science Day, Ensysce Biosciences, Houston, Texas. (October 27, 2009)

     
     

    "Thermal Destruction of Cancer Using Radiofrequency Heating of Carbon Nanotubes and Fullerenes." 215th Spring Meeting of The Electrochemical Society, San Francisco, California. (May 25, 2009)

     
     

    "Gadolinium encapsulated carbon nanostructures for biological and medical applications." Gulf Coast Consortia; Alliance for Nanohealth; Center for Protein Folding Machinery, Houston, Texas. (November 6, 2008) With Adrian Lee

     
     

    "Gadonanotubes as MRI contrast agents and more." Gordon Research Conference on In Vivo Magnetic Resonance, Andover, New Hampshire. (July 22, 2008)

     
     

    "211AtCl@US-tube Nanocapsule: A New Concept in Radiotherapeutic Agent Design." 211th Meeting of the Electrochemical Society, Chicago, Illinois. (May 8, 2007) With K. Hartman

     
     

    "Carbon Nanostructure-Reinforced Nanocomposites for Bone Tissue Engineering." 211th Meeting of the Electrochemical Society, Chicago, Illinois. (May 9, 2007) With B. Sitharaman, X. Shi and A. Mikos

     
     

    "Comparative in vivo Toxicity Assessment of Single-Walled Carbon Nanotubes in Mice." 211th Meeting of the Electrochemical Society, Chicago, Illinois. (May 8, 2007) With F. Moussa, K. Hartman, J. Kolosnjaj, N. Gharbi and S. Boudjemaa

     
     

    "Engineering Carbon Nanostructures for High-Performance Magnetic Resonance Imaging." Department of Bioengineering, Rice University, Houston, Texas. (August 18, 2007)

     
     

    "Gadolinium-Encapsulated Carbon Nanostructures for Cancer Theragnostics." Vanderbilt University Institute for Imaging Science, Nashville, Tennessee. (November 9, 2007)

     
     

    "Gadolinium-Encapsulated Carbon Nanostructures for Cancer Theragnostics." Memorial Sloan-Kettering Cancer Center, New York, New York. (December 4, 2007)

     
     

    "Gadolinium-Encapsulated Carbon Nanostructures for Cancer Theragnostics." Imaging 2020, Jackson Hole, Wyoming. (September 26, 2006)

     
     

    "Gd3+@ US-tube(Dex): Dextran-Coated Gadonanotubes as Water-soluble and Biocompatible High-Performance MRI Contrast Agents." 211th Meeting of the Electrochemical Society, Chicago, Illinois. (May 8, 2007) With J. Ananta

     
     

    "MRI-guided Therapy with Superparamagnetic Carbon Nanostructures." International Society for Magnetic Resonance in Medicine Workshop on Molecular and Cellular Imaging Cruise, Galveston, Texas. (February 8, 2007)

     
     

    "Carbon Nanostructures in Medicine: Tiny Weapons with Giant Potential." School of Continuing Education, Rice University, Houston, Texas. (September 28, 2006)

     
     

    "Fullerene Immunotherapy (FIT): A New Targeted Cancer Therapy." 209th Annual Meeting of the Electrochemical Society, Denver, Colorado. (May 7-11, 2006)

     
     

    "Gadonanotubes as pH-sensitive MRI Contrast Agents." 5th Annual Meeting of the Society for Molecular Imaging, Waikoala, Hawaii. (August 29-September 2, 2006)

     
     

    "Carbon Nanotechnology in Medicine: Tiny Weapons with Giant Potential." Food and Drug Administration Center for Veterinary Medicine, Rockville, Maryland. (October 20, 2005)

     
     

    "Fullerenes Are Good but Nanotubes Are Better: Filling Carbon Nanostructures for Medical Applications." Department of Chemistry, Indiana University, Bloomington, Indiana. (April 14, 2005)

     
     

    "Fullerenes Are Good but Nanotubes Are Better: Filling Carbon Nanostructures for Medical Applications." Department of Chemistry, Purdue University, West Lafayetter, Indiana. (April 12, 2005)

     
     

    "New Carbon Nanostructures for Imaging and Therapy of Breast Cancer." San Antonio Breast Cancer Symposium, San Antonio, Texas. (December 8, 2005)

     
     

    "Buckyballs and Medicine: Tiny Weapons with Giant Potential." Rice Alumni College, Rice University, Houston, Texas. (March 13, 2004)

     
     

    "Carbon Nanostructures in Medicine." United Kingdom/Texas Symposium, Imperial College, London, England. (March 29, 2004)

     
     

    "Gadofullerene and Gadonanotubes as MRI Contrast Agents: How They Work and What Is Their Future?." United Kingdom/Texas Symposium, Texas A&M University, College Station, Texas. (October 25, 2004)

     
     

    "Relaxometric Studies of Gd@C60-Based MRI Contrast Agents." 205th Meeting of the Electrochemical Society, San Antonio, Texas. (May 12, 2004) With B. Sitharaman, R. Bolskar, A. Merbach, E. Toth and L. Helm

     
     

    "Targeted-Fullerene Cancer Therapy: Design and Synthesis of a Pacltaxel-Fullerene-Antibody Conjugate." 205th Meeting of he Electrochemical Society, San Antonio, Texas. (May 12, 2004) With T. Zakharian, J. Ashcroft, R. B. Weisman, D. Tsyboulski, V. Knight and M. G. Rosenblum

     
     

    "Buckyballs and Medicine: Tiny Weapons with Giant Potential." University of Lausanne, Lausanne, Switzerland. (July, 2003)

     
     

    "Buckyballs and Medicine: Tiny Weapons with Giant Potential." University of Basel, Basel, Switzerland. (July, 2003)

     
     

    "Buckyballs and Medicine: Tiny Weapons with Giant Potential." University of Florence, Florence, Italy. (July, 2003)

     
     

    "Endohedral Metallofullerenes for Medical Imaging." Materials Research Society, Boston, MA. (December, 2003)

     
     

    "Development of Gd@C60 Based MRI Contrast Enhancing Agents." 201st Meeting of the Electrochemical Society, Philadelphia, Pennsylvania. (May 14, 2002) With R. D. Bolskar, J. M. Alford, A. F. Benedetto, L. O. Husebo

     
     

    "Fullerene-Derived Drugs and Their Targeted Delivery." M. D. Anderson Cancer Center Symposium on Fullerenes in Medicine, Houston, Texas. (January 25, 2002)

     
     

    "Functionalization of C60 with Diphosphonate Groups: A Route to Bone-Vectored Fullerenes." 201st Meeting of the Electrochemical Society, Philadelphia, Pennsylvania. (May 14, 2002) With A. Mirakyan

     
     

    "Functionalized Gd@C60 Fullerenes. A Promising New Type of MRI Contrast Agent." International Conference on Coordination Chemistry, ICCC 35, Heidelberg, Germany. (July 22, 2002) With G. Gonzalez, L. Helm, A. E. Merbach, E. Toth, A. F. Benedetto, R. D. Boskar and J. M. Alford

     
     

    "Highly-iodinated Fullerene as a Contrast Agent for X-ray Imaging." 201st Meeting of the Electrochemical Society, Philadelphia, Pennsylvania. (May 14, 2002) With T. Wharton

     
     

    "Will Metallofullerenes Replace Metal Chelates for Radioimmunotherapy?." International Conference on Monoclonal Antibodies in Cancer, Banff, Canada. (August, 2002) With J. Ashcroft, M. G. Rosenblum

     
     Lectures
     

    "Gadonanotubes as Nanolabels for Cellular Magnetic Resonance Imaging." 213th Spring Meeting of the Electrochemical Society, Phoenix, Arizona. (May 22, 2008) With L. A. Tran

     
     

    "In Vivo Testing of a Bone-Selective Fullerene: Preliminary Safety and Efficacy Testing." 213th Spring Meeting of the Electrochemical Society, Phoenix, Arizona. (May 22, 2008) With I. R. G. Peralta, C. G. Ambrose

     
     

    "In Vitro Studies of Vascular Cell Types Exposed to Single-Walled Carbon Nanotubes." 207th National Meeting of the Electrochemical Society, Quebec City, Canada. (May 15-20, 2005) With P. Cherukuri, K. B. Hartman, K. Kissell, J. L. Hudson, J. M. Tour, R. B. Weisman and J. L. Conyers

     
     

    "Iodine-filled Single-walled Carbon Nanotubes as Computerized Tomography (CT) Contrast Agents." 207th National Meeting of the Electrochemical Society, Quebec City, Canada. (May 15-20, 2005) With K. Kissell, K. Hartman, P. Van der Heide

     
     

    "Buckyballs and Medicine in the New Millennium." Association of Rice Alumni, Austin Chapter, Austin, Texas. (February 23, 2002)

     
     Other
     

    "Nanobiology for Cancer Diagnosis and Therapy." Collaborative Research Center Symposium, Texas Medical Center, Houston, Texas. (November 28, 2006)

     
     

    " Progress Toward C Sixty Inc. Research Projects ." C Sixty Inc., Retreat, Houston, Texas. (June 25, 2002)

     
     

    "Progress Toward Lanthanide and Actinide Clathrochelates." Bracco Research USA Inc., Princeton, New Jersey. (November 1, 2002) With Y. Zhang

     
     

    "Bucky in the News ." Whitehall Club, River Oaks Country Club, Houston, Texas. (January 19, 2001)

     
     

    "Buckyballs and Medicine in the New Millennium." University of Texas at Dallas, Dallas, Texas. (April 25, 2001)

     
     

    "Buckyballs and Medicine in the New Millennium." Baylor College of Medicine, Houston, Texas. (January 9, 2001)

     
     

    "Derivatization of C60 with Diphosphonate Groups." 199th Meeting of the Electrochemical Society, Washington, DC. (March, 2001) With Andrey L. Mirakyan

     
     

    "Medical Applications for Metallofullerenes." 14th International Symposium on Radiopharmaceutical Chemistry, Interlaken. Switzerland. (June, 2001)

     
     

    "Tissue Targeting/Imaging with C60." C-Sixty Retreat, Houston, Texas. (June, 2001)

     
     

    "Buckyballs in Medicine in the New Millennium." New Horizons in Science Briefing sponsored by the Council for the Advancement of Scientific Writing, Inc., Houston, TX. (November, 2000)

     
     

    "Buckyballs in Medicine in the New Millennium." Rice University Continuing Studies Course on Nanotechnology, Houston, Texas. (March, 2000)

     
     

    "Buckyballs in Medicine in the New Millennium." Rice University Alumni College 2000, Houston, Texas. (March, 2000)

     
     

    "Future of Fullerene Technology in Medicine." Seminar, TDA Research, Inc., Wheat Ridge, Colorado. (June, 2000)

     
     

    "Halogenated Fullerenes ." C-Sixty, Inc. Symposium, Toronto, Ontario, Canada. (October, 2000)

     
     

    "Lanthanofullerenes in Medicine." Peptide 2000 Conference on Radiopharmaceuticals , Rome, Italy. (May, 2000) With With Dawson W. Cagle, Colby McLaurin, Thomas P. Thrash, Steven J. Kennel, Saed Mirzadeh, J. Michael Alford and Gary J. Ehrhardt

     
     

    "Paramagnetic Malonodiamide Derivatives of C60 as MRI Contrast Agent Precursors." 197th Meeting of the Electrochemical Society, Toronto, Ontario, Canada. (May, 2000) With With Tim Wharton, J. Michael Alford, Lars O. Husebo

     
     

    "Those Good-for-Something-After-All Buckyballs." "Western Slopes" American Chemical Society Meeting, Fort Lewis College, Durango, Colorado. (September, 2000)

     
     

    "Future of Fullerene Technology in Medicine." Seminar, TDA Research, Inc., Wheat Ridge, Colorado. (April, 1999)

     
     

    "Medical Applications of Halogenated Fullerenes." C-Sixty, Inc. Symposium, Toronto, Ontario, Canada. (December, 1999)

     
     

    "Paramagnetic Fullerols for Magnetic Resonance Imaging." 199th Joint International Meeting of the Electrochemical Society, Honolulu, Hawaii. (October, 1999) With L. Husebo

     
     

    "Tissue Targeting of Fullerene-Based Materials: Vectoring C60 to Bone." 195th Meeting, Electrochemical Society, Seattle, Washington. (May, 1999) With K. Gonzalez, W. Wu and G. Nancollas

     
     

    "Toward Fullerene-Based X-ray Contrast Agents." 199th Joint International Meeting of the Electrochemical Society, Honolulu, Hawaii. (October, 1999) With T. Wharton

     
     

    "Biodistribution Study of an Endohedral Metallofullerol Radiotracer." 193rd Meeting of the Electrochemistry Society, San Diego, CA. (May, 1998)

     
     

    "Metallofullerene Drug Design." XXXIII International Conference on Coordination Chemistry, Florence, Italy. (September, 1998)

     
     

    "Nuclear Medicine Applications for Metallofullerenes." 215th National Meeting of the American Chemical Society, Dallas, TX. (March, 1998) With D. Cagle

     
     Posters
     

    "In Vivo Anticancer Activities of Cisplatin-loaded Ultra-short Carbon Nanocapsules (Cisplatin@US-tubes)." 221st Spring Meeting of The Electrochemical Society, Seattle, Washington. (May, 2012)

     
     

    "Evaluation of gadolinium- and dysprosium-encapsulating ultra-short single-walled carbon nanotubes as intracellular labeling agents for high magnetic fields." International Society for Magnetic Resonance in Medicine Workshop on MRI-based Cell Tracking, Miami Beach, Florida. (January 31, 2012) With J. T. Rosenberg, M. Matson, B. T. Cisneros, M. Sokoll, F. Calixo-Bejarano, and S. C. Grant

     
     

    "Multifunctional nanoconstructs for tumor visualization using contast enhanced MRI." American Association for Cancer Research Annual Meeting 2012, Chicago, Illinois. (April, 2012) With R. Sethi, J. Ananta, A. Gizzatov, X. Liu, C. Karmonik, P. Decuzzi

     
     

    "Nanoconstructs for Imaging and Therapeutic Applications." Biomedical Engineering Society 2012 Annual Meeting, Atlanta, Georgia. (October 24-27, 2012) With A. Gizzatov, J. Ananta, A. Cervadoro, X. Liu, M. Ferrari, and P. Decuzzi

     
     

    "Nanoconstructs for Imaging and Therapeutic Applications." Physical Sciences in Oncology Annual Site Visit, Houston, Texas. (October 4, 2012 ) With A. Gizzatov, J. Ananta, A. Cervadoro, C. Stigliano, A. Guven, X. Liu, M. Ferrari, and P. Decuzzi

     
     

    "Superparamagnetic Ion Nanoconstructs for Imaging and Therapeutic Applications." Third Annual Physical Sciences - Oncology Centers (PS-OCs) Network Investigators Meeting, Tampa, Florida. (April 16-18, 2012) With A. Gizzatov, J. Ananta, A. Cervadoro, X. Liu, M. Ferrari, and P. Decuzzi

     
     

    "X-ray absorption Spectroscopy Study of Gd3+ loaded ultra short carbon nanotubes." 15th International Conference on X-ray Absorption Fine Structure, Beijing, China. (July 22-28, 2012) With Q. Ma, M. Jebb, M. Tweedle

     
     

    "Gadonanotubes as a Theranostic Agent: Cancer Detection and Therapy by Radiofrequency-induced Hyperthermia." Imaging in 2020, Jackson Hole, Wyoming. (September 18-22, 2011) With M. Cheney, S. A. Curley

     
     

    "Gadonanotubes as a Theranostic Agent: Cancer Detection and Therapy by Radiofrequency-induced Hyperthermia." Center for Transport Oncophysics Annual Symposium, The Methodist Hospital Research Institute, Houston, Texas. (November 3-4, 2011) With M. A. Cheney and S. A. Curley

     
     

    "High Relaxivity Nanoporous Silicon Particles for the Analysis of Vascular Transport and Adhesion Dynamics." Center for Transport Oncophysics Annual Symposium, The Methodist Hospital Research Institute, Houston, Texas. (November 3-4, 2011) With R. Sethi, J. S. Ananta, Y. Mackeyev, M. Ferrari, and P. Decuzzi

     
     

    "Magnetic-Assisted Retention of MRI-active Gadonanotube-labeled Stem Cells in Cardiac Tissue." Imaging in 2020, Jackson Hole, Wyoming. (September 18-22, 2011) With L. A. Tran, Y. Zheng, M. L. Matson, M. G. Cabreira-Hansen, J. T. Willerson, E. C. Perin

     
     

    "Magnetizing Breast Cancer Cells for Magnetic Isolation of Tumor Initiating Cells." Breast Cancer Research and Education Program, Montgomery, Texas. (September 18-19, 2011) With M. Jebb and M. T. Lewis

     
     

    "Optimized Radiofrequency Heating of Nanoparticles for the Thermal Ablation of Cancer Cells." Second Annual Physical Sciences - Oncology Centers Network Investigators' Meeting, La Jolla, California. (April 9-13, 2011) With S. Phounsavath and S. Corr

     
     

    "Relaxivity Enhancement by Nanoscale Confinement of Magnevist® within Mesoporous Silicon Nanoparticles ." Imaging in 2020, Jackson Hole, Wyoming. (September 18-22, 2011) With R. Sethi, J. S. Ananta, P. Decuzzi

     
     

    "Relaxivity Enhancement by Nanoscale Confinement of Magnevist® within Porous Nanostructures for Early Detection of Breast Cancer." Gulf Coast Women's Health Research Forum, Houston, Texas. (September 30, 2011) With R. Sethi, J. S. Ananta, and P. Decuzzi

     
     

    "Superparamagnetic Nanoconstructs for Cell Internalization and Tracking." Center for Transport Oncophysics Annual Symposium, The Methodist Hospital Research Institute, Houston, Texas. (November 3-4, 2011) With A. Gizzatov, J. S. Ananta, A. Cervadoro, M. Ferrari and P. Decuzzi

     
     

    "Comparison of Gadolinium Loaded and Empty Carbon Nanotubes as High Performance MRI Contrast Agents." World Molecular Imaging Congress, Montreal, Canada. (September 24, 2009)

     
     

    "Gadonanotubes as Dual Modal T1 and T2 MRI Contrast Agents: Magnetic Property Characterization by SQUID Magnetometry." International Society for Magnetic Resonance in Medicine (ISMRM2009) Conference, Honolulu, Hawaii. (April 23, 2009)

     
     

    "Gadonanotubes as Magnetic Nanolabels for Stem Cell Detection." Imaging in 2020 IV, Jackson Hole, Wyoming. (September 14, 2009)

     
     

    "Low-field MR Imaging Using Gadonanotubes." Imaging in 2010 IV, Jackson Hole, Wyoming. (September 15, 2009)

     
     

    "Shape Dependency of Gold Nanoparticle Heating Rates in an External Radiofrequency Field." Nanotech Conference and Expo 2009, Houston, Texas. (May 4, 2009)

     
     

    "In Vitro Relaxivities Studies of Gadolinium Carbon Nanotubes at 0.2T." International Society for Magnetic Resonance in Medicine, Toronto, Ontario, Canada. (May 4-8, 2008) With J. Ananta

     
     

    "In Vitro Relaxivities Studies of Gadolinium Carbon Nanotubes at 3T." International Society for Magnetic Resonance in Medicine, Toronto, Ontario, Canada. (May 4-8, 2008) With J. Ananta

     
     

    "Low-Field (0.015 T) Relaxation Studies of Superparamagnetic Gadonanotubes." 2008 World Molecular Imaging Congress, Nice, France. (September 8-14, 2008) With J. Ananta, B. Sitharaman, K. B. Hartman

     
     

    "Astatination of Ultra-short Carbon Nanotubes to be Used as a Scaffold for New Cancer Therapy Agents." 97th Annual Meeting of the American Association for Cancer Research, Washington, DC. (April 1-5, 2006) With K. B. Hartman, D. K. Hamlin, D. S. Wilbur

     
     

    "Fabrication and Characterization of Carbon Nanostructure In Situ Crosslinkable Composites for Bone Tissue Engineering." 2006 Regenerate World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, Pennsylvania. (April 25-26, 2006) With B. Sitharaman, L. A. Tran, P. P. Spicer, I. Rusakova, A. G. Mikos

     
     

    "Fullerene(C60)-Immunoconjugates: Interaction of Customized Water-Soluble C60 Derivatives with the Murine Anti-gp240 Melanoma Antibody." 97th Annual Meeting of the American Association for Cancer Research, Washington, DC. (April 1-5, 2006) With J. M. Ashcroft, J. W. Marks and M. G. Rosenblum

     
     

    "Gadofullerenes as High-performance Stem Cell Labeling Agents Detectable by MRI." Southwestern Medical School Symposium on in vivo Medical Imaging, Dallas, Texas. (November 17, 2006) With J. Ananta, S. Berger, K. Hartman, P. Misra, I. Pralta

     
     

    "Gadofullerenes as High-performance Stem Cell Labeling Agents Detectable by MRI." 5th Annual Meeting of the Society for Molecular Imaging, Waikoala, Hawaii. (August 29-September 2, 2006)

     
     

    "Gadonanotubes as pH-sensitive MRI Contrast Agents." Southwestern Medical School Symposium on in vivo Medical Imaging, Dallas, Texas. (November 17, 2006)

     
     

    "Gd@(Carbon Nanostructures) as Nanoprobes for Cellular Magnetic Resonance Imaging: An Initial Evaluation." International Society for Magnetic Resonance in Medicine 14th Annual Meeting, Seattle, Washington. (May 6-12, 2006) With B. Sitharaman, R. Muthupillai, L. A. Tran, R. D. Bolskar, S. D. Flamm, A. G. Mikos

     
     

    "Gdn3+@SWNTs: Will the Next Generation MRI Contrast Agent by Single-Wall Carbon Nanotube Based?." Imaging in 2020 Conference on Molecular Imaging, Jackson Hole, Wyoming. (September 25-29, 2005)

     
     

    "Gdn3+US-tubes: Ultra-Short Carbon Nanotube Capsules as MRI Contrast Agents." 207th National Meeting of the Electrochemical Society, Quebec City, Canada. (May, 2005) With K. B. Hartman, B. Sitharaman, K. R. Kissell, L. A. Tran, L. J. Wilson, A. Baikalov, Irene Rusakova, Y. Sun, H. A. Khant, S. J. Ludtke, W. Chiu

     
     

    "Design and Synthesis of a Paclitaxel-Fullerene Conjugate." American Chemical Society National Meeting, New Orleans, LA. (March, 2003) With T. Zakharian

     
     

    "Fullerene (C60)-Antibody Conjugates for Targeted Therapy." American Chemical Society National Meeting, New Orleans, LA. (March, 2003) With J. Ashcroft and M. Rosenblum

     
     

    "Fullerene(C60)-Vancomycin Conjugates as Improved Antibiotics." American Chemical Society National Meeting, New Orleans, LA. (March, 2003) With A. Mirakyan and M. P. Cubbage

     
     

    "Gd@C60(OH)x and Gd@C60(C(COOH)2)10: Dynamic Light Scattering Studies in Aqueous Solution of Two Metallofullerene-based MRI Contrast Agents." Materials Research Society, Boston, MA. (December, 2003) With B. Sitharaman and B. Bolakar

     
     Seminar Speaker
     

    "Carbon Nanotube Capsules for Medical Imaging and Therapy." Faculté de Pharmacie de Châtenay-Malabry, Université Paris XI, Paris, France. (September 30, 2010)

     
     

    "Gadonanotubes: A New Nanotechnological Paradigm in MRI Contrast Agent Design." University of Puerto Rice, San Juan, Puerto Rico. (February 8, 2010)

     
     

    "Gadolinium-Encapsulated Carbon Nanostructures for Cancer Theragnostics." Wichita State University, Wichita, Kansas. (April 2, 2008)

     
     

    "Gadolinium-encapsulated Carbon Nanostructures for Cancer Theragnostics." Department of Chemistry, Fort Lewis College, Durango, Colorado. (October 17, 2008)

     
     

    "Detecting and Treating Early State Cancer with SWNT Agents." NSF-CBEN Site Visit, Rice University, Houston, Texas. (May 30, 2007)

     
     Session Chair
     

    "Carbon Nanotubes and Nanostructures: Medicine and Biology Symposium." 213th Spring Meeting of the Electrochemical Society, Phoenix, Arizona. (May 22, 2008)

     
     Workshops
     

    "Magnetic Nanoparticle-facilitated Isolation of Quiescent Breast Cancer Cells." Telluride Science Research Center Workshop on Frontiers in BioMagnetic Particles, Telluride, Colorado. (June 2013) With M. H. Jebb

     
     

    "Magnetic Retention of Gadonaotube-labeled Stem Cells for Cellular Cardiomyoplasty." Telluride Science Research Center Workshop on Frontiers in BioMagnetic Particles, Telluride, Colorado. (June, 2013) With L. A. Tran, M. Hernandez-Rivera, A. N. Berlin, Y. Zheng, L. Sampaio, C. Bove, M. G. Cabriera-Hansen, J. T. Willerson, E. C. Perin

     
    Supervised Theses & Dissertations
     John Timothy Wharton, Ph.D. Highly-iodinated Fullerene as a Contrast Agent for X-ray Imaging. (2002) (Thesis Director)

     Lars Olav Husebo, Ph.D. Fullerenol Radical Anions. (2004) (Thesis Director)

     Balaji Sitharaman, Ph.D. Biologically-Compatible Gd@(Carbon Nanostructures) as Advanced Contrast Agents for Magnetic Resonance Imaging. (2005) (Thesis Director)

     Kyle Kissell, Ph.D. Preparation of I2@SWNTs and I2@US-tubes: Synthesis and Spectroscopic Characterization of I2-loaded SWNTs for Computed Tomography Molecular Imaging. (2006) (Thesis Director)

     Jared Ashcroft, PhD Immunoconjugates of Carbon Nanostructures. (2006) (Thesis Director)

     Keith B. Hartman, PhD Ultra-short Carbon Nanotubes as Nanocapsules for Medical Imaging and Therapy. (2008) (Thesis Director)

     Cafer T. Yavuz, Ph.D. Accessible and Green Manufacturing of Magnetite (Fe3O4 Nanocrystals and Their Use in Magnetic Separations. (2008) (Thesis Committee Member)

     Laura Anne McJilton, Ph.D. Controlled Synthesis of Single-Walled Carbon Nanotubes. (2008) (Thesis Committee Member)

     Merlyn Pulikkathara, PhD Functionalized Single-walled Carbon Nanotubes for Composite Applications and Radiation Studies. (2009) (Thesis Director)

     Jennifer A. Jamison, PhD Characterization of Nanocrystals and Gold Nanoparticle-Protein Assemblies. (2009) (Thesis Committee Member)

     Jonathan J. Brege, Ph.D. Metal Ion Interactions with Single Walled Carbon Nanotubes. (2009) (Thesis Committee Member)

     Jelena Kolosnjaj Tabi, Ph.D. In vivo behavior of full length and ultra-short single-walled carbon nanotubes. (2010) (Thesis Committee Member)

     Ivana R. G. Peralta, PhD In Vivo Studies of C60-Bis(bisphosphonate) and Synthesis of a C60-Bisphosphonate-Beta-Blocker Conjugate for the Prevention and Treatment of Osteoporosis. (2010) (Thesis Director)

     Jeyarama Subramanian Ananta Narayanan, Ph.D. Carbon-Based Nanostructures as Advanced Contrast Agents for Magnetic Resonance Imaging. (2011) (Thesis Director)

     Michael L Matson, Ph.D. Ultra-short, Single-walled Carbon Nanotube Capsules for Diagnostic Imaging and Radiotherapy. (2012) (Thesis Director)

     Christopher Jones, PhD Iron: From Synthesis, Characterization, and Application of Sulfide Green Rust to Viability in Arsenic Water Treatment. (2013) (Thesis Committee Member)

     Meghan Jebb, Ph. D. Magnetic nanomaterials for applications in magnetic resonance imaging and cancer stem cell biology . (2014) (Thesis Director)

     Matthew Cheney, Ph. D. Radiofrequency-induced cellular hyperthermia: Water-soluble fullerene as a new cancer therapeutic agent . (2014) (Thesis Director)

     Sophia Phounsavath, Ph.D. RF heating of ultra-short single-walled carbon nanotubes and gadonanotubes for non-invasive cancer hyperthermia. (2014) (Thesis Director)

     Justin Law, Ph.D. Ultrashort Single-Walled Carbon Nanotubes: A Platform for Medical Imaging and Therapy. (2015) (Thesis Director)

     Ayrat Gizzatov, Ph.D. Carbon and Silicon Nanomaterials for Medical Nanotechnology Applications. (2015) (Thesis Director)

     Ashley D. Leonard, PhD Functionalized and Modification of Single-Walled Carbon Nanotubes for Their Use as Drug Delivery Agents and for the Storage of Hydrogen. (Thesis Committee Member)

     Richa Sethi, Ph.D. Nanosystems: From their design to applications as advanced MRI contrast agents. (Thesis Director)

     Lesa A Tran, Ph.D. An Assessment of Gadonanotubes as Magnetic Nanolabels for Improved Stem Cell Detection and Retention in Cardiomyoplasty. (Thesis Director)

     Anna T Kelly, PhD Synthesis, Characterization, and Functionalization of Transition Metal Phosphide Nanomaterials from Single Source Molecular Precursors. (Thesis Committee Member)

     Arnab Mukherjee, PhD Reductive Functionalization of Carbon Nanomaterials. (Thesis Committee Member)

     Christopher Scott Berger, M.S. Gd@C60-(ZME-018) Immunoconjugate Targeting of A375 Melanoma Cells. (Thesis Director)

     Adem Guven, Ph.D. Cisplatin@US-tube Carbon Nanocapsules for Enchanced Chemotherapeutic Delivery. (Thesis Director)

     Christopher Scott Berger, Ph.D. Toward Fullerene Immunotherapy with Water-Soluble Paclitaxel-Fullerene Conjugates. (Thesis Director)

    Awards, Prizes, & Fellowships
     John L Margrave Innovation Award, Department of Chemistry, Rice University (April, 2011)

     Outstanding Teacher Award in course entitled "Cellular and Molecular Imaging", International Society for Magnetic Resonance in Medicine (April 24, 2009)

     Distinguished Faculty Associate, Sid Richardson College (April 24, 2006)

     Distinguished Faculty Associate, Sid Richardson College (4/19/2004)

     The Outstanding Associate 2003, Sid Richardson College (2003)

     Outstanding Faculty Associate, Sid Richardson College (2002)