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Han Xiao
Assistant Professor
Norman Hackerman-Welch Young Investigator
 
e-mail:Han.Xiao@rice.edu
 
  • Ph.D. Chemistry (2015) The Scripps Research Institute, La Jolla, CA
  • B.S. Chemistry (2010) University of Science and Technology of China, Hefei, China
 
Primary Department
   Department of Chemistry
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Department Affiliations
 
  • Department of BioSciences
  • Department of Bioengineering
  • Department of Chemistry
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    Websites
     Xiao Lab
     
    Research Areas
     Chemical Biology, Organic Chemistry, Bioorthogonal Chemistry
     
    Teaching Areas
     Chemical Biology
     
    Selected Publications
     Refereed articles
     

    Cao, Yu; Rodgers, David T; Du, Juanjuan; Ahmad, Insha; Hampton, Eric N; Ma, Jennifer SY; Mazagova, Magdalena; Choi, Sei-hyun; Yun, Hwa Young; Xiao, Han; "Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer." Angewandte Chemie, 128 (2016) : 7646-7650.

     
     

    Liu, Tao; Wang, Yan; Luo, Xiaozhou; Li, Jack; Reed, Sean A; Xiao, Han; Young, Travis S; Schultz, Peter G; "Enhancing protein stability with extended disulfide bonds." Proceedings of the National Academy of Sciences (2016) : 201605363.

     
     

    Xiao, Han; Schultz, Peter G; "At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code." Cold Spring Harbor Perspectives in Biology, 8 (2016) : a023945.

     
     

    Xiao, Han; Woods, Elliot C; Vukojicic, Petar; Bertozzi, Carolyn R; "Precision glycocalyx editing as a strategy for cancer immunotherapy." Proceedings of the National Academy of Sciences (2016) : 201608069.

     
     

    Xiao, Han; Nasertorabi, Fariborz; Choi, Sei-hyun; Han, Gye Won; Reed, Sean A; Stevens, Raymond C; Schultz, Peter G; "Exploring the potential impact of an expanded genetic code on protein function." Proceedings of the National Academy of Sciences, 112 (2015) : 6961-6966.

     
     

    Xiao, Han; Xuan, Weimin; Shao, Sida; Liu, Tao; Schultz, Peter G; "Genetic incorporation of e-N-2-hydroxyisobutyryl-lysine into recombinant histones." ACS chemical biology, 10 (2015) : 1599-1603.

     
     

    Xiao, Han; Xuan, Weimin; Shao, Sida; Liu, Tao; Schultz, Peter G; "Genetic incorporation of e-N-2-hydroxyisobutyryl-lysine into recombinant histones." ACS chemical biology, 10 (2015) : 1599-1603.

     
     

    Chatterjee, Abhishek; Lajoie, Marc J; Xiao, Han; Church, George M; Schultz, Peter G; "A Bacterial Strain with a Unique Quadruplet Codon Specifying Non-native Amino Acids." ChemBioChem, 15 (2014) : 1782-1786.

     
     

    Xiao, Han; Peters, Francis B; Yang, Peng-Yu; Reed, Sean; Chittuluru, Johnathan R; Schultz, Peter G; "Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase." ACS chemical biology, 9 (2014) : 1092-1096.

     
     

    Xiao, Han; Peters, Francis B; Yang, Peng-Yu; Reed, Sean; Chittuluru, Johnathan R; Schultz, Peter G; "Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase." ACS chemical biology, 9 (2014) : 1092-1096.

     
     

    Chatterjee, Abhishek; Sun, Sophie B; Furman, Jennifer L; Xiao, Han; Schultz, Peter G; "A versatile platform for single-and multiple-unnatural amino acid mutagenesis in Escherichia coli." Biochemistry, 52 (2013) : 1828-1837.

     
     

    Chatterjee, Abhishek; Xiao, Han; Bollong, Michael; Ai, Hui-Wang; Schultz, Peter G; "Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells." Proceedings of the National Academy of Sciences, 110 (2013) : 11803-11808.

     
     

    Chatterjee, Abhishek; Xiao, Han; Bollong, Michael; Ai, Hui-Wang; Schultz, Peter G; "Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells." Proceedings of the National Academy of Sciences, 110 (2013) : 11803-11808.

     
     

    Chatterjee, Abhishek; Xiao, Han; Yang, Peng-Yu; Soundararajan, Gautam; Schultz, Peter G; "A Tryptophanyl-tRNA Synthetase/tRNA Pair for Unnatural Amino Acid Mutagenesis in E. coli." Angewandte Chemie International Edition, 52 (2013) : 5106-5109.

     
     

    Mei, T-S; Leow, D; Xiao, H; Laforteza, BN; Yu, J-Q; "Pd (II)-Catalyzed C–H Activation Route to Indolines." Synfacts, 9 (2013) : 1163-1163.

     
     

    Mei, Tian-Sheng; Leow, Dasheng; Xiao, Han; Laforteza, Brian N; Yu, Jin-Quan; "Synthesis of Indolines via Pd (II)-Catalyzed Amination of C–H Bonds Using PhI (OAc) 2 as the Bystanding Oxidant." Organic letters, 15 (2013) : 3058-3061.

     
     

    Xiao, Han; Chatterjee, Abhishek; Choi, Sei-hyun; Bajjuri, Krishna M; Sinha, Subhash C; Schultz, Peter G; "Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells." Angewandte Chemie International Edition, 52 (2013) : 14080-14083.

     
     

    Xiao, Han; Chatterjee, Abhishek; Choi, Sei-hyun; Bajjuri, Krishna M; Sinha, Subhash C; Schultz, Peter G; "Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells." Angewandte Chemie International Edition, 52 (2013) : 14080-14083.

     
     

    Xiao, Han; Chatterjee, Abhishek; Choi, Sei-hyun; Bajjuri, Krishna M; Sinha, Subhash C; Schultz, Peter G; "Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells." Angewandte Chemie International Edition, 52 (2013) : 14080-14083.

     
     

    Chatterjee, Abhishek; Xiao, Han; Schultz, Peter G; "Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli." Proceedings of the National Academy of Sciences, 109 (2012) : 14841-14846.

     
     

    Han, Zhi-Yong; Guo, Rui; Wang, Pu-Sheng; Chen, Dian-Feng; Xiao, Han; Gong, Liu-Zhu; "Enantioselective concomitant creation of vicinal quaternary stereogenic centers via cyclization of alkynols triggered addition of azlactones." Tetrahedron Letters, 52 (2011) : 5963-5967.

     
     

    Chen, Xiao-Hua; Wei, Qiang; Luo, Shi-Wei; Xiao, Han; Gong, Liu-Zhu; "Organocatalytic synthesis of spiro [pyrrolidin-3, 3'-oxindoles] with high enantiopurity and structural diversity." Journal of the American Chemical Society, 131 (2009) : 13819-13825.

     
     

    Chen, Xiao-Hua; Wei, Qiang; Luo, Shi-Wei; Xiao, Han; Gong, Liu-Zhu; "Organocatalytic synthesis of spiro [pyrrolidin-3, 3'-oxindoles] with high enantiopurity and structural diversity." Journal of the American Chemical Society, 131 (2009) : 13819-13825.

     
     

    Han, Zhi-Yong; Xiao, Han; Chen, Xiao-Hua; Gong, Liu-Zhu; "Consecutive intramolecular hydroamination/asymmetric transfer hydrogenation under relay catalysis of an achiral gold complex/chiral brønsted acid binary system." Journal of the American Chemical Society, 131 (2009) : 9182-9183.

     
     

    Han, Zhi-Yong; Xiao, Han; Gong, Liu-Zhu; "Dynamic kinetic asymmetric transfer hydrogenation of racemic 2, 4-diaryl-2, 3-dihydrobenzo [b][1, 4] diazepines catalyzed by chiral phosphoric acids." Bioorganic & medicinal chemistry letters, 19 (2009) : 3729-3732.

     
    Presentations
     Invited Talks
     

    "

    Precision Glycocalyx Editing for Cancer Immunotherapy

    ." Department of Bioengineering, Rice University, (09/12/2017)

     
     

    "

    Precision Glycocalyx Editing for Cancer Immunotherapy

    ." Baylor College of Medicine, Department of Pharmacology & Chemical Biology, (08/08/2017)

     
     

    "Precision Glycocalyx Editing as a Strategy for Cancer Immunotherapy." University of Science and Technology of China, Department of Biology, (04/13/2017)

     
     

    "Precision Glycocalyx Editing as a Strategy for Cancer Immunotherapy." Tsinghua University, Department of Chemistry, (03/31/2017)

     
     

    "Precision Glycocalyx Editing as a Strategy for Cancer Immunotherapy." Smalley-Curl Institute, Rice University, (09/27/2017)

     
     

    "Precision Glycocalyx Editing as a Strategy for Cancer Immunotherapy." Wuhan University, Department of Biology, (04/16/2017)

     
     

    "Precision Glycocalyx Editing for Cancer Immunotherapy." Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, (04/11/2017)

     
    Awards, Prizes, & Fellowships
     Norman Hackerman - Welch Young Investigator, Welch Foundation (2017)

     CPRIT Faculty Recruitment Award, Cancer Prevention & Research Institute of Texas (2017)