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Scholarly Interest Report
         
Kyriacos Zygourakis
Professor
A.J. Hartsook Professor in Chemical Engineering and Professor of Bioengineering
 
e-mail:kyzy@rice.edu
 
  • Dipl.Chem.Eng. Chemical Engineering (1975) National Technical University, Athens, Greece
  • Ph.D. Chemical Engineering (Minor: Mathematics) (1981) University of Minnesota, Minneapolis, MN
 
Primary Department
   Department of Chemical and Biomolecular Engineering
Picture
 
Department Affiliations
 
  • Department of Bioengineering
  • Institute of Biosciences and Bioengineering
  • Ken Kennedy Institute for Information Technology
  •  
    Websites
     Home Page for Kyriacos Zygourakis
     
    Research Areas
     Chemical reaction engineering; thermal analysis; biochar production for soil amendment and carbon sequestration; biofuels; cellular engineering; transport phenomena in tissue engineering.
     
    RESEARCH STATEMENT
     

    My research interests span several important areas of bioengineering and reaction engineering. Applied mathematics, computer simulations, video microscopy, and digital image processing are integral parts of my research methodology.

    TISSUE ENGINEERING: The proliferation and migration of anchorage-dependent mammalian cells are important processes for many biomedical applications. Using video microscopy, digital image analysis and computer simulations, my group is studying the mechanisms through which cell migration and proliferation affect the growth of three-dimensional tissues. Experimental data and model predictions are used to analyze the dynamic behavior of large cell populations proliferating on three-dimensional scaffolds and find how tissue growth rates are modulated by the presence of growth factors in the culture media, cell-substrate interactions, the spatial distribution of seed cells, the heterogeneity of cell populations and the specific tissue architecture. The objective of these studies is the development of a suite of experimental and computational tools that allow accurate predictions of tissue growth rates using only a few key measurements.


    MECHANICAL FORCES AND CELL FUNCTION: Our research in this area focuses on elucidating the effect of mechanical forces on the biochemical pathways of lymphocyte adhesion and migration. We have recently demonstrated that lymphocytes cultured in low-shear bioreactors (rotating wall vessel or RWV reactors) exhibit similar adhesion strength but higher motility than lymphocytes cultured under static conditions (i.e on standard tissue culture plates). Using NMR and image analysis techniques, we are investigating the hypothesis that these motility changes are modulated by prolonged stimulation of protein kinase C (PKC) occurring via phosphatidylcholine (PC) cycles that generate second messengers such as diacylglycerol (DAG). We are also extending our studies to include lymphocytes exposed to high-shear conditions in cone-and-plate or rotating plate viscometers. Identification of the pathways involved in the observed cell motility changes will have significant implications for space biology (i.e. eadverse effects of microgravity on the human immune system) and may help us understand the beneficial effects of RWV culture for tissue engineering applications.


    CATALYTIC REACTORS FOR AIR POLLUTION CONTROL: We are working to develop integrated computer simulation and visualization tools for the optimal design of emission control reactors that incorporate some the most advanced adsorption and catalytic reaction technologies. Computer simulation is essential for the application of these technologies because of the complex interactions of transport, adsorption, heterogeneous reaction and catalyst deactivation phenomena occurring in emission control reactors. Optimization tools are also incorporated in our codes to allow for easy determination of optimal values of process parameters. These simulators will move computer-aided design into the hands of reactor engineers, so that they can meet the air pollution control challenges in small and medium-size operations


    GAS-SOLID AND LIQUID-SOLID REACTIONS: Our research in this area focuses on the dynamic behavior of gas-solid or liquid-solid reacting systems with temporally evolving structures. Theoretical and experimental studies are carried out to determine which structural and process parameters control (a) the reactivity of porous carbonaceous materials and (b) the release rates of bioactive agents from multicomponent bioerodible systems. Video microscopy and digital image processing facilities support the experimental studies on coal pyrolysis and combustion. Our primary objective here is the analysis of transient phenomena such as coal particle swelling, macropore formation and heterogeneous or homogeneous ignitions. This information is then used to develop theoretical models that can guide thel design of coal utilization processes.

     
    RESEARCH STATEMENT
     My research interests span several important areas of bioengineering and reaction engineering. Applied mathematics, computer simulations, video microscopy, and digital image processing are integral parts of my research methodology.


    TISSUE ENGINEERING: The proliferation and migration of anchorage-dependent mammalian cells are important processes for many biomedical applications. Using video microscopy, digital image analysis and computer simulations, my group is studying the mechanisms through which cell migration and proliferation affect the growth of three-dimensional tissues. Experimental data and model predictions are used to analyze the dynamic behavior of large cell populations proliferating on three-dimensional scaffolds and find how tissue growth rates are modulated by the presence of growth factors in the culture media, cell-substrate interactions, the spatial distribution of seed cells, the heterogeneity of cell populations and the specific tissue architecture. The objective of these studies is the development of a suite of experimental and computational tools that allow accurate predictions of tissue growth rates using only a few key measurements.


    MECHANICAL FORCES AND CELL FUNCTION: Our research in this area focuses on elucidating the effect of mechanical forces on the biochemical pathways of lymphocyte adhesion and migration. We have recently demonstrated that lymphocytes cultured in low-shear bioreactors (rotating wall vessel or RWV reactors) exhibit similar adhesion strength but higher motility than lymphocytes cultured under static conditions (i.e on standard tissue culture plates). Using NMR and image analysis techniques, we are investigating the hypothesis that these motility changes are modulated by prolonged stimulation of protein kinase C (PKC) occurring via phosphatidylcholine (PC) cycles that generate second messengers such as diacylglycerol (DAG). We are also extending our studies to include lymphocytes exposed to high-shear conditions in cone-and-plate or rotating plate viscometers. Identification of the pathways involved in the observed cell motility changes will have significant implications for space biology (i.e. eadverse effects of microgravity on the human immune system) and may help us understand the beneficial effects of RWV culture for tissue engineering applications.


    CATALYTIC REACTORS FOR AIR POLLUTION CONTROL: We are working to develop integrated computer simulation and visualization tools for the optimal design of emission control reactors that incorporate some the most advanced adsorption and catalytic reaction technologies. Computer simulation is essential for the application of these technologies because of the complex interactions of transport, adsorption, heterogeneous reaction and catalyst deactivation phenomena occurring in emission control reactors. Optimization tools are also incorporated in our codes to allow for easy determination of optimal values of process parameters. These simulators will move computer-aided design into the hands of reactor engineers, so that they can meet the air pollution control challenges in small and medium-size operations


    GAS-SOLID AND LIQUID-SOLID REACTIONS: Our research in this area focuses on the dynamic behavior of gas-solid or liquid-solid reacting systems with temporally evolving structures. Theoretical and experimental studies are carried out to determine which structural and process parameters control (a) the reactivity of porous carbonaceous materials and (b) the release rates of bioactive agents from multicomponent bioerodible systems. Video microscopy and digital image processing facilities support the experimental studies on coal pyrolysis and combustion. Our primary objective here is the analysis of transient phenomena such as coal particle swelling, macropore formation and heterogeneous or homogeneous ignitions. This information is then used to develop theoretical models that can guide thel design of coal utilization processes.

     
    Research Interests of Kyriacos Zygourakis
     My research interests span several important areas of bioengineering and reaction engineering. Applied mathematics, computer simulations, video microscopy, and digital image processing are integral parts of my research methodology.

    Dynamic Behavior of Cell Populations Growing Under Mass Transport Limitations: Tissue growth in biomimetic scaffolds is strongly influenced by the dynamics and the heterogeneity of cell populations. A significant source of heterogeneity is the depletion of nutrients and growth factors due to transport limitations. Cells slow down, stop dividing or even die when the concentrations of key nutrients and growth factors drop below certain levels in the scaffold interior. As a result, tissue engineers have not yet been able to grow in vitro tissue samples thicker than a few millimeters for metabolically active cells.

    In order to better understand these processes, my group is developing a multi-scale, hybrid framework that integrates biology with mathematical, computational, and experimental tools to study heterogeneous cell populations growing in three-dimensional scaffolds. We use a discrete, stochastic model to describe the population dynamics of migrating, interacting and proliferating cells. The diffusion and consumption of nutrients and growth factors are modeled by partial differential equations that are subject to boundary conditions appropriate for the bioreactors used in each case. These PDEs are solved numerically and the computed concentration profiles are fed to receptor-mediated binding/trafficking models or simplified kinetic expressions (i.e. Monod kinetics) to modulate cell proliferation rates and migration speeds. To meet the significant computational requirements of this model, parallel implementations of the hybrid algorithms have been developed for Linux clusters.

    Finally, video microscopy and digital image analysis are used to experimentally observe the dynamic behavior of cell populations and find how cell migration and proliferation are influenced by the concentrations of nutrients and growth factors in the culture media, as well as by cell-substrate interactions.

    Gas-solid and Liquid-Solid Reactions: Our research in this area focuses on the dynamic behavior of gas-solid or liquid-solid reacting systems with temporally evolving structures. Theoretical and experimental studies are carried out to determine which structural and process parameters control (a) the reactivity of porous carbonaceous materials and (b) the release rates of bioactive agents from multicomponent bioerodible systems. State-of-the-art video microscopy and digital image processing facilities support the experimental studies on coal pyrolysis and combustion. Our primary objective here is the analysis of transient phenomena such as coal particle swelling, macropore formation and heterogeneous or homogeneous ignitions. This information is crucial for the development of theoretical models that can be used for the optimal design of coal utilization processes.
     
    Research Interests of Kyriacos Zygourakis
     My research interests span several important areas of bioengineering and reaction engineering. Applied mathematics, computer simulations, video microscopy, and digital image processing are integral parts of my research methodology.

    Dynamic Behavior of Cell Populations Growing Under Mass Transport Limitations: Tissue growth in biomimetic scaffolds is strongly influenced by the dynamics and the heterogeneity of cell populations. A significant source of heterogeneity is the depletion of nutrients and growth factors due to transport limitations. Cells slow down, stop dividing or even die when the concentrations of key nutrients and growth factors drop below certain levels in the scaffold interior. As a result, tissue engineers have not yet been able to grow in vitro tissue samples thicker than a few millimeters for metabolically active cells.

    In order to better understand these processes, my group is developing a multi-scale, hybrid framework that integrates biology with mathematical, computational, and experimental tools to study heterogeneous cell populations growing in three-dimensional scaffolds. We use a discrete, stochastic model to describe the population dynamics of migrating, interacting and proliferating cells. The diffusion and consumption of nutrients and growth factors are modeled by partial differential equations that are subject to boundary conditions appropriate for the bioreactors used in each case. These PDEs are solved numerically and the computed concentration profiles are fed to receptor-mediated binding/trafficking models or simplified kinetic expressions (i.e. Monod kinetics) to modulate cell proliferation rates and migration speeds. To meet the significant computational requirements of this model, parallel implementations of the hybrid algorithms have been developed for Linux clusters.

    Finally, video microscopy and digital image analysis are used to experimentally observe the dynamic behavior of cell populations and find how cell migration and proliferation are influenced by the concentrations of nutrients and growth factors in the culture media, as well as by cell-substrate interactions.

    Gas-solid and Liquid-Solid Reactions: Our research in this area focuses on the dynamic behavior of gas-solid or liquid-solid reacting systems with temporally evolving structures. Theoretical and experimental studies are carried out to determine which structural and process parameters control (a) the reactivity of porous carbonaceous materials and (b) the release rates of bioactive agents from multicomponent bioerodible systems. State-of-the-art video microscopy and digital image processing facilities support the experimental studies on coal pyrolysis and combustion. Our primary objective here is the analysis of transient phenomena such as coal particle swelling, macropore formation and heterogeneous or homogeneous ignitions. This information is crucial for the development of theoretical models that can be used for the optimal design of coal utilization processes.
     
    Teaching Areas
     Reaction Engineering, Applied Mathematics, Material and Energy Balances, Sustainability, Chemical Engineering Lab, Introduction to Chemical Engineering.
     
    Selected Publications
     Abstracts
     

    A. A. Gooding and K. Zygourakis "Thermal Conversion of Biomass: Pyrolysis Reaction Networks for Optimal Reactor Design ." Procs. 2014 Annual Meeting of the AIChE (2014) : 729d.

     
     

    A. Amiri, C.E. Brewer and K. Zygourakis "A Partial-Combustion Pyrolysis Model for an Energy + Biochar Reactor Design ." Procs. 2014 Annual Meeting of the AIChE (2014) : 30g.

     
     

    C.E. Brewer and K. Zygourakis " Biomass Pyrolysis Reaction Kinetics Using Step-Isothermal Thermogravimetry and TGA/MS ." Procs. 2014 International Congress on Energy (ICE) (2014) : 596a.

     
     

    Caroline Masiello, Catherine Brewer, Brandon Dugan, Zuolin Liu, Helge Gonnermann, Kyriacos Zygourakis, Christian Davies, Pietro Panzacchi, Xiaodong Gao, and Lacey Pyle "Charcoal’s physical properties are key to understanding its environmental behavior." Geophysical Research Abstracts, 16 (2014) : EGU2014-13651.

     
     

    X. Xie, K. Zygourakis and M. Pasquali "Computing White Blood Cell Deformation in Shear Flow."  (2004)

     
     

    Z. Mu, S. Asokan, K. Ausman, V. Colvin, K. Zygourakis, M.S. Wong and N. Mantzaris "Experimental and Theoretical Study on the Evolution of CdSe Nanoparticle Size Distributions."  (2004)

     
     Refereed articles
     

    A. A. Gooding, C. E. Brewer, and K. Zygourakis "“Producing Biochars with Consistent Properties from a Variety of Forest Residues: Spatial Variations of Temperature History in a Reactor Guide the Choice of Pyrolysis Conditions." In Progress

     
     

    Caroline A. Masiello, Ye Chen, Xiaodong Gao, Shirley Liu, Hsiao-Ying Cheng, Matthew R. Bennett, Jennifer A. Rudgers, Daniel S. Wagner, Kyriacos Zygourakis, and Jonathan J. Silberg "Biochar and Microbial Signaling: Production Conditions Determine Effects on Microbial Communication ." Environ. Sci. Technol., 47 (2013) : 11496−11503.

     
     

    Catherine E. Brewer, Eric Hall, Jeffery Rudisill, Klaus Schmidt-Rohr, David A. Laird, Robert C. Brown, Kyriacos Zygourakis "Temperature and Reaction Atmosphere Oxygen Effects on Biochar Properties." Industrial & Engineering Chemistry ResearchSubmitted

     
     

    Catherine E. Brewer, Victoria J. Chuang, Caroline A. Masiello, Helge Gonnermann, Xiaodong Gao, Brandon Dugan, Laura E. Driver, Pietro Panzacchi, Kyriacos Zygourakis, Christian A. Davies "New approaches to measuring biochar density and porosity." Biomass and Bioenergy, 66 (2014) : 176-185.

     
     

    Hao Sun, Catherine E. Brewer, Caroline A. Masiello, Kyriacos Zygourakis "Nutrient Transport in Soils Amended with Biochar: A transient model with two stationary phases and intraparticle diffusion ." Industrial & Engineering Chemistry Research, in press.In Press

     
     

    Lynn Gai, C. E. Brewer, and K. Zygourakis "Pyrolysis temperature history controls reaction kinetics and biochar properties." In Progress

     
     

    B. B. Youssef, G. Cheng, K. Zygourakis and P. Markenscoff "Parallel Implementation of a Cellular Automaton Modeling the Growth of Three-Dimensional Tissues." Journal of High Performance Computer Applications (2006) In Press

     
     

    G. Cheng, B. B. Youssef P. Markenscoff and K. Zygourakis "Cell Population Dynamics Modulate the Rates of Tissue Growth Processes." Biophysical Journal, 90 (2006) : 713-724.

     
     

    G. Cheng, P. A. Markenscoff and K. Zygourakis "A Hybrid Three-Dimensional Model Describing Cell Population and Mass Transport Dynamics in Growing Bioartificial Tissues." Biophysical JournalSubmitted

     
     

    K. Spetsieris, K. Zygourakis and N. V. Mantzaris "Determining the distributions required for inverse cell population balance modeling using fluorescence microscopy and image processing." Biotechnology and Bioengineering (2006) Submitted

     
     

    Zygourakis, K. "A Multi-Scale Transient Model for Combustion of Highly-Porous Chars." Industrial Engineering Chemistry Research (2002) In Press

     
     

    Zygourakis, K. "Adhesion and Migration of Marrow-Derived Osteoblasts on in Situ Crosslinkable Poly(propylene fumarate co-ethylene glycol) Based Hydrogels with a Covalently Linked RGDS Peptide for Bone Tissue Engineering." J Biomed Mater Res. (2002) In Press

     
     

    Zygourakis, K. "Pore Structure Effects on Char Reactivity in the Regime of Diffusional Limitations." Energy & Fuels (2002) Submitted

     
     

    E. Behravesh, S.Jo, K. Zygourakis, A.G. Mikos "Synthesis of In Situ Crosslinkable Macroporous Biodegradable Poly(Propylene Fumarate-b-Ethylene Glycol) Hydrogels." Biomacromolecules, 3 (2002) : 374-381.

     
     

    K. Zygourakis "A Multi-Scale Transient Model for Combustion of Highly Porous Chars." Ind. Eng. Chemistry Research (2002) In Press

     
     

    K. Zygourakis "Macropore Structure Affects the Reactivity of Chars in the Regime of Diffusional Limitations." Energy & Fuels (2002) Submitted

     
     Articles
     

    A. Ismail and K. Zygourakis "The Effect of Pyrolysis Conditions on Coal Particle Swelling and Devolatilization Rates." Ind. Eng. Chem. Res (2004) Submitted

     
     

    B. Youssef, G. Cheng, K. Zygourakis, and P. Markenscoff "Parallel Implementation of a Discrete Computational Model for Tissue Regeneration Processes." High Performance Computing Applications (2004) Submitted

     
     

    D. S. Perkins, II and K. Zygourakis "Detection and Characterization of Coal and Char Particle Ignitions." Ind. Eng. Chem. Res, 43: 3085-3091.

     
     

    G. Cheng, B. Youssef, P. Markenscoff and K. Zygourakis "Cell Migration and Population Dynamics Modulate the Growth Rates of Tissues in Three Dimensional Scaffolds." Chemical Engineering Science (2004) Submitted

     
     

    H. Shin, K. Zygourakis, M. C. Farach-Carson, M. J. Yaszemski and A. G. Mikos "Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide." Biomaterials, 25 (2004) : 895?906.

     
     

    H. Shin, K. Zygourakis, M. C. Farach-Carson, M. J. Yaszemski, A. G. Mikos "Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides." J. Biomed. Mater. Res. Part A, 69A (2004) : 535-543.

     
     

    K. Zygourakis "Chemical Engineering at Rice University." Chem. Eng. Education (2004) : 88-93.

     
     Book chapters
     G. Cheng and K. Zygourakis, ¿Cell Migration,¿ Tissue Engineering and Artificial Organs,The Biomedical Engineering Handbook, 3rd Edition, J. D. Bronzino, Ed., Taylor and Francis, CRC Press (2006).
     
     Refereed conference papers
     

    K. Zygourakis "A Parallel Model for Wound Healing in Tissues with Mixed and Segregated Cell Populations." Procs. 2002 Annual Meeting of the AIChE, Paper 274i (2002)

     
     

    K. Zygourakis "Hybrid Multi-Scale Model Describing the Growth of 3-Dimensional Tissues under Diffusional Limitations." Procs. 2002 Annual Meeting of the AIChE, Paper 318h, (2002)

     
     

    S. Mani, K. Zygourakis and P. Markenscoff "Modeling Wound Healing: Effects of Cell Heterogeneity and Tissue Structure." Procs. 2nd Joint Conference of the IEEE Engineering in Medicine and Biology Society and the Biomedical Engineering Society (2002)

     
     Conference papers
     

    J. Feng, P. A. Markenscoff and K. Zygourakis "Mass Transport Dynamics, Cell Population Heterogeneity and Domain Geometry Modulate the Architecture of Regenerating Tissues." Procs. 2006 Annual Meeting of the American Institute of Chemical Engineers (2006)

     
     

    G. Cheng, P. Markenscoff and K. Zygourakis "A Hybrid Three-Dimensional Model for Early Tumor Invasion."  (2004)

     
     

    G. Cheng, P. Markenscoff and K. Zygourakis "A Hybrid Three-Dimensional Model for Tissue Growth in a Perfusion System."  (2004)

     
     

    K. Zygourakis "Temporal Evolution of Pore Structure in Non-Catalytic Gas-Solid Reactions."  (2004)

     
     Other
     

    A.J. Bergman and K. Zygourakis "Migration and Adhesion of Lymphocytes Cultured Under Low-Shear Conditions ." submitted to J. Leukocyte Biology (2001)

     
     

    B. Y. Belgacem, K., Zygourakis and P. Markenscoff "A Computational Model for Tissue Regeneration and Wound Healing." Procs. 3rd Chemical Engineering Symposium, Athens, Greece, vol. 2 (2001) : 1133-1136.

     
     

    D.S. Perkins and K. Zygourakis "Detection of Coal and Char Particle Ignitions." submitted to Industrial & Engineering Chemistry Research (2001)

     
     

    A. Ismail and K. Zygourakis "Effects of Pyrolysis Conditions on Coal Particle Swelling and Devolatilization Rates." Industrial & Engineering Chemistry Research (submitted)

     
     

    A.J. Bergman and K. Zygourakis "Migration of lymphocytes on fibronectin-coated surfaces: temporal evolution of migratory parameters." Biomaterials, 20 (2000) : 2235-2244.

     
     

    B. Ben Youssef, K. Zygourakis and P. Markenscoff "A Stochastic Model for Tissue Regeneration and Wound Healing." Procs. 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cell and Tissue Engineering (2000) : A318.

     
     

    F. Boissiere and K. Zygourakis "Effect of Pyrolysis Conditions on the Macropore Structure of Char Particles: An Image Analysis Study." Energy and Fuels (submitted)

     
     

    K. Zygourakis and P. Markenscoff "Design of Biodegradable Scaffolds for Tissue Engineering: Effects of Pore Structure and Hydration Rates." Procs. 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Biocompatibility (2000) : G201.

     
     

    S. Kouvroukoglou, K. C. Dee, R. Bizios, L.V. McIntire and K. Zygourakis "Endothelial Cell Migration on Surfaces Modified with Covalently-Bound Adhesive Peptides." Biomaterials, 21 (2000) : 1725-1733.

     
     

    A. Ismail and K. Zygourakis "The Effect of Pyrolysis Conditions on Coal Particle Swelling and Devolatilization Rates."  (in preparation)

     
     

    A.J. Bergman and K. Zygourakis "Migration and Adhesion of Lymphocytes Cultured Under Low Shear Conditions." Procs.1999 BMES/EMBS Conference, IEEE 99CH37015C (1999) : 780.

     
     

    Ahmad Ismail, D. S. Perkins and K. Zygourakis "A Mathematical Model for the Ignition of Devolatilized Char Particles."  (in preparation)

     
     

    B. Y. Belgacem, K., Zygourakis and P. Markenscoff "Modeling the Growth of Three-Dimensional Tissues." Procs.1999 BMES/EMBS Conference, IEEE 99CH37015C (1999) : 1180.

     
     

    D.S. Perkins and K. Zygourakis "Detection of Coal and Char Particle Ignitions."  (in preparation)

     
     

    P. Markenscoff and K. Zygourakis "Pore Structure and Hydration Rates Modulate the Release of Bioactive Agents from Degradable Scaffolds." Procs. 1999 BMES/EMBS Conference, IEEE 99CH37015C (1999) : 720.

     
     

    S. Kouvroukoglou, M. Wong, A. Gurlek, G.R.D. Evans and K. Zygourakis "Spreading and Migration of Irradiated Endothelial Cells."  (in preparation)

     
     

    A. Ambani, K. Zygourakis and P. Markenscoff "Modeling the Migration and Proliferation of Endothelial Cells with Changing Shape and Size." Biophysical J. (submitted)

     
     

    S. Kouvroukoglou, C. L. Lakkis, J. D. Wallace, K. Zygourakis and D. E. Epner "Bioenergetics of Rat Prostate Cancer Cell Migration." Prostate, 34 (1998) : 137-144.

     
     

    S. Kouvroukoglou, K.C. Dee, R. Bizios, L.V. McIntire and K. Zygourakis "Endothelial Cell Migration on Surfaces Modified with Immobilized Adhesive Peptides." Biomaterials (submitted)

     
     

    S. Neelamegham and K, Zygourakis "A Quantitative Assay for Intercellelular Aggregation." Annals Biomed. Engrg., 25 (1997) : 180-189.

     
     

    S. Neelamegham, L.L. Munn and K. Zygourakis "A Mathematical Model for the Kinetics of Homotypic Cellular Aggregation under Static conditions." Biophysical J., 72 (1997) : 51-64.

     
    Presentations
     Conference Paper
     

    "A Partial-Combustion Pyrolysis Model for an Energy + Biochar Reactor Design." 2014 Annual Meeting of the AIChE, Atlanta, GA. (November 16, 2014) With A. Amiri and C.E. Brewer

     
     

    "Biomass Pyrolysis Reaction Kinetics Using Step-Isothermal Thermogravimetry and TGA/MS." 2014 International Congress on Energy (ICE), Atlanta, GA. (November 19, 2014) With C.E. Brewer

     
     

    "Charcoal's physical properties are key to understanding its environmental behavior." EGU General Assembly 2014, Vienna, Austria. (May 1, 2014) With C. Masiello, C. Brewer, B. Dugan, Z. Liu, H. Gonnermann, C. Davies, P. Panzacchi, X. Gao, and L. Pyle

     
     

    "Thermal Conversion of Biomass: Pyrolysis Reaction Networks for Optimal Reactor Design ." 2014 Annual Meeting of the AIChE, Atlanta, GA. (November 20, 2014) With A. A. Gooding

     
     Invited Papers
     

    Presenter.  "A Parallel Model for Wound Healing in Tissues with Mixed and Segregated Cell Populations." 2002 Annual Meeting of the AIChE, Indianapolis, IN. (November 4, 2002) With J. Feng and P. Markenscoff

     
     

    Co-Author.  "Hybrid Multi-Scale Model Describing the Growth of 3-Dimensional Tissues under Diffusional Limitations." 2002 Annual Meeting of the AIChE, Indianapolis, IN. (November 6, 2002) With G. Cheng and P. Markenscoff

     
     Invited Talks
     

    "Computational Modeling for In Vitro Tissue Cultivation." 2014 Advances in Tissue Engineering, Houston, TX.

     
     

    Presenter.  "Biocomplexity Meets Chemical Engineering: Dynamic Behavior of Cell Populations Growing Under Mass Transport Limitations." Tufts University, Medford, MA. (October 16, 2006)

     
     

    Presenter.  "Dynamics of Heterogeneous Cell Populations Growing Under Mass Transport Limitations." Rutgers University, New Brunswick, NJ. (December 13, 2006)

     
     

    "3-D Tissue Growth Under Transport Limitations." University of California at Los Angeles (UCLA), Chemical Engineering Department, Los Angeles, CA. (May 21, 2004)

     
     

    "Biocomplexity Meets Chemical Engineering: Tissue Growth Under Transport Limitations." National Technical University of Athens, Chemical Engineering Department, Athens, Greece. (June 8, 2004)

     
     

    "Biocomplexity Meets Chemical Engineering: Tissue Growth Under Transport Limitations." University of Patras, Chemical Engineering Department, Patras, Greece. (December 18, 2003)

     
     

    "Challenges and Future Research Directions for Chemical Engineering." National Technical University of Athens, Chemical Engineering Department, Athens, Greece. (June 10, 2004)

     
     

    "Temporal Evolution of Pore Structure in Non-Catalytic Gas-Solid Reactions." 2004 Annual Meeting of the AIChE, Austin, TX. (November 2004)

     
     

    Presenter.  "Clean Air by Design." Chemistry Department, Rice University, Houston, TX. (October 2, 2002)

     
     

    Presenter.  "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Chemical Engineering Department, Tulane University, New Orleans, LA. (March 15, 2002)

     
     Keynote Speaker
     

    Presenter.  "The Potential and Importance of Biomass." Conference on Biomass to Chemicals and Fuels: Science, Technology and Public Policy, James A. Baker III Institute for Public Policy, Houston, TX. (September 25-26, 2006)

     
     Lectures
     

    "Fluorescence Microscopy Based Inverse Cell Population Balance Modeling ." 2006 Annual Meeting of the American Institute of Chemical Engineers, San Francisco, CA. (November 17, 2006) With K. Spetsieris and N. Mantzaris

     
     

    Presenter.  "Mass Transport Dynamics, Cell Population Heterogeneity and Domain Geometry Modulate the Architecture of Regenerating Tissues." 2006 Annual Meeting of the American Institute of Chemical Engineers, San Francisco, CA. (November 16, 2006) With J. Feng and P. A. Markenscoff

     
     

    "Quantifying the Effect of Cell Population Heterogeneity on Proliferation Rates." 2007 Annual Meeting of the American Institute of Chemical Engineers, San Francisco, CA. (November 17, 2006) With R. Vargo

     
     Other
     

    "Cell Migration." 12th Annual Short Course on Advances in Tissue Engineering, Rice University, Houston, TX. (August 11, 2004)

     
     

    "A Computational Model for Tissue Regeneration and Wound Healing." 3rd Chemical Engineering Symposium, Athens, Greece. (June 1, 2001) With B. Ben Youssef and P. Markenscoff.

     
     

    "A Parallel Computational Model for Growth of Tissues with Multiple Cell Types." 2001 Annual Meeting of the American Institute of Chemical Engineers,, Reno, NV. ((November 4-9, 2001)) With Srivatsan Mani and P. Markenscoff..

     
     

    "Computational Advances in Tissue Engineering." Invited Seminar, University of Naples, Department of Chemical Engineering, (May 22, 2001)

     
     

    "Experimental and Computational Approaches to Wound Healing: Tissues with Multiple Cell Types." Invited Seminar, Princeton University, Chemical Engineering Department, Princeton, NJ. (October 24, 2001)

     
     

    "Pathways of Lymphocyte Motility." 2001 Annual Meeting of the American Institute of Chemical Engineers, Reno, NV. (November 4-9, 2001) With A. J. Bergman and S. P. Lennon.

     
     

    "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Invited Seminar, Chemical Engineering Research Institute, Patras, Greece. (June 5, 2001)

     
     

    "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Invited Seminar, Washington University, Department of Chemical Engineering, (March 5, 2001)

     
     

    "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Invited Seminar, University of Bologna, Department of Chemical Engineering , (May 15, 2001)

     
     

    "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Invited Seminar, Campus Biomedico, Department of Biomedical Engineering, Rome, Italy. (May 24, 2001)

     
     

    "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Invited Seminar, Aristotle University of Thessaloniki, Greece, Department of Chemical Engineering, (May 28, 2001)

     
     

    "Tissue Regeneration and Wound Healing: Experimental and Computational Approaches." Invited Seminar, Washington University, Department of Chemical Engineering. (March 5, 2001)

     
     

    "A Stochastic Model for Tissue Growth in Three-Dimensional Scaffolds." HSEMB 18th Annual Conference, Houston, TX. (February 10-11, 2000) With B. Y. Belgacem and P. Markenscoff

     
     

    "A Stochastic Model for Tissue Regeneration and Wound Healing." 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, IL. (July 23-28, 2000) With B. Ben Youssef and P. Markenscoff

     
     

    "Design of Biodegradable Scaffolds for Tissue Engineering: Effects of Pore Structure and Hydration Rates." 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, IL. (July 23-28, 2000) With P. Markenscoff

     
     

    "Migration and Adhesion of Jurkat Cells Cultured in a Rotating Wall Vessel." HSEMB 18th Annual Meeting, Houston, TX. (February 10-11, 2000) With A. J. Bergman

     
     

    "Modeling Tissue Regeneration and Wound Healing Processes." 2000 Annual Meeting of the American Institute of Chemical Engineers, Los Angeles, CA. (November 12-17, 2000) With B. Y. Belgacem and P. Markenscoff

     
     

    "Modeling the Degradation of Scaffolds Used for Tissue Engineering Applications." 1st SIAM Conference on Computational Science and Engineering, Washington, DC. (September 21-24, 2000) With P. Markenscoff

     
     

    "Optimization of Coal Utilization Processes: A Multi-Scale Transient Model for Char Combustion." 2000 Annual Meeting of the American Institute of Chemical Engineers, Los Angeles, CA. (November 12-17, 2000) With Yingwei Cai

     
     

    "Parallel Implementation of a Stochastic Model for Growth of Three-Dimensional Tissues." HSEMB 18th Annual Meeting, Houston, TX. (February 10-11, 2000) With B. Y. Belgacem and P. Markenscoff

     
     

    "Parallel Implementation of a Stochastic Model for Tissue Growth." 1st SIAM Conference on Computational Science and Engineering, Washington, DC. (September 21-24, 2000) With Ben Y. Belgacem and P. Markenscoff

     
     

    "Pore Structure and Hydration Rates Modulate the Erosion Rates and the Release Rates of Bioactive Agents from Degradable Scaffolds." HSEMB 18th Annual Meeting, Houston, TX. (February 10-11, 2000) With P. Markenscoff

     
     

    "A Stochastic Model for Tissue Growth in Three-Dimensional Scaffolds." 1999 Annual Meeting of the American Institute of Chemical Engineers, Dallas, TX. (October 31 ? November 5, 1999) With B.Y. Belgacem and P. Markenscoff

     
     

    "Effects of Low Shear Cell Culture on Lymphocyte Adhesion and Migration." 1999 Annual Meeting of the American Institute of Chemical Engineers, Dallas, TX. (October 31 ? November 5, 1999) With A.J. Bergman

     
     

    "Lymphocyte Migration and Adhesion on Fibronectin-Coated Polystyrene Surfaces." 17th Annual Conference on Biomedical Engineering Research, Houston, TX. (February 11-12, 1999) With A.J. Bergman

     
     

    "Mechanisms and Optimization of Coal Combustion." 1999 University Coal Research Conference, Pittsburgh, PA. (June 1-2, 1999) With Y.W. Cai.

     
     

    "Migration and Adhesion of Lymphocytes Cultured Under Low Shear Conditions." 1999 EMBS/BMES Conference, Atlanta, GA. (October 13-16, 1999) With A.J. Bergman

     
     

    "Migration and Adhesion of Lymphocytes Cultured in a Low-Shear Environment." 17th Annual Conference on Biomedical Engineering Research, Houston, TX. (February 11-12, 1999) With A.J. Bergman

     
     

    "Modeling the Growth of Three-Dimensional Tissues." 1999 EMBS/BMES Conference, Atlanta, GA. (October 13-16, 1999) With B.Y. Belgacem and P. Markenscoff

     
     

    "Parallel Implementation of a Cellular Automaton Modeling the Growth of Three-Dimensional Tissues." 1999 Annual Meeting of the American Institute of Chemical Engineers, Dallas, TX. (October 31 ? November 5, 1999) With B.Y. Belgacem and P. Markenscoff

     
     

    "Pore Structure and Hydration Rates Modulate the Release of Bioactive Agents from Degradable Scaffolds." 1999 EMBS/BMES Conference, Atlanta, GA.. (October 13-16, 1999) With P. Markenscoff

     
     

    "Temporal Evolution of Lymphocyte Migratory Parameters on Fibronectin-Coated Surfaces." 1999 Annual Meeting of the American Institute of Chemical Engineers, Dallas, TX. (October 31 ? November 5, 1999) With A.J. Bergman

     
     

    "Characterization of Lymphocyte Motility Using the Persistent Random Walk Model." 16th Annual HSEMB Conference on Biomedical Engineering Research, Houston, TX. (April 2-3, 1998) With A. Bergman

     
     

    "Degradation of Bioerodible Scaffolds: Effects of Porosity and Phase Heterogeneity." 16th Annual HSEMB Conference on Biomedical Engineering Research, Houston, TX. (April 2-3, 1998) With P. Markenscoff

     
     

    "Lymphocyte Motility and Adhesion Mediated Through the beta-1 Integrin." 1998 Annual Meeting of the American Institute of Chemical Engineers, Miami Beach, FL. (November 15-20, 1998) With A. Bergman

     
     

    "Migration of Lymphocytes on Fibronectin-coated Surfaces." 1998 Annual Fall Meeting, Biomedical Engineering Society, Cleveland, OH. (October 10-13, 1998) With A. Bergman

     
     

    "The Effects of Structural Parameters on the Degradation of Bioerodible Scaffolds." 1998 Annual Fall Meeting, Biomedical Engineering Society, Cleveland, OH. (October 10-13, 1998) With P. Markenscoff

     
     

    "Cellular Automata Models for Two Dimensional Tissues." 1997 Annual Meeting of the AIChE, Los Angeles, CA. (November 16-21, 1997) With A. Ambani and P. Markenscoff

     
     

    "Computer-Aided Design of Bioerodible Devices: Diffusion Controlled Release." 1997 Annual Meeting of the AIChE, Los Angeles, CA. (November 16-21, 1997) With P. Markenscoff

     
     

    "Modeling the Migration and Proliferation of Endothelial Cells with Changing Shape and Size." 1997 Annual Fall Meeting of the Biomedical Engrg. Society, San Diego, CA. (October 2-5, 1997) With A. Ambani and P. Markenscoff

     
     

    "Radiation Effects on Endothelial Cell Migration and Morphology." 1997 Annual Meeting of the AIChE, Los Angeles, CA. (November 16-21, 1997) With S. Kouvroukoglou, M. Wong, A. Gurlek and G.R.D. Evans

     
     

    "Spreading and Migration of Irradiated Endothelial Cells." 1997 Annual Fall Meeting of the Biomedical Engrg. Society, San Diego, CA. (October 2-5, 1997) With S. Kouvroukoglou, M. Wong, A. Gurlek and G.R.D. Evans

     
     

    "Surface Modification with Adhesive Peptides: Spatial Distribution of Peptides and Effects on Cell Migration." 1997 Annual Meeting of the AIChE, Los Angeles, CA. (November 16-21, 1997) With S. Kouvroukoglou, K.C. Dee, R. Bizios, J.L. West and L.V. McIntire

     
     Posters
     

    "A Hybrid Three-Dimensional Model for Early Tumor Invasion." 2004 AIChE Annual Meeting, Austin, TX. (November 2004) With G. Cheng, and P. Markenscoff

     
     

    "A Hybrid Three-Dimensional Model for Tissue Growth in a Perfusion System." 2004 AIChE Annual Meeting, Austin, TX. (November 2004) With G. Cheng and P. Markenscoff

     
     

    "Computing White Blood Cell Deformation in Shear Flow." 2004 AIChE Annual Meeting, Austin, TX. (November 2004) With X. Xie and M. Pasquali

     
     

    "Experimental and Theoretical Study on the Evolution of CdSe Nanoparticle Size Distributions." 2004 AIChE Annual Meeting, Austin, TX. (November 2004) With Z. Mu, S. Asokan, K. Ausman, V. Colvin, M.S. Wong and N. Mantzaris

     
     Seminar Speaker
     

    "Modeling Nutrient Transport in Soils Amended with Biochar." National Technical University, Athens, Greece. (December 9, 2014)

     
    Supervised Theses & Dissertations
     Xueying Xie, PhD Modeling Viscoelastic Free Surface and Interfacial Flows, with Applications to the Deformation of Droplets and Blood Cells. (2006) (Co-Director)

     Lucas A Kinard, PhD Synthetic Hydrogel Delivery of Growth Factors and Demineralized Bone Matrix for Bone Augmentation. (2014) (Committee Member)

     Rebecca L. Dahlin, Ph.D. Co-Cultures of Articular Chondrocytes and Mesenchymal Stem Cells for Cartilage Tissue Engineering. (2014) (Committee Member)

     Julia Vidonish, Ph.D. Pyrolytic Remediation of Soil Contaminated with Heavy Hydrocarbons. (2017) (Co-Director)

    Awards, Prizes, & Fellowships
     A.J. Hartsook Chair, Rice University (2001)

     Fellow, American Institute of Biological and Medical Engineers (AIMBE) (2012)

     Invited Keynote Speaker, North American Society for Chemical Reaction Engineering (NASCRE) (February 7, 2007)

     Member, Texas Council on Environmental Technology , (2001 ? present)

     Organizer and Chair of Symposium on "Applied Mathematics in Bioengineering", Annual Meeting of the American Institute of Chemical Engineers,Reno, NV (November 4-9, 2001)

     Member, Multipollutant and Long Term Strategies Subcommittee , Regional Air Quality Planning Committee, Houston-Galveston Area Council (2000 ? present)

     Session Chair, "Mathematical Modeling in Tissue Engineering", Session TU-A318 Track 08, 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, IL, July 25, 2000, Biomedical Engineering Society

     Session Organizer and Chair, "Applied Mathematics in Bioengineering", Session 271, 2000 Annual Meeting of the American Institute of Chemical Engineers, Los Angeles, CA, November 15, 2000, American Institute of Chemical Engineers

     Session Organizer and Chair, "Applied Mathematics in Bioengineering I", 1999 Annual Meeting, American Institute of Chemical Engineers (October 31 - November 5, 1999)

     Session Organizer and Chair, "Applied Mathematics in Bioengineering II", 1999 Annual Meeting, American Institute of Chemical Engineers (October 31 - November 5, 1999)

     Session Organizer and Chair, "Stochastic Processes", 1999 Annual Meeting, American Institute of Chemical Engineers (October 31 - November 5, 1999)

    Positions Held
     Member, Texas Council on Environmental Technology. (2001 - 2005)

     Member of Advisory Committee, Foundation of Research and Technology - Hellas. (2006 - 2006)

     Member, Texas Council of Environmental Technology. (2003 - 2003)

     Member, Texas Council of Environmental Technology (TCET). (2002 - 2002)