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Scholarly Interest Report
         
Dmitri Lapotko
Faculty Fellow
Faculty Fellow in Biochemistry and Cell Biology
 
e-mail:Dmitri.Lapotko@rice.edu
 
  • D.Sc. Thermal physics (2003) A.V.Lykov Heat and Mass Transfer Institute, Minsk, Belarus
  • Ph.D. Molecular and thermal physics (1988) Belarussian State University, Minsk
 
Primary Department
   Department of BioSciences
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Department Affiliations
 
  • Department of Physics and Astronomy
  • Institute of Biosciences and Bioengineering
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    Websites
     http://lapotko.rice.edu
     
    Research Areas
     photothermal interactions at micro- and nanoscale, imaging and microscopy, heat- and mass-transfer at nanoscale, nanomedicine, theranostics, bomedical nanomaterials, plasmon resonance, nanophotonics, gene therapy, microsurgery, early diagnostics
     

    2013 Research Statement

     

    What does “nano” mean for biology and medicine? Since their invention, nanoparticles demonstrated both unique properties and an even more unique ability to manipulate energy at nanoscale. Although research into the biological, and especially the medical, applications of nanoparticles will result in entirely new knowledge and medicine, it is yet at the very beginning. In an effort to develop nanoparticle medicine into true nanomedicine, Lapotko’s lab engaged at nanoscale the two major life-supporting phenomena, light and heat. Using a mechanism of plasmon resonance in gold nanoparticles, we developed novel, tunable and stealth type nanoprobes, plasmonic nanobubbles (PNBs), tiny vapor bubbles that are generated around gold nanoparticles with short laser pulses. PNBs will provide molecular and cellular imaging, diagnosis, therapy and theranostics (diagnosis and treatment united in one fast procedure) with the speed, selectivity and precision far beyond the limits of modern medicine. Our interdisciplinary research includes three major avenues: fundamental studies of physics, optics and biology of PNBs, studies of PNB-induced bioeffects in cells and organisms, and the development of PNB technologies for cell level imaging, theranostics, surgery, gene therapy and drug delivery.

     
    Selected Publications
     Refereed articles
     

    E.Y. Lukianova-Hleb, A.N. Volkov, X. Wu and D.O. Lapotko "Transient enhancement and spectral narrowing of the photothermal effect of plasmonic nanoparticles under pulsed excitation." Adv Mater (2013) : DOI:10.1002/adma.201204083.

     
     

    E.Y. Lukianova-Hleb, D.O. Lapotko "Nano-theranostics with plasmonic nanobubbles." IEEE J Sel Top Quant (2013)

     
     

    E.Y. Lukianova-Hleb, K.M. Campbell, P.E. Constantinou, J. Braam, J.S. Olson, R.E. Ware, D.J. Sullivan and D.O. Lapotko "Hemozoin-generated vapor nanobubbles for transdermal reagent and needle-free detection of malaria." Proc Natl Acad Sci USA (2013)

     
     

    E.Y.Lukianova-Hleb, X.Ren, R.R. Sawant, X. Wu, V.P. Torchilin, D.O.Lapotko "On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles." Nature Medicine: DOI:10.1038/nm.3484.In Press


    DOI:10.1038/nm.3484
     
     

    W.Lu, E.Y. Lukianova-Hleb, P. Parekh, D.O. Lapotko, YL Zu "ssDNA Aptamer guided “nanobomb” specific for cancer cells ." FASEB J, 27 (2013)

     
     

    B. P. Danysh, P. E. Constantinous, E. Y. Lukianova-Hleb, D. O. Lapotko and D. D. Carson, The MUC1 ectodomain: A novel and efficient target for gold nanoparticle clustering and vapor nanobubble generation, Theranostics (2012) 2, 777-787.

     
     

    E. Lukianova-Hleb, D. Wagner, M. Brenner, D. Lapotko, Cell-specific transmembrane injection of molecular cargo with gold nanoparticle-generated transient plasmonic nanobubbles, Biomaterials (2012) 33, 5441-5450.

     
     

    E.Y. Lukianova-Hleb and D.O. Lapotko, Experimental techniques for imaging and measuring transient vapor nanobubbles, Appl Phys Lett (2012) 101, 264102.

     
     

    E.Y. Lukianova-Hleb, A. Belyanin, S. Kashinath, X. Wu and D. Lapotko, Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells, Biomaterials (2012) 33, 1821-1826.

     
     

    E.Y. Lukianova-Hleb, A.N. Volkov, X. Wu and D.O. Lapotko, Transient enhancement and spectral narrowing of the photothermal effect of plasmonic nanoparticles under pulsed excitation, Adv Mater (2012) DOI:10.1002/adma.201204083.

     
     

    E.Y. Lukianova-Hleb, E. Sassaroli, A. Jones and D. Lapotko, Transient photothermal spectra of plasmonic nanobubbles, Langmuir (2012) 28, 4858-4866.

     
     

    E.Y. Lukianova-Hleb, J. Braam, J. Olson, R. Ware, D. Sullivan and D.O. Lapotko, Hemozoin- and laser pulse-induced vapor nanobubbles rapidly detect and destroy malaria parasites, Nature Nanotechnology (2012) (under review).

     
     

    E.Y. Lukianova-Hleb, M. Mutonga and D.O. Lapotko,  Cell-specific multifunctional processing of heterogeneous cell systems in a single laser pulse treatment, ACS Nano (2012) 6, 10973-10981.

     
     

    E.Y. Lukianova-Hleb, R. Sawant, X. Ren, X. Wu, V. P. Torchilin and D.O.Lapotko, On-demand cancer cell-specific plasmonic nanobubble-mediated enhancement of intracellular drug release and radiation effects, Nature Medicine (2012) (under review).

     
     

    E.Y. Lukianova-Hleb, X. Ren, D. Townley, X. Wu, M. Kupferman and D. Lapotko, Plasmonic nanobubbles rapidly detect and destroy drug-resistant tumors, Theranostics (2012) 2, 976-987.

     
     

    E.Y. Lukianova-Hleb, X. Ren, J.A. Zasadzinski, X. Wu and D. Lapotko, Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells, Adv Mater (2012) 24, 3831-3837.

     
     

    E.Y. Lukianova-Hleb, X. Ren, P.E. Constantinou, B.P. Danysh, D.L. Shenefelt, D.D. Carson, M.C. Farach-Carson, V.A. Kulchitsky, X. Wu, D.S. Wagner and D.O. Lapotko, Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems, PLos ONE (2012) 7, e34537.

     
     

    D. Lapotko, Plasmonic nanobubbles as tunable cellular probes for cancer theranostics, Cancers2011.- Vol.3.- p.802-840

     
     

     Lukianova-Hleb E., Samaniego A., Wen J., Metelitsa L., Chang C.-C., Lapotko D., Selective gene transfection of individual cells in vitro with plasmonic nanobubbles, J Control Release – 2011.- Vol.152.- p.286-293.

     
     

      Lukianova-Hleb E.Y., Belyanin A., Kashinath S., Wu X., Lapotko D. Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells. Biomaterials2011 –DOI: 10.1016/j.biomaterials.2011.11.015.

     
     

     Lukianova-Hleb E.Y., Koneva I.I., Oginsky A.O., La Francesca S., Lapotko D.O. Selective and self-guided micro-ablation of tissue  with plasmonic nanobubbles. J. Surgic. Research 2011.- Vol.166.- p.e2-13.

     
     

    Lukianova-Hleb E.Y., Oginsky A.O., Olson J.S., Lapotko D.O.  Short laser pulse-induced irreversible photothermal effects in red blood cells. Laser Surg. Med.2011.- Vol.43.- p.249-260.

     
     

    Lukianova-Hleb E.Y., Oginsky A.O., Samaniego A.P., Shenefelt D.L., Wagner D.S., Hafner J.H., Farach-Carson M.C., Lapotko D.O., Tunable plasmonic nanoprobes for theranostics of prostate cancer, Theranostics – 2011.- Vol.1.- p.3-17.

     
     

     Lukianova-Hleb E.Y., Orinsky A.O., Shenefelt D.L., Drezek R.D., Hafner J.H., Farach-Carson M.C., Lapotko D.O., Rainbow plasmonic nanobubbles: synergistic activation of gold nanoparticle clusters, J Nanomed Nanotech  - 2011.- Vol.2.- p.1-8.

     
     

    D.S. Wagner, N.A. Delk, E.Y. Lukianova-Hleb, J.H. Hafner, M.C. Farach-Carson, D.O. Lapotko, The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts, Biomaterials (2010) 31, 7567-7574.

     
     

    E. Lukianova-Hleb, C. Santiago, D. Wagner, J. Hafner, D. Lapotko, Generation and detection of plasmonic nanobubbles in zebrafish, Nanotechnology (2010) 21, 225102.

     
     

    E. Lukianova-Hleb, I. Koneva, A. Oginsky, S. La Francesca, D. Lapotko, Selective and self-guided micro-ablation of tissue with plasmonic nanobubbles, J. Surg. Res. (2010), DOI: 10.1016/j.jss.2010.10.039.

     
     

    E. Lukianova-Hleb, L. Anderson, S. Lee, J. Hafner, D. Lapotko, Hot plasmonic interactions: a new look at the photothermal efficacy of gold nanoparticles, Phys. Chem. Chem. Phys. (2010) 12, 12237-12244.

     
     

    E. Lukianova-Hleb, Y. Hu, L. Latterini, L. Tarpani, S. Lee, R. Drezek, J. Hafner, D. Lapotko, Plasmonic nanobubbles as transient vapor nanobubbles generated around plasmonic nanoparticles, ACS Nano (2010) 4, 2109–2123.

     
     

    E.Y. Lukianova-Hleb, A.O. Oginsky, J.S. Olson, D.O. Lapotko, Short laser pulse-induced irreversible photothermal effects in red blood cells, Laser Surg. Med. (2011) DOI: 10.1002/lsm.21043.

     
     

    E.Y. Lukianova-Hleb, E.Y. Hanna, J.H. Hafner, D.O. Lapotko, Tunable plasmonic nanobubbles for cell theranostics, Nanotechnology (2010) 21, 085102.

     
     

    E.Y. Lukianova-Hleb, J. Wen, L. Metelitsa, C. Chang, D.O. Lapotko, Selective gene transfection of individual cells in vitro with plasmonic nanobubbles, J. Controlled Release (2010) (under review).

     
     Book chapters
     

    Lukianova-Hleb E.Y, Lapotko D.O. "Plasmonic Nanobubbles for Cancer Theranostics." Engineering in Translational Medicine (2013)

     
     

    D. Lapotko. Photothermal theranostic agents. In: Emerging Applications of Colloidal Noble Metals in Cancer Nanomedicine. Zhang J & Lakowicz JR (Eds). Future Medicine, London, UK (2012), pp. 38-53.

     
     Refereed conference papers
     

    E.Y. Lukianova-Hleb, S. Kashinath and D.O. Lapotko, Multifunctional cell therapeutics with plasmonic nanobubbles, Proc SPIE (2012) 8231, 823109 (10 pages).

     
     

    E.Y. Lukianova-Hleb, S. Kashinath and D.O. Lapotko, Plasmonic nanobubbles for cell theranostics, Proc SPIE (2012) 8234, 82341F (10 pages).

     
     

    E.Y. Lukianova-Hleb, X. Ren, A. Belyanin, J.A. Zasadzinski, X. Wu and D.O. Lapotko, Guided intracellular drug delivery and release with plasmonic nanobubbles in drug-resistant cancer cells. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res (2012) 72(8 Suppl) DOI:1538-7445.AM2012-5693.

     
     

      E. Lukianova-Hleb, J. Wen, L. Metelitsa, M. Brenner, J. Chang, D.O. Lapotko, Plasmonic nanobubbles for intracellular targeting and gene therapy, In: Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy, Chapter 4: Materials for Drug & Gene Delivery.- 2011.- Vol.3.- p.291-294.

     
     

    E. Lukianova-Hleb, P. Constantinou, B. Danysh D.S. Wagner, R.A. Drezek, J.H. Hafner, M.C. Farach-Carson, D.D. Carson, D.O. Lapotko, Plasmonic nanobubbles as tunable theranostic agents, In: Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy, Chapter 5: Cancer Nanotechnology.- 2011.- Vol.3.- p.367-370.

     
     

    E. Lukianova-Hleb, C. Santiago, D. Wagner, J. Hafner, D. Lapotko, Zebrafish as a universal in v,ivo model for plasmonic nanoparticle medicine (2010) Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, 3, pp. 412-415.

     
     

    E. Lukianova-Hleb, R. Drezek, J. Hafner, D. Lapotko, Plasmonic nanobubbles: Tunable and transient probes for cancer diagnosis, therapy and theranostics(2010) Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, 3, pp. 432-435.

     
     Other
     

    D.O. Lapotko "Nanophotonics and theranostics: will light do the magic?." Theranostics special issue, Guest editor, 3(3) (2013) : 138-140.

     
    Presentations
     Invited Talks
     

    "ACS National Fall Meeting." Indianapolis, IN. (September 8, 2013)

     
     

    "Multifunctional Cell Processing with Plasmonic Nanobubbles." International Conference on Bioscience and Engineering, Paris. (November 6 - 7, 2013)

     
     

    "Photo-activated Drug Release of a Liposomal Carrier: Comparisons between Hollow Gold Nanoparticles and Copper Sulfide Nanoparticles." 2013 Annual Meeting of the American Institute of Chemical Engineering, San Francisco, CA. (November 6, 2013)

     
     

      D. Lapotko, How a splash of nanotechnology enables macro movement, World Theranostics Congress USA 2011, November 15-17, 2011, San Diego, CA.

     
     

    D. Lapotko, Nanotechnology for Treating Cancers, Annual Conference and Science, Engineering and Technology Seminars (SETS) of the Association of Chinese American Professionals, June 4, 2011, Sugar Land, TX.

     
     

    D. Lapotko, Applications of plasmonic nanobubbles for cancer treatment, Annual Meeting of the Board of the Institute of International Education, 2010, May 5, Washington, D.C.

     
     

    D. Lapotko, Future of oncology: plasmonic nanobubbles, Cancer Clinics
    of Excellence Annual Meeting 2010, April 13-17, Philadelphia, PA.

     
     

    D. Lapotko, Joint researc US-Belarussian Lab for Fundamental and Biomedical Nanophotonics,  A report to the Scientific Council of A.V.Lykov Heat and Mass Transfer Institute, 2010 November 10, Minsk, Belarus.

     
     Lectures
     

     E. Lukianova-Hleb, P. Constantinou, B. Danysh D.S. Wagner, R.A. Drezek, J.H. Hafner, M.C. Farach-Carson, D.D. Carson, D.O. Lapotko, Plasmonic nanobubbles as tunable theranostic agents, Nanotech 2011, June 13-16, 2011, Boston, MA.

     
     

    E. Lukianova-Hleb, J. Wen, L. Metelitsa, M. Brenner, J. Chang, D.O. Lapotko, Plasmonic nanobubbles for intracellular targeting and gene therapy, Nanotech 2011, June 13-16, 2011, Boston, MA.

     
     

    D. Lapotko, Nanotechnology for Treating Cancers, Annual Conference and Science, Engineering and Technology Seminars (SETS) of the Association of Chinese American Professionals 2010 June 12, 2010, Sugar Land, TX.

     
     

    D. Lapotko, Plasmonic Nanobubbles: tunable and transient probes for
    cancer diagnosis, therapy and theranostics, TechConnect World Conference and
    Trade Show, June 21-25, 2010, Anaheim, California, U.S.A.

     
     

    D. Lapotko, Plasmonic nanobubbles: tunable multifunctional agents for diagnosis, treatment and theranostics, Alliance for Nanohealth: ANH Investigators Meeting 2010, February 23, Houston, TX.

     
     Posters
     

    D. Lapotko, Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine,
    TechConnect World Conference and Trade Show, June 21-25, 2010, Anaheim, California, U.S.A.

     
     Seminar Speaker
     

    D. Lapotko, Plasmonic Nanobubble Lab at Rice, Colloquium of the Department of Physics and Astronomy, Rice University, 2010. October 6, Houston, TX.

     
     

    D. Lapotko, Plasmonic Nanobubbles, Colloquium of the Department of Biochemistry and Cell Biology, Rice University, 2010. October 6, Houston, TX.

     
     

    D. Lapotko, Plasmonic nanobubbles and their biomedical applications. Texas Children Cancer Center Seminar, 2010, March 1, Houston, TX.

     
    Editorial Positions
     Member of the Editorial Board, Theranostics. (2013 - 2013)

     Member of the Editorial Board, Journal of Nanotechnology and Nanomedicine. (2013 - 2013)

     Other, Guest editor: Theranostics, special issue "Nanophotonics and theranostics: will light do the magic?" . (2013 - 2013)

     Member of the Editorial Board, Nanomedicine and Nanotechnology. (2010 - 2010)

     Member of the Editorial Board, Theranostics. (2010 - 2010)

    Positions Held
     Assistant Professor, Department of Thermal Physics, Belarussian State University. (2010 - 2010)

     Founding Director, Laboratory for Laser Cytotechnologies, A.V.Lykov Heat and Mass Transfer Institute. (2010 - 2010)

     Faculty Fellow, Department of Biochemistry & Cell Biology, Rice University. (2011 - 2011)

     Director, Joint American-Belarussian Laboratory for Fundamental and Biomedical Nanophotonics, Rice University. (2010 - 2010)

     Research Scientist, Department of Physics and Astronomy, Rice University. (2010 - 2010)